ME and CFS Medical Abnormalities – Reproductive


Following is a list of articles about abnormalities with pain issues in ME and CFS.

Links to the more than 1,000 peer-reviewed journal articles are listed on the ME and CFS Medical Abnormalities page of this website.


Chao CH, Chen HJ, Wang HY, Li TC, Kao CH. Increased risk of organic erectile dysfunction in patients with chronic fatigue syndrome: a nationwide population-based cohort study. Andrology. 2015 Jul;3(4):666-71. PMID: 26198797

Compared with a  non-CFS cohort, the incidence density rate of organic erectile dysfunction was 1.88-fold higher in a CFS cohort.


Boneva RS, Lin JM, Unger ER. Early menopause and other gynecologic risk indicators for chronic fatigue syndrome in women. Menopause. 2015 Aug;22(8):826-34. PMID: 25647777

Women with CFS reported significantly more gynecologic conditions and surgical operations than controls.


Boneva RS, Maloney EM, Lin JM, Jones JF, Wieser F, Nater UM, Heim CM, Reeves WC. Gynecological history in chronic fatigue syndrome: a population-based case-control study. J Womens Health (Larchmt). 2011 Jan;20(1):21-8. PMID: 21091051

A greater proportion of women with CFS than controls reported pelvic pain unrelated to menstruation, endometriosis, and periods of amenorrhea. Compared to controls, women in the CFS group had a higher mean number of pregnancies and gynecological surgeries. Among menopausal women, 76% of the CFS group reported hysterectomy vs. 54.6% of controls, and 56% of women with CFS reported oophorectomy vs. 34.3% of controls.


Blazquez A, Alegre J, Ruiz E. Women with chronic fatigue syndrome and sexual dysfunction: past, present, and future. J Sex Marital Ther. 2009 Oct;35(5):347-59. PMID: 20183003

Sexual dysfunction is a problem experienced by patients with chronic fatigue syndrome (CFS).


Harlow BL, Signorello LB, Hall JE, Dailey C, Komaroff AL. Reproductive correlates of chronic fatigue syndrome. Am J Med. 1998 Sep 28;105(3A):94S-99S. PMID: 9790489

Women with CFS reported increased gynecologic complications, a lower incidence of premenstrual symptomatology. Issues included self-reported irregular cycles, periods of amenorrhea, sporadic bleeding between menstrual periods, and factors suggestive of abnormal ovarian function (such as a history of polycystic ovarian syndrome, hirsutism, and ovarian cysts).



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