Fusarium Literature – Reproductive System

 

 

Neonatal

Koraïchi Farah, Inoubli Lilia, Lakhdari Nadjem, et al. Neonatal exposure to zearalenone induces long term modulation of ABC transporter expression in testis. Toxicology. 2013;310C:29–38.

Fang Haiqin, Wu Yingliang, Guo Jiabin, et al. T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway. Apoptosis : an international journal on programmed cell death. 2012;17:895–907.

Zhao Yinghui, Zhu Xiaoming, Wu Huihui, et al. Evaluation of fetal skeletal malformations in deoxynivalenol-treated mice using microarray analysis. Archives of environmental contamination and toxicology. 2012;63:445–452.

Hou Hai-Feng F., Li Jin-Ping P., Ding Guo-Yong Y., Ye Wen-Jing J., Jiao Peng, Li Qun-Wei W.. [The cytotoxic effect and injury mechanism of deoxynivalenol on articular chondrocytes in human embryo]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2011;45:629–632.

Tiemann U., Brüssow K-P P., Dannenberger D., et al. The effect of feeding a diet naturally contaminated with deoxynivalenol (DON) and zearalenone (ZON) on the spleen and liver of sow and fetus from day 35 to 70 of gestation. Toxicology letters. 2008;179:113–117.

Dänicke S., Brüssow K-P P., Goyarts T., Valenta H., Ueberschär K-H H., Tiemann U.. On the transfer of the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) from the sow to the full-term piglet during the last third of gestation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007;45:1565–1574.

Goyarts T., Dänicke S., Brüssow K-P P., Valenta H., Ueberschär K-H H., Tiemann U.. On the transfer of the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) from sows to their fetuses during days 35-70 of gestation. Toxicology letters. 2007;171:38–49.

Malekinejad Hassan, Schoevers Eric J., Daemen Ineke J., et al. Exposure of oocytes to the Fusarium toxins zearalenone and deoxynivalenol causes aneuploidy and abnormal embryo development in pigs. Biology of reproduction. 2007;77:840–847.

Le Dréan G., Auffret M., Batina P., et al. Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34+ hematopoietic progenitor. Toxicology in vitro : an international journal published in association with BIBRA. 2005;19:1015–1024.

Sehata Shinya, Kiyosawa Naoki, Atsumi Fusako, et al. Microarray analysis of T-2 toxin-induced liver, placenta and fetal liver lesions in pregnant rats. Experimental and toxicologic pathology. 2005;57:15–28.

Fu Y. T., Lin W. G., BaoCheng Z., Quan G.. The effect of T-2 toxin on IL-1beta and IL-6 secretion in human fetal chondrocytes. International orthopaedics. 2001;25:199–201.

Ishigami N., Shinozuka J., Katayama K., Nakayama H., Doi K.. Apoptosis in mouse fetuses from dams exposed to T-2 toxin at different days of gestation. Experimental and toxicologic pathology. 2001;52:493–501.

Ishigami N., Shinozuka J., Katayama K., Uetsuka K., Nakayama H., Doi K.. Apoptosis in the developing mouse embryos from T-2 toxin-inoculated dams. Histology and histopathology. 1999;14:729–733.

Juhász J., Nagy P., Huszenicza G., Szigeti G., Reiczigel J., Kulcsár M.. Long term exposure to T-2 Fusarium mycotoxin fails to alter luteal function, follicular activity and embryo recovery in mares. Equine veterinary journal. Supplement. 1997:17–21.

Veselý D., Veselá D.. [Embryotoxic effects of a combination of zearalenone and vomitoxin (4-dioxynivalenole) on the chick embryo]. Veterinární medicína. 1995;40:279–281.

Holladay S. D., Blaylock B. L., Comment C. E., Heindel J. J., Luster M. I.. Fetal thymic atrophy after exposure to T-2 toxin: selectivity for lymphoid progenitor cells. Toxicology and applied pharmacology. 1993;121:8–14.

Morrell C. M., Adams J. A.. Toxicity of verrucarin A to gametes and embryos of the purple sea urchin (Arbacia punctulata). Bulletin of environmental contamination and toxicology. 1993;51:889–894.

