Fusarium Literature – Protective Agents

 

 

Binders

Yuan CW, Huang JT, Chen CC, Tang PC, Huang JW, Lin JJ, Huang SY, Chen SE. Evaluation of efficacy and toxicity of exfoliated silicate nanoclays as a feed additive for fumonisin detoxification. J Agric Food Chem. 2017 Jul 17. PMID: 28712299

Samik A, Safitri E. Mycotoxin binders potential on histological of ovary mice exposed by zearalenone. Vet World. 2017 Mar;10(3):353-357. PMID: 28435200

Marković M, Daković A, Rottinghaus GE, Kragović M, Petković A, Krajišnik D, Milić J, Mercurio M, de Gennaro B. Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant. Colloids Surf B Biointerfaces. 2017 Mar 1;151:324-332. PMID: 28040664

Frobose HL, Erceg JA, Fowler SQ, Tokach MD, DeRouchey JM, Woodworth JC, Dritz SS, Goodband RD. The progression of deoxynivalenol-induced growth suppression in nursery pigs and the potential of an algae-modified montmorillonite clay to mitigate these effects. J Anim Sci. 2016 Sep;94(9):3746-3759. PMID: 27898884

Abdel-Wahhab MA, El-Kady AA, Hassan AM, Abd El-Moneim OM, Abdel-Aziem SH. Effectiveness of activated carbon and Egyptian montmorillonite in the protection against deoxynivalenol-induced cytotoxicity and genotoxicity in rats. Food Chem Toxicol. 2015 Sep;83:174-82. PMID: 26115597

Denli M, Blandon JC, Guynot ME, Salado S, Pérez JF. Efficacy of activated diatomaceous clay in reducing the toxicity of zearalenone in rats and piglets. J Anim Sci. 2015 Feb;93(2):637-45. PMID: 26020748

Denli M, Blandon JC, Salado S, Guynot ME, Casas J, Pérez JF. Efficacy of AdiDetox in reducing the toxicity of fumonisin B1 in rats. Food Chem Toxicol. 2015 Apr;78:60-3. PMID: 25660482

Liao YJ, Yang JR, Chen SE, Wu SJ, Huang SY, Lin JJ, Chen LR, Tang PC. Inhibition of fumonisin B1 cytotoxicity by nanosilicate platelets during mouse embryo development. PLoS One. 2014 Nov 10;9(11):e112290. PMID: 25383881

Devreese M, Antonissen G, De Backer P, Croubels S. Efficacy of active carbon towards the absorption of deoxynivalenol in pigs. Toxins (Basel). 2014 Oct 21;6(10):2998-3004. PMID: 25337799

Goossens Joline, Vandenbroucke Virginie, Pasmans Frank, et al. Influence of mycotoxins and a mycotoxin adsorbing agent on the oral bioavailability of commonly used antibiotics in pigs. Toxins. 2012;4:281–295.

Qiang Zhiyi, Truong My, Meynen Koen, Murphy Patricia A., Hendrich Suzanne. Efficacy of a mycotoxin binder against dietary fumonisin, deoxynivalenol, and zearalenone in rats. Journal of agricultural and food chemistry. 2011;59:7527–7533.

Cavret S., Laurent N., Videmann B., Mazallon M., Lecoeur S.. Assessment of deoxynivalenol (DON) adsorbents and characterisation of their efficacy using complementary in vitro tests. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2010;27:43–53.

Dänicke Sven, Goyarts Tanja, Valenta Hana. On the specific and unspecific effects of a polymeric glucomannan mycotoxin adsorbent on piglets when fed with uncontaminated or with Fusarium toxins contaminated diets. Archives of animal nutrition. 2007;61:266–275.

Sabater-Vilar Monica, Malekinejad Hassan, Selman M. H., Doelen M. A., Fink-Gremmels Johanna. In vitro assessment of adsorbents aiming to prevent deoxynivalenol and zearalenone mycotoxicoses. Mycopathologia. 2007;163:81–90.

