Health Effects of Stachybotrys Chartarum – Reproductive Issues

 

 

This page lists medical journal articles discussing reproductive issues associated with Stachybotrys exposures.

The Health Effects of Stachybotrys Chartarum page of the Paradigm Change site provides further information on the effects of this toxic mold.

 

Hastings C, Rand T, Bergen HT, Thilveris JA, Shaw AR, Lombaert GA, Mantsch HH, Giles BL, Dakshinamurti S, Scott JE. Stachybotrys chartarum alters surfactant related phospholipid synthesis and CTP: cholinephosphate cytidylyltransferase activity in isolated fetal rat type II cells. Toxicological sciences : an official journal of the Society of Toxicology. 2005;84:186–194. PMID: 15574675

Previous studies suggest spore products may depress formation of disaturated phosphatidylcholine (DSPC), the major surface-active component of pulmonary surfactant (PS). If S. chartarum can affect formation of this phospholipid, then mold exposure may be a significant issue for pulmonary function in both mature lung and developing fetal lung. These results support previous observations that mold products alter PS metabolism and may pose a risk in developing lung, inhibiting surfactant synthesis. Different isolates of the same species of fungus are not equivalent in terms of potential exposure risks.

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Peltola J, Niessen L, Nielsen KF, Jarvis BB, Andersen B, Salkinoja-Salonen M, Moller EM. Toxigenic diversity of two different RAPD groups of Stachybotrys chartarum isolates analyzed by potential for trichothecene production and for boar sperm cell motility inhibition. Canadian journal of microbiology. 2002;48:1017–1029. PMID: 12556129

Thirty-one isolates of Stachybotrys chartarum from indoor and outdoor environments were analyzed for the presence of the trichodiene synthase (Tri5) gene, trichothecenes, boar sperm cell motility inhibition, and randomly amplified polymorphic DNA banding patterns (RAPDs). Nineteen S. chartarum isolates, distributed among the Tri5 gene negative and positive groups, inhibited boar spermatozoan motility at concentrations of < or = 60 microg of crude cell extract/mL. The inhibition of motility was independent of satratoxins or atranones.

 

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