Veselý D., Veselá D., Jelínek R.. Embryotoxicity of T-2 toxin and secalonic acid in embryonic chicks varies with the site of administration. Teratology. 1992;46:131–136.

Rotter B. A., Thompson B. K., Prelusky D. B., Trenholm H. L.. Evaluation of potential interactions involving trichothecene mycotoxins using the chick embryotoxicity bioassay. Archives of environmental contamination and toxicology. 1991;21:621–624.

Tutel’ian V. A., Krinitskaia N. A., Avren’eva L. I., Kuz’mina E. E., Levitskaia A. B., Kravchenko L. V.. [Embryotoxic effects of deoxynivalenol mycotoxin (vomitoxin) in rats]. Gigiena i sanitariia. 1991:49–51.

Moran E. T., Ferket P. R., Lun A. K.. Impact of high dietary vomitoxin on yolk yield and embryonic mortality. Poultry science. 1987;66:977–982.

Rousseaux C. G., Schiefer H. B.. Maternal toxicity, embryolethality and abnormal fetal development in CD-1 mice following one oral dose of T-2 toxin. Journal of applied toxicology : JAT. 1987;7:281–288.

Blakley B. R., Hancock D. S., Rousseaux C. G.. Embryotoxic effects of prenatal T-2 toxin exposure in mice. Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire. 1987;51:399–403.

Rousseaux C. G., Schiefer H. B., Hancock D. S.. Reproductive and teratological effects of continuous low-level dietary T-2 toxin in female CD-1 mice for two generations. Journal of applied toxicology : JAT. 1986;6:179–184.

Khera K. S., Whalen C., Angers G.. A teratology study on vomitoxin (4-deoxynivalenol) in rabbits. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1986;24:421–424.

Hood R. D.. Effects of concurrent prenatal exposure to rubratoxin B and T-2 toxin in the mouse. Drug and chemical toxicology. 1986;9:185–190.

Levitskaia A. B., Kravchenko L. V., Tutel’ian V. A.. [Embryotoxic action of trichothecene mycotoxins]. Gigiena i sanitariia. 1986:19–20.

Xia Q. J.. [Effects of fusarium T-2 toxin on cultured human fetal esophagus]. Zhonghua bing li xue za zhi Chinese journal of pathology. 1985;14:81–84.

Morrissey R. E.. Teratological study of Fischer rats fed diet containing added vomitoxin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1984;22:453–457.

Hsia C. C., Tzian B. L., Harris C. C.. Proliferative and cytotoxic effects of Fusarium T2 toxin on cultured human fetal esophagus. Carcinogenesis. 1983;4:1101–1107.

Ito Y., Ohtsubo K., Saito M.. Effects of fusarenon-X, a trichothecene produced by Fusarium nivale, on pregnant mice and their fetuses. The Japanese journal of experimental medicine. 1980;50:167–172.

Hood R. D., Kuczuk M. H., Szczech G. M.. Effects in mice of simultaneous prenatal exposure to ochratoxin A and T-2 toxin. Teratology. 1978;17:25–29.

Stanford G. K., Hood R. D., Hayes A. W.. Effect of prenatal administration of T-2 toxin to mice. Research communications in chemical pathology and pharmacology. 1975;10:743–746.

Khera K. S., Whalen C., Angers G., Vesonder R. F., Kuiper-Goodman T.. Embryotoxicity of 4-deoxynivalenol (vomitoxin) in mice. Bulletin of environmental contamination and toxicology. 1982;29:487–491.

Sheu C. W., Moreland F. M., Lee J. K., Dunkel V. C.. Morphological transformation of BALB/3T3 mouse embryo cells in vitro by vomitoxin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1988;26:243–245.