Díaz-Llano G., Smith T. K.. The effects of feeding grains naturally contaminated with Fusarium mycotoxins with and without a polymeric glucomannan adsorbent on lactation, serum chemistry, and reproductive performance after weaning of first-parity lactating sows. Journal of animal science. 2007;85:1412–1423.

Díaz-Llano G., Smith T. K.. Effects of feeding grains naturally contaminated with Fusarium mycotoxins with and without a polymeric glucomannan mycotoxin adsorbent on reproductive performance and serum chemistry of pregnant gilts. Journal of animal science. 2006;84:2361–2366.

Avantaggiato G., Solfrizzo M., Visconti A.. Recent advances on the use of adsorbent materials for detoxification of Fusarium mycotoxins. Food additives and contaminants. 2005;22:379–388.

García A. R., Avila E., Rosiles R., Petrone V. M.. Evaluation of two mycotoxin binders to reduce toxicity of broiler diets containing ochratoxin A and T-2 toxin contaminated grain. Avian diseases. 2003;47:691–699.

Swamy H. V., Smith T. K., MacDonald E. J., Boermans H. J., Squires E. J.. Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent. Journal of animal science. 2002;80:3257–3267.

Murthy T. N., Reddy B. N., Devegowda G.. Evaluation of glucomannan for its adsorbing ability of Aflatoxin B1 and T-2 Toxin in the Gastrointestinal Tract of Broiler Chickens. Mycotoxin research. 2002;18 Suppl 1:20–23.

Diaz G. J.. Evaluation of the efficacy of a feed additive to ameliorate the toxic effects of 4,15-diacetoxiscirpenol in growing chicks. Poultry science. 2002;81:1492–1495.

Raju M. V., Devegowda G.. Influence of esterified-glucomannan on performance and organ morphology, serum biochemistry and haematology in broilers exposed to individual and combined mycotoxicosis (aflatoxin, ochratoxin and T-2 toxin). British poultry science. 2000;41:640–650.

Raymond S. L., Smith T. K., Swamy H. V.. Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on feed intake, serum chemistry, and hematology of horses, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. Journal of animal science. 2003;81:2123–2130.

Edrington T. S., Kubena L. F., Harvey R. B., Rottinghaus G. E.. Influence of a superactivated charcoal on the toxic effects of aflatoxin or T-2 toxin in growing broilers. Poultry science. 1997;76:1205–1211.

 

Microbes

Yuan CW, Huang JT, Chen CC, Tang PC, Huang JW, Lin JJ, Huang SY, Chen SE. Evaluation of efficacy and toxicity of exfoliated silicate nanoclays as a feed additive for fumonisin detoxification. J Agric Food Chem. 2017 Jul 17. PMID: 28712299

Wilson NM, McMaster N, Gantulga D, Soyars C, McCormick SP, Knott K, Senger RS, Schmale DG. Modification of the Mycotoxin Deoxynivalenol Using Microorganisms Isolated from Environmental Samples. Toxins (Basel). 2017 Apr 15;9(4). PMID: 28420137

Taheur FB, Fedhila K, Chaieb K, Kouidhi B, Bakhrouf A, Abrunhosa L. Adsorption of aflatoxin B1, zearalenone and ochratoxin A by microorganisms isolated from Kefir grains. Int J Food Microbiol. 2017 Jun 19;251:1-7. PMID: 28376398

Gratz SW, Dinesh R, Yoshinari T, Holtrop G, Richardson AJ, Duncan G, MacDonald S, Lloyd A, Tarbin J. Masked trichothecene and zearalenone mycotoxins withstand digestion and absorption in the upper GI tract but are efficiently hydrolyzed by human gut microbiota in vitro. Mol Nutr Food Res. 2017 Apr;61(4). PMID: 27921366

