Jill Carnahan, M.D., wrote an article for her blog called “How To Reverse Estrogen Dominance Naturally – Detox, Food & Supplements.”
From the article:
We often oversimplify estrogen. First we lump three different types together, then we don’t acknowledge the different effects estrogen has on receptors, and finally estrogen metabolites are often missing from the conversation.
Not only do you need proper balance and breakdown to keep estrogen in check, these different types antagonize one another in the body. These three different types of estrogen bind to two different types of estrogen receptors – alpha receptors that promote cell growth and beta receptors which inhibit cell growth.
Many tissues throughout the body have both types of receptors where estrogen antagonizes against itself via alpha and beta receptors.
Estrone (E1) – This form of estrogen primarily activates alpha receptors in a 5 to 1 ratio, which increases cell proliferation.
Estradiol (E2) – E2 binds to both alpha and beta receptors equally.
Estriol (E3) – This estrogen is mostly activate beta receptors in a 3 to 1 ratio, which inhibits cell proliferation but at a lower rate than E1.
Estrogen’s effects on different receptors make the type of the estrogen dominant in a body important. Estrogen metabolites are also important. Estrogen is broken down along two pathways into two metabolites:
2-Hydroxyestrone – Generally, this metabolite works to block stronger estrogens.
16Beta-Hydroxyestrone – While this metabolite promotes cell proliferation, Higher levels of 16Beta-Hydroxyestrone have been associated with obesity, hypothyroidism, pesticide toxicity, and higher levels of omega-6 fatty acids.
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