Fusarium Literature – Clearance



Fleck SC, Churchwell MI, Doerge DR. Metabolism and pharmacokinetics of zearalenone following oral and intravenous administration in juvenile female pigs. Food Chem Toxicol. 2017 Aug;106(Pt A):193-201. PMID: 28552786

Pestka JJ, Clark ES, Schwartz-Zimmerman HE, Berthiller F. Sex is a determinant for deoxynivalenol metabolism and elimination in the mouse. Toxins (Basel), 2017 Aug 4; 9(8), PMID: 28777306.

Bernhoft A, Høgåsen HR, Rosenlund G, Ivanova L, Berntssen MHG, Alexander J, Eriksen GS, Fæste CK. Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary-exposed Atlantic salmon (Salmo salar). Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 May 22:1-14. PMID: 28490257

Binder SB, Schwartz-Zimmermann HE, Varga E, Bichl G, Michlmayr H, Adam G, Berthiller F. Metabolism of Zearalenone and Its Major Modified Forms in Pigs. Toxins (Basel). 2017 Feb 8;9(2). PMID: 28208710

Habler K, Geissinger C, Hofer K, Schüler J, Moghari S, Hess M, Gastl M, Rychlik M. Fate of Fusarium Toxins during Brewing. J Agric Food Chem. 2017 Jan 11;65(1):190-198. PMID: 27931101

Ivanova L, Uhlig S, Devreese M, Croubels S, Fæste CK. Biotransformation of the mycotoxin enniatin B1 in pigs: A comparative in vitro and in vivo approach. Food Chem Toxicol. 2017 Jul;105:506-517. PMID: 28472676

Payros D, Alassane-Kpembi I, Pierron A, Loiseau N, Pinton P, Oswald IP. Toxicology of deoxynivalenol and its acetylated and modified forms. Arch Toxicol. 2016 Dec;90(12):2931-2957. PMID: 27663890

Burgess KM, Renaud JB, McDowell T, Sumarah MW. Mechanistic Insight into the Biosynthesis and Detoxification of Fumonisin Mycotoxins. ACS Chem Biol. 2016 Sep 16;11(9):2618-25. PMID: 27444057

Tadpetch K, Kaewmee B, Chantakaew K, Kantee K, Rukachaisirikul V, Phongpaichit S. Synthesis and cytotoxic activities of semisynthetic zearalenone analogues. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3612-6. PMID: 27311894

He JW, Hassan YI, Perilla N, Li XZ, Boland GJ, Zhou T. Bacterial Epimerization as a Route for Deoxynivalenol Detoxification: the Influence of Growth and Environmental Conditions. Front Microbiol. 2016 Apr 21;7:572. PMID: 27148248

Gajęcka M, Sławuta P, Nicpoń J, Kołacz R, Kiełbowicz Z, Zielonka Ł, Dąbrowski M, Szweda W, Gajęcki M, Nicpoń J. Zearalenone and its metabolites in the tissues of female wild boars exposed per os to mycotoxins. Toxicon. 2016 May;114:1-12. PMID: 26908292

Rodríguez-Carrasco Y, Heilos D, Richter L, Süssmuth RD, Heffeter P, Sulyok M, Kenner L, Berger W, Dornetshuber-Fleiss R. Mouse tissue distribution and persistence of the food-born fusariotoxins Enniatin B and Beauvericin. Toxicol Lett. 2016 Apr 15;247:35-44. PMID: 26892719

Kongkapan J, Giorgi M, Poapolathep S, Isariyodom S, Poapolathep A. Toxicokinetics and tissue distribution of nivalenol in broiler chickens. Toxicon. 2016 Mar 1;111:31-6. PMID: 26739759

Ajandouz el H, Berdah S, Moutardier V, Bege T, Birnbaum DJ, Perrier J, Di Pasquale E, Maresca M. Hydrolytic Fate of 3/15-Acetyldeoxynivalenol in Humans: Specific Deacetylation by the Small Intestine and Liver Revealed Using in Vitro and ex Vivo Approaches. Toxins (Basel). 2016 Jul 28;8(8). PMID: 27483321