Chang C, Wang K, Zhou SN, Wang XD, Wu JE. Protective Effect of Saccharomyces boulardii on Deoxynivalenol-Induced Injury of Porcine Macrophage via Attenuating p38 MAPK Signal Pathway. Appl Biochem Biotechnol. 2017 May;182(1):411-427. PMID: 27878744

Vanhoutte I, De Mets L, De Boevre M, Uka V, Di Mavungu JD, De Saeger S, De Gelder L, Audenaert K. Microbial Detoxification of Deoxynivalenol (DON), Assessed via a Lemna minor L. Bioassay, through Biotransformation to 3-epi-DON and 3-epi-DOM-1. Toxins (Basel). 2017 Feb 13;9(2). PMID: 28208799

Ahad R, Zhou T, Lepp D, Pauls KP. Microbial detoxification of eleven food and feed contaminating trichothecenemycotoxins. BMC Biotechnol. 2017 Mar 15;17(1):30. PMID: 28298196

Yang WC, Hsu TC, Cheng KC, Liu JR. Expression of the Clonostachys rosea lactonohydrolase gene by Lactobacillus reuteri to increase its zearalenone-removing ability. Microb Cell Fact. 2017 Apr 24;16(1):69. PMID: 28438205

Zhao H, Wang X, Zhang J, Zhang J, Zhang B. The mechanism of Lactobacillus strains for their ability to remove fumonisins B1 and B2. Food Chem Toxicol. 2016 Nov;97:40-46. PMID: 27575882

Nathanail AV, Gibson B, Han L, Peltonen K, Ollilainen V, Jestoi M, Laitila A. The lager yeast Saccharomyces pastorianus removes and transforms Fusariumtrichothecene mycotoxins during fermentation of brewer’s wort. Food Chem. 2016 Jul 15;203:448-55. PMID: 26948637

Pierron A, Mimoun S, Murate LS, Loiseau N, Lippi Y, Bracarense AP, Schatzmayr G, He JW, Zhou T, Moll WD, Oswald IP. Microbial biotransformation of DON: molecular basis for reduced toxicity. Sci Rep. 2016 Jul 6;6:29105. PMID: 27381510

Zhang H, Dong M, Yang Q, Apaliya MT, Li J, Zhang X. Biodegradation of zearalenone by Saccharomyces cerevisiae: Possible involvement of ZEN responsive proteins of the yeast. J Proteomics. 2016 Jun 30;143:416-23. PMID: 27109348

Abbès S, Ben Salah-Abbès J, Jebali R, Younes RB, Oueslati R. Interaction of aflatoxin B1 and fumonisin B1 in mice causes immunotoxicity and oxidative stress: Possible protective role using lactic acid bacteria. J Immunotoxicol. 2016;13(1):46-54. PMID: 25585958

Zhang J, Qiao Y, Wang X, Pei J, Zheng J, Zhang B. Absorption of fumonisin B1 and B2 by Lactobacillus plantarum ZJ8. Wei Sheng Wu Xue Bao. 2014 Dec 4;54(12):1481-8. Chinese. PMID: 25876334

Ferrer M, Manyes L, Mañes J, Meca G. Influence of prebiotics, probiotics and protein ingredients on mycotoxin bioaccessibility. Food Funct. 2015 Mar;6(3):987-94. PMID: 25673154

Sun X, He X, Xue Ks, Li Y, Xu D, Qian H. Biological detoxification of zearalenone by Aspergillus niger strain FS10. Food Chem Toxicol. 2014 Oct;72:76-82. PMID: 25007785

Khalil AA, Abou-Gabal AE, Abdellatef AA, Khalid AE. Protective role of probiotic lactic acid bacteria against dietary fumonisin B1-induced toxicity and DNA-fragmentation in sprague-dawley rats. Prep Biochem Biotechnol. 2015 Aug 18;45(6):530-50. PMID: 25036875

Taranu I, Marin DE, Pistol GC, Motiu M, Pelinescu D. Induction of pro-inflammatory gene expression by Escherichia coli and mycotoxin zearalenone contamination and protection by a Lactobacillus mixture in porcine IPEC-1 cells. Toxicon. 2015 Apr;97:53-63. PMID: 25640651

Tan H, Hu Y, He J, Wu L, Liao F, Luo B, He Y, Zuo Z, Ren Z, Zhong Z, Peng G, Deng J. Zearalenone degradation by two Pseudomonas strains from soil. Mycotoxin Res. 2014 Nov;30(4):191-6. PMID: 24879510

McCormick Susan P.. Microbial Detoxification of Mycotoxins. Journal of chemical ecology. 2013.