 

OTHER

Yu M, Chen L, Peng Z, Wang D, Song Y, Wang H, Yao P, Yan H, Nüssler AK, Liu L, Yang W. Embryotoxicity Caused by DON-Induced Oxidative Stress Mediated by Nrf2/HO-1 Pathway. Toxins (Basel). 2017 Jun 9;9(6). PMID: 28598396

Woźny M, Obremski K, Zalewski T, Mommens M, Łakomiak A, Brzuzan P. Transfer of zearalenone to the reproductive system of female rainbow trout spawners: A potential risk for aquaculture and fish consumers? Food Chem Toxicol. 2017 Jul 5;107(Pt A):386-394. PMID: 28689064

Yu M, Chen L, Peng Z, Nüssler AK, Wu Q, Liu L, Yang W. Mechanism of deoxynivalenol effects on the reproductive system and fetus malformation: Current status and future challenges. Toxicol In Vitro. 2017 Jun;41:150-158. PMID: 28286114

Gerez JR, Desto SS, Bracarense AP. Deoxynivalenol induces toxic effects in the ovaries of pigs: An ex vivo approach. Theriogenology. 2017 Mar 1;90:94-100. PMID: 28166994

Zhang GL, Sun XF, Feng YZ, Li B, Li YP, Yang F, Nyachoti CM, Shen W, Sun SD, Li L. Zearalenone exposure impairs ovarian primordial follicle formation via down-regulation of Lhx8 expression in vitro. Toxicol Appl Pharmacol. 2017 Feb 15;317:33-40. PMID: 28089945

Gao X, Sun L, Zhang N, Li C, Zhang J, Xiao Z, Qi D. Gestational Zearalenone Exposure Causes Reproductive and Developmental Toxicity in Pregnant Rats and Female Offspring. Toxins (Basel). 2017 Jan 5;9(1). PMID: 28067781

Long M, Yang S, Wang Y, Li P, Zhang Y, Dong S, Chen X, Guo J, He J, Gao Z, Wang J. The Protective Effect of Selenium on Chronic Zearalenone-Induced Reproductive System Damage in Male Mice. Molecules. 2016 Dec 7;21(12). PMID: 27941626

Zhu Y, Yao X, Leung LK. Zeranol induces COX-2 expression through TRPC-3 activation in the placental cells JEG-3. Toxicol In Vitro. 2016 Sep;35:17-23. PMID: 27224899

Long M, Yang S, Zhang Y, Li P, Han J, Dong S, Chen X, He J. Proanthocyanidin protects against acute zearalenone-induced testicular oxidative damage in male mice. Environ Sci Pollut Res Int. 2017 Jan;24(1):938-946. PMID: 27761864

Zhang Y, Han J, Zhu CC, Tang F, Cui XS, Kim NH, Sun SC. Exposure to HT-2 toxin causes oxidative stress induced apoptosis/autophagy in porcine oocytes. Sci Rep. 2016 Sep 23;6:33904. PMID: 27658477

Yuan Z, Matias FB, Yi JE, Wu J. T-2 toxin-induced cytotoxicity and damage on TM3 Leydig cells. Comp Biochem Physiol C Toxicol Pharmacol. 2016 Mar-Apr;181-182:47-54. PMID: 26707243

Han J, Wang QC, Zhu CC, Liu J, Zhang Y, Cui XS, Kim NH, Sun SC. Deoxynivalenol exposure induces autophagy/apoptosis and epigenetic modification changes during porcine oocyte maturation. Toxicol Appl Pharmacol. 2016 Jun 1;300:70-6. PMID: 26988607

Adibnia E, Razi M, Malekinejad H. Zearalenone and 17 β-estradiol induced damages in male rats reproduction potential; evidence for ERα and ERβ receptors expression and steroidogenesis. Toxicon. 2016 Sep 15;120:133-46. PMID: 27527272

Kunishige K, Kawate N, Inaba T, Tamada H. Exposure to Zearalenone During Early Pregnancy Causes Estrogenic Multitoxic Effects in Mice. Reprod Sci. 2017 Mar;24(3):421-427. PMID: 27485361

Schoevers EJ, Santos RR, Fink-Gremmels J, Roelen BA. Toxicity of beauvericin on porcine oocyte maturation and preimplantation embryo development. Reprod Toxicol. 2016 Oct;65:159-169. PMID: 27474255

Dai M, Jiang S, Yuan X, Yang W, Yang Z, Huang L. Effects of zearalenone-diet on expression of ghrelin and PCNA genes in ovaries of post-weaning piglets. Anim Reprod Sci. 2016 May;168:126-37. PMID: 27020865

