What I’ve Learned (So Far) About Getting Set Up for Ozone Therapy

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Using the Synergy WPS-100 ozone generator to do an inhaled treatment of ozone bubbled through olive oil in order to try to treat infections in the sinuses.

July 23, 2015

By Lisa Petrison

With almost no exceptions, I have found mold avoidance and detoxification to be the most helpful treatments I have used in moving toward wellness.

I was sick for more than a decade with M.E. (myalgic encephalomyelitis) and nearly bedridden from it for more than a year. Although many treatments seemed individually a little helpful to me, my health over the years was on a continual downward trajectory.

In 2007, I realized that toxic mold was playing a role in my illness and moved away from my problematic house, leaving all my possessions behind. I since have spent a great deal of time seeking out the most pristine locations I could find.

Clean living (such as a diet consisting solely of high-quality organic foods) and intensive detoxification (including cholestyramine, coffee enemas, sweating, nutritional supplements and other things) also have been focal points for me.

This all has been enormously helpful. The vast majority of my symptoms (most of them previously severe) are no longer an issue. My brain has been working at almost pre-illness levels. My reactivity has gone way down and I have been living without incident in a regular house in a good location in civilization.

What have remained are gut problems, especially of my small intestine. Specifically, I’ve had severe adhesions and other gut issues that did not respond sufficiently to diet or any of the many other treatments that I tried. The gut problems became bad enough that my health in general took a hit, with a lot of fatigue and periods of foggy thinking.

Trichothecene mold toxins are (as one paper put it) “exquisitely toxic” to the small intestine, and other toxicity does not seem to be very good for the gut either. I still believe that getting all those toxins out of my brain and other organs was a really good thing, but the downside to detoxifying them seems to have been the damage that the toxins did to my gut as they made their way out of my system.

(Erik Johnson has said that he feels that sweating out the toxins through exercise is safer than detoxifying them through the intestines, and after this experience I tend to think that he is correct about that.)

Eventually I came to believe that the adhesions were caused by some kind of infection (likely fungal) living between the fascia and the skin, in the wake of the toxicity issues. I suspect that other pathogen problems have been playing a role in my gut problems as well.

That being the case, I found it interesting that three mold avoiders who have recovered much of their health – Dave Asprey of Bulletproof Executive, Scott Forsgren of Better Health Guy, and A.M. Runyan of Grow Your Life – all spoke highly of ozone treatments as a way to address chronic Lyme infections and other pathogen issues.

In addition, I was intrigued to read that rectal ozone was encouraged by the Gerson Institute as one of the extremely few non-protocol treatments that they found to be allowable.

In the book The Gerson Therapy, Charlotte Gerson and Morton Walker state: “Ozone given by rectal insufflation is also very valuable since it increases blood oxygenation, energy, and the ability of organ systems to function at higher levels.”

I don’t have any opinion one way or the other with regard to whether the Gerson Therapy is appropriate for people with cancer, and I don’t know whether it would be a good idea for most people with M.E.

However, I do feel like it is surprisingly effective at promoting detoxification in ways that are minimally harmful to the system and at ridding the system of intestinal biofilms.

Of the many things that I had done to try to address my gut issues before starting ozone therapy, eight weeks of full Gerson Therapy seemed to be the most helpful – mostly, I think, by addressing biofilm issues.

So their enthusiastic endorsement of ozone seemed relevant to me.

(Note: I am going to be writing a blog about the Gerson therapy soon and am interested in including summaries of experiences of those with chronic multisystem illnesses. Please send these to me at info@paradigmchange.me for inclusion in the article.)

In addition, I once had some rectal ozone treatments when getting colonics (before my intestinal problems got so overtly bad) and felt that they were at least mildly helpful and certainly not harmful.

So all things considered, ozone therapy seemed worth pursuing a bit more.

Even after I decided that ozone therapy was worth a try though, it took me a couple of months to actually be able to start using it. It is a complex treatment with a lot of scattered information that took a while to track down and understand.

After I mentioned in the Facebook group that I run, Mold Avoiders, that I was trying ozone therapy, I started getting a whole lot of questions about setting up the equipment.

This blog is designed to convey what I have found out about setting up to do ozone therapy to others, to make the learning process easier for them if they decide that this is something that they want to do.

It is emphatically not designed to encourage anyone to try ozone therapy. I have only been set up to do ozone therapy for a couple of weeks myself.

So far, I do believe that – especially in conjunction with the two months’ worth of full Gerson that I did prior to the starting the ozone – it has been very helpful to me in terms of addressing my own gut issues.

My gut is not wholly healed, but it is much better than it was even a week or two ago. It is working more normally and the adhesions are better. I also am less tired and foggy feeling.

So far, I have done daily rectal insufflations; daily cupping (mostly on the upper part of the small intestine and also on my liver and spleen); a few vaginal insufflations; and drinking of ozonated water.

I’ve also used ozonated oil for abdominal massage, with the goal of loosening adhesions.

For the past few days, I’ve been experimenting with breathing in ozone after it was bubbled through olive oil.  I was interested enough in this to buy the device because other than avoidance, avoidance and more avoidance, treatment of sinus infections (both MARCoNS and fungal) so far has come up at the top of the heap of the treatment alternatives on the Mold Avoidance Survey.

(Data for the survey is still being collected – if you’ve done any mold avoidance of any kind, please participate!)

I did have very bad sinus infections when I was living in the moldy house and actually used the exact same treatment that Dr. Joseph Brewer is now promoting (prescribed by Dr. Dale Guyer) at that time.

I don’t know that my sinuses are an issue now, but ozone directed at the sinuses seemed worth trying out since sinus treatments in general have been reported as helpful to others.

Note:  Regular ozone from the machine should NEVER be breathed since this can cause severe lung damage.  Bubbling the ozone through oil is a special technique designed to make it safe to breathe.

I also have done a few earscope treatments. I didn’t have any problems, but now I am a little nervous about those because someone experienced with ozone just wrote:

“With ear insufflations, there is a very high risk of developing excruciating pain due to blocked eustachian tubes. Often, as part of a Herxheimer reaction to the EIs, the ears start discharging oxidized toxins in the form of lymph fluid. That can lead to inflammation inside the ears and blockage. The resulting pain is among the most agonizing experiences one can imagine.”

This makes me not want to do earscope treatments myself at all and to hesitate to bring them up as a possibility to others. Information on doing this treatment is included in this article, but please be careful.

One ozone treatment not discussed in this article is IV ozone. I had this treatment a few times from a doctor several years ago and didn’t have any problems with it, but it seems to me to have too many things that can go wrong for most people to consider doing at home.

Certainly, insofar as anyone wants to attempt IV ozone treatment on their own, I don’t want to be responsible for encouraging them. I personally do not think it’s a good idea to be doing it without medical supervision and don’t have enough knowledge about IV’s to be giving instructions to anyone else about how to do them.

So I am leaving that treatment out entirely.

As for the ozone treatments that I do discuss here: as I say, I am emphatically not recommending them either. I’m just consolidating information about them that I learned from other sources, in order to make it easier for people to understand what others have recommended.

I encourage everyone to research this topic thoroughly and to consult with a professional medical provider about the issues involved before proceeding with this type of treatment approach.


Video: Dr. Robert Rowen – who specializes in the therapeutic uses of ozone – speaks to the Silicon Valley Health Institute.

Purposes of Ozone Therapy

From what I have been able to gather, ozone therapy works by at least three basic mechanisms.

First, it kills pathogens.

Second, if used extensively enough, if may have some effects in terms of degrading toxins.

Third, it has a hormesis-type effect with regard to oxidative stress, in that it encourages the body to ramp up its production of protective enzymes.

