Fusarium Literature – Liver



Renner L, Kahlert S, Tesch T, Bannert E, Frahm J, Barta-Böszörményi A, Kluess J, Kersten S, Schönfeld P, Rothkötter HJ, Dänicke S. Chronic DON exposure and acute LPS challenge: effects on porcine liver morphology and function. Mycotoxin Res. 2017 Aug;33(3):207-218. PMID: 28474303

Mary VS, Arias SL, Otaiza SN, Velez PA, Rubinstein HR, Theumer MG. The aflatoxin B1 -fumonisin B1 toxicity in BRL-3A hepatocytes is associated to induction of cytochrome P450 activity and arachidonic acid metabolism. Environ Toxicol. 2017 Jun;32(6):1711-1724. PMID: 28181396

Poór M, Kunsági-Máté S, Bálint M, Hetényi C, Gerner Z, Lemli B. Interaction of mycotoxin zearalenone with human serum albumin. J Photochem Photobiol B. 2017 May;170:16-24. PMID: 28365492

Zhou H, George S, Hay C, Lee J, Qian H, Sun X. Individual and combined effects of Aflatoxin B1, Deoxynivalenol and Zearalenone on HepG2 and RAW 264.7 cell lines. Food Chem Toxicol. 2017 May;103:18-27. PMID: 28223122

Peng Z, Chen L, Nüssler AK, Liu L, Yang W. Current sights for mechanisms of deoxynivalenol-induced hepatotoxicity and prospective views for future scientific research: A mini review. J Appl Toxicol. 2017 May;37(5):518-529. PMID: 27996102

Wang X, Wang Y, Wang Y, Sun L, Gooneratne R. Preparation of T-2-glucoronide with Rat Hepatic Microsomes and Its Use along with T-2 for Activation of the JAK/STAT Signaling Pathway in RAW264.7 Cells. J Agric Food Chem. 2017 Jun 14;65(23):4811-4818. PMID: 28556663

Qian G, Tang L, Lin S, Xue KS, Mitchell NJ, Su J, Gelderblom WC, Riley RT, Phillips TD, Wang JS. Sequential dietary exposure to aflatoxin B1 and fumonisin B1 in F344 rats increases liver preneoplastic changes indicative of a synergistic interaction. Food Chem Toxicol. 2016 Sep;95:188-95. PMID: 27430420

Szabó A, Szabó-Fodor J, Fébel H, Mézes M, Repa I, Kovács M. Acute hepatic effects of low-dose fumonisin B(1) in rats. Acta Vet Hung. 2016 Dec;64(4):436-448. PMID: 27993098

Sheik Abdul N, Nagiah S, Chuturgoon AA. Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells. Toxicon. 2016 Sep 1;119:336-44. PMID: 27390038

Ye W, Chen Y, Li H, Zhang W, Liu H, Sun Z, Liu T, Li S. Two Trichothecene Mycotoxins from Myrothecium roridum Induce Apoptosis of HepG-2 Cells via Caspase Activation and Disruption of Mitochondrial Membrane Potential. Molecules. 2016 Jun 17;21(6). PMID: 27322225

Mishra G, Ananth V, Shelke K, Sehgal D, Deepak J. Classification of anti hepatitis peptides using Support Vector Machine with hybrid Ant Colony OptimizationThe Luxembourg database of trichothecene type B F. graminearum and F. culmorum producers. Bioinformation. 2016 Jan 31;12(1):12-4. PMID: 27212838

Yoshioka M, Takenouchi T, Kitani H, Okada H, Yamanaka N. Establishment of SV40 large T antigen-immortalized bovine liver sinusoidal cell lines and their immunological responses to deoxynivalenol and lipopolysaccharide. Cell Biol Int. 2016 Dec;40(12):1372-1379. PMID: 27624824

Yang L, Yu Z, Hou J, Deng Y, Zhou Z, Zhao Z, Cui J. Toxicity and oxidative stress induced by T-2 toxin and HT-2 toxin in broilers and broiler hepatocytes. Food Chem Toxicol. 2016 Jan;87:128-37. PMID: 26683309

