Fusarium Literature – Cancer and Tumors



Zhang J, Lai Z, Huang W, Ling H, Lin M, Tang S, Liu Y, Tao Y. Apicidin Inhibited Proliferation and Invasion and Induced Apoptosis via Mitochondrial Pathway in Non-small Cell Lung Cancer GLC-82 Cells. Anticancer Agents Med Chem. 2017 Apr 19. PMID: 28425856

Ostry V, Malir F, Toman J, Grosse Y. Mycotoxins as human carcinogens-the IARC Monographs classification. Mycotoxin Res. 2017 Feb;33(1):65-73. PMID: 27888487

Liu Y, Gao X, Deeb D, Zhang Y, Shaw J, Valeriote FA, Gautam SC. Mycotoxin verrucarin A inhibits proliferation and induces apoptosis in prostate cancer cells by inhibiting prosurvival Akt/NF-kB/mTOR signaling. J Exp Ther Oncol. 2016 Nov;11(4):251-260. PMID: 27849335

Abassi H, Ayed-Boussema I, Shirley S, Abid S, Bacha H, Micheau O. The mycotoxin zearalenone enhances cell proliferation, colony formation and promotes cell migration in the human colon carcinoma cell line HCT116. Toxicol Lett. 2016 Jul 8;254:1-7. PMID: 27084041

Deeb D, Gao X, Liu Y, Zhang Y, Shaw J, Valeriote FA, Gautam SC. The inhibition of cell proliferation and induction of apoptosis in pancreatic ductal adenocarcinoma cells by verrucarin A, a macrocyclic trichothecene, is associated with the inhibition of Akt/NF-кB/mTOR prosurvival signaling. Int J Oncol. 2016 Sep;49(3):1139-47. PMID: 27573873

De Ruyck K, De Boevre M, Huybrechts I, De Saeger S. Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review. Mutat Res Rev Mutat Res. 2015 Oct-Dec;766:32-41. PMID: 26596546

Belhassen H, Jiménez-Díaz I, Arrebola JP, Ghali R, Ghorbel H, Olea N, Hedili A. Zearalenone and its metabolites in urine and breast cancer risk: a case-control study in Tunisia. Chemosphere. 2015 Jun;128:1-6. PMID: 25602441

Frehse MS, Martins MI, Ono EY, Bracarense AP, Bissoqui LY, Teixeira EM, Santos NJ, Freire RL. Aflatoxins ingestion and canine mammary tumors: There is an association? Food Chem Toxicol. 2015 Oct;84:74-8. PMID: 26271706

Hou Yiju, Yuan Zhonghai, Guo Wei, Wang Huiyan. [Effects of T-2 toxin of fusarium on proliferation’ and apoptosis of human acute promyelocytic leukemia cell line HL60]. Wei sheng yan jiu = Journal of hygiene research. 2013;42:381–385.

Palanivel Kandasamy, Kanimozhi Veerasamy, Kadalmani Balamuthu, Akbarsha Mohammad Abdulkader A.. Verrucarin A, a protein synthesis inhibitor, induces growth inhibition and apoptosis in breast cancer cell lines MDA-MB-231 and T47D. Biotechnology letters. 2013;35:1395–1403.

Liu Jing, Xing Xin, Xing Lingxiao, Zhou Bingjuan. [Effects of deoxynivalenol on apoptosis of human gastric carcinoma cell line SGC-7901, BGC-823 in vitro]. Wei sheng yan jiu = Journal of hygiene research. 2009;38:408–412.

Ma Yi Yi Y., Guo Hong Wei W.. Mini-review of studies on the carcinogenicity of deoxynivalenol. Environmental toxicology and pharmacology. 2008;25:1–9.

Hsia Chu Chieh C., Wu Ze Yuan Y., Li Yun Sian S., Zhang Fan, Sun Zong Tang T.. Nivalenol, a main Fusarium toxin in dietary foods from high-risk areas of cancer of esophagus and gastric cardia in China, induced benign and malignant tumors in mice. Oncology reports. 2004;12:449–456.