While all of these things are good in theory, all of them may have negative effects for those multisystem illness patients who are not in a position to handle them.

Certainly, forcing die-off and detox for people who living in a particularly problematic environment or who have systems that are still currently very weak is never a good idea.

These individuals may not be capable of responding to a stimulus by creating more helpful enzymes either.

Very likely, the reason that I have found ozone helpful is because I already am very far along in the recovery process and just have a few specific problems left, rather than a system that is wholly in meltdown mode.

Probably I would not have been able to tolerate any kind of ozone therapy when I was still living in the bad environment or soon after moving out. And I would not expect others who are still being exposed or in early recovery to be able to tolerate it either.

As background, here is what Dr. Sarah Carnes of the Sophia Institute (run by Dr. Dietrich Klinghardt) says about ozone therapy in this kind of disease:

What ozone does in the body is not a one word answer. It has different actions depending on its concentration and how it’s administered. As a detox agent, it stimulates the body’s antioxidant systems by offering a mild prooxidant challenge. The challenge is not enough to cause oxidant damage, but enough that the body increases its production of the enzymes: glutathione peroxidase, reductase, super oxide dismutase, and catalase, setting off a response where free radicals are swept away all over the body, even though the ozone may have introduced into only one area. Bacteria, viruses, and some types of unhealthy cells don’t have that same enzymatic protection from oxidation, so they are made non-viable, while human cells survive.


Here is the description of the mechanism of action from the peer-reviewed published paper “Ozone Therapy” A Clinical Review” by A.M. Elvis and J.S. Ekta:

Inactivation of bacteria, viruses, fungi, yeast and protozoa: Ozone therapy disrupts the integrity of the bacterial cell envelope through oxidation of the phospholipids and lipoproteins. In fungi, O3 inhibits cell growth at certain stages. With viruses, the O3 damages the viral capsid and upsets the reproductive cycle by disrupting the virus-to-cell contact with peroxidation. The weak enzyme coatings on cells which make them vulnerable to invasion by viruses make them susceptible to oxidation and elimination from the body, which then replaces them with healthy cells.

Stimulation of oxygen metabolism: Ozone therapy causes an increase in the red blood cell glycolysis rate. This leads to the stimulation of 2,3-diphosphoglycerate which leads to an increase in the amount of oxygen released to the tissues. Ozone activates the Krebs cycle by enhancing oxidative carboxylation of pyruvate, stimulating production of ATP. It also causes a significant reduction in NADH and helps to oxidize cytochrome C. There is a stimulation of production of enzymes which act as free radical scavengers and cell-wall protectors: glutathione peroxidase, catalase and superoxide dismutase. Production of prostacyline, a vasodilator, is also induced by O3 

Activation of the immune system: Ozone administered at a concentration of between 30 and 55 μg/cc causes the greatest increase in the production of interferon and the greatest output of tumor necrosis factor and interleukin-2. The production of interleukin-2 launches an entire cascade of subsequent immunological reactions.

Mechanism of action of O3 on the human lung: Ozone exposure induces a significant mean decrement in vital capacity. It significantly increases mean airway resistance and specific airway resistance but does not change dynamic or static pulmonary compliance or viscous or elastic work. It also significantly reduces maximal transpulmonary pressure. And further more significantly increases respiratory rate and decreased tidal volume.


Video: An overview of how to set up ozone equipment by Promolife.


The rest of this article focuses not on whether or why to set up ozone equipment, but rather on how those who appear to be experts suggest setting up and using the equipment.

The Promolife video just above this section is a good accompaniment to the discussion here, since the viewer can actually see the equipment being used and thus get more of a sense of it.

More detailed information about using ozone can be found in the overview article “A Review of Ozone Therapy Applications” by Jeffrey Taylor.

Another detailed article possibly worth reading is called “How to Apply Ozone (O3) Therapy at Home.”

Note that one key concept of ozone is ug/ml, which often is called “gamma.” This refers to the amount of ozone in each milliliter of gas that comes out of the machine.

A higher gamma refers to a higher-strength ozone.

Generally speaking, ozone used for therapeutic applications may range from 20-80 gamma.

Most machines have more than one setting – a lower setting (to make weaker ozone) and higher settings (to make stronger ozone).

Note though that the strength of the ozone will be determined not just by the setting chosen but also by how fast the oxygen is going into the machine.

If the oxygen is going in more slowly, then each milliliter of oxygen will be more saturated with O3 particles and the ozone will be stronger.

Each ozone machine comes with a chart that shows how to calculate the gamma, based on both how fast the oxygen is going into the ozone machine (liters per minute or LPM) and the setting chosen.

Here is the chart from the Synergy WPS-100 machine:


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The best choice in terms of LPM and setting varies depending on the application being used and also how much ozone the person being treated can tolerate.

Generally, people who are further along in the recovery process can tolerate a higher gamma level.



The Promolife O3 Elite oxygen generator.


The first piece of equipment needed in order to do ozone therapy is the ozone generator. This converts oxygen (O2) into ozone (O3).

There are three main companies that I have encountered that sell ozone generators that are used for therapeutic purposes – Longevity Resources, Promolife, and Synergy Water Systems.

Longevity Resources is based in British Columbia, Canada. It sells ozone machines and related products mostly to professionals providing ozone therapy to others. Their products are said to be high-quality but also are relatively expensive.

Although the prices are not listed on the Longevity website, a recent price list is available for viewing. The well-known ozone specialist Dr. Robert Rowen, M.D., often recommends Longevity products for home use.

Promolife is a somewhat more moderately priced company based in Arkansas. It sells several ozone machines and a wide range of related products to both consumers and professionals.

The Promolife website is very user-friendly with a number of easy-to-follow videos. The company also has a number of equipment packages that allow people to purchase all the supplies that they might need for particular applications without having to think much about it.

Synergy Water Systems is a small American company that makes two reasonably priced ozone machines and no accessories. It states that the machines are made in the U.S. for water purification purposes.

Although the Synergy machines are significantly less expensive than the other companies’ products, I did not find anyone (of the many people I encountered online who had purchased the machines) who said anything negative about them. Therefore, the more basic of the company’s machines is the one that I purchased to start out.

Note that despite the wide range of accessories available that obviously pertain to ozone therapy, all of these machines are officially offered for water purification purposes rather than medical therapy.

Following are some details about the more reasonably priced machines from each of these companies.



Synergy Water Systems:

One of the most reasonably priced entry-level ozone machines on the market is the Synergy Water Purification System WPS-100. It makes ozone up to 80 gamma and comes in its own carrying case.

The price stated for the WPS-100 on the Synergy website is $499, but it currently is available at a group discount to those joining the Facebook group Ozone to Health for $375.

Synergy also makes a dual machine called the WPS-400, priced at $999 on the company’s website.


Promolife Generators

Promolife O3 Elite:

Promolife sells the O3 Elite single ozone generator for $799 and a O3 Elite dual ozone generator for $1195.

A short video from the company provides some details about the products.


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The Longevity EXT50 ozone generator.

Longevity EXT50:

The Longevity EXT50 is a simple ozone machine with a maximum output of 55 gamma. The price for just the ozone machine is $995.

The Longevity EXT50 Basics Package includes the ozone generator, a tubing accessory package, a 640 liter oxygen tank, a pediatric oxygen regulator, a 500 ml glass flask for ozonating water, and an ozone destruct unit. The price is $1695.

The Longevity EXT50 Complete Briefcase Package includes the ozone generator, a briefcase, a 50 ml glass bubbler, a 50 ml glass trap, a bubbler stand, a 500 ml glass flask for ozonating water, catalytic ozone destruct, a tubing accessories package, a 240 liter oxygen tank, and a pediatric oxygen regulator. The price is $1995.