Gratz Silvia W., Duncan Gary, Richardson Anthony J.. The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3-glucoside and may be responsible for urinary deepoxy-deoxynivalenol. Applied and environmental microbiology. 2013;79:1821–1825.

Berthiller Franz, Crews Colin, Dall’Asta Chiara, et al. Masked mycotoxins: a review. Molecular nutrition & food research. 2013;57:165–186.

Dall’Erta Andrea, Cirlini Martina, Dall’Asta Margherita, Del Rio Daniele, Galaverna Gianni, Dall’Asta Chiara. Masked mycotoxins are efficiently hydrolyzed by human colonic microbiota releasing their aglycones. Chemical research in toxicology. 2013;26:305–312.

Islam Rafiqul, Zhou Ting, Young J. Christopher, Goodwin Paul H., Pauls K. Peter. Aerobic and anaerobic de-epoxydation of mycotoxin deoxynivalenol by bacteria originating from agricultural soil. World journal of microbiology & biotechnology. 2012;28:7–13.

Jossé Lyne, Li Xingmin, Coker Raymond D., Gourlay Campbell W., Evans Ivor H.. Transcriptomic and phenotypic analysis of the effects of T-2 toxin on Saccharomyces cerevisiae: evidence of mitochondrial involvement. FEMS yeast research. 2011;11:133–150.

Franco T. S., Garcia S., Hirooka E. Y., Ono Y. S., Santos J. S.. Lactic acid bacteria in the inhibition of Fusarium graminearum and deoxynivalenol detoxification. Journal of applied microbiology. 2011;111:739–748.

Boguhn Jeannette, Neumann Dominik, Helm André, et al. Effects of concentrate proportion in the diet with or without Fusarium toxin-contaminated triticale on ruminal fermentation and the structural diversity of rumen microbial communities in vitro. Archives of animal nutrition. 2010;64:467–483.

McLaughlin John E., Bin-Umer Mohamed Anwar A., Tortora Andrew, Mendez Natasha, McCormick Susan, Tumer Nilgun E.. A genome-wide screen in Saccharomyces cerevisiae reveals a critical role for the mitochondria in the toxicity of a trichothecene mycotoxin. Proceedings of the National Academy of Sciences of the United States of America. 2009;106:21883–21888.

Young J. Christopher, Zhou Ting, Yu Hai, Zhu Honghui, Gong Jianhua. Degradation of trichothecene mycotoxins by chicken intestinal microbes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007;45:136–143.

Kobayashi Yoshifumi, Mizunuma Masaki, Osada Hiroyuki, Miyakawa Tokichi. Identification of Saccharomyces cerevisiae ribosomal protein L3 as a target of curvularol, a G1-specific inhibitor of mammalian cells. Bioscience, biotechnology, and biochemistry. 2006;70:2451–2459.

Katsev A. M., Goĭster O. S., Starodub N. F.. [Effect of mycotoxin T-2 on bioluminescence intensity of bacteria]. Ukrainskiĭ biokhimicheskiĭ zhurnal. 2003;75:99–103.

Sundstøl Eriksen G., Pettersson H.. Lack of de-epoxidation of type B trichothecenes in incubates with human faeces. Food additives and contaminants. 2003;20:579–582.

El-Nezami H. S., Chrevatidis A., Auriola S., Salminen S., Mykkänen H.. Removal of common Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium. Food additives and contaminants. 2002;19:680–686.