Minervini F., Fornelli F., Flynn K. M.. Toxicity and apoptosis induced by the mycotoxins nivalenol, deoxynivalenol and fumonisin B1 in a human erythroleukemia cell line. Toxicology in vitro : an international journal published in association with BIBRA. 2004;18:21–28.

Huang Xiang-hua H., Zhang Xiang-hong H., Li Yue-hong H., et al. [Carcinogenic effects of sterigmatocystin and deoxynivalenol in NIH mice]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. 2004;26:705–708.

Kim Hyung-Jin J., Jang Seon Il I., Kim Young-Jun J., et al. 4-Acetyl-12,13-epoxyl-9-trichothecene-3, 15-diol from Isaria japonica mediates apoptosis of rat bladder carcinoma NBT-II cells by decreasing anti-apoptotic Bcl-2 expression and increasing pro-apoptotic Bax expression. The American journal of Chinese medicine. 2004;32:377–387.

Pae H. O., Oh G. S., Choi B. M., et al. Induction of apoptosis by 4-acetyl-12,13-epoxyl-9-trichothecene-3,15-diol from Isaria japonica Yasuda through intracellular reactive oxygen species formation and caspase-3 activation in human leukemia HL-60 cells. Toxicology in vitro : an international journal published in association with BIBRA. 2003;17:49–57.

Holme J. A., Morrison E., Samuelsen J. T., et al. Mechanisms involved in the induction of apoptosis by T-2 and HT-2 toxins in HL-60 human promyelocytic leukemia cells. Cell biology and toxicology. 2003;19:53–68.

Konishi Kazuhide, Iida Akira, Kaneko Masafumi, et al. Cancer preventive potential of trichothecenes from Trichothecium roseum. Bioorganic & medicinal chemistry. 2003;11:2511–2518.

Nagase M., Alam M. M., Tsushima A., Yoshizawa T., Sakato N.. Apoptosis induction by T-2 toxin: activation of caspase-9, caspase-3, and DFF-40/CAD through cytosolic release of cytochrome c in HL-60 cells. Bioscience, biotechnology, and biochemistry. 2001;65:1741–1747.

Pestka J. J., Zhou H. R.. Interleukin-6-deficient mice refractory to IgA dysregulation but not anorexia induction by vomitoxin (deoxynivalenol) ingestion. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2000;38:565–575.

Groves F. D., Zhang L., Chang Y. S., et al. Fusarium mycotoxins in corn and corn products in a high-risk area for gastric cancer in Shandong Province, China. Journal of AOAC International. 1999;82:657–662.

Juranić Z., Stojiljković M. P., Bocarov-Stancić A., et al. T-2 toxin affects proliferation of three different neoplastic cell lines. Journal of experimental & clinical cancer research : CR. 1998;17:33–40.

Ueno Y., Umemori K., Niimi E., et al. Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells. Natural toxins. 1995;3:129–137.

Chu F. S., Li G. Y.. Simultaneous occurrence of fumonisin B1 and other mycotoxins in moldy corn collected from the People’s Republic of China in regions with high incidences of esophageal cancer. Applied and environmental microbiology. 1994;60:847–852.

Yoshizawa T., Yamashita A., Luo Y.. Fumonisin occurrence in corn from high- and low-risk areas for human esophageal cancer in China. Applied and environmental microbiology. 1994;60:1626–1629.

Luo Y., Yoshizawa T., Katayama T.. Comparative study on the natural occurrence of Fusarium mycotoxins (trichothecenes and zearalenone) in corn and wheat from high- and low-risk areas for human esophageal cancer in China. Applied and environmental microbiology. 1990;56:3723–3726.

Goetsch L., Thomasset N., Vila J., Philip I., Doré J. F.. Selective effect of trichotecolone on hemopoietic tumor cells. Anticancer research. 1990;10:1013–1017.