Gao R, Meng Q, Li J, Liu M, Zhang Y, Bi C, Shan A. Modified halloysite nanotubes reduce the toxic effects of zearalenone in gestating sows on growth and muscle development of their offsprings. J Anim Sci Biotechnol. 2016 Feb 29;7:14. PMID: 26933493

Zheng W, Pan S, Wang G, Wang YJ, Liu Q, Gu J, Yuan Y, Liu XZ, Liu ZP, Bian JC. Zearalenone impairs the male reproductive system functions via inducing structural and functional alterations of sertoli cells. Environ Toxicol Pharmacol. 2016 Mar;42:146-55. PMID: 26851377

Zouaoui N, Mallebrera B, Berrada H, Abid-Essefi S, Bacha H, Ruiz MJ. Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells. Food Chem Toxicol. 2016 Mar;89:92-103. PMID: 26802678

Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Yiliyasi M, Kato T, Kuwahara A, Irahara M. Prenatal undernutrition results in greater lipopolysaccharide-induced changes in hypothalamic TNF-α expression, but does not affect the equivalent changes in the serum levels of luteinizing hormone and testosterone, in adult male rats. Int J Dev Neurosci. 2016 Feb;48:80-3. PMID: 26674468

Somoskői B, Kovács M, Cseh S. Effects of T-2 mycotoxin on in vitro development and chromatin status of mouse embryos in preimplantation stages. Toxicol Ind Health. 2016 Jul;32(7):1260-5. PMID: 25425537

Cheraghi S, Razi M, Malekinejad H. Involvement of cyclin D1 and E2f1 in zearalenone-induced DNA damage in testis of rats. Toxicon. 2015 Nov;106:108-16. PMID: 26408962

Gajęcka M, Zielonka Ł, Gajęcki M. The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs–A Review. Molecules. 2015 Nov 19;20(11):20669-87. PMID: 26610443

Ali N, Blaszkewicz M, Al Nahid A, Rahman M, Degen GH. Deoxynivalenol Exposure Assessment for Pregnant Women in Bangladesh. Toxins (Basel). 2015 Sep 24;7(10):3845-57. PMID: 26404372

Huuskonen P, Auriola S, Pasanen M. Zearalenone metabolism in human placental subcellular organelles, JEG-3 cells, and recombinant CYP19A1. Placenta. 2015 Sep;36(9):1052-5. PMID: 26188906

Zielonka Ł, Gajęcka M, Żmudzki J, Gajęcki M. The effect of selected environmental Fusarium mycotoxins on the ovaries in the female wild boar (Sus scrofa). Pol J Vet Sci. 2015;18(2):391-9. PMID: 26172190

Halenar M, Medvedova M, Maruniakova N, Kolesarova A. Assessment of a potential preventive ability of amygdalin in mycotoxin-induced ovarian toxicity. J Environ Sci Health B. 2015;50(6):411-6. PMID: 25844862

Maruniakova N, Kadasi A, Sirotkin AV, Leśniak A, Ferreira AM, Bulla J, Kolesarova A. Assessment of T-2 toxin effect and its metabolite HT-2 toxin combined with insulin-like growth factor I, leptin and ghrelin on progesterone secretion by rabbit ovarian fragments. J Environ Sci Health B. 2015;50(2):128-34. PMID: 25587782

Chen XX, Yang CW, Huang LB, Niu QS, Jiang SZ, Chi F. Zearalenone Altered the Serum Hormones, Morphologic and Apoptotic Measurements of Genital Organs in Post-weaning Gilts. Asian-Australas J Anim Sci. 2015 Feb;28(2):171-9. PMID: 25557812

Li Y, He X, Yang X, Huang K, Luo Y, Zhu L, Li Y, Xu W. Zinc inhibits the reproductive toxicity of Zearalenone in immortalized murine ovarian granular KK-1 cells. Sci Rep. 2015 Sep 23;5:14277. PMID: 26395757

Lai FN, Ma JY, Liu JC, Wang JJ, Cheng SF, Sun XF, Li L, Li B, Nyachoti CM, Shen W. The influence of N-acetyl-l-cysteine on damage of porcine oocyte exposed to zearalenone in vitro. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):341-8. PMID: 26386189