Eriksen G. S., Pettersson H., Johnsen K., Lindberg J. E.. Transformation of trichothecenes in ileal digesta and faeces from pigs. Archiv für Tierernährung. 2002;56:263–274.

Adam G., Mitterbauer R., Raditschnig A., et al. Molecular mechanisms of deoxynivalenol resistance in the yeast Saccharomyces cerevisiae. Mycotoxin research. 2001;17 Suppl 1:19–23.

Böhm J., Grajewski J., Asperger H., Cecon B., Rabus B., Razzazi E.. Study on biodegradation of some A- and B-trichothecenes and ochratoxin A by use of probiotic microorganisms. Mycotoxin research. 2000;16 Suppl 1:70–74.

Engler K. H., Coker R. D., Evans I. H.. Uptake of aflatoxin B1 and T-2 toxin by two mycotoxin bioassay microorganisms: Kluyveromyces marxianus and Bacillus megaterium. Archives of microbiology. 2000;174:381–385.

Ali-Vehmas T., Rizzo A., Westermarck T., Atroshi F.. Measurement of antibacterial activities of T-2 toxin, deoxynivalenol, ochratoxin A, aflatoxin B1 and fumonisin B1 using microtitration tray-based turbidimetric techniques. Zentralblatt für Veterinärmedizin. Reihe A. 1998;45:453–458.

Li J., Shimizu T.. Course of apoptotic changes in the rat gastric mucosa caused by oral administration of fusarenon-X. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 1997;59:191–199.

Rasooly L., Pestka J. J.. Vomitoxin-induced dysregulation of serum IgA, IgM and IgG reactive with gut bacterial and self antigens. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1992;30:499–504.

Zaĭchenko A. M., Nagornaia S. S., Kirillova L. M., Ganova L. A., Kriukova O. V.. [The antibiotic properties of macrocyclic trichothecene mycotoxins]. Mikrobiologicheskiĭ zhurnal. 1992;54:34–40.

Koshinsky H. A., Cosby R. H., Khachatourians G. G.. Effects of T-2 toxin on ethanol production by Saccharomyces cerevisiae. Biotechnology and applied biochemistry. 1992;16:275–286.

Fernandez-Lobato M., Cannon M., Mitlin J. A., Mount R. C., Jimenez A.. Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics. The Biochemical journal. 1990;267:709–713.

Kuvaeva I. B., Boltianskaia E. V., Kroiakova E. A.. [The search for microorganisms sensitive to deoxynivalenol, zearalenone and aflatoxin B1]. Voprosy pitaniia. 1989:64–67.

Koshinsky H., Honour S., Khachatourians G.. T-2 toxin inhibits mitochondrial function in yeast. Biochemical and biophysical research communications. 1988;151:809–814.

Swanson S. P., Nicoletti J., Rood H. D., Buck W. B., Cote L. M., Yoshizawa T.. Metabolism of three trichothecene mycotoxins, T-2 toxin, diacetoxyscirpenol and deoxynivalenol, by bovine rumen microorganisms. Journal of chromatography. 1987;414:335–342.

Schappert K. T., Khachatourians G. G.. Effects of T-2 toxin on induction of petite mutants and mitochondrial function in Saccharomyces cerevisiae. Current genetics. 1986;10:671–676.

Trusal L. R.. Metabolism of T-2 mycotoxin by cultured cells. Toxicon. 1986;24:597–603.

Schappert K. T., Khachatourians G. G.. Influence of the membrane on T-2 toxin toxicity in Saccharomyces spp. Applied and environmental microbiology. 1984;47:681–684.

Kiessling K. H., Pettersson H., Sandholm K., Olsen M.. Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria. Applied and environmental microbiology. 1984;47:1070–1073.

Pavanasasivam G., Jarvis B. B.. Microbial transformation of macrocyclic trichothecenes. Applied and environmental microbiology. 1983;46:480–483.

