Fusarium Literature – Genotoxicity



Suzuki T, Iwahashi Y. Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity. Toxins (Basel). 2016 Feb 6;8(2):42. PMID: 26861396

Wan D, Wang X, Wu Q, Lin P, Pan Y, Sattar A, Huang L, Ahmad I, Zhang Y, Yuan Z. Integrated Transcriptional and Proteomic Analysis of Growth Hormone Suppression Mediated by Trichothecene T-2 Toxin in Rat GH3 Cells. Toxicol Sci. 2015 Oct;147(2):326-38. PMID: 26141394

Yang JY, Zhang YF, Meng XP, Li YX, Ma KW, Bai XF. T-2 toxin inhibits gene expression and activity of key steroidogenesis enzymes in mouse Leydig cells. Toxicol In Vitro. 2015 Aug;29(5):1166-71. PMID: 25962641

Pan Xiao, Whitten Douglas A., Wilkerson Curtis G., Pestka James J.. Dynamic changes in ribosome-associated proteome and phosphoproteome during deoxynivalenol-induced translation inhibition and ribotoxic stress. Toxicological sciences : an official journal of the Society of Toxicology. 2014;138:217–233.

Takakura N, Nesslany F, Fessard V, Le Hegarat L. Absence of in vitro genotoxicity potential of the mycotoxin deoxynivalenol in bacteria and in human TK6 and HepaRG cell lines. Food Chem Toxicol. 2014 Apr;66:113-21. PMID: 24468671

Zhou HR, He K, Landgraf J, Pan X, Pestka JJ. Direct activation of ribosome-associated double-stranded RNA-dependent protein kinase (PKR) by deoxynivalenol, anisomycin and ricin: a new model for ribotoxic stress response induction. Toxins (Basel). 2014 Dec 16;6(12):3406-25. PMID: 25521494

Schmeits Peter C., Katika Madhumohan R., Peijnenburg Ad A., Loveren Henk, Hendriksen Peter J.. DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells. Toxicology letters. 2014;224:395–406.

Horvatovich Katalin, Hafner Dóra, Bodnár Zsófia, et al. Dose-related genotoxic effect of T-2 toxin measured by comet assay using peripheral blood mononuclear cells of healthy pigs. Acta veterinaria Hungarica. 2013;61:175–186.

Gürbüzel Mehmet, Uysal Handan, Kizilet Halit. Assessment of genotoxic potential of two mycotoxins in the wing spot test of Drosophila melanogaster. Toxicology and industrial health. 2013.

He Kaiyu, Pan Xiao, Zhou Hui-Ren R., Pestka James J.. Modulation of inflammatory gene expression by the ribotoxin deoxynivalenol involves coordinate regulation of the transcriptome and translatome. Toxicological sciences : an official journal of the Society of Toxicology. 2013;131:153–163.

Moon Dong-Oh O., Asami Yukihiro, Long He, et al. Verrucarin A sensitizes TRAIL-induced apoptosis via the upregulation of DR5 in an eIF2α/CHOP-dependent manner. Toxicology in vitro : an international journal published in association with BIBRA. 2013;27:257–263.

Schweiger Wolfgang, Pasquet Jean-Claude C., Nussbaumer Thomas, et al. Functional characterization of two clusters of Brachypodium distachyon UDP-glycosyltransferases encoding putative deoxynivalenol detoxification genes. Molecular plant-microbe interactions : MPMI. 2013;26:781–792.

He Kaiyu, Zhou Hui-Ren R., Pestka James J.. Mechanisms for ribotoxin-induced ribosomal RNA cleavage. Toxicology and applied pharmacology. 2012;265:10–18.

He Kaiyu, Zhou Hui-Ren R., Pestka James J.. Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage. Toxicological sciences : an official journal of the Society of Toxicology. 2012;127:382–390.

Fleck Stefanie C., Hildebrand Andreas A., Müller Elisabeth, Pfeiffer Erika, Metzler Manfred. Genotoxicity and inactivation of catechol metabolites of the mycotoxin zearalenone. Mycotoxin research. 2012;28:267–273.

Awad W. A., Ghareeb K., Dadak A., et al. Genotoxic effects of deoxynivalenol in broiler chickens fed low-protein feeds. Poultry science. 2012;91:550–555.

Suzuki Tadahiro, Iwahashi Yumiko. Comprehensive gene expression analysis of type B trichothecenes. Journal of agricultural and food chemistry. 2012;60:9519–9527.

