ME and CFS Medical Abnormalities – Mycoplasma


Following is a list of articles about abnormalities with mycoplasma in ME and CFS.

Links to the more than 1,000 peer-reviewed journal articles are listed on the ME and CFS Medical Abnormalities page of this website.


Endresen GK. Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes. Rheumatol Int. 2003 Sep;23(5):211-5. PMID: 12879275

Mycoplasma blood infection has been detected in about 50% of patients with CFS and/or FMS. Most patients with CFS/FMS who have mycoplasma infection appear to recover and reach their pre-illness state after long-term antibiotic therapy with doxycycline.


Nijs J, Nicolson GL, De Becker P, Coomans D, De Meirleir K. High prevalence of Mycoplasma infections among European chronic fatigue syndrome patients. Examination of four Mycoplasma species in blood of chronic fatigue syndrome patients. FEMS Immunol Med Microbiol. 2002 Nov 15;34(3):209-14. PMID: 12423773

Compared to American CFS patients (M. pneumoniae>M. hominis>M. penetrans), a slightly different pattern of mycoplasmal infections was found in European CFS patients (M. hominis>M. pneumoniae, M. fermentansz.Gt;M. penetrans).


Nasralla M, Haier J, Nicolson GL. Multiple mycoplasmal infections detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia syndrome. Eur J Clin Microbiol Infect Dis. 1999 Dec;18(12):859-65. PMID:10691196

More than 60% of patients with CFS were found to have mycoplasmal blood infections, such as Mycoplasma fermentans infection. More than half the patients had multiple infections.


Vojdani A, Choppa PC, Tagle C, Andrin R, Samimi B, Lapp CW. Detection of Mycoplasma genus and Mycoplasma fermentans by PCR in patients with Chronic Fatigue Syndrome. FEMS Immunol Med Microbiol. 1998 Dec;22(4):355-65. PMID: 9879928

A polymerase chain reaction (PCR)-based assay was used to detect Mycoplasma genus and M. fermentans genomes in peripheral blood mononuclear cells (PBMC) of CFS patients. Mycoplasma genus and M. fermentas were found in 52% and 24% of CFS samples, vs. 14% and 8% of control subjects (P<0.0001).


Choppa PC, Vojdani A, Tagle C, Andrin R, Magtoto L.  Multiplex PCR for the detection of Mycoplasma fermentans, M. hominis and M. penetrans in cell cultures and blood samples of patients with chronic fatigue syndrome. Mol Cell Probes. 1998 Oct;12(5):301-8. PMID: 9778455

The percentage of Mycoplasma infection was found to be 52% in CFS patients and 15% in healthy individuals. Mycoplasma fermentans, M. hominis andM. penetrans were detected in 32%, 9% and 6% of the CFS patients, compared to 8%, 3% and 2% of the healthy control subjects, respectively.


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