Bae EY, Lee SW, Seong S, Cho W, Ahn JS, Cho HS. Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells. Molecules. 2015 May 19;20(5):8988-96. PMID: 25996208

Jebali A, Yasini Ardakani SA, Shahdadi H, Balal Zadeh MH, Hekmatimoghaddam S. Modification of nanocellulose by poly-lysine can inhibit the effect of fumonisin B1 on mouse liver cells. Colloids Surf B Biointerfaces. 2015 Feb 1;126:437-43. PMID: 25601749

Zhou C, Zhang Y, Yin S, Jia Z, Shan A. Biochemical changes and oxidative stress induced by zearalenone in the liver of pregnant rats. Hum Exp Toxicol. 2015 Jan;34(1):65-73. PMID: 24717317

Juan-García A, Ruiz MJ, Font G, Manyes L. Enniatin A1, enniatin B1 and beauvericin on HepG2: Evaluation of toxic effects. Food Chem Toxicol. 2015 Oct;84:188-96. PMID: 26342765

Sun LH, Lei MY, Zhang NY, Gao X, Li C, Krumm CS, Qi DS. Individual and combined cytotoxic effects of aflatoxin B1, zearalenone, deoxynivalenol and fumonisin B1 on BRL 3A rat liver cells. Toxicon. 2015 Mar;95:6-12. PMID: 25549941

Nadjia B, Fatima LD. Beneficial effects of Androctonus australis hector venom and its non-toxic fraction in the restoration of early hepatocyte-carcinogenesis induced by FB1 mycotoxin: Involvement of oxidative biomarkers. Exp Mol Pathol. 2015 Oct;99(2):198-206. PMID: 26142225

Manafi M, Pirany N, Noor Ali M, Hedayati M, Khalaji S, Yari M. Experimental pathology of T-2 toxicosis and mycoplasma infection on performance and hepatic functions of broiler chickens. Poult Sci. 2015 Jul;94(7):1483-92. PMID: 25910901

Kinoshita A, Keese C, Beineke A, Meyer U, Starke A, Sauerwein H, Dänicke S, Rehage J. Effects of Fusarium mycotoxins in rations with different concentrate proportions on serum haptoglobin and hepatocellular integrity in lactating dairy cows. J Anim Physiol Anim Nutr (Berl). 2015 Oct;99(5):887-92. PMID: 25845993

Chuturgoon AA, Phulukdaree A, Moodley D. Fumonisin B₁ inhibits apoptosis in HepG2 cells by inducing Birc-8/ILP-2. Toxicol Lett. 2015 Jun 1;235(2):67-74. PMID: 25800559

Juan-García A, Juan C, König S, Ruiz MJ. Cytotoxic effects and degradation products of three mycotoxins: alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in liver hepatocellular carcinoma cells. Toxicol Lett. 2015 May 19;235(1):8-16. PMID: 25772259

Sun LH, Lei MY, Zhang NY, Zhao L, Krumm CS, Qi DS. Hepatotoxic effects of mycotoxin combinations in mice. Food Chem Toxicol. 2014 Dec;74:289-93. PMID: 25445755

Chuturgoon AA, Phulukdaree A, Moodley D. Fumonisin B₁ modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b. Toxicol Lett. 2014 May 16;227(1):50-5. PMID: 24614526

Pietsch C, Schulz C, Rovira P, Kloas W, Burkhardt-Holm P. Organ damage and hepatic lipid accumulation in carp (Cyprinus carpio L.) after feed-borne exposure to the mycotoxin, deoxynivalenol (DON). Toxins (Basel). 2014 Feb 21;6(2):756-78. PMID: 24566729

Chuturgoon A, Phulukdaree A, Moodley D. Fumonisin B1 induces global DNA hypomethylation in HepG2 cells – An alternative mechanism of action. Toxicology. 2014 Jan 6;315:65-9. PMID: 24280379

