ME and CFS Abnormalities – Toxicity and Reactivities


Following is a list of articles about issues related to toxicity and reactivities in ME and CFS.

Links to the more than 1,000 peer-reviewed journal articles are listed on the ME and CFS Medical Abnormalities page of this website.


Principi N, Esposito S. Aluminum in vaccines: Does it create a safety problem? Vaccine. 2018 Aug 20. PMID: 30139653

Analysis of the literature showed that no apparent reason exists to support the elimination of aluminum from vaccines for fear of neurotoxicity. The only problem that deserves attention is the suggested relationship between aluminum oxyhydroxide-containing vaccines and macrophagic myofaciitis or myalgic encephalomyelitis/chronic fatigue syndrome.


Uhde M, Indart AC, Yu XB, Jang SS, De Giorgio R, Green PHR, Volta U, Vernon SD, Alaedini A. Markers of non-coeliac wheat sensitivity in patients with myalgic encephalomyelitis/chronic fatigue syndrome. Gut. 2018 Mar 17. PMID: 29550784


Crépeaux G, Gherardi RK, Authier FJ. ASIA, chronic fatigue syndrome, and selective low dose neurotoxicity of aluminum adjuvants. J Allergy Clin Immunol Pract. 2018 Mar – Apr;6(2):707. PMID: 29525002


Feiring B, Laake I, Bakken IJ, Greve-Isdahl M, Wyller VB, Håberg SE, Magnus P, Trogstad L. HPV vaccination and risk of chronic fatigue syndrome/myalgic encephalomyelitis: A nationwide register-based study from Norway. Vaccine. 2017 Jul 24;35(33):4203-4212. PMID: 28648542

The researchers studied the association between HPV vaccination and risk of CFS/ME and also assessed medical history in relation to both risk of CFS/ME and HPV vaccine uptake. No indication of increased risk of CFS/ME following HPV vaccination was observed among girls in the first 6 birth cohorts offered HPV vaccine through the national immunisation programme in Norway.


Rowe PC, Marden CL, Jasion SE, Cranston EM, Flaherty MA, Kelly KJ. Cow’s milk protein intolerance in adolescents and young adults with chronic fatigue syndrome. Acta Paediatr. 2016 Sep;105(9):e412-8. PMID: 27177188

In a two-year prospective study of 55 adolescents and young adults with chronic fatigue syndrome, we defined intolerance to milk protein if subjects reported (i) no evidence of immediate or anaphylactic reactions to milk, (ii) at least 2 of the following 3 chronic symptoms: gastroesophageal reflux, early satiety and epigastric/abdominal pain, (iii) improvement in upper gastrointestinal symptoms on a milk protein elimination diet and (iv) at least 2 recurrences of upper gastrointestinal symptoms >two hours following open re-exposure to milk protein. The authors concluded that cow’s milk protein intolerance is a common problem in young people with chronic fatigue syndromeand is a treatable contributor to their symptoms.



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