Broekaert N, Devreese M, De Mil T, Fraeyman S, Antonissen G, De Baere S, De Backer P, Vermeulen A, Croubels S. Oral Bioavailability, Hydrolysis, and Comparative Toxicokinetics of 3-Acetyldeoxynivalenol and 15-Acetyldeoxynivalenol in Broiler Chickens and Pigs. J Agric Food Chem. 2015 Oct 7;63(39):8734-42. PMID: 26343882

Dänicke S, Winkler J. Invited review: Diagnosis of zearalenone (ZEN) exposure of farm animals and transfer of its residues into edible tissues (carry over). Food Chem Toxicol. 2015 Oct;84:225-49. PMID: 26277628

Guerre P. Fusariotoxins in Avian Species: Toxicokinetics, Metabolism and Persistence in Tissues. Toxins (Basel). 2015 Jun 23;7(6):2289-305. PMID: 26110506

Maul R, Warth B, Schebb NH, Krska R, Koch M, Sulyok M. In vitro glucuronidation kinetics of deoxynivalenol by human and animal microsomes and recombinant human UGT enzymes. Arch Toxicol. 2015 Jun;89(6):949-60. PMID: 24927789

Ebrahem M, Kersten S, Valenta H, Breves G, Dänicke S. Residues of deoxynivalenol (DON) and its metabolite de-epoxy-DON in eggs, plasma and bile of laying hens of different genetic backgrounds. Arch Anim Nutr. 2014;68(5):412-22. PMID: 25139221

Nagl V, Woechtl B, Schwartz-Zimmermann HE, Hennig-Pauka I, Moll WD, Adam G, Berthiller F. Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs. Toxicol Lett. 2014 Aug 17;229(1):190-7. PMID: 24968060

Saengtienchai Thanit, Poapolathep Saranya, Isariyodom Supaporn, Ikenaka Yoshinori, Ishizuka Mayumi, Poapolathep Amnart. Toxicokinetics and tissue depletion of Fusarenon-X and its metabolite nivalenol in piglets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014;66:307–312.

Ito Michihiro, Sato Ikuo, Ishizaka Masumi, et al. Bacterial cytochrome P450 system catabolizing the Fusarium toxin deoxynivalenol. Applied and environmental microbiology. 2013;79:1619–1628.

Grenier Bertrand, Bracarense Ana-Paula P., Schwartz Heidi E., et al. Biotransformation Approaches To Alleviate the Effects Induced by Fusarium Mycotoxins in Swine. Journal of agricultural and food chemistry. 2013.

Warth Benedikt, Sulyok Michael, Berthiller Franz, Schuhmacher Rainer, Krska Rudolf. New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone. Toxicology letters. 2013;220:88–94.

Wu Qinghua, Dohnal Vlastimil, Kuca Kamil, Yuan Zonghui. Trichothecenes: structure-toxic activity relationships. Current drug metabolism. 2013;14:641–660.

Osselaere Ann, Devreese Mathias, Goossens Joline, et al. Toxicokinetic study and absolute oral bioavailability of deoxynivalenol, T-2 toxin and zearalenone in broiler chickens. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013;51:350–355.

Shang Shufeng, Jiang Jun, Deng Yiqun. Chicken Cytochrome P450 1A5 Is the Key Enzyme for Metabolizing T-2 Toxin to 3’OH-T-2. International journal of molecular sciences. 2013;14:10809–10818.

Rafai Pál, Papp Zoltán, Jakab László. Biotransformation of trichothecenes alleviates the negative effects of T-2 toxin in pigs. Acta veterinaria Hungarica. 2013;61:333–343.

Yuan Yiyang, Zhou Xiaojie, Yang Jiannan, Li Mei, Qiu Xinghui. T-2 toxin is hydroxylated by chicken CYP3A37. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013;62:622–627.

Weidner Maria, Welsch Tanja, Hübner Florian, Schwerdt Gerald, Gekle Michael, Humpf Hans-Ulrich U.. Identification and apoptotic potential of T-2 toxin metabolites in human cells. Journal of agricultural and food chemistry. 2012;60:5676–5684.

Lohölter Malte, Meyer Ulrich, Döll Susanne, et al. Effects of the thermal environment on metabolism of deoxynivalenol and thermoregulatory response of sheep fed on corn silage grown at enriched atmospheric carbon dioxide and drought. Mycotoxin research. 2012;28:219–227.