Kang C, Lee H, Yoo YS, Hah DY, Kim CH, Kim E, Kim JS. Evaluation of Oxidative DNA Damage Using an Alkaline Single Cell Gel Electrophoresis (SCGE) Comet Assay, and the Protective Effects of N-Acetylcysteine Amide on Zearalenone-induced Cytotoxicity in Chang Liver Cells. Toxicol Res. 2013 Mar;29(1):43-52. PMID: 24278628

Goossens J., De Bock L., Osselaere A., et al. The mycotoxin T-2 inhibits hepatic cytochrome P4503A activity in pigs. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013;57:54–56.

Gazzah Amel Chatti C., Camoin Luc, Abid Salwa, Bouaziz Chayma, Ladjimi Moncef, Bacha Hassen. Identification of proteins related to early changes observed in Human hepatocellular carcinoma cells after treatment with the mycotoxin Zearalenone. Experimental and toxicologic pathology. 2013;65:809–816.

Maul Ronald, Warth Benedikt, Kant Jill-Sandra S., et al. Investigation of the hepatic glucuronidation pattern of the Fusarium mycotoxin deoxynivalenol in various species. Chemical research in toxicology. 2012;25:2715–2717.

Welsch Tanja, Humpf Hans-Ulrich U.. HT-2 Toxin 4-Glucuronide as New T-2 Toxin Metabolite: Enzymatic Synthesis, Analysis, and Species Specific Formation of T-2 and HT-2 Toxin Glucuronides by Rat, Mouse, Pig, and Human Liver Microsomes. Journal of agricultural and food chemistry. 2012.

Wang Jianshe, Jiang Jun, Zhang Hongxia, et al. Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes. Molecular & cellular proteomics : MCP. 2011;10.

Wu Qinghua, Huang Lingli, Liu Zhaoying, et al. A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp. Xenobiotica; the fate of foreign compounds in biological systems. 2011;41:863–873.

Casteel Maximilian, Nielsen Carina, Kothlow Sonja, Dietrich Richard, Märtlbauer Erwin. Impact of DUSP1 on the apoptotic potential of deoxynivalenol in the epithelial cell line HepG2. Toxicology letters. 2010;199:43–50.

Sahu Saura C., O’Donnell Michael W., Wiesenfeld Paddy L.. Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture. Journal of applied toxicology : JAT. 2010;30:566–573.

He Cheng-Hua H., Fan Yan-Hong H., Wang Ying, Huang Chao-Ying Y., Wang Xi-Chun C., Zhang Hai-Bin B.. The individual and combined effects of deoxynivalenol and aflatoxin b(1) on primary hepatocytes of cyprinus carpio. International journal of molecular sciences. 2010;11:3760–3768.

Döll Susanne, Schrickx Jan A., Dänicke Sven, Fink-Gremmels Johanna. Interactions of deoxynivalenol and lipopolysaccharides on cytokine excretion and mRNA expression in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures. Toxicology letters. 2009;190:96–105.

Döll Susanne, Schrickx Jan A., Valenta Hana, Dänicke Sven, Fink-Gremmels Johanna. Interactions of deoxynivalenol and lipopolysaccharides on cytotoxicity protein synthesis and metabolism of DON in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures. Toxicology letters. 2009;189:121–129.

Vasatkova Anna, Krizova Sarka, Adam Vojtech, Zeman Ladislav, Kizek Rene. Changes in metallothionein level in rat hepatic tissue after administration of natural mouldy wheat. International journal of molecular sciences. 2009;10:1138–1160.

Nielsen Carina, Lippke Harald, Didier Andrea, Dietrich Richard, Märtlbauer Erwin. Potential of deoxynivalenol to induce transcription factors in human hepatoma cells. Molecular nutrition & food research. 2009;53:479–491.