Park Seong Hwan H., Choi Hye Jin J., Do Kee Hun H., Yang Hyun, Kim Juil, Moon Yuseok. Chronic Nod2 stimulation potentiates activating transcription factor 3 and paradoxical superinduction of epithelial proinflammatory chemokines by mucoactive ribotoxic stressors via RNA-binding protein human antigen R. Toxicological sciences : an official journal of the Society of Toxicology. 2012;125:116–125.

Wang Xu, Liu Qin, Ihsan Awais, et al. JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin. Toxicological sciences : an official journal of the Society of Toxicology. 2012;127:412–424.

Katika Madhumohan R., Hendriksen Peter J., Shao Jia, Loveren Henk, Peijnenburg Ad. Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights. Toxicology and applied pharmacology. 2012;264:51–64.

Schmidt-Heydt M., Parra R., Geisen R., Magan N.. Modelling the relationship between environmental factors, transcriptional genes and deoxynivalenol mycotoxin production by strains of two Fusarium species. Journal of the Royal Society, Interface / the Royal Society. 2011;8:117–126.

Casteel Maximilian, Nielsen Carina, Didier Andrea, Dietrich Richard, Märtlbauer Erwin. Induction of MAPK-dependent transcription factors by deoxynivalenol in human cell lines. Mycotoxin research. 2010;26:9–14.

Rakkestad Kirsten E., Skaar Ida, Ansteinsson Vibeke E., et al. DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. Toxicological sciences : an official journal of the Society of Toxicology. 2010;115:140–155.

Bae Heekyong, Gray Jennifer S., Li Maoxiang, Vines Laura, Kim Joon, Pestka James J.. Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2010;115:444–452.

Pestka James J.. Deoxynivalenol-induced proinflammatory gene expression: mechanisms and pathological sequelae. Toxins. 2010;2:1300–1317.

Park Seong-Hwan H., Choi Hye Jin J., Yang Hyun, Do Kee Hun H., Kim Juil, Moon Yuseok. Repression of peroxisome proliferator-activated receptor gamma by mucosal ribotoxic insult-activated CCAAT/enhancer-binding protein homologous protein. Journal of immunology (Baltimore, Md. : 1950). 2010;185:5522–5530.

Choi Hye Jin J., Yang Hyun, Park Seong Hwan H., Moon Yuseok. HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol. Toxicology and applied pharmacology. 2009;240:46–54.

Chaudhari Manjari, Jayaraj R., Bhaskar A. S., Lakshmana Rao P. V.. Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells. Toxicology. 2009;262:153–161.

Zhang Xiaoou, Jiang Liping, Geng Chengyan, Cao Jun, Zhong Laifu. The role of oxidative stress in deoxynivalenol-induced DNA damage in HepG2 cells. Toxicon. 2009;54:513–518.

Yang Hyun, Park Seong Hwan H., Choi Hye Jin J., Moon Yuseok. Epithelial cell survival by activating transcription factor 3 (ATF3) in response to chemical ribosome-inactivating stress. Biochemical pharmacology. 2009;77:1105–1115.

Pestka J. J.. Mechanisms of deoxynivalenol-induced gene expression and apoptosis. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2008;25:1128–1140.

Pestka James J., Amuzie Chidozie J.. Tissue distribution and proinflammatory cytokine gene expression following acute oral exposure to deoxynivalenol: comparison of weanling and adult mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008;46:2826–2831.

Gray Jennifer S., Bae Hee Kyong K., Li James C., Lau Allan S., Pestka James J.. Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2008;105:322–330.

Baltriukiene Daiva, Kalvelyte Audrone, Bukelskiene Virginija. Induction of apoptosis and activation of JNK and p38 MAPK pathways in deoxynivalenol-treated cell lines. Alternatives to laboratory animals : ATLA. 2007;35:53–59.

Gray Jennifer S., Pestka James J.. Transcriptional regulation of deoxynivalenol-induced IL-8 expression in human monocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2007;99:502–511.

Sakai Ayako, Suzuki Chihiro, Masui Yasuko, Kuramashi Ai, Takatori Kosuke, Tanaka Noriho. The activities of mycotoxins derived from Fusarium and related substances in a short-term transformation assay using v-Ha-ras-transfected BALB/3T3 cells (Bhas 42 cells). Mutation research. 2007;630:103–111.

Wollenhaupt K., Dänicke S., Brüssow K-P P., Tiemann U.. In vitro and in vivo effects of deoxynivalenol (DNV) on regulators of cap dependent translation control in porcine endometrium. Reproductive toxicology (Elmsford, N.Y.). 2006;21:60–73.

