Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994 Dec 15;121(12):953-9.
Clinically evaluated, unexplained, persistent or relapsing chronic fatigue that is
* of new or definite onset (has not been lifelong)
* is not the result of ongoing exertion
* is not substantially alleviated by rest and
* results in substantial reduction in previous levels of occupational, educational, social or personal activities
The concurrent occurrence of four or more of the following symptoms, all of which must have persisted or recurred during 6 or months of illness and must have predated the fatigue:
1. Self-reported impairment in short-term memory or concentration severe enough to cause substantial reduction in previous levels of occupational, educational, social or personal activities.
2. Sore throat
3. Tender cervical or axillary lymph nodes
4. Muscle pain
5. Multi-joint pain without joint swelling or redness
6. Headaches of a new type, pattern or severity
7. Unrefreshing sleep
8. Post-exertional malaise lasting more than 24 hours
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