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Longevity EXT120 briefcase package.

Longevity EXT120:

The Longevity EXT120 is a higher-output ozone machine going up to 120 gamma. The cost for the basic machine is $1895.

The Longevity EXT120 Basics Package includes the ozone generator, a tubing accessory package, a 640 liter oxygen tank, a pediatric oxygen regulator, a 500 ml glass flask for ozonating water, and an ozone destruct unit. The price is $2695.

The Longevity EXT50 Complete Briefcase Package includes the ozone generator, a briefcase, a 50 ml glass bubbler, a 50 ml glass trap, a bubbler stand, a 500 ml glass flask for ozonating water, catalytic ozone destruct, a tubing accessories package, a 240 liter oxygen tank, and a pediatric oxygen regulator. The price is $2900.


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The A2Z Ozone Aqua 6.

A2Z Ozone Aqua 6:

The A2Z Ozone Aqua 6 ozone generator is not really comparable to the others discussed in this article. The main reason is that it does not use a source of pure oxygen. Instead, it just ozonates the air from the environment.

(Note that only 21% of the total molecules in the air are oxygen. Air is mostly made up of nitrogen, with small amounts of other molecules such as carbon dioxide also present.)

I purchased this machine a few years ago.  It seems to work fine for water purification purposes, to kill microorganisms and possibly degrade toxins somewhat. My produce lasts much longer without getting moldy if I put it in a sink full of water and then let it ozonate for a while. Water tastes better to me after it has been ozonated.

Recently I have been hand-washing all of my clothes and bedding, and sometimes I run the ozonator in the sink with my white items. It also works for air-freshening purposes (and is strong enough that it’s necessary to leave the environment when it’s running).

So these are approved uses of this machine.

However, Amazon reviews also show dozens of people stating that they have benefited from using the freshly ozonated water from this machine for therapeutic purposes – for instance, by drinking the water, using it for enemas, or washing their sinuses with it.

Some knowledgeable individuals (including physicians) have expressed concern about the use of water from machines such as this one, due to the fact that the alteration of the nitrogen in the air by the ozone machine results in a substance that they believe to be toxic.

Their position is that any sort of treatments done with ozone should be with ozone machines that use pure or almost-pure sources of oxygen (e.g. a tank or concentrator).

Personally, I have consumed freshly ozonated water from this machine and also used it to dilute coffee enemas, prior to learning about the issue with the nitrogen.

I didn’t feel that I reacted negatively to that freshly ozonated water. I more felt that it seemed mildly beneficial enough that I was inclined to look into better equipment for more intensive ozone treatments.

Now that I am aware of the concerns about the nitrogen and also now that I have the equipment that uses just oxygen, I am not using freshly ozonated water from the machine for drinking or enemas any more.

I do think it’s a nice little machine for other household purposes.

The price is currently $70 on Amazon.


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A medical oxygen tank (left) and two sizes of industrial oxygen tanks.


For those who have a doctor willing to prescribe medical oxygen, medical oxygen is widely available and may be covered by insurance.

Industrial oxygen (used for welding and other applications) is the same purity as medical oxygen and also is used by many people for ozone therapy.

Both medical oxygen and industrial oxygen are available in small tanks appropriate for traveling.

Both medical and industrial oxygen tanks need to be used with a special low-flow regulator that allows only a small amount of oxygen to be released from the tank at a time.

A possible alternative to using an oxygen tank is an oxygen concentrator, which is a machine which converts the oxygen from the air into a fairly pure source of oxygen.


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Fittings for medical oxygen (left) and industrial oxygen.

Oxygen Tanks:

For those with a prescription, suppliers of medical oxygen are present in most towns of any size.

Suppliers of industrial oxygen are widely present as well. The easiest way to find them seems to be to check for welding suppliers (often associated with hardware or home-improvement stores) on the Internet.

Most welding shops will sell an industrial oxygen tank to consumers and fill it with oxygen.

Often when people come to get the tank refilled, it will be exchanged for a different tank already filled with oxygen rather than refilled on the spot.

Smaller tanks may be sold at welding shops and may be appropriate since the flow rate of oxygen used for ozoning is so small.

(Regardless of tank size, do be careful not to leave the tank open when not using the oxygen or all the oxygen will leak out!  Insofar as the tank is not left open, refills for ozone therapy will not need to be done very often even with a small tank since the amount of oxygen used is so small.)

For comparison purposes, the tank that I bought at the hardware store in my small New Mexico town holds 255 liters of oxygen and is about 14″ high. It cost about $130 filled with oxygen and about $25 for a refill.

If an industrial or medical tank is not available locally, then it is possible to purchase one on the Internet and have it shipped. However, these tend to be really expensive (in part because of the shipping costs), and some local oxygen providers will not fill tanks that do not belong to them.

Therefore, checking out the situation at local oxygen sources before mail-ordering a tank seems the best strategy.

For those who need to purchase an industrial tank through the Internet, they may be available through Promolife, NetWelder, or other companies.


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A medical oxygen regulator (left) and an industrial oxygen regulator (right).

Low-Flow Regulators:

Another needed piece of equipment for oxygen therapy is the low-flow oxygen regulator.

The regulator decreases the amount of oxygen coming out of the oxygen tank from a large spray to a tiny trickle.

While most medical and industrial uses of oxygen require fairly high amounts of oxygen (such as 1 or more liters per minute), ozone machines require smaller amounts (such as 1/8 liters per minute or even less) in order to make gas that is highly concentrated with ozone.

The low-flow regulator needed to do ozone therapy thus seems to be a fairly unusual piece of equipment.

For medical oxygen, this is often called a “pediatric regulator” (although not all pediatric regulators are low-flow enough for ozone therapy purposes).

For industrial oxygen, low-flow regulators seem to be made mostly for ozone machines.

Therefore, purchasing from an ozone manufacturer may be necessary.

For instance, Promolife sells low-flow regulators designed for this purpose for both medical tanks and for industrial tanks. The usual cost is $170 (currently discounted to $90-100).

Longevity sells low-flow regulators for medical or industrial tanks for $225.

Low-flow regulators sporadically may be available elsewhere for a much lower cost, however.

For instance, the medical supply company CPR Savers is currently selling a low-flow regulator that seems appropriate for using therapeutic ozone with an industrial tank for only $33.

A challenge with buying a less expensive regulator is that there are several issues that need to be considered if the right unit is to be obtained.

Following are the things that need to be considered:

* Is it right for your tank?  Medical oxygen tanks require a regulator marked “870” that fits on top of the tank and then is screwed on by hand.  Industrial oxygen tanks require a regulator marked “540” that is attached to the outside of the tank and then screwed on with a wrench.

* Are the flow options right? At minimum, the regulator should have options of 1, 1/2, 1/4 and 1/8 lpm. It would be better if it went down further (the one made by Promolife also has 1/16 and 1/32 options).

* Does it have a barb outlet? Regulators may have one of two types of outlet for the oxygen to pass through. The barb outlet tapers toward the bottom so that a tube can be easily fitted on, while a diss outlet is flat. Although an adapter such as a Christmas tree connector can be used to fit a tube to a diss outlet, this may leak and is an extra item to purchase.


DISS outlet

An industrial oxygen regulator with a diss outlet. Photo credit: Ozone to Health user group.


Barb outlet-001

An industrial oxygen regulator with barb outlet. Photo credit: Ozone to Health user group.


Unfortunately, when oxygen regulators are being sold on (say) Amazon or eBay, the relevant information may not be supplied or may be inaccurate. I purchased two inappropriate regulators online before giving up and shelling out the money for the Promolife regulator. I would have saved a lot of time if I’d just done that first.