Bony Sylvie, Carcelen Monique, Olivier Laurence, Devaux Alain. Genotoxicity assessment of deoxynivalenol in the Caco-2 cell line model using the Comet assay. Toxicology letters. 2006;166:67–76.

Frankic T., Pajk T., Rezar V., Levart A., Salobir J.. The role of dietary nucleotides in reduction of DNA damage induced by T-2 toxin and deoxynivalenol in chicken leukocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2006;44:1838–1844.

Severino Lorella, Luongo Diomira, Bergamo Paolo, Lucisano Antonia, Rossi Mauro. Mycotoxins nivalenol and deoxynivalenol differentially modulate cytokine mRNA expression in Jurkat T cells. Cytokine. 2006;36:75–82.

Kristensen Ralf, Torp Mona, Kosiak Barbara, Holst-Jensen Arne. Phylogeny and toxigenic potential is correlated in Fusarium species as revealed by partial translation elongation factor 1 alpha gene sequences. Mycological research. 2005;109:173–186.

Chung Yong-Joo J., Zhou Hui-Ren R., Pestka James J.. Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin). Toxicology and applied pharmacology. 2003;193:188–201.

Yang G. H., Li S., Pestka J. J.. Down-regulation of the endoplasmic reticulum chaperone GRP78/BiP by vomitoxin (Deoxynivalenol). Toxicology and applied pharmacology. 2000;162:207–217.

Shifrin V. I., Anderson P.. Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. The Journal of biological chemistry. 1999;274:13985–13992.

Zhou H. R., Yan D., Pestka J. J.. Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (Deoxynivalenol): differential toxin-induced hyporesponsiveness and recovery. Toxicology and applied pharmacology. 1998;151:347–358.

Tsuda S., Kosaka Y., Murakami M., et al. Detection of nivalenol genotoxicity in cultured cells and multiple mouse organs by the alkaline single-cell gel electrophoresis assay. Mutation research. 1998;415:191–200.

Li S., Ouyang Y. L., Dong W., Pestka J. J.. Superinduction of IL-2 gene expression by vomitoxin (deoxynivalenol) involves increased mRNA stability. Toxicology and applied pharmacology. 1997;147:331–342.

Pfohl-Leszkowicz A., Chekir-Ghedira L., Bacha H.. Genotoxicity of zearalenone, an estrogenic mycotoxin: DNA adduct formation in female mouse tissues. Carcinogenesis. 1995;16:2315–2320.

Azcona-Olivera J. I., Ouyang Y., Murtha J., Chu F. S., Pestka J. J.. Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition. Toxicology and applied pharmacology. 1995;133:109–120.

Thompson W. L., Wannemacher R. W.. In vivo effects of T-2 mycotoxin on synthesis of proteins and DNA in rat tissues. Toxicology and applied pharmacology. 1990;105:483–491.

Middlebrook J. L., Leatherman D. L.. Binding of T-2 toxin to eukaryotic cell ribosomes. Biochemical pharmacology. 1989;38:3103–3110.

Zhu G. F., Cheng S. J., Li M. H.. [The genotoxic effects of T-2 toxin, a trichothecene produced by fusarium fungi]. Shi yan sheng wu xue bao. 1987;20:129–134.

Thust R., Kneist S., Hühne V.. Genotoxicity of Fusarium mycotoxins (nivalenol, fusarenon-X, T-2 toxin, and zearalenone) in Chinese hamster V79-E cells in vitro. Archiv für Geschwulstforschung. 1983;53:9–15.

Lafarge-Frayssinet C., Decloitre F., Mousset S., Martin M., Frayssinet C.. Induction of DNA single-strand breaks by T2 toxin, a trichothecene metabolite of fusarium: effect on lymphoid organs and liver. Mutation research. 1981;88:115–123.

Norppa H., Penttilä M., Sorsa M., Hintikka E. L., Ilus T.. Mycotoxin T-2 of Fusarium tricinctum and chromosome changes in Chinese hamster bone marrow. Hereditas. 1980;93:329–332.

Agrelo C. E., Schoental R.. Synthesis of DNA in human fibroblasts treated with T-2 toxin and HT-2 toxin (the trichothecene metabolites of Fusarium species) and the effects of hydroxyurea. Toxicology letters. 1980;5:155–160.

Munsch N., Müller W. E.. Effects of T2 toxin on DNA polymerases and terminal deoxynucleotidyl transferase of Molt4 and Nu8 cell lines. Immunopharmacology. 1980;2:313–318.