Osselaere A., Devreese M., Watteyn A., et al. Efficacy and safety testing of mycotoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines. Poultry science. 2012;91:2046–2054.

Nagl Veronika, Schwartz Heidi, Krska Rudolf, et al. Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats. Toxicology letters. 2012;213:367–373.

Lattanzio Veronica M., Solfrizzo Michele, De Girolamo Annalisa, Chulze Sofía N., Torres Adriana M., Visconti Angelo. LC-MS/MS characterization of the urinary excretion profile of the mycotoxin deoxynivalenol in human and rat. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011;879:707–715.

Berthiller Franz, Krska Rudolf, Domig Konrad J., et al. Hydrolytic fate of deoxynivalenol-3-glucoside during digestion. Toxicology letters. 2011;206:264–267.

Wu Qinghua, Dohnal Vlastimil, Huang Lingli, Kuca Kamil, Yuan Zonghui. Metabolic pathways of trichothecenes. Drug metabolism reviews. 2010;42:250–267.

Yunus Agha Waqar W., Valenta Hana, Abdel-Raheem Sherif M., Döll Susanne, Dänicke Sven, Böhm Josef. Blood plasma levels of deoxynivalenol and its de-epoxy metabolite in broilers after a single oral dose of the toxin. Mycotoxin research. 2010;26:217–220.

Dänicke S., Beyer M., Breves G., Valenta H., Humpf H-U U.. Effects of oral exposure of pigs to deoxynivalenol (DON) sulfonate (DONS) as the non-toxic derivative of DON on tissue residues of DON and de-epoxy-DON and on DONS blood levels. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2010;27:1558–1565.

Königs Maika, Mulac Dennis, Schwerdt Gerald, Gekle Michael, Humpf Hans-Ulrich U.. Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture. Toxicology. 2009;258:106–115.

Döll Susanne, Dänicke Sven, Valenta Hana. Residues of deoxynivalenol (DON) in pig tissue after feeding mash or pellet diets containing low concentrations. Molecular nutrition & food research. 2008;52:727–734.

Keese Christina, Meyer Ulrich, Rehage Jürgen, et al. Ruminal fermentation patterns and parameters of the acid base metabolism in the urine as influenced by the proportion of concentrate in the ration of dairy cows with and without Fusarium toxin-contaminated triticale. Archives of animal nutrition. 2008;62:287–302.

Poapolathep A., Poapolathep S., Sugita-Konishi Y., et al. Fate of fusarenon-X in broilers and ducks. Poultry science. 2008;87:1510–1515.

Dohnal Vlastimil, Jezkova Alena, Jun Daniel, Kuca Kamil. Metabolic pathways of T-2 toxin. Current drug metabolism. 2008;9:77–82.

Königs Maika, Lenczyk Marlies, Schwerdt Gerald, Holzinger Hildegard, Gekle Michael, Humpf Hans-Ulrich U.. Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture. Toxicology. 2007;240:48–59.

Sundstøl Eriksen G., Pettersson H., Lundh T.. Comparative cytotoxicity of deoxynivalenol, nivalenol, their acetylated derivatives and de-epoxy metabolites. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2004;42:619–624.

Dänicke S., Valenta H., Döll S.. On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig. Archives of animal nutrition. 2004;58:169–180.

Poapolathep Amnart, Sugita-Konishi Yoshiko, Doi Kunio, Kumagai Susumu. The fates of trichothecene mycotoxins, nivalenol and fusarenon-X, in mice. Toxicon. 2003;41:1047–1054.

Eriksen G. S., Pettersson H., Lindberg J. E.. Absorption, metabolism and excretion of 3-acetyl DON in pigs. Archiv für Tierernährung. 2003;57:335–345.

Lewis C. W., Smith J. E., Anderson J. G., Freshney R. I.. Increased cytotoxicity of food-borne mycotoxins toward human cell lines in vitro via enhanced cytochrome p450 expression using the MTT bioassay. Mycopathologia. 1999;148:97–102.

Hedman R., Pettersson H., Lindberg J. E.. Absorption and metabolism of nivalenol in pigs. Archiv für Tierernährung. 1997;50:13–24.