Here is what the medical oxygen tank and the low-flow regulator should look like once it is set up:


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Medical oxygen tank with low-flow regulator attached.


And here is what the industrial oxygen tank should look like with the low-flow regulator attached:


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Industrial oxygen tank with low-flow regulator attached.


Oxygen Concentrators:

An alternative to buying oxygen in tanks is an oxygen concentrator. This is a large machine that takes oxygen from the air and converts it into mostly-pure oxygen.

Oxygen concentrators do not make oxygen that is as pure as either medical oxygen or industrial oxygen, and so they are not recommended for ozone administered through IV.

Some experts (such as Dr. Robert Rowen) suggest that they are not a good idea even for other uses such as insufflation, due to the small amount of nitrogen still present in the oxygen being converted into a supposedly toxic substance by the ozone machine.

Concentrators also are quite bulky, usually fairly noisy, and require electricity. They are generally inappropriate for travel, therefore.

Even refurbished concentrators generally cost at least $300-700.

For mold avoiders, concentrators are just one more electronic item encased in plastic that has the potential of going bad and needing to be discarded.

Concentrators need to be set up for the low flow of oxygen. Often 1/8 lpm is the lowest setting (another disadvantage of using a concentrator).

Here is a refurbished low-flow concentrator being sold by Promolife.


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A refurbished oxygen concentrator sold by Promolife.


On the positive side, concentrators do not require obtaining an oxygen prescription or finding a welding shop to supply oxygen. They are easily purchased through the Internet and can be delivered within a few days.

They require just one purchase.

In most cases, they are sturdy machines that last many years and that can be resold to someone else if need be.


Promolife Bag

The ozone-proof rectal insufflation bag from Promolife.


One of the most popular ozone treatments is the insertion of small amounts of ozone into the rectum, through the use of a catheter.

The use of ozone in this way is said to have the potential of penetrating the entire body almost as effectively as IV ozone (though likely more slowly).

Insofar as gut issues are a problem (as they are for all or nearly all chronic multisystemic illness patients), using ozone rectally may have a direct effect.

In its most basic form, these kinds of insufflations involve attaching a catheter to the silicone tubing that comes out of the ozone machine.

The catheter is inserted a few inches or more into the rectum. The most important thing here seems to be that it feels comfortable.

Then the oxygen and ozone is turned on so that ozone can flow into the intestinal tract.

Typically, ozone strength of 30-45 gamma is advised for insufflations. An even lower gamma may be desirable for beginners.

Choosing the lowest flow rate possible to achieve that gamma (in order to introduce a minimal amount of gas into the system) is generally advised.

For instance, for the Synergy WPS-100, 30-45 gamma could be achieved at 1/4 lpm (on the medium or high setting) or at 1/8 lpm (on the low setting). Since the latter setting is a lower flow rate, that may be considered more appropriate.

The introduction of too much total gas into the rectum is to be avoided. Usually it is recommended that only 500 ml (one-half of a liter) of gas or less be inserted at one time.

For those starting out, inserting an even smaller amount (such as 150 ml) may be a very good idea. Especially when individuals are feeling ill, die-off reactions as a result of starting too fast can be significant. In addition, the insertion of more than a small amount of gas can be uncomfortable for those starting out.

These limits lead to very short treatment times.

For instance, at 1/8 LPM, the treatment time to get to 500 ml would be only four minutes.

For a beginner, the treatment time might be one minute or less. Keeping a log and increasing very gradually may be a good idea.

Catheters are available from therapeutic ozone supply companies as well as from many other places.

For instance, Promolife makes PVC catheters ($3 each or $62 for a box of 30 with catheter adapter).

Catheters also may be called colon tubes, as is the case with some of the PVC ones ($18 for set of 10) on Amazon.


Promolife Catheter Adapter

The catheter adapter from Promolife.

While some PVC catheters may attach snugly onto the silicone tubing coming from the machine, other catheters (especially silicone ones) may leak or not fit onto the tubing at all. Having a catheter adapter on hand (such as the one sold by Promolife for $4.95 or included in boxes of catheters) will allow a wider variety of choices to be used.

Following are some other general issues to consider when doing rectal insufflations.

* Clearing the colon of material before the treatment is important. If fecal matter is present in the colon, the ozone may for the most part be spent breaking it down rather than having a therapeutic effect. Having a bowel movement is helpful but may not be sufficient to wholly resolve the problem. An enema or colonic is often used for additional clearing. Some people also do a rectal insufflation to loosen things up, have a bowel movement, and then do another insufflation.

* The efficacy of rectal ozone depends on the goals. Many individuals have problems in the gut (such as biofilms, bacterial/yeast infections or parasitical infections). Rectal ozone possibly may be especially effective at addressing those issues. However, this also may mean that rectal ozone in people with gut issues may be less likely to be absorbed into the rest of the system. For people with gut problems, the use of other forms of ozone may be more effective if systemic treatment is the goal.

* Natural lubricants of the catheter are essential. For instance, coconut oil or olive oil may be used.

* Try lying on your side. In particular, lying on the right side may allow the ozone to travel further up the digestive tract.

* After the treatment, give it 30 minutes to sink in. It often is suggested that it takes up to 30 minutes for ozone to do its work in the digestive tract or to be absorbed, and so waiting that length of time before having a bowel movement, passing gas or doing an enema may be preferable.

* Consider an insufflation bag. Especially for those just starting out, using an ozone-proof bag for rectal insufflations can decrease the risks and guesswork since it is easier to note exactly how much gas is being inserted. The bag is filled with ozone from the machine and then used when desired. This video (from The Power of Ozone) provides some details.

* Consider a humidifier. While this is not necessary for rectal ozone, some people prefer them. See the section on ear insufflation for a discussion of humidifier options.

* Many people re-use their catheters at least a few times. They can be cleaned with soap and water, along with possibly a little hydrogen peroxide.

Addendum (3/13/16): Since writing this article, I have heard a report about an ozone machine that malfunctioned and released too much gas into the colon, causing a rupture to occur. Although I do not have details about this incident, it seems that this is enough of a concern that it may be prudent for anyone using rectal ozone to do so with the use of an insufflation bag. Bags of apparently high quality are now available for a low cost from Promolife.



A catheter for vaginal or rectal use.


Vaginal insufflation is similar in many ways to rectal insufflation.

Ozone therapy has the potential of helping those who have vaginal issues (such as vulvodynia or yeast infections).

The ozone that is not used in the reproductive area itself appears to have a more systemic effect.

It typically is thought that the issue of not wanting too much volume of gas to be inserted is less of a problem for the vagina than it is for the intestinal tract.

Typically, vaginal insufflations may be at a lower gamma (such as 20-30 gamma) and go on for a more extended period of time (such as up to 15 minutes).

The catheters used are the same ones used for rectal ozone.

As with rectal ozone, humidification may be used but is not required. See the section on ear insufflations for a discussion of options.



Oil bubbler by Promolife filled with olive oil.


Ordinarily, ozone cannot be breathed without causing severe lung damage.

Please do not breathe ozone straight out of the machine!

However, bubbling ozone through oil softens the ozone sufficiently so that it can be breathed much more safely.

Usually olive oil is used for this purpose.

One potentially attractive thing about breathing ozone bubbled through olive oil is that the ozone gets into the sinuses, which tend to be a weak spot for patients with mold illness or related conditions.

Although drugs are usually suggested to address the fungal infections or MARCoNS infections that often occur in the sinuses, conceivably this kind of treatment could have a positive effect as well.

Doing this treatment requires a special oil bubbling device, pictured above.

At least a few inches of olive oil are added to the bottom of the glass container. Ozone is delivered to the device, so that it is released into the oil.

