Articles on the Ability of Treatments to Degrade Mycotoxins


Following are some journal articles on the topic of the ability of ozone, ultra violet light and probiotic bacteria to degrade mycotoxins.



Luo X, Wang R, Wang L, Li Y, Wang Y, Chen Z. Detoxification of aflatoxin in corn flour by ozone. J Sci Food Agric. 2014 Aug;94(11):2253-8.

Luo X, Wang R, Wang L, Li Y, Zheng R, Sun X, Wang Y, Chen Z, Tao G. Analyses by UPLC Q-TOF MS of products of aflatoxin B(1) after ozone treatment. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(1):105-10.

Chen R, Ma F, Li PW, Zhang W, Ding XX, Zhang Q, Li M, Wang YR, Xu BC. Effect of ozone on aflatoxins detoxification and nutritional quality of peanuts. Food Chem. 2014 Mar 1;146:284-8.

Diao E, Hou H, Chen B, Shan C, Dong H. Ozonolysis efficiency and safety evaluation of aflatoxin B1 in peanuts. Food Chem Toxicol. 2013 May;55:519-25.

Diao E, Shan C, Hou H, Wang S, Li M, Dong H. Structures of the ozonolysis products and ozonolysis pathway of aflatoxin B1 in acetonitrile solution. J Agric Food Chem. 2012 Sep 12;60(36):9364-70.

Freitas-Silva O, Venâncio A. Ozone applications to prevent and degrade mycotoxins: a review. Drug Metab Rev. 2010 Nov;42(4):612-20.

Zorlugenç B, Kiroğlu Zorlugenç F, Oztekin S, Evliya IB. The influence of gaseous ozone and ozonated water on microbial flora and degradation of aflatoxin B(1) in dried figs. Food Chem Toxicol. 2008 Dec;46(12):3593-7.

Young JC, Zhu H, Zhou T. Degradation of trichothecene mycotoxins by aqueous ozone. Food Chem Toxicol. 2006 Mar;44(3):417-24.

Proctor AD, Ahmedna M, Kumar JV, Goktepe I. Degradation of aflatoxins in peanut kernels/flour by gaseous ozonation and mild heat treatment. Food Addit Contam. 2004 Aug;21(8):786-93.

Lemke SL, Mayura K, Ottinger SE, McKenzie KS, Wang N, Fickey C, Kubena LF, Phillips TD. Assessment of the estrogenic effects of zearalenone after treatment with ozone utilizing the mouse uterine weight bioassay. J Toxicol Environ Health A. 1999 Feb 26;56(4):283-95.

Kim JG, Yousef AE, Dave S. Application of ozone for enhancing the microbiological safety and quality of foods: a review. J Food Prot. 1999 Sep;62(9):1071-87.

McKenzie KS, Kubena LF, Denvir AJ, Rogers TD, Hitchens GD, Bailey RH, Harvey RB, Buckley SA, Phillips TD. Aflatoxicosis in turkey poults is prevented by treatment of naturally contaminated corn withozone generated by electrolysis. Poult Sci. 1998 Aug;77(8):1094-102.

McKenzie KS, Sarr AB, Mayura K, Bailey RH, Miller DR, Rogers TD, Norred WP, Voss KA, Plattner RD, Kubena LF, Phillips TD. Oxidative degradation and detoxification of mycotoxins using a novel source of ozone. Food Chem Toxicol. 1997 Aug;35(8):807-20.

Chatterjee D, Mukherjee SK. Destruction of phagocytosis-suppressing activity of aflatoxin B1 by ozone. Lett Appl Microbiol. 1993 Aug;17(2):52-4.


Ultraviolet Radiation

Zhu Y, Koutchma T, Warriner K, Zhou T. Reduction of patulin in apple juice products by UV light of different wavelengths in the UVC range. J Food Prot. 2014 Jun;77(6):963-71.

Zhu Y, Koutchma T, Warriner K, Shao S, Zhou T. Kinetics of patulin degradation in model solution, apple cider and apple juice by ultraviolet radiation. Food Sci Technol Int. 2013 Aug;19(4):291-303.

Assatarakul K, Churey JJ, Manns DC, Worobo RW. Patulin reduction in apple juice from concentrate by UV radiation and comparison of kinetic degradation models between apple juice and apple cider.  J Food Prot. 2012 Apr;75(4):717-24.

Murata H, Yamaguchi D, Nagai A, Shimada N. Reduction of deoxynivalenol contaminating corn silage by short-term ultraviolet irradiation: a pilot study. J Vet Med Sci. 2011 Aug;73(8):1059-60.

Dong Q, Manns DC, Feng G, Yue T, Churey JJ, Worobo RW. Reduction of patulin in apple cider by UV radiation. J Food Prot. 2010 Jan;73(1):69-74.

Murata H, Mitsumatsu M, Shimada N. Reduction of feed-contaminating mycotoxins by ultraviolet irradiation: an in vitro study. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Sep;25(9):1107-10.