Hernández F., Cannon M.. Inhibition of protein synthesis in Saccharomyces cerevisiae by the 12,13-epoxytrichothecenes trichodermol, diacetoxyscirpenol and verrucarin A. Reversibility of the effects. The Journal of antibiotics. 1982;35:875–881.

Lafont J., Romand A., Lafont P.. [Effect of mycotoxins on the rate of fermentation in Saccharomyces cerevisiae]. Mycopathologia. 1981;74:119–123.

Salazar S., Fromentin H., Mariat F.. [Effects of diacetoxyscirpenol on experimental candidiasis of mice]. Comptes rendus des séances de l’Académie des sciences. Série D, Sciences naturelles. 1980;290:877–878.

Fromentin H., Salazar-Mejicanos S., Mariat F.. [Pathogenicity of “Candida albicans” for normal mice and mice treated by the mycotoxin diacetoxyscirpenol (author’s transl)]. Annales de microbiologie. 1980;131B:39–46.

Yoshizawa T., Onomoto C., Morooka N.. Microbial acetyl conjugation of T-2 toxin and its derivatives. Applied and environmental microbiology. 1980;39:962–966.

Cooper T. G., Bossinger J.. Selective inhibition of protein synthesis initiation in Saccharomyces cerevisiae by low concentrations of cycloheximide. The Journal of biological chemistry. 1976;251:7278–7280.

 

Selenium

Yin H, Zhang Y, Zhang F, Hu JT, Zhao YM, Cheng BL. Effects of Selenium on Fusarium Growth and Associated Fermentation Products and the Relationship with Chondrocyte Viability. Biomed Environ Sci. 2017 Feb;30(2):134-138. PMID: 28292351

Cheng B, Zhang Y, Tong B, Yin H. Influence of Selenium on the Production of T-2 Toxin by Fusarium poae. Biol Trace Elem Res. 2017 Jul;178(1):147-152. PMID: 27885556

Wang X, Zuo Z, Zhao C, Zhang Z, Peng G, Cao S, Hu Y, Yu S, Zhong Z, Deng J, Ren Z. Protective role of selenium in the activities of antioxidant enzymes in piglet splenic lymphocytes exposed to deoxynivalenol. Environ Toxicol Pharmacol. 2016 Oct;47:53-61. PMID: 27620958

Lei R, Jiang N, Zhang Q, Hu S, Dennis BS, He S, Guo X. Prevalence of Selenium, T-2 Toxin, and Deoxynivalenol in Kashin-Beck Disease Areas in Qinghai Province, Northwest China. Biol Trace Elem Res. 2016 May;171(1):34-40. PMID: 26349761

Zhou X, Yang H, Guan F, Xue S, Song D, Chen J, Wang Z. T-2 Toxin Alters the Levels of Collagen II and Its Regulatory Enzymes MMPs/TIMP-1 in a Low-Selenium Rat Model of Kashin-Beck Disease. Biol Trace Elem Res. 2016 Feb;169(2):237-46. PMID: 26123163

Salimian J, Arefpour MA, Riazipour M, Poursasan N. Immunomodulatory effects of selenium and vitamin E on alterations in T lymphocyte subsets induced by T-2 toxin. Immunopharmacol Immunotoxicol. 2014 Aug;36(4):275-81. PMID: 2495312

Guan Fang, Li Siyuan, Wang Zhi-Lun L., et al. Histopathology of chondronecrosis development in knee articular cartilage in a rat model of Kashin-Beck disease using T-2 toxin and selenium deficiency conditions. Rheumatology international. 2013;33:157–166.

Chen Jing-hong H., Xue Senghai, Li Siyuan, et al. Oxidant damage in Kashin-Beck disease and a rat Kashin-Beck disease model by employing T-2 toxin treatment under selenium deficient conditions. Journal of orthopaedic research. 2012;30:1229–1237.

Lu Minling, Cao Junling, Liu Fuqiang, et al. The effects of mycotoxins and selenium deficiency on tissue-engineered cartilage. Cells, tissues, organs. 2012;196:241–250.