Bauer J.. [The metabolism of trichothecenes in swine]. DTW. Deutsche tierärztliche Wochenschrift. 1995;102:50–52.

Yagen B., Bialer M.. Metabolism and pharmacokinetics of T-2 toxin and related trichothecenes. Drug metabolism reviews. 1993;25:281–323.

Giroir L. E., Ivie G. W., Huff W. E.. Comparative fate of the tritiated trichothecene mycotoxin, T-2 toxin, in chickens and ducks. Poultry science. 1991;70:1138–1143.

Ueno Y., Takai Y., Baba Y.. Analysis of T-2 toxin metabolites in tissues and excreta of rats. Journal of environmental pathology, toxicology and oncology. 1990;10:31–40.

Barel S., Yagen B., Bialer M.. Pharmacokinetics of the trichothecene mycotoxin verrucarol in dogs. Journal of pharmaceutical sciences. 1990;79:548–551.

Wang J. S., Busby W. F., Wogan G. N.. Comparative tissue distribution and excretion of orally administered [3H]diacetoxyscirpenol (anguidine) in rats and mice. Toxicology and applied pharmacology. 1990;103:430–440.

Prelusky D. B., Hartin K. E., Trenholm H. L.. Distribution of deoxynivalenol in cerebral spinal fluid following administration to swine and sheep. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1990;25:395–413.

Lun A. K., Moran E. T., Young L. G., McMillan E. G.. Absorption and elimination of an oral dose of 3H-deoxynivalenol in colostomized and intact chickens. Bulletin of environmental contamination and toxicology. 1989;42:919–925.

Johnsen H., Odden E., Johnsen B. A., Fonnum F.. Metabolism of T-2 toxin by blood cell carboxylesterases. Biochemical pharmacology. 1988;37:3193–3197.

Ványi A., Bata A., Fekete S., Tamás J.. Study of the metabolism and excretion of T-2 toxin, a trichothecene fusariotoxin, in rabbits. Acta veterinaria Hungarica. 1988;36:213–220.

Prelusky D. B., Hartin K. E., Trenholm H. L., Miller J. D.. Pharmacokinetic fate of 14C-labeled deoxynivalenol in swine. Fundamental and applied toxicology. 1988;10:276–286.

Sintov A., Bialer M., Yagen B.. Pharmacokinetics and protein binding of trichothecene mycotoxins, T-2 toxin and HT-2 toxin, in dogs. Toxicon. 1988;26:153–160.

Kobayashi J., Horikoshi T., Ryu J. C., Tashiro F., Ishii K., Ueno Y.. The cytochrome P-450-dependent hydroxylation of T-2 toxin in various animal species. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1987;25:539–544.

Sintov A., Bialer M., Yagen B.. Pharmacokinetics of T-2 tetraol, a urinary metabolite of the trichothecene mycotoxin, T-2 toxin, in dog. Xenobiotica; the fate of foreign compounds in biological systems. 1987;17:941–950.

Lake B. G., Phillips J. C., Walters D. G., et al. Studies on the metabolism of deoxynivalenol in the rat. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1987;25:589–592.

Prelusky D. B., Veira D. M., Trenholm H. L., Foster B. C.. Metabolic fate and elimination in milk, urine and bile of deoxynivalenol following administration to lactating sheep. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1987;22:125–148.

Prelusky D. B., Veira D. M., Trenholm H. L., Hartin K. E.. Excretion profiles of the mycotoxin deoxynivalenol, following oral and intravenous administration to sheep. Fundamental and applied toxicology. 1986;6:356–363.

Sintov A., Bialer M., Yagen B.. Pharmacokinetics of T-2 toxin and its metabolite HT-2 toxin, after intravenous administration in dogs. Drug metabolism and disposition: the biological fate of chemicals. 1986;14:250–254.

Prelusky D. B., Hamilton R. M., Trenholm H. L., Miller J. D.. Tissue distribution and excretion of radioactivity following administration of 14C-labeled deoxynivalenol to White Leghorn hens. Fundamental and applied toxicology. 1986;7:635–645.