Dänicke Sven, Beineke Andreas, Goyarts Tanja, Valenta Hana, Beyer Marita, Humpf Hans-Ulrich U.. Effects of a Fusarium toxin-contaminated triticale, either untreated or treated with sodium metabisulphite (Na2S2O5, SBS), on weaned piglets with a special focus on liver function as determined by the 13C-methacetin breath test. Archives of animal nutrition. 2008;62:263–286.

Sahu Saura C., Garthoff Larry H., Robl Martin G., et al. Rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products: hepatotoxicity of deoxynivalenol. Journal of applied toxicology : JAT. 2008;28:765–772.

Bouaziz Chayma, Sharaf El Dein Ossama, El Golli Emna, et al. Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells. Toxicology. 2008;254:19–28.

Königs Maika, Schwerdt Gerald, Gekle Michael, Humpf Hans-Ulrich U.. Effects of the mycotoxin deoxynivalenol on human primary hepatocytes. Molecular nutrition & food research. 2008;52:830–839.

Moon Yuseok, Kim Hyoung-Kab K., Suh Hyunho, Chung Duk-Hwa H.. Toxic alterations in chick embryonic liver and spleen by acute exposure to Fusarium-producing mycotoxin deoxynivalenol. Biological & pharmaceutical bulletin. 2007;30:1808–1812.

Gouze M. E., Laffitte J., Rouimi P., Loiseau N., Oswald I. P., Galtier P.. Effect of various doses of deoxynivalenol on liver xenobiotic metabolizing enzymes in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2006;44:476–483.

Mikami Osamu, Yamamoto Sachiko, Yamanaka Noriko, Nakajima Yasuyuki. Porcine hepatocyte apoptosis and reduction of albumin secretion induced by deoxynivalenol. Toxicology. 2004;204:241–249.

Atroshi F., Rizzo A., Sankari S., Biese I., Westermarck T., Veijalainen P.. Liver enzyme activities of rats exposed to ochratoxin A and T-2 toxin with antioxidants. Bulletin of environmental contamination and toxicology. 2000;64:586–592.

Guerre P., Eeckhoutte C., Burgat V., Galtier P.. The effects of T-2 toxin exposure on liver drug metabolizing enzymes in rabbit. Food additives and contaminants. 2000;17:1019–1026.

Norred W. P., Plattner R. D., Dombrink-Kurtzman M. A., Meredith F. I., Riley R. T.. Mycotoxin-induced elevation of free sphingoid bases in precision-cut rat liver slices: specificity of the response and structure-activity relationships. Toxicology and applied pharmacology. 1997;147:63–70.

Knasmüller S., Bresgen N., Kassie F., et al. Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes. Mutation research. 1997;391:39–48.

Yabe T., Hashimoto H., Sekijima M., et al. Effects of nivalenol on hepatic drug-metabolizing activity in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1993;31:573–581.

Ueno Y., Yabe T., Hashimoto H., et al. Enhancement of GST-P-positive liver cell foci development by nivalenol, a trichothecene mycotoxin. Carcinogenesis. 1992;13:787–791.

Naseem S. M., Mereish K. A., Solow R., Hines H. B.. Microcystin-induced activation of prostaglandin synthesis and phospholipid metabolism in rat hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 1991;5:341–345.

Suneja S. K., Wagle D. S., Ram G. C.. Effect of oral administration of T-2 toxin on glutathione shuttle enzymes, microsomal reductases and lipid peroxidation in rat liver. Toxicon. 1989;27:995–1001.

Coddington K. A., Swanson S. P., Hassan A. S., Buck W. B.. Enterohepatic circulation of T-2 toxin metabolites in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1989;17:600–605.

Pace J. G., Watts M. R.. Hepatic subcellular distribution of [3H]T-2 toxin. Toxicon. 1989;27:1307–1311.

Suneja S. K., Wagle D. S., Ram G. C.. T-2 toxin induced changes in liver and serum enzymes of rats. Toxicon. 1987;25:793–796.

Suneja S. K., Wagle D. S., Ram G. C.. Liver lipid metabolism in T-2 toxicosis. I. Effects of a single dose feeding of T-2 toxin to rats. Archives of toxicology. 1987;60:382–387.