Fushimi Y, Takagi M, Monniaux D, Uno S, Kokushi E, Shinya U, Kawashima C, Otoi T, Deguchi E, Fink-Gremmels J. Effects of Dietary Contamination by Zearalenone and Its Metabolites on Serum Anti-Müllerian Hormone: Impact on the Reproductive Performance of Breeding Cows. Reprod Domest Anim. 2015 Oct;50(5):834-9. PMID: 26303354

Zhu CC, Zhang Y, Duan X, Han J, Sun SC. Toxic effects of HT-2 toxin on mouse oocytes and its possible mechanisms. Arch Toxicol. 2016 Jun;90(6):1495-505. PMID: 26138683

Capcarova M, Petruska P, Zbynovska K, Kolesarova A, Sirotkin AV. Changes in antioxidant status of porcine ovarian granulosa cells after quercetin and T-2 toxin treatment. J Environ Sci Health B. 2015;50(3):201-6. PMID: 25602153

Wu J, Tu D, Yuan LY, Yi JE, Tian Y. T-2 toxin regulates steroid hormone secretion of rat ovarian granulosa cells through cAMP-PKA pathway. Toxicol Lett. 2015 Feb 3;232(3):573-9. PMID: 25542145

Li Y, Zhang B, Huang K, He X, Luo Y, Liang R, Luo H, Shen XL, Xu W. Mitochondrial proteomic analysis reveals the molecular mechanisms underlying reproductive toxicity of zearalenone in MLTC-1 cells. Toxicology. 2014 Oct 3;324:55-67. PMID: 25058043

Yuan G, Wang Y, Yuan X, Zhang T, Zhao J, Huang L, Peng S. T-2 toxin induces developmental toxicity and apoptosis in zebrafish embryos. J Environ Sci (China). 2014 Apr 1;26(4):917-25. PMID: 25079423

Apoptosis and gene expression in the developing mouse brain of fusarenon-X-treated pregnant mice. Toxicol Lett. 2014 Aug 17;229(1):292-302. PMID: 24983900

Voss KA, Riley RT, Gelineau-van Waes J. Fumonisin B₁ induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet. Mol Nutr Food Res. 2014 Jun;58(6):1190-8. PMID: 24585430

Zhu CC, Hou YJ, Han J, Cui XS, Kim NH, Sun SC. Zearalenone exposure affects epigenetic modifications of mouse eggs. Mutagenesis. 2014 Nov;29(6):489-95. PMID: 25155023

Liu Q, Wang Y, Gu J, Yuan Y, Liu X, Zheng W, Huang Q, Liu Z, Bian J. Zearalenone inhibits testosterone biosynthesis in mouse Leydig cells via the crosstalk of estrogen receptor signaling and orphan nuclear receptor Nur77 expression. Toxicol In Vitro. 2014 Jun;28(4):647-56. PMID: 24512812

Molina-Molina JM, Real M, Jimenez-Diaz I, Belhassen H, Hedhili A, Torné P, Fernández MF, Olea N. Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays. Food Chem Toxicol. 2014 Dec;74:233-9.PMID: 25455890

Zielonka Ł, Gajęcka M, Rozicka A, Dąbrowski M, Żmudzki J, Gajęcki M. The effect of environmental mycotoxins on selected ovarian tissue fragments of multiparous female wild boars at the beginning of astronomical winter. Toxicon. 2014 Oct;89:26-31. PMID: 25016169

Zhao F, Li R, Xiao S, Diao H, El Zowalaty AE, Ye X. Multigenerational exposure to dietary zearalenone (ZEA), an estrogenic mycotoxin, affects puberty and reproduction in female mice. Reprod Toxicol. 2014 Aug;47:81-8. PMID: 24972337

Zhu CC, Hou YJ, Han J, Liu HL, Cui XS, Kim NH, Sun SC. Effect of mycotoxin-containing diets on epigenetic modifications of mouse oocytes by fluorescence microscopy analysis. Microsc Microanal. 2014 Aug;20(4):1158-66. PMID: 24810297

Yin S, Zhang Y, Gao R, Cheng B, Shan A. The immunomodulatory effects induced by dietary Zearalenone in pregnant rats. Immunopharmacol Immunotoxicol. 2014 Jun;36(3):187-94. PMID: 24754511