Côté L. M., Dahlem A. M., Yoshizawa T., Swanson S. P., Buck W. B.. Excretion of deoxynivalenol and its metabolite in milk, urine, and feces of lactating dairy cows. Journal of dairy science. 1986;69:2416–2423.

Yoshizawa T., Sakamoto T., Kuwamura K.. Structures of deepoxytrichothecene metabolites from 3’-hydroxy HT-2 toxin and T-2 tetraol in rats. Applied and environmental microbiology. 1985;50:676–679.

Prelusky D. B., Veira D. M., Trenholm H. L.. Plasma pharmacokinetics of the mycotoxin deoxynivalenol following oral and intravenous administration to sheep. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1985;20:603–624.

Pace J. G., Watts M. R., Burrows E. P., et al. Fate and distribution of 3H-labeled T-2 mycotoxin in guinea pigs. Toxicology and applied pharmacology. 1985;80:377–385.

Visconti A., Mirocha C. J.. Identification of various T-2 toxin metabolites in chicken excreta and tissues. Applied and environmental microbiology. 1985;49:1246–1250.

Bauer J., Bollwahn W., Gareis M., Gedek B., Heinritzi K.. Kinetic profiles of diacetoxyscirpenol and two of its metabolites in blood serum of pigs. Applied and environmental microbiology. 1985;49:842–845.

Kravchenko L. V., Avren’eva L. I., Tutel’ian V. A.. [Mechanism of the protective effect of modifiers of the liver enzyme systems metabolyzing xenobiotics in acute T-2 mycotoxicosis]. Doklady Akademii nauk SSSR. 1984;276:1270–1273.

Bata A., Ványi A., Sándor G. S.. Metabolization of trichothecene toxins (T-2 toxin and diacetoxyscirpenol) in embryonated hen’s egg. Acta veterinaria Hungarica. 1983;31:189–192.

Yoshizawa T., Mirocha C. J., Behrens J. C., Swanson S. P.. Metabolic fate of T-2 toxin in a lactating cow. Food and cosmetics toxicology. 1981;19:31–39.

Yoshizawa T., Swanson S. P., Mirocha C. J.. T-2 metabolites in the excreta of broiler chickens administered 3H-labeled T-2 toxin. Applied and environmental microbiology. 1980;39:1172–1177.

Robison T. S., Mirocha C. J., Kurtz H. J., Behrens J. C., Weaver G. A., Chi M. S.. Distribution of tritium-labeled T-2 toxin in swine. Journal of agricultural and food chemistry. 1979;27:1411–1413.

Nakano N., Nagahara A., Shimizu T., et al. The tissue distribution and the pattern of excretion of [14C]-13-labeled 12, 13-epoxytrichothec-9-ene in mice and rats. Japanese journal of medical science & biology. 1979;32:269–279.

Matsumoto H., Ito T., Ueno Y.. Toxicological approaches to the metabolities of fusaria. XII. Fate and distribution of T-2 toxin in mice. The Japanese journal of experimental medicine. 1978;48:393–399.

Ohta M., Matsumoto H., Ishii K., Ueno Y.. Metabolism of trichothecene mycotoxins. II. Substrate specificity of microsomal deacetylation of trichothecenes. Journal of biochemistry. 1978;84:697–706.

Chi M. S., Robison T. S., Mirocha C. J., Swanson S. P., Shimoda W.. Excretion and tissue distribution of radioactivity from tritium-labeled T-2 toxin in chicks. Toxicology and applied pharmacology. 1978;45:391–402.

Patterson D. S.. Metabolic activation and detoxification of mycotoxins. Annales de la nutrition et de l’alimentation. 1977;31:901–910.

Ohta M., Ishii K., Ueno Y.. Metabolism of trichothecene mycotoxins. I. Microsomal deacetylation of T-2 toxin in animal tissues. Journal of biochemistry. 1977;82:1591–1598.

Ueno Y., Ishii K., Sakai K., Kanaeda S., Tsunoda H.. Toxicological approaches to the metabolites of Fusaria. IV. Microbial survey on “bean-hulls poisoning of horses” with the isolation of toxic trichothecenes, neosolaniol and T-2 toxin of Fusarium solani M-1-1. The Japanese journal of experimental medicine. 1972;42:187–203.