Dr. Jill Carnahan wrote a blog article on “The Surprising Link Between Ehlers-Danlos Syndrome and Mast Cell Activation Syndrome.”
From the article:
Researchers believe that there is a link between MCAS and EDS. Mast cells adhere to proteins called fibronectin and vitronectin in the extracellular matrix, and this interaction can lead to the production and release of various proinflammatory molecules called cytokines. Since EDS are caused by defects in collagen, they suggest that the abnormal internal signals caused by these mutations can lead to changes in mast cell behavior, leading to MCAS.
In one study, researchers have found that a subpopulation (approximately 66%) of patients with hEDS and Postural Tachycardia Syndrome (POTS, lightheadedness and rapid heartbeat upon standing) also had MCAS. Patients with hEDS and POTS also exhibited symptoms consistent with MCAS. Therefore, it is possible that there is also a link among these three conditions.
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