Abbès S, Ben Salah-Abbès J, Jebali R, Younes RB, Oueslati R. Interaction of aflatoxin B1 and fumonisin B1 in mice causes immunotoxicity and oxidative stress: Possible protective role using lactic acid bacteria. J Immunotoxicol. 2015 Jan 14:1-9.

Chang X, Wu Z, Wu S, Dai Y, Sun C. Degradation of ochratoxin A by Bacillus amyloliquefaciens ASAG1. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(4):564-71.

Jebali R, Abbès S, Salah-Abbès JB, Younes RB, Haous Z, Oueslati R. Ability of Lactobacillus plantarum MON03 to mitigate aflatoxins (B1 and M1) immunotoxicities in mice. J Immunotoxicol. 2015 Jul-Sep;12(3):290-9.

Zhang W, Xue B, Li M, Mu Y, Chen Z, Li J, Shan A. Screening a strain of Aspergillus niger and optimization of fermentation conditions for degradation of aflatoxin B₁. Toxins (Basel). 2014 Nov 13;6(11):3157-72.

Sangare L, Zhao Y, Folly YM, Chang J, Li J, Selvaraj JN, Xing F, Zhou L, Wang Y, Liu Y. Aflatoxin B₁ degradation by a Pseudomonas strain. Toxins (Basel). 2014 Oct 23;6(10):3028-40.

Ferenczi S, Cserháti M, Krifaton C, Szoboszlay S, Kukolya J, Szőke Z, Kőszegi B, Albert M, Barna T, Mézes M, Kovács KJ, Kriszt B. A new ochratoxin A biodegradation strategy using Cupriavidus basilensis Őr16 strain. PLoS One. 2014 Oct 10;9(10):e109817.

Abrunhosa L, Inês A, Rodrigues AI, Guimarães A, Pereira VL, Parpot P, Mendes-Faia A, Venâncio A. Biodegradation of ochratoxin A by Pediococcus parvulus isolated from Douro wines. Int J Food Microbiol. 2014 Oct 1;188:45-52.

Tan H, Hu Y, He J, Wu L, Liao F, Luo B, He Y, Zuo Z, Ren Z, Zhong Z, Peng G, Deng J. Zearalenone degradation by two Pseudomonas strains from soil. Mycotoxin Res. 2014 Nov;30(4):191-6.

Ben Salah-Abbès J, Abbès S, Jebali R, Haous Z, Oueslati R. Potential preventive role of lactic acid bacteria against aflatoxin M₁ immunotoxicity and genotoxicity in mice. J Immunotoxicol. 2015 Apr-Jun;12(2):107-14.

Shi L, Liang Z, Li J, Hao J, Xu Y, Huang K, Tian J, He X, Xu W. Ochratoxin A biocontrol and biodegradation by Bacillus subtilis CW 14. J Sci Food Agric. 2014 Jul;94(9):1879-85.

Zuo RY, Chang J, Yin QQ, Wang P, Yang YR, Wang X, Wang GQ, Zheng QH. Effect of the combined probiotics with aflatoxin B₁-degrading enzyme on aflatoxin detoxification, broiler production performance and hepatic enzyme gene expression. Food Chem Toxicol. 2013 Sep;59:470-5.

Abbès S, Ben Salah-Abbès J, Sharafi H, Oueslati R, Noghabi KA. Lactobacillus paracasei BEJ01 prevents immunotoxic effects during chronic zearalenone exposure in Balb/c mice. Immunopharmacol Immunotoxicol. 2013 Jun;35(3):341-8.

Gratz SW, Duncan G, Richardson AJ. The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3-glucoside and may be responsible for urinary deepoxy-deoxynivalenol. Appl Environ Microbiol. 2013 Mar;79(6):1821-5.

Abbès S, Salah-Abbès JB, Sharafi H, Jebali R, Noghabi KA, Oueslati R. Ability of Lactobacillus rhamnosus GAF01 to remove AFM1 in vitro and to counteract AFM1 immunotoxicity in vivo. J Immunotoxicol. 2013 Jul-Sep;10(3):279-86.

Gil-Serna J, Patiño B, Cortés L, González-Jaén MT, Vázquez C. Mechanisms involved in reduction of ochratoxin A produced by Aspergillus westerdijkiae using Debaryomyces hansenii CYC 1244. Int J Food Microbiol. 2011 Nov 15;151(1):113-8.

Rodriguez H, Reveron I, Doria F, Costantini A, De Las Rivas B, Muňoz R, Garcia-Moruno E. Degradation of ochratoxin a by Brevibacterium species. J Agric Food Chem. 2011 Oct 12;59(19):10755-60.

Krifaton C, Kriszt B, Szoboszlay S, Cserháti M, Szucs A, Kukolya J. Analysis of aflatoxin-B1-degrading microbes by use of a combined toxicity-profiling method. Mutat Res. 2011 Nov 27;726(1):1-7.