As the oil bubbles, “softened” ozone molecules are released into the empty part of the container. These can be directed to the body for a treatment using an oxygen mask or nasal cannula.

The olive oil can be reused many times until it becomes thick and milky colored. Then it can be used as ozonated olive oil, for a variety of applications.

Promolife makes a very nice 200 ml glass oil bubbler ($160, currently on sale for $120). It has its own plexiglass stand so that it will not fall over and also comes with a nasal cannula. A video from the company describes the equipment used.

Longevity makes a much smaller 50 ml glass bubbler ($80) that can be used for oil bubbling or humidification purposes.

The Power of Ozone has a video demonstrating the use of ozone bubbled through olive oil, with suggestions for a less expensive setup.

Following are some additional suggestions about using the oil bubbler.

* Attach the tubing correctly. Be sure that the tube going into the bubbler (from the ozone machine) directs the ozone down into the oil. You should see bubbles at the higher flow rates if it is hooked up right. The smell will be much milder than with other applications where the ozone is not bubbled through oil.

* Start low and slow. About 1/4 LPM will be needed to produce bubbles in the oil, but a lower LPM will work too. Usually the suggested gamma is from 20-50. Start at a few minutes and then work up to longer or stronger treatments as tolerated.

* Wait a few minutes after the oil starts bubbling before beginning the treatment. It will take a while for ozone levels in the container to build up and then to start moving out through the tubing.

Use good-quality olive oil. Even if it’s marked organic and sold in a specialty shop, most olive oil is diluted with cheaper quality oils and may be contaminated with undesirable chemicals. This is especially the case with products from Italy. Choosing a certified olive oil from California is safer. A good test: real olive oil will solidify in the refrigerator. My own favorite olive oils (all organic) are from Berkeley Olive Grove, from Casa Rosa Farms and from Oils of Paicines. Ordering by the gallon from one of the first two companies is the best deal.

Promolife Earscope

The Promolife earscope.


For ear insufflations, a special stethoscope (sometimes called an earscope) is used to direct ozone to the ears.

The device is useful since it allows ozone to be equally directed to both ears without any tubes needing to be held.

Ear insufflations are said to be useful at getting ozone into the blood and lymphatic systems of the head. Infections and toxicity in the head (including in areas such as in the eyes) thus may have the potential of being addressed.

However, of all ozone-relate treatments, ear insufflations seem to pose the most risk of negative side effects in the early stages for individuals with chronic multisystem illnesses.

Apparently the treatment leads to the discharge of toxins in the lymph fluid, very often resulting in the discharge of the lymph fluid inside the ears and blocked eustachian tubes. Excruciating pain can result.

Therefore, it is especially important to go very low and slow with ear insufflation treatments, to make sure that this does not happen.

Any sort of pain is a sign that the ear insufflations are going too fast. Stopping treatment until the problems resolve and then resuming at a lower gamma or shorter treatment time is critical.

Itching, pain, swelling or discharge from the ears also may be a sign that detoxification is occurring too fast and that slowing down or taking at least a temporary break may be a good idea.

In addition, it is important to use a low LPM for ear insufflations, since too much pressure has the potential of causing harm to the ear drum.

Following is some basic information about ear insufflations.

* Use the lowest available LPM. 1/32 is preferable, but 1/8 is said to be acceptable.

* Use short treatments. Especially with a very low LPM, gamma on many machines may be fairly high even at a low setting. Therefore, very short treatments (such as a minute or less) may be needed at first to prevent too much exposure to ozone from occurring.

* Increase very slowly. A maximum of three treatments per week at a few minutes each for many months may be needed to prevent ear problems from occurring. Eventually sessions of up to 20 minutes each may be used.

* Stop treatments if ear problems occur. In particular, the experience of any pain suggests that ear insufflations should be ceased for a time and then re-started extremely cautiously. Other ear problems should be treated as warning signs as well.

* Choose an earscope or stethoscope designed for ear insufflations. These are available from Promolife ($60, currently on sale for $50) or Longevity ($55).


Promolife Humidifier

The Promolife humidifier.

* Consider a humidifier. Without the use of a humidifier to muffle the sound, the noise from the ozone machine can be very loud. Whether the humidifier should be used with water during insufflations rather than kept empty seems to be a question mark, however. While some people suggest that the use of humidification in the ears may help with dryness, others suggest that it actually can exacerbate problems. Smaller humidifiers are convenient and are available from Promolife ($160, currently on sale for $120) and Longevity ($80). Larger humidifiers such as the ones made by Promolife ($125-140) provide a bonus of ozonated water to drink after a longer treatment. Promolife also has videos related to humidification that discuss equipment usage and ozone strength. An oil bubbler (filled with water instead of oil) also will work for humidification purposes.

* Consider the use of oil. It often is suggested that natural oil (such as olive oil or coconut oil) may be used in the ears in order to prevent irritation from using ozone. Since I have been using the oil bubbling system for breathing, I have tried also using that in connection with the earscopes and found it to be quite pleasant.  In asking around, I have found a few other people who have reported positive experiences with using the stethoscope in connection with the oil bubbler as well. However, one person suggested that the oil eventually could clog up the earscope, and there may be other disadvantages of which I am currently unaware. I’d like to hear comments on this topic.


Promolife Check Valve

The check valve from Promolife.

* If using a humidifier, use a check valve. If water runs back through the tubing into the ozone generator, the machine will be damaged or destroyed. A check valve (such as the one sold by Promolife for $7) will prevent this from occurring.


Steam Sauna

The Durherm Portable Personal Folding Home Steam Sauna.


A popular ozone treatment is done through the use of a sauna (especially a steam sauna). When the pores are open through the use of a sauna, the ozone is absorbed relatively easily through the skin and lymphatic system. It then may make its way throughout the body, having a systemic effect.

I have yet to try sauna therapy with ozone yet and thus am just sharing what I have learned from others.

A key with sauna therapy is obviously to let the body receive access to the ozone without breathing it in. Therefore, the sauna needs to be designed so that the head is outside.


Screenshot (873)

The Longevity Steam Sauna.

Longevity sells high-quality, hard-sided steam sauna cabinets that can be used with ozone equipment for $2500 or above.

Since this is very expensive, many individuals interested in ozone sauna therapy have tried portable steam saunas in combination with their ozone equipment.

For instance, one that has received positive reviews is the Durherm Portable Personal Folding Home Steam Sauna available on Amazon (list price $250, currently available for $120).

Addendum (3/13/16): Promolife now sells a sauna combining far infrared heat and ozone for use while lying down for $1,895 (not including the ozone generator).


Promolife Full Body Bag

The Promolife full body bag.

Another option for those who want to expose their full body (except for their head) to ozone is the Promolife full body ozone bag ($60). It folds up compactly and can be used easily while traveling. Here is a brief video on setting up the equipment.


Promolife Limb Bag

The Promolife limb bag.

Another possibility is the Promolife limb bag ($70), which targets ozone to one arm or leg at a time. Here is a brief descriptive video on how it works.

Promolife also sells a simpler Teflon limb bag for ozone therapy ($40), with a brief video explaining its usage.

Ozone for use with saunas or bags is usually applied at a higher volume (such as 1/2 or 1/4 LPM) and a gamma of 20-40.

Starting at a short period of time (such as 10 minutes) and then working up to more extended sessions is usually suggested.

A frequent problem with ozone saunas or bagging is that rashes or other skin irritation can result. Possibly this is due to the release either of pathogens or toxicity from the system.

I’ve actually experienced rashes subsequent to the use of rectal ozone as well (in the upper section of my abdomen over the area with the most problematic adhesions – nowhere near where the ozone entered my body).