Hou YJ, Zhu CC, Xu YX, Cui XS, Kim NH, Sun SC. Zearalenone exposure affects mouse oocyte meiotic maturation and granulosa cell proliferation. Environ Toxicol. 2015 Sep;30(10):1226-33. PMID: 24733567

Zatecka E, Ded L, Elzeinova F, Kubatova A, Dorosh A, Margaryan H, Dostalova P, Korenkova V, Hoskova K, Peknicova J. Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice. Reprod Toxicol. 2014 Jun;45:20-30. PMID: 24412631

Zhang Y, Jia Z, Yin S, Shan A, Gao R, Qu Z, Liu M, Nie S. Toxic effects of maternal zearalenone exposure on uterine capacity and fetal development in gestation rats. Reprod Sci. 2014 Jun;21(6):743-53. PMID: 24357638

Maruniakova N, Kadasi A, Sirotkin AV, Bulla J, Kolesarova A. T-2 toxin and its metabolite HT-2 toxin combined with insulin-like growth factor-I modify progesterone secretion by porcine ovarian granulosa cells. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2014;49(4):404-9. PMID: 24345238

Hou YJ, Xiong B, Zheng WJ, Duan X, Cui XS, Kim NH, Wang Q, Xu YX, Sun SC. Oocyte quality in mice is affected by a mycotoxin-contaminated diet. Environ Mol Mutagen. 2014 May;55(4):354-62. PMID: 24288346

Maruniakova Nora, Kadasi Attila, Sirotkin Alexander V., Bulla Jozef, Kolesarova Adriana. T-2 toxin and its metabolite HT-2 toxin combined with insulin-like growth factor-I modify progesterone secretion by porcine ovarian granulosa cells. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2014;49:404–409.

Wu Jing, Tu Di, Yuan Li-Yun Y., Yuan Hui, Wen Li-Xin X.. T-2 toxin exposure induces apoptosis in rat ovarian granulosa cells through oxidative stress. Environmental toxicology and pharmacology. 2013;36:493–500.

Cortinovis Cristina, Pizzo Fabiola, Spicer Leon J., Caloni Francesca. Fusarium mycotoxins: effects on reproductive function in domestic animals–a review. Theriogenology.  2013;80:557–564.

Hepworth S. J., Hardie L. J., Fraser L. K., et al. Deoxynivalenol exposure assessment in a cohort of pregnant women from Bradford, UK. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2012;29:269–276.

Yang Jianying, Zhang Yongfa, Jing Aihua, Ma Kaiwang, Gong Qiang, Qin Cuili. Effects of T-2 toxin on testosterone biosynthesis in mouse Leydig cells. Toxicology and industrial health. 2012.

Piekkola S., Turner P. C., Abdel-Hamid M., et al. Characterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian women. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2012;29:962–971.

Medvedova Marina, Kolesarova Adriana, Capcarova Marcela, et al. The effect of deoxynivalenol on the secretion activity, proliferation and apoptosis of porcine ovarian granulosa cells in vitro. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2011;46:213–219.

Wu Jing, Jing Li, Yuan Hui, Peng Shuang-qing Q.. T-2 toxin induces apoptosis in ovarian granulosa cells of rats through reactive oxygen species-mediated mitochondrial pathway. Toxicology letters. 2011;202:168–177.

Kovács M., Tornyos G., Matics Zs, et al. Subsequent effect of subacute T-2 toxicosis on spermatozoa, seminal plasma and testosterone production in rabbits. Animal : an international journal of animal bioscience. 2011;5:1563–1569.

Nielsen Jeanette K., Vikström Anna C., Turner Paul, Knudsen Lisbeth E.. Deoxynivalenol transport across the human placental barrier. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011;49:2046–2052.

Schoevers E. J., Fink-Gremmels J., Colenbrander B., Roelen B. A.. Porcine oocytes are most vulnerable to the mycotoxin deoxynivalenol during formation of the meiotic spindle. Theriogenology. 2010;74:968–978.

Yang Jian Ying Y., Zhang Yong Fa F., Liang Ai Min M., et al. Toxic effects of T-2 toxin on reproductive system in male mice. Toxicology and industrial health. 2010;26:25–31.