Ikunaga Y, Sato I, Grond S, Numaziri N, Yoshida S, Yamaya H, Hiradate S, Hasegawa M, Toshima H, Koitabashi M, Ito M, Karlovsky P, Tsushima S. Nocardioides sp. strain WSN05-2, isolated from a wheat field, degrades deoxynivalenol, producing the novel intermediate 3-epi-deoxynivalenol. Appl Microbiol Biotechnol. 2011 Jan;89(2):419-27.

Edlayne G, Simone A, Felicio JD. Chemical and biological approaches for mycotoxin control: a review. Recent Pat Food Nutr Agric. 2009 Jun;1(2):155-61. Review.

Mobashar M, Hummel J, Blank R, Südekum KH. Ochratoxin A in ruminants−A review on its degradation by gut microbes and effects on animals. Toxins (Basel). 2010 Apr;2(4):809-39.

Wu Q, Jezkova A, Yuan Z, Pavlikova L, Dohnal V, Kuca K. Biological degradation of aflatoxins. Drug Metab Rev. 2009;41(1):1-7.

de Felice DV, Solfrizzo M, De Curtis F, Lima G, Visconti A, Castoria R. Strains of Aureobasidium pullulans can lower ochratoxin A contamination in wine grapes. Phytopathology. 2008 Dec;98(12):1261-70.

Fuchs S, Sontag G, Stidl R, Ehrlich V, Kundi M, Knasmüller S. Detoxification of patulin and ochratoxin A, two abundant mycotoxins, by lactic acid bacteria. Food Chem Toxicol. 2008 Apr;46(4):1398-407.

Young JC, Zhou T, Yu H, Zhu H, Gong J. Degradation of trichothecene mycotoxins by chicken intestinal microbes. Food Chem Toxicol. 2007 Jan;45(1):136-43.

Del Prete V, Rodriguez H, Carrascosa AV, de las Rivas B, Garcia-Moruno E, Muñoz R. In vitro removal of ochratoxin A by wine lactic acid bacteria. J Food Prot. 2007 Sep;70(9):2155-60.

Schatzmayr G, Zehner F, Täubel M, Schatzmayr D, Klimitsch A, Loibner AP, Binder EM. Microbiologicals for deactivating mycotoxins. Mol Nutr Food Res. 2006 May;50(6):543-51.

Teniola OD, Addo PA, Brost IM, Färber P, Jany KD, Alberts JF, van Zyl WH, Steyn PS, Holzapfel WH. Degradation of aflatoxin B(1) by cell-free extracts of Rhodococcus erythropolis and Mycobacterium fluoranthenivorans sp. nov. DSM44556(T). Int J Food Microbiol. 2005 Nov 25;105(2):111-7.

Varga J, Péteri Z, Tábori K, Téren J, Vágvölgyi C. Degradation of ochratoxin A and other mycotoxins by Rhizopus isolates. Int J Food Microbiol. 2005 Apr 1;99(3):321-8.

Hormisch D, Brost I, Kohring GW, Giffhorn F, Kroppenstedt RM, Stackebrandt E, Färber P, Holzapfel WH. Mycobacterium fluoranthenivorans sp. nov., a fluoranthene and aflatoxin B1 degrading bacterium from contaminated soil of a former coal gas plant. Syst Appl Microbiol. 2004 Nov;27(6):653-60.

Fuchs E, Binder EM, Heidler D, Krska R. Structural characterization of metabolites after the microbial degradation of type A trichothecenes by the bacterial strain BBSH 797. Food Addit Contam. 2002 Apr;19(4):379-86.

Peltonen K, el-Nezami H, Haskard C, Ahokas J, Salminen S. Aflatoxin B1 binding by dairy strains of lactic acid bacteria and bifidobacteria. J Dairy Sci. 2001 Oct;84(10):2152-6.

Färber P, Brost I, Adam R, Holzapfel W. HPLC based method for the measurement of the reduction of aflatoxin B1 by bacterial cultures isolated from different African foods. Mycotoxin Res. 2000 Jun;16 Suppl 2:141.

D’Souza DH, Brackett RE. The role of trace metal ions in aflatoxin B1 degradation by Flavobacterium aurantiacum. J Food Prot. 1998 Dec;61(12):1666-9.

Megharaj M, Garthwaite I, Thiele JH. Total biodegradation of the oestrogenic mycotoxin zearalenone by a bacterial culture. Lett Appl Microbiol. 1997 May;24(5):329-33.

Beeton S, Bull AT. Biotransformation and detoxification of T-2 toxin by soil and freshwater bacteria. Appl Environ Microbiol. 1989 Jan;55(1):190-7.

Kiessling KH, Pettersson H, Sandholm K, Olsen M. Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria. Appl Environ Microbiol. 1984 May;47(5):1070-3.