In my case, I feel like massage with ozonated oils have been helpful in soothing the rashes.

I would be interested in hearing reports of how other people have successfully dealt with rashes resulting from ozone treatments.


Promolife Three Inch Cup

The Promolife three-inch cup.


Cupping is a way to direct ozone to a specific area of the body, for a more intensive treatment.

Often it is used to direct ozone toward specific organs that may need more help, such as the liver, kidneys, pancreas, spleen or heart.

Insofar as the intestines are particular problems, cupping may be a way to direct ozone to areas higher in the small intestine than rectal ozone might be likely to go.

It also could be used on other parts of the body, such as on the top of the skull (for instance, to attempt to treat issues in the head more intensively than can be accomplished through ear insufflations) or on almost any other body part except for the eyes, nose or mouth (for instance, to get a skin infection under control).

The cups come in various sizes (such as 1″ to 5″). Larger cups are a little more expensive than smaller ones.

As an example, Promolife sells a 3″ cup for $90 (currently on sale for $80). Longevity sells a 3″ cup for $130.

The cups from both companies are made of glass and have an ozonation destruction system on them so that ozone will not leak out during the treatment.

My experience is that it is important to not lift the cup up too fast after the treatment is done, since some ozone will be left in the cup for a little while after the ozone generator is turned off. And the cups definitely should not be lifted up during the treatment.

The one time that I breathed in enough ozone to have a negative effect on my lungs was from lifting up a cup.

The procedure should be to turn off the ozone generator, turn off the oxygen tank or concenrator, wait a minute or more, and then lift up the cup.

Using a fan directed at the face or body while doing this treatment is a particularly good idea.

Cupping is said to be best done with a high strength of ozone (such as 40-80 gamma) and for extended periods of time (such as 10 minutes or longer). Insofar as no negative effects occur, it may be done multiple times per day.

Here is a brief video on using ozone cups by Promolife.


Promolife Water Bubbler

The Promolife water bubbler.


Ozonated water can be consumed to target ozone to the upper part of the digestive tract and for general systemic effects.

It also can be used for other applications such as enemas, rinsing the sinuses or (in large quantities) bathing.

Ozonating the water can be done at as high of a gamma and as high of a volume as the machine will allow. This could be anywhere from 20-80 gamma, and anywhere from 1/8 to 1/2 LPM.

Fully ozonating water takes some time, especially when a large quantity of water is present.

The usual amounts of time suggested to me were: 1 glass (8-10 oz): 5-7 minutes. 2 glasses: 10-15 minutes. 3-4 glasses: 20-30 minutes. Gallon: 30-40 minutes.

An important issue to consider when ozonating water is that the ozone may escape into the air and then cause damage if breathed in.

Conceivably, ozonating the water in a separate room with a dish towel covering the water container and a fan blowing across the area toward a window would be enough to reduce the problem. Stepping into the room just to turn off the ozone machine (without breathing in) and then vacating for a minute or two would be advised.

Otherwise, buying a special container with a destruct system in it could be a good idea.


Promolife Humidifier Bubbler

The Promolife combination humidifier and water bubbler.


For instance, Promolife sells a 1000 ml water bubbler ($140, currently on sale for $100) and a water bubbler/humidifier combination ($150-165).  Both of these have the destruction systems included.

Longevity sells 500 and 1000 ml glass flasks ($120-130), but the destruct system ($60) is sold separately.

Although it is not necessary to use a bubbling stone when ozonating water, doing so may help the ozone to more evenly fill the water. I have been using a diffuser stone that came with the Synergy ozone machine and also ones that came with the A2Z water ozonator.


Longevity Water Snake

The Longevity water snake.

Longevity also sells a water snake ($65) that can be used for water ozonation.

Although filtered water or other high-quality water can be used for ozonation purposes, cold distilled water is said to have the potential of holding the most ozone.

Ozonated water preferably would be used right away (or at least within an hour or two), since the ozone gradually will be released from the water into the surrounding air.

As with all applications using water or oil, a check valve to prevent liquid from backing up into the ozone machine and ruining it is suggested.

The Power of Ozone offers a video on making ozonated water.


Promolife Ozonated OIl

Ozonated oils.


In theory, it is possible to make ozonated oils using any of the ozone machines discussed here.

However, in practice, it seems that most people who use therapeutic ozone usually buy their ozonated oils.

Ozonated oils take a very long time to make. For instance, the machine may need to run for an hour a day for many weeks. Those with experience also warn about the possibility of the oils catching on fire.


Promolife Oil Making System

The Promolife system for making ozonated oils.


Special equipment set-ups for making ozonated oils are available. The one from Promolife is $250-265.

Apparently bubbling ozone through olive oil for breathing eventually will result in ozonated olive oil as well.

Otherwise, purchasing ozonated oils tends to be the popular choice.

Promolife sells a wide variety of Pur O3 ozonated oils. From the strongest to the weakest (in terms of amount of ozone in the oil), they are hemp, sunflower, sesame, olive, avocado, jojoba, castor and coconut. A few of these can be purchased scented with essential oils.


Promolife Ozonated OIls

Pur 03 trial-size jars.

Trial-size versions of these oils are available for $2 each through Promolife. I purchased several different kinds and ended up liking the unscented olive oil the best, however.

So far, I have just used the ozonated oils for abdominal massage to try to address intestinal adhesions. I do feel that using these oils has been much more helpful for that purpose than using regular unozonated oils.

Ozonated oils are said to be helpful for a variety of other skin problems, especially when pathogens are thought to be involved. For instance, I’ve heard from enough mold avoiders who believe that they have fungal infections in their scalp that I would consider it for scalp massages if I had that issue.

One person suggested that possibly breathing in vapors from ozonated oils could be effective with regard to treating fungal or bacterial infections in the sinuses. Thus far, I’ve not found that to seem terribly effective and I also am not crazy about the smell.


Promolife Suppositories

Ozone suppositories.

Because castor oil enemas have been helpful to me, I also am interested in OzoMedic ozone suppositories (which come in castor oil, hemp oil and olive oil versions). These are supposed to release the ozone gradually into the digestive tract and also be helpful for constipation.

Because they are expensive (15 for $49) and because I haven’t gotten any reliable reports from others, I have yet to try them, however.



Silicone tubing for ozone applications.


Here is a discussion of just a few more supplies not mentioned above.

Quality tubing (or “hose”) is needed to connect the ozone machine to the oxygen source and then also to the desired accessories for application.

The tubing running between the oxygen source (tank or concentrator) and the ozone machine can be clear plastic. For instance, Promolife sells this for $1.99 per foot.

On the other hand, the tubing that is used after the machine has converted the oxygen into ozone must be silicone, since ozone will degrade conventional plastic tubing. This is a little more expensive – for instance, $3 per foot from Promolife. It is milky colored rather than clear.

If buying from other sources, the size should be 3/16″ ID (inner diameter) and 5/16″ OD (outer diameter).

In many cases, the machine or accessories chosen will come with tubing, meaning that you may not have to buy any or as much.



Silicone hose connectors from Promolife.


A silicone hose connector may come in handy and is inexpensively priced ($3.50) from Promolife.


Oxygen Destruct

The Oxygen Destruct system from Promolife.


An independent ozone destruct system ($50 from Promolife) may be useful for some applications, such as ozonating larger amounts of water.


Promolife Ozone Destruct

Ozone destruct (manganese dioxide) from Promolife.

Insofar as any items purchased have ozone destruct (manganese dioxide), they eventually will become saturated with ozone and need to be replaced. Promolife sells the raw material for $5 per ounce.



Promolife cupping system being used with Synergy WPS-100.