Ramu A., Yagen B., Ramu N.. The cytotoxicity of T-2 toxin and related 12,13-epoxytrichothecenes to Adriamycin-sensitive and -resistant P388 leukemia cells. Cancer chemotherapy and pharmacology. 1989;24:264–267.

Craddock V. M., Hill R. J., Henderson A. R.. Acute and chronic effects of diacetoxyscirpenol on cell replication in rat esophagus and stomach. Cancer letters. 1988;41:287–294.

Hsia C. C., Wu J. L., Lu X. Q., Li Y. S.. Natural occurrence and clastogenic effects of nivalenol, deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in corn from a high-risk area of esophageal cancer. Cancer detection and prevention. 1988;13:79–86.

Li M. X.. [Mutagenicity and carcinogenicity of T-2 toxin, a trichothecene produced by Fusarium fungi]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. 1988;10:326–329.

Xia Q. J., Lu X. Q., Wu J. L., Li Y. S.. [Trichothecenes in staple food from a high-incidence area of carcinoma of the esophagus and gastric cardia and their carcinogenic potential]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. 1988;10:4–8.

Corrier D. E., Norman J. O.. Effects of T-2 mycotoxin on tumor susceptibility in mice. American journal of veterinary research. 1988;49:2147–2150.

Sasajima K., Willey J. C., Banks-Schlegel S. P., Harris C. C.. Effects of tumor promoters and cocarcinogens on growth and differentiation of cultured human esophageal epithelial cells. Journal of the National Cancer Institute. 1987;78:419–423.

Jaskiewicz K., Rensburg S. J., Marasas W. F., Gelderblom W. C.. Carcinogenicity of Fusarium moniliforme culture material in rats. Journal of the National Cancer Institute. 1987;78:321–325.

Craddock V. M.. Effect of the trichothecene mycotoxin diacetoxyscirpenol on nitrosamine-induced oesophageal cancer and on relevant enzymes in oesophagus and liver. IARC scientific publications. 1987:266–269.

Craddock V. M., Hill R. J., Henderson A. R.. Stimulation of DNA replication in rat esophagus and stomach by the trichothecene mycotoxin diacetoxyscirpenol. Cancer letters. 1987;38:199–208.

Craddock V. M., Henderson A. R.. Effect of the esophageal carcinogen methylbenzylnitrosamine and of a putative potentiating factor, a trichothecene mycotoxin, on O6-methylguanine-dna methyl transferase in rat esophagus and liver. Cancer letters. 1987;37:81–86.

Craddock V. M., Sparrow S., Henderson A. R.. The effect of the trichothecene mycotoxin diacetoxyscirpenol on nitrosamine-induced esophageal cancer in the rat. Cancer letters. 1986;31:197–204.

Niell H. B., Soloway M. S., Wood C. A.. Effect of concentration and time of drug exposure on clonal growth of murine bladder cancer. Urology. 1985;25:267–272.

Rogers C. G., Héroux-Metcalf C.. Cytotoxicity and absence of mutagenic activity of vomitoxin (4-deoxynivalenol) in a hepatocyte-mediated mutation assay with V79 Chinese hamster lung cells. Cancer letters. 1983;20:29–35.

Schoental R.. Relationships of Fusarium toxins to tumours and other disorders in livestock. Journal of veterinary pharmacology and therapeutics.  1981;4:1–6.

Saito M., Horiuchi T., Ohtsubo K., Hatanaka Y., Ueno Y.. Low tumor incidence in rats with long-term feeding of fusarenon-X, a cytotoxic trichothecene produced by Fusarium nivale. The Japanese journal of experimental medicine. 1980;50:293–302.

Marasas W. F., Rensburg S. J., Mirocha C. J.. Incidence of Fusarium species and the mycotoxins, deoxynivalenol and zearalenone, in corn produced in esophageal cancer areas in Transkei. Journal of agricultural and food chemistry. 1979;27:1108–1112.