Fusarium Literature – Interactions




Tesch T, Bannert E, Kluess J, Frahm J, Hüther L, Kersten S, Breves G, Renner L, Kahlert S, Rothkötter HJ, Dänicke S. Relationships between body temperatures and inflammation indicators under physiological and pathophysiological conditions in pigs exposed to systemic lipopolysaccharide and dietary deoxynivalenol. J Anim Physiol Anim Nutr (Berl). 2017 Mar 6. PMID: 28262996

Dänicke S, Valenta H, Ganter M, Brosig B, Kersten S, Diesing AK, Kahlert S, Panther P, Kluess J, Rothkötter HJ. Lipopolysaccharides (LPS) modulate the metabolism of deoxynivalenol (DON) in the pig. Mycotoxin Res. 2014 Aug;30(3):161-70. PMID: 24948114

Obremski K. The effect of in vivo exposure to zearalenone on cytokine secretion by Th1 and Th2 lymphocytes in porcine Peyer’s patches after in vitro stimulation with LPS. Pol J Vet Sci. 2014;17(4):625-32. PMID: 25638976

Dänicke Sven, Brosig Bianca, Kersten Susanne, et al. The Fusarium toxin deoxynivalenol (DON) modulates the LPS induced acute phase reaction in pigs. Toxicology letters. 2013;220:172–180.

Kullik K., Brosig B., Kersten S., et al. Interactions between the Fusarium toxin deoxynivalenol and lipopolysaccharides on the in vivo protein synthesis of acute phase proteins, cytokines and metabolic activity of peripheral blood mononuclear cells in pigs. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013;57:11–20.

Stanek Cassandra, Reinhardt Nicole, Diesing Anne-Kathrin K., et al. A chronic oral exposure of pigs with deoxynivalenol partially prevents the acute effects of lipopolysaccharides on hepatic histopathology and blood clinical chemistry. Toxicology letters. 2012;215:193–200.

Halawa Amal, Dänicke Sven, Kersten Susanne, Breves Gerhard. Effects of deoxynivalenol and lipopolysaccharide on electrophysiological parameters in growing pigs. Mycotoxin research. 2012;28:243–252.

Dänicke Sven, Brosig Bianca, Kahlert Stefan, et al. The plasma clearance of the Fusarium toxin deoxynivalenol (DON) is decreased in endotoxemic pigs. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012;50:4405–4411.

Islam Zahidul, Pestka James J.. LPS priming potentiates and prolongs proinflammatory cytokine response to the trichothecene deoxynivalenol in the mouse. Toxicology and applied pharmacology. 2006;211:53–63.

Islam Zahidul, King Louis E., Fraker Pamela J., Pestka James J.. Differential induction of glucocorticoid-dependent apoptosis in murine lymphoid subpopulations in vivo following coexposure to lipopolysaccharide and vomitoxin (deoxynivalenol). Toxicology and applied pharmacology. 2003;187:69–79.

Islam Zahidul, Pestka James J.. Role of IL-1(beta) in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2003;74:93–102.

Zhou H. R., Harkema J. R., Hotchkiss J. A., Yan D., Roth R. A., Pestka J. J.. Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs. Toxicological sciences : an official journal of the Society of Toxicology. 2000;53:253–263.

Zhou H. R., Harkema J. R., Yan D., Pestka J. J.. Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol). Journal of toxicology and environmental health. Part A. 1999;57:115–136.

Taylor M. J., Lafarge-Frayssinet C., Luster M. I., Frayssinet C.. Increased endotoxin sensitivity following T-2 toxin treatment is associated with increased absorption of endotoxin. Toxicology and applied pharmacology. 1991;109:51–59.



Alassane-Kpembi I, Schatzmayr G, Taranu I, Marin D, Puel O, Oswald IP. Mycotoxins co-contamination: Methodological aspects and biological relevance of combined toxicity studies. Crit Rev Food Sci Nutr. 2017 Nov 2;57(16):3489-3507. PMID: 26918653

Schmidt R, Etalo DW, de Jager V, Gerards S, Zweers H, de Boer W, Garbeva P. Microbial Small Talk: Volatiles in Fungal-Bacterial Interactions. Front Microbiol. 2016 Jan 5;6:1495. PMID: 26779150

Hossain MZ, Mari N, Goto T. The relationship between ergosterol and mycotoxin contamination in maize from various countries. Mycotoxin Res. 2015 May;31(2):91-9. PMID: 25600135