Following is a summary of settings and times suggested for various ozone applications. These are mostly based on information provided by the Ozone to Health user group on Facebook, although some alterations have been made to incorporate recommendations made elsewhere.

1 gamma = 1 ug/ml = 1 mcg/ml = 1 microgram per milliliter.

LPM = liters per minute.

Rectal Insufflations (without a bag)20-50 gamma, 1/8 LPM or less. Insert a maximum volume of 500 ml of gas for each insufflation (this chart from Ozone to Health tells how long it will take to generate this volume). At 1/8 LPM, this would be 4 minutes maximum.

Rectal Insufflations (with a bag): 20-50 gamma, with sufficient oxygen flow to produce this gamma. Use a maximum volume of 500 ml of gas for each insufflation. Empty bag slowly over a period of 20-30 minutes.

Vaginal Insufflations: 20-40 gamma, 1/8 LPM (or lower). Start with 5 minutes and work up as tolerated. Do not use if a tear/wound in the vagina is suspected. Since the treatment may increase blood flow, this is something to keep in mind when considering whether to use this treatment during menstruation.

Bubbled Through Olive Oil Breathing: 20-50 gamma, 1/8 to 1/4 LPM. Start at 5 minutes or less per session. Work up to a likely maximum of 30 minutes per session, as many times per day as needed and tolerated. Do not EVER breathe ozone straight from the hose – it must be bubbled through oil first!

Ear Insufflations: 15 to 40 gamma, 1/8 LPM or less (preferably 1/32 LPM – higher air flows risk blowing an eardrum). Start at 2 minutes or less per session, at a maximum of three times a week. Be sure to point a fan at the face to blow away any excess ozone so that it is not breathed in. Since early reactions can result in extreme pain, going very low and slow and then increasing as tolerated is critical. If pain results, stop ear insufflations until this goes away and then resume treatments (if desired) at a lower strength or for less time. Be especially cautious if other ear symptoms result as well. Otherwise, session length may be increased slowly until a maximum of 20 minutes for each session.

Sauna: 20-40 gamma, 1/4 to 1/2 LPM. Start at 10-15 minutes maximum and work up to 30 minutes or more as tolerated.

Cupping: 40-80 gamma, 1/8 LPM or less. Minimum of 10 minutes. May be done as many times per day as needed and tolerated. After turning the ozone machine off at the end of the treatment, let the cup remain in place for a minute or so to let the excess ozone be destroyed so that it is not breathed in. Use of a fan to blow away excess ozone is strongly suggested.

Ozonated Water: 20-80 gamma, 1/8 to 1/2 LPM. 1 glass (8-10 oz): 5-7 minutes. 2 glasses: 10-15 minutes. 3-4 glasses: 20-30 minutes. Gallon: 30-40 minutes. Use a destruct system or stay out of the room when this treatment is being done.



Here are some things to keep in mind when using ozone therapy that have been suggested to me.

* Never use ozone in the eye area.

* Do not breathe ozone without first bubbling it through oil.

* The use of a fan blowing at the face to remove any escaped ozone in order to protect the lungs is suggested for all applications, especially cupping and ear insufflations.

* Concentrations should remain at 80 gamma or below for all applications.

* Especially for people who are ill with chronic multisystem illnesses, starting with the lowest gamma and a short period of time and then working up as tolerated is strongly suggested.

* If you are using an oxygen tank, figure out a way to remind yourself to turn it off after treatments or it will be empty the next time you go to use it.

* With regard to the topic of ear insufflations (EIs), the owner of the website/blog “The Power of Ozone” states: “It’s true that the EIs can trigger an extremely painful experience but they also offer the most powerful way to treat any type of inflammatory or infectious conditions or cancers in the brain with ozone without having to resort to IVs. So especially with conditions like encephalitis, MS or autism, they can offer great relief to complete symptom reversal and are relatively easy and quick to perform.  Itching, discharge or crust are normal herx reactions with EI. What is a sign that too much ozone is being introduced is pain. It starts as short sharp pain, then it builds up to more continuous pain and increases in intensity over a few days and can stay that way for a week after which it slowly starts going down over another week (provided one has stopped the EIs during that time). Pain is definitely a sign to stop the EIs immediately. Itching, discharge or crusts are normal and in probably 80% of the cases unavoidable.”

* Some professionals experienced with ozone therapy suggest that individuals using this kind of approach should be taking adequate antioxidants and other supplements (such as B vitamins, Vitamin A, Vitamin C, Vitamin E, zinc and selenium), at other times of the day than when they are using the ozone.

* My own experience is that using rectal ozone therapy and cupping in combination with Gerson Therapy has been maximally effective for me. The ozone seems to be killing pathogens and releasing toxic debris, which then seem to be profitably cleansed from the body with the Gerson protocol (including large quantities of fresh juice, soluble vegetable and oatmeal fiber, ingested castor oil, rectal castor oil and coffee enemas). I get much more toxic when I try to do ozone treatments without also doing the Gerson components.

* A.M. Runyan of “Grow Your Life” states the following with regard to her own experiences with ozone: “I have sometimes found that other hormesis treatments improve my ability to tolerate ozone. So that means starting out with, say, Meriva curcumin, ashwagandha and other Nrf2 activators, to counteract the way that mold can inhibit Nrf2. After using those, it’s easier for me to get on ozone.”



Supplier Websites:

The Longevity Resources website and price list.

The Promolife website.

The Synergy Water Systems website.


Patient Groups:

The Ozone to Health group on Facebook discusses all kinds of ozone therapies, with a focus on affordable ones.

The Ozone for Wellness group on Facebook focuses largely on the home use of ozone using Longevity equipment.

A group called Ozone, Chelation and Paleo Diet on Facebook is run by the website “The Power of Ozone.”

A group called Ozone Therapy Enthusiasts on Facebook is run by Peter Jovanovic.

A group called Ozone Theory and Practices on Facebook draws attention to ozone therapy.


Therapeutic Uses of Ozone:

Clinical review article on the therapeutic uses of ozone published in a medical journal.

A detailed review of ozone therapy applications by Jeffrey Taylor.

An article on ozone basics by Jeffrey Taylor.

A long article on The Story of Ozone by Dr. Saul Pressman.

A book called The Oxygen Prescription written by Nathaniel Altman.

A book called Medical Ozone Therapy written by Peter Jovanovic.


Equipment Usage:

A clear overview video on the setting up ozone equipment by Promolife.

A Promolife video on whether humidification affects the strength of ozone.

A Promolife video on choosing an oxygen source for ozone therapy.

Instructions from Heal Yourself at Home for using ozone equipment.

A page on doing rectal insufflations by the Chung Institute.

A video on doing rectal insufflations using a bag by The Power of Ozone.

A video on breathing ozone bubbled through olive oil by The Power of Ozone.

A video on making ozonated water by The Power of Ozone.


Practitioner Discussions:

Dave Asprey interviews Dr. Robert Rowen about the use of ozone for Ebola and other therapeutic applications.

Dave Asprey interviews Dr. Robin Benson about the use of ozone therapy in her practice.

A presentation by Dr. Robert Rowen to the Silicon Valley Health Institute.

Dr. Mercola interviews Dr. Robert Rowen about the benefits of oxidative medicine and about the possibility that Ebola may be effectively treated with ozone therapy.

An interview with Dr. Garry Gordon on the benefits of ozone therapy on “Live to 110.”

An interview with Dr. Bob Beck on healing with ozonated water.

Dr. Howard Robins discusses the use of IV ozone for a variety of conditions.


Use in Chronic Multisystem Illness:

An article about the use of ozone therapy by Dr. Sarah Carnes (a practitioner associated with Dr. Dietrich Klinghardt).

A mention of the use of ozone in Lyme disease by Scott Forsgren of Better Health Guy.

