Oxford Criteria for CFS (1991)


Sharpe MC, Archard LC, Banatvala JE, Borysiewicz LK, Claire AW, David A, Edwards RH, Hawton KE, Lambert HP, Lane RJ. A Report–Chronic Fatigue Syndrome: guidelines for research. Journal of the Royal Society of Medicine, 84(2), 118-121, 1991 February.


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Severe disabling fatigue of at least a 6-month duration that affects both physical and mental functioning, and that is present for more than 50% of the time.

Other symptoms — particularly myalgia, sleep and mood disturbances — may be present.


Exclusion criteria:

* Active, unresolved or suspected disease that is likely to cause fatigue

* Psychotic, melancholic or bipolar depression (but not uncomplicated major depression)

* Psychotic disorders

* Dementia

* Anorexia or bulimia nervosa


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