Côté L. M., Buck W., Jeffery E.. Lack of hepatic microsomal metabolism of deoxynivalenol and its metabolite, DOM-1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1987;25:291–295.

Suneja S. K., Wagle D. S., Ram G. C.. Effects of T-2 toxin gavage on the synthesis and contents of rat-liver macromolecules. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1987;25:387–392.

Knupp C. A., Swanson S. P., Buck W. B.. Comparative in vitro metabolism of T-2 toxin by hepatic microsomes prepared from phenobarbital-induced or control rats, mice, rabbits and chickens. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1987;25:859–865.

Ahmed N., Ram G. C.. Nuclear lipid peroxidation induced in rat liver by T-2 mycotoxin. Toxicon. 1986;24:947–949.

Gareis M., Hashem A., Bauer J., Gedek B.. Identification of glucuronide metabolites of T-2 toxin and diacetoxyscirpenol in the bile of isolated perfused rat liver. Toxicology and applied pharmacology. 1986;84:168–172.

Trusal L. R., O’Brien J. C.. Ultrastructural effects of T-2 mycotoxin on rat hepatocytes in vitro. Toxicon. 1986;24:481–488.

Johnsen H., Odden E., Lie O., Johnsen B. A., Fonnum F.. Metabolism of T-2 toxin by rat liver carboxylesterase. Biochemical pharmacology. 1986;35:1469–1473.

Kranauskas A. E., Kravchenko L. V., Kon’ Ia I. a., Tutel’ian V. A.. [Activity of enzymes of xenobiotic metabolism in the liver of rats with vitamin A deficiency and mycotoxicosis T-2]. Voprosy medit͡sinskoĭ khimii. 1986;32:130–134.

Pace J. G.. Metabolism and clearance of T-2 mycotoxin in perfused rat livers. Fundamental and applied toxicology. 1986;7:424–433.

Kravchenko L. V., Khvylia S. I., Levitskaia A. B.. [Hepatocyte ultrastructure in mice with chronic T-2 mycotoxicosis]. Biulleten’ eksperimental’noĭ biologii i meditsiny. 1986;102:482–485.

Bradlaw J. A., Swentzel K. C., Alterman E., Hauswirth J. W.. Evaluation of purified 4-deoxynivalenol (vomitoxin) for unscheduled DNA synthesis in the primary rat hepatocyte-DNA repair assay. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1985;23:1063–1067.

Yoshizawa T., Sakamoto T., Okamoto K.. In vitro formation of 3’-hydroxy T-2 and 3’-hydroxy HT-2 toxins from T-2 toxin by liver homogenates from mice and monkeys. Applied and environmental microbiology. 1984;47:130–134.

Suneja S. K., Ram G. C., Wagle D. S.. Effect of T-2 toxin administration to rats on lipid metabolism in liver. Toxicology letters. 1984;22:113–118.

Tsuchida M., Miura T., Shimizu T., Aibara K.. Elevation of thiobarbituric acid values in the rat liver intoxicated by T-2 toxin. Biochemical medicine. 1984;31:147–166.

Farnworth E. R., Hamilton R. M., Thompson B. K., Trenholm H. L.. Liver lipid levels in White Leghorn hens fed diets that contained wheat contaminated by deoxynivalenol (vomitoxin). Poultry science. 1983;62:832–836.

Kravchenko L. V., Avren’eva L. I., Tutel’ian V. A.. [Lowering the content of SH-glutathione and glutathione transferase activity in the liver as a factor in increasing the toxicity of T-2 toxin]. Voprosy medit͡sinskoĭ khimii. 1983;29:135–137.

Morel-Chany E., Lafarge-Frayssinet C., Trincal G.. Cytotoxic and cytostatic effect of T2-toxin on epithelial cell lines derived from rat liver. Toxicological European research. Recherche européenne en toxicologie. 1981;3:125–129.