Journalist Jill Neimark and Dr. Byron White discuss the use of therapeutic ozone.

A discussion by the Pangaea Clinic of Naturopathic Medicine of the use of ozone in Lyme.

An article about therapeutic ozone on the website From Lyme to Life.

Deborah Waroff of “ME/CFS Alert” discusses her experiences getting IV ozone from a physician.


Practitioner Websites:

The website of Dr. Robert Rowen focuses on ozone therapy.

A section of the website of Dr. Frank Shallenberger is devoted to ozone therapy.

The website of Dr. Howard Robins discusses IV ozone therapy.

A discussion of ozone therapy by Dr. Kent Holtorf on a page of his organization’s website.


Other Websites:

website/blog and a series of videos by The Power of Ozone.

A website by Peter Jovanovic.


More Ozone Resources:

The American Academy of Ozone Therapy website.

A list of physicians using ozone therapy in their practices.

The Ozone Research Center page of SilverMedicine.org.

A 2013 account in the Telegraph of a trial against a practitioner using IV ozone therapy in the UK.

The Wikipedia article on ozone therapy.

The Quackwatch take on ozone therapy.


Paradigm Change Resources:

The Paradigm Change website provides information on the role of mold toxins in chronic multisystem illness.

The Paradigm Change blog provides information on mold toxins and on advocacy efforts for myalgic encephalomyelitis (M.E.).

The Living Clean in a Dirty World blog (this blog) provides treatment-oriented information for those recovering from toxic mold illness and other chronic multisystem illnesses.

Screenshot (881)The Living Clean in a Dirty World page on Facebook provides links to treatment-oriented information from a variety of sources.

The book A Beginner’s Guide to Mold Avoidance (written by Erik Johnson and me) provides information on mold avoidance and related treatments. It is available for free to those signing up for occasional email updates from Rabbit Hole.

My other book, Back from the Edge, tells the story of mold avoidance pioneer Erik Johnson. It is available for free to those signing up for occasional email updates from Paradigm Change.

The page on Mold Avoidance on the Paradigm Change website provides information about mold avoidance resources available from my organization Rabbit Hole.

The Mold Avoiders group on Facebook (which I run) discusses issues related to healing through mold avoidance and other treatments.

Those who have done any kind of mold avoidance are requested to fill out the Mold Avoidance Survey presented by Northwestern University and Paradigm Change. The current deadline for responses is July 31, 2015.


Lisa using a stethoscope for an ozone treatment.

Lisa using a stethoscope for an ozone treatment.


Lisa Petrison is the executive director of Paradigm Change. Her books include “A Beginner’s Guide to Mold Avoidance” (co-authored with Erik Johnson) and “Back from the Edge.”

She also runs the Facebook group Mold Avoiders, where various modalities of healing from toxic mold illness and related conditions are frequently discussed.



Nothing in this blog post should be taken as medical advice. Please see our About page for more information.

No health claims for the techniques discussed here have been evaluated by the United States Food and Drug Administration (FDA), nor has the FDA approved these techniques to diagnose, cure or prevent disease.

Please do not decide to pursue ozone therapy or any other kind of therapy based on the information in this blog or based on anything else that I might say.

Please also note that I am not an expert in terms of how to do ozone therapy and am only summarizing instructions that others have given rather than giving medical advice.

My suggestion is that everyone do their own due diligence in learning as much as they can about any healthcare treatment they are thinking about pursuing and then discuss it with a trusted healthcare provider before proceeding.

Please share additional information about doing ozone therapy or your experiences with it in the comments section.

Any and all civil comments from actual humans are welcome on this blog.

If you submit a comment and it doesn’t go through, please assume that it is due to inappropriate spam filtering and let us know via email at info at paradigmchange dot me.

Note that the links on this page are in orange type (no underlining).

Thanks very much for reading this blog.


Copyright 2015, Paradigm Change.

All rights reserved. In accordance with the doctrine of Fair Use, brief quotations of up to 300 words may be used without permission as long as proper attribution is provided.

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  • What a great overview of ozone therapy!

  • I do have a couple comments related to ear insulflations. I did them for a while until my ears itched so badly I couldn’t sleep. Since I value sleep over nearly everything else, I stopped the insulflations.

    Later, I learned that the itching may have been caused because I didn’t humidify the ozone through a water bubbler. The itching is supposedly a result of the drying effect from ozone. I never got around to testing this but thought it might be of interest.

    Also, on my ozone setup, the regulator flows a given amount of oxygen regardless of the pressure. In other words, if you put your finger over the open tube coming off the regulator, you’ll notice that the pressure increases as the regulator works to maintain the set flow rate.

    Related to ear insulflations, I always wondered about using stethoscopes. I could easily see building up too much pressure on the inner ear if the stethoscope is firmly placed into the ears. In my opinion, they should be loosely fitting so the ozone washes over the eardrum and then exits without resistance. I can assure you that if you create a pressure differential across your eardrum, it’s going to hurt! Anyway, it’s just a thought.

  • Ei

    Excellent, in depth article. I did sauna and rectal ozone followed by IV ozone several days a week for a year. It kept me alive.

  • J Noellea

    I always love hearing that others are having success with ozone. I bought my own equipment 2 years ago but just started doing rectal insufflations after finding out that I have SIBO. I hope it helps because all other measures that I’ve tried so far haven’t worked long term. Thanks for sharing!

  • Laura Adams

    So would you recommend this? Has it helped you?

  • Paradigm Change

    Here are links to a couple of other companies selling ozone equipment. I don’t know anything about them though.



  • Paradigm Change

    Dave Asprey discusses ozone therapy for chronic Lyme disease and mold-related illness in this podcast:


  • Paradigm Change
  • Paradigm Change

    Here is a new video on using ozone therapy in the sinuses. I would be a little nervous to do this but it is interesting.


  • Paradigm Change
  • Robert Ryans

    I have purchased my equipment from Promolife and have been drinking, breathing and taking ozone in my personal sauna (Amazon about $80) for about two months. My BP is now normal, my blood sugar levels are now normal to very close to normal. I feel fantastic. Even the tingling in my feet has gone away by about 50%. I am going to a Doc that ozonates ones blood next week. The entire set up has cost me around $2000. and it has been worth every penny!!
    Think about this if you are taking BP or diabetes meds…. Ever seen those TV commercials with lawyers asking if you have ever taken this or that drug and have had any of the LONG list of side effects to include death call me now? Well the drugs that YOU are taking now verry well could be on the TV in 5 or 10 years from now. DO YOU WANT TO TAKE THAT CHANCE??? Not me! For me, OZONE is the way to go!!
    PS, my wife has been using the sauna w/ ozone and the vanes in her legs have gotten better!

    • Elizabeth Blane

      Robert; I am in a similar situation to what you were in. My question to you is this; both Promolife and Longevity seem to be reliable companies, but there seems to be a “ceramic vs. glass” war between them. I have not decided if there is any validity to either side. Did you ever come to a conclusion about that? (Seems that you must have as you got the Promolife, which uses ceramic).

  • Haleh

    Thanks for all this wonderful information! I am new to ozone therapy and am looking for resources to educate myself. You have done so much research and have included such a wealth of information, I’m grateful that I came across your blog. Blessings to you.

  • harley121

    Wonderful page, full of good clear info! I have one question; I have been looking for 3/16 silicone bard connectors (like Promo Life offers) that are more reasonably priced. I just find it crazy that people settle and are willing to pay around $3.50 for a single little connector.
    Does anyone have an alternative source for these?
    Many thanks and Merry Christmas to all!
    Bob R

  • Lisa Petrison

    A new article on clinic ozone therapy.


  • Lisa Petrison