Gutzwiller A., Gafner J-L L.. Fertility of sows exposed to zearalenone and deoxynivalenol-a case report. Mycotoxin research. 2009;25:21–24.

Gutzwiller Andreas, Gafner Jean-Louis L., Stoll Peter. Effects of a diet containing fusarium toxins on the fertility of gilts and on bulbourethral gland weight in barrows. Archives of animal nutrition. 2009;63:16–25.

Tiemann U., Brüssow K-P P., Küchenmeister U., et al. Changes in the spleen and liver of pregnant sows and full-term piglets after feeding diets naturally contaminated with deoxynivalenol and zearalenone. Veterinary journal (London, England : 1997). 2008;176:188–196.

Perazzo Juan Carlos C., Boviez Juan, Lago Néstor, Diaz Silvina Laura L.. Growth and reproductive problems in a colony of laboratory rats. Diagnosis: Mycotoxin poisoning. Lab animal. 2008;37:153–155.

Tiemann U., Brüssow K-P P., Danicke S., Vanselow J.. Feeding of pregnant sows with mycotoxin-contaminated diets and their non-effect on foetal and maternal hepatic transcription of genes of the insulin-like growth factor system. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2008;25:1365–1373.

Doi Kunio, Ishigami Noriaki, Sehata Shinya. T-2 toxin-induced toxicity in pregnant mice and rats. International journal of molecular sciences. 2008;9:2146–2158.

Tiemann U., Dänicke S.. In vivo and in vitro effects of the mycotoxins zearalenone and deoxynivalenol on different non-reproductive and reproductive organs in female pigs: a review. Food additives and contaminants. 2007;24:306–314.

Collins Thomas F., Sprando Robert L., Black Thomas N., et al. Effects of deoxynivalenol (DON, vomitoxin) on in utero development in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2006;44:747–757.

Alm H., Brüssow K-P P., Torner H., et al. Influence of Fusarium-toxin contaminated feed on initial quality and meiotic competence of gilt oocytes. Reproductive toxicology (Elmsford, N.Y.). 2006;22:44–50.

Sprando Robert L., Collins Thomas F., Black Thomas N., et al. Characterization of the effect of deoxynivalenol on selected male reproductive endpoints. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2005;43:623–635.

Sehata Shinya, Kiyosawa Naoki, Sakuma Kyoko, et al. Gene expression profiles in pregnant rats treated with T-2 toxin. Experimental and toxicologic pathology. 2004;55:357–366.

Poapolathep Amnart, Sugita-Konishi Yoshiko, Phitsanu Tulayakul, Doi Kunio, Kumagai Susumu. Placental and milk transmission of trichothecene mycotoxins, nivalenol and fusarenon-X, in mice. Toxicon. 2004;44:111–113.

Golinski P. K., Nowak T.. Dietary origin of mycotoxins with estrogenic potential and possible health implications to female dogs. Polish journal of veterinary sciences. 2004;7:337–341.

Döll S., Dänicke S., Schnurrbusch U.. The effect of increasing concentrations of Fusarium toxins in piglet diets on histological parameters of the uterus and vagina. Archives of animal nutrition. 2004;58:413–417.

Tiemann U., Viergutz T., Jonas L., Schneider F.. Influence of the mycotoxins alpha- and beta-zearalenol and deoxynivalenol on the cell cycle of cultured porcine endometrial cells. Reproductive toxicology (Elmsford, N.Y.). 2003;17:209–218.

Döll S., Dänicke S., Schnurrbusch U.. The effect of increasing concentrations of Fusarium toxins in the diets for piglets on histological parameters of the uterus. Mycotoxin research. 2003;19:73–76.

Döll S., Dänicke S., Ueberschär K. H., et al. Effects of graded levels of Fusarium toxin contaminated maize in diets for female weaned piglets. Archiv für Tierernährung. 2003;57:311–334.

Alm H., Greising T., Brüssow K-P P., Torner H., Tiemann U.. The influence of the mycotoxins deoxynivalenol and zearalenol on in vitro maturation of pig oocytes and in vitro culture of pig zygotes. Toxicology in vitro : an international journal published in association with BIBRA. 2002;16:643–648.

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