ME and CFS Abnormalities – Opthomological


Following is a list of articles about opthomological issues  in ME and CFS.

Links to the more than 1,000 peer-reviewed journal articles are listed on the ME and CFS Medical Abnormalities page of this website.


Chen CS, Cheng HM, Chen HJ, Tsai SY, Kao CH, Lin HJ, Wan L, Yang TY. Dry eye syndrome and the subsequent risk of chronic fatigue syndrome-a prospective population-based study in Taiwan. Oncotarget. 2018 Jul 17;9(55):30694-30703. PMID: 30093979

We identified 884 patients with dry eye syndrome (DES) and 3,536 matched controls in baseline and estimated the hazard ratios for incident CFS in the follow-up period. Patients with DES had a 2.08-fold considerably increasing risk of developing CFS, compared to non-DES group.


Godts D, Moorkens G, Mathysen DG. Binocular Vision in Chronic Fatigue Syndrome. Am Orthopt J. 2016 Jan;66(1):92-97. PMID: 27799582

This study compares binocular vision measurements between Chronic Fatigue Syndrome(CFS) patients and healthy controls. Patients with CFS showed highly significant smaller fusion amplitudes, reduced convergence capacity, and a smaller accommodation range compared to the control group.


Hutchinson CV, Maltby J, Badham SP, Jason LA. Vision-related symptoms as a clinical feature of chronic fatigue syndrome/myalgic encephalomyelitis? Evidence from the DePaul Symptom Questionnaire. Br J Ophthalmol. 2014 Jan;98(1):144-5. PMID: 24187048

People diagnosed with CFS/ME consistently report that they experience vision-related symptoms associated with their illness.


Badham SP, Hutchinson CV. Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome. Graefes Arch Clin Exp Ophthalmol. 2013 Aug 6. PMID: 23918092

ME/CFS patients showed relatively intact ability to accurately fixate the target (prosaccades), but were impaired when required to focus accurately in a specific position opposite the target (antisaccades). Patients were most markedly impaired when required to direct their gaze as closely as possible to a smoothly moving target (smooth pursuit).


Hutchinson CV, Badham SP. Patterns of abnormal visual attention in myalgic encephalomyelitis. Optom Vis Sci. 2013 Jun;90(6):607-14. PMID: 23689679

Patients and controls performed similarly on the processing speed subtest of the Useful Field of View. However, patients exhibited marginally worse performance compared with controls on the divided attention subtest and significantly worse performance on the selective attention subtest. In the spatial cueing task, they were slower than controls to respond to the presence of the target, particularly when cues were invalid. They were also impaired, relative to controls, on visual search tasks.


Jhanji V, Beltz J, Vajpayee RB. Contact lens-related acanthamoeba keratitis in a patient with chronic fatigue syndrome. Eye Contact Lens. 2008 Nov;34(6):5-6.33 PMID: 18997544

Contact lens-related Acanthamoeba keratitis was diagnosed in a 58-year-old man with a history of CFS. After medical management failed to prevail, a penetrating keratoplasty was performed in the affected eye.


Caffery BE, Josephson JE, Samek MJ. The ocular signs and symptoms of chronic fatigue syndrome. J Am Optom Assoc. 1994 Mar;65(3):187-91. PMID: 8201170

Significant ocular symptoms were present in all 25 of a group of CFS patients. The most common clinical findings were abnormalities of the preocular tear film and ocular surface and reduced accommodation for age.


Potaznick W, Kozol N. Ocular manifestations of chronic fatigue and immune dysfunction syndrome. Optom Vis Sci. 1992 Oct;69(10):811-4. PMID: 1437004

CFS patients are especially likely to report a wide variety of eye problems.


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