Self Hacked on “Understanding CIRS/Mold Illness”
September 1, 2017
Joe Cohen and his colleagues at Self Hacked have written several articles on topics related to mold illness.
These include:
Underlying Causes of CIRS/Mold Illness
Proven Uses for Cholestyramine
How To Treat Histamine Intolerance
Interview with Dr. Ritchie Shoemaker
From the article called “Underlying Causes of CIRS/Mold Illness”:
When you have low oxygen (hypoxia), your mitochondria don’t work as well and for good reason. Oxygen needs to be there to accept electrons in the mitochondria. When you have low oxygen, it can’t accept electrons, so your body wants to slow mitochondrial function down.
When you have low oxygen, your body responds by slowing the conversion of NADH to NAD+ (less oxidation). Therefore, you have a buildup of NADH and a relative reduction of NAD+.
The more NAD+ levels increase, the more SIRT1 is active (on the other hand, Nicotinamide blocks SIRT1 activity) (R).
When you have high NAD+ levels, it means you likely have been using your energy up and have a negative energy balance – you’re expending more calories than you’re consuming. It also likely means you’re well oxygenated.
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