Antonissen G, Devreese M, Van Immerseel F, De Baere S, Hessenberger S, Martel A, Croubels S. Chronic exposure to deoxynivalenol has no influence on the oral bioavailability of fumonisin B1 in broiler chickens. Toxins (Basel). 2015 Feb 16;7(2):560-71. PMID: 25690690

Bensassi F, Gallerne C, Sharaf el Dein O, Hajlaoui MR, Lemaire C, Bacha H. In vitro investigation of toxicological interactions between the fusariotoxins deoxynivalenol and zearalenone. Toxicon. 2014 Jun;84:1-6. PMID: 24680766

Cortinovis C, Caloni F, Schreiber NB, Spicer LJ. Effects of fumonisin B1 alone and combined with deoxynivalenol or zearalenoneon porcine granulosa cell proliferation and steroid production. Theriogenology. 2014 May;81(8):1042-9. PMID: 24576714

Wu Wenda, Bates Melissa A., Bursian Steven J., et al. Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicological sciences : an official journal of the Society of Toxicology. 2013;131:279–291.

Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013;272:191–198. PMID: 23735874

Klarić Maja. Adverse effects of combined mycotoxins. Arhiv za higijenu rada i toksikologiju. 2012;63:519–530.

Ruiz M. J., Franzova P., Juan-García A., Font G.. Toxicological interactions between the mycotoxins beauvericin, deoxynivalenol and T-2 toxin in CHO-K1 cells in vitro. Toxicon.  2011;58:315–326.

Grenier Bertrand, Loureiro-Bracarense Ana-Paula P., Lucioli Joelma, et al. Individual and combined effects of subclinical doses of deoxynivalenol and fumonisins in piglets. Molecular nutrition & food research. 2011;55:761–771.

Pál László, Dublecz Károly, Weber Mária, et al. Effect of combined treatment with aflatoxin B1 and T-2 toxin and metabolites on some production traits and lipid peroxide status parameters of broiler chickens. Acta veterinaria Hungarica. 2009;57:75–84.

McKean Christopher, Tang Lili, Billam Madhavi, et al. Comparative acute and combinative toxicity of aflatoxin B1 and T-2 toxin in animals and immortalized human cell lines. Journal of applied toxicology : JAT. 2006;26:139–147.

Creppy Edmond E., Chiarappa Patrizia, Baudrimont Isabelle, Borracci Pietro, Moukha Serge, Carratù Maria R.. Synergistic effects of fumonisin B1 and ochratoxin A: are in vitro cytotoxicity data predictive of in vivo acute toxicity?  Toxicology.  2004;201:115–123.

Li B., Guo H.. Study on the combined toxicity of aflatoxin B1 and deoxynivalenol. Wei sheng yan jiu = Journal of hygiene research.  2000;29:393–395.

Thuvander A., Wikman C., Gadhasson I.. In vitro exposure of human lymphocytes to trichothecenes: individual variation in sensitivity and effects of combined exposure on lymphocyte function. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1999;37:639–648.

Kubena L. F., Edrington T. S., Harvey R. B., Phillips T. D., Sarr A. B., Rottinghaus G. E.. Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and diacetoxyscirpenol or ochratoxin A in turkey poults. Poultry science. 1997;76:256–264.

Jones T. J., Koshinsky H. A., Khachatourians G. G.. Effect of T-2 toxin and verrucarin A in combination on Kluyveromyces marxianus. Natural toxins. 1995;3:104–108.

Kubena L. F., Harvey R. B., Huff W. E., Corrier D. E., Philips T. D., Rottinghaus G. E.. Influence of ochratoxin A and T-2 toxin singly and in combination on broiler chickens. Poultry science. 1989;68:867–872.

Schoental R.. The toxic oil syndrome in Spain. Was it due to a combined action of trichothecene mycotoxins and of inhibitors of carboxyesterase? Human toxicology. 1988;7:365–366.

Huff W. E., Kubena L. F., Harvey R. B., Doerr J. A.. Mycotoxin interactions in poultry and swine. Journal of animal science. 1988;66:2351–2355.

Huff W. E., Harvey R. B., Kubena L. F., Rottinghaus G. E.. Toxic synergism between aflatoxin and T-2 toxin in broiler chickens. Poultry science. 1988;67:1418–1423.