Sun Li-Yan Y., Li Qiang, Meng Fan-Gang G., Fu Ying, Zhao Zhi-Jun J., Wang Li-Hua H.. T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kaschin-Beck disease endemic areas of Qinghai Province. Biological trace element research. 2012;150:371–375.

Chen Jinghong, Chu Yonglie, Cao Junling, Wang Wei, Liu Jiayuan, Wang Jiali. Effects of T-2 toxin and selenium on chondrocyte expression of matrix metalloproteinases (MMP-1, MMP-13), α2-macroglobulin (α2M) and TIMPs. Toxicology in vitro : an international journal published in association with BIBRA. 2011;25:492–499.

Cao Pei-hua H., Cao Jun-ling L., Cao Li-min M., Yang Ya-juan J., Li Wei-bo B.. [Effect of Nivalenol and selenium on IL-1beta and TNF-alpha secretion in cultured chondrocytes]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2010;26:313–315.

Levkut M., Revajová V., Levkutova M., et al. Leukocytic responses of broilers following dietary contamination with deoxynivalenol and/or treatment by dietary selenium supplementation. British poultry science. 2009;50:181–187.

Placha I., Borutova R., Gresakova L., Petrovic V., Faix S., Leng L.. Effects of excessive selenium supplementation to diet contaminated with deoxynivalenol on blood phagocytic activity and antioxidative status of broilers. Journal of animal physiology and animal nutrition. 2009;93:695–702.

Li Si-Yuan Y., Cao Jun-Ling L., Shi Zhong-Li L., et al. Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. Journal of Zhejiang University. Science. B. 2008;9:22–33.

Dvorska Julia E., Pappas Athanasios C., Karadas Filiz, Speake Brian K., Surai Peter F.. Protective effect of modified glucomannans and organic selenium against antioxidant depletion in the chicken liver due to T-2 toxin-contaminated feed consumption. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2007;145:582–587.

Chen Jinghong, Chu Yonglie, Cao Junling, Yang Zhantian, Guo Xiong, Wang Zhilun. T-2 toxin induces apoptosis, and selenium partly blocks, T-2 toxin induced apoptosis in chondrocytes through modulation of the Bax/Bcl-2 ratio. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2006;44:567–573.

Chen Jing-hong H., Cao Jun-ling L., Chu Yong-lie L., et al. [Protective effect of selenium against T-2 toxin-induced inhibition of chondrocyte aggrecan and collagen II synthesis]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2006;26:381–385.

Peng Shuang-qing Q., Yang Jin-sheng S.. [Effect of deoxynivalenol on action potentials of cultured cardiomyocytes and the protective effects of selenium]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2003;37:423–425.

Keshavarz S. A., Memarbashi A., Balali M.. Preventive effect of selenium on T-2 toxin membrane toxicity. Advances in experimental medicine and biology. 2001;500:463–466.

Obol’skiĭ O. L., Kravchenko L. V., Avren’eva L. I., Tutel’ian V. A.. [Effect of dietary selenium on the activity of UDP-glucuronosyltransferases and metabolism of mycotoxin deoxynivalenol in rats]. Voprosy pitaniia. 1998:18–23.

Tutelyan V. A., Kravchenko L. V., Kuzmina E. E., Avrenieva L. I., Kumpulainen J. T.. Dietary selenium protects against acute toxicity of T-2 toxin in rats. Food additives and contaminants. 1990;7:821–827.

Kravchenko L. V., Kuz’mina E. E., Avren’eva L. I., Tutel’ian V. A.. Protective effect of selenium in acute T-2 mycotoxicosis. Voprosy medit͡sinskoĭ khimii. 1990;36:36–38.

 

Vitamins

Weber Maria, Stiller S., Balogh K., Wágner L., Erdélyi Márta, Mézes M.. Effect of feeding T-2 toxin contaminated feed on the utilisation of vitamin E in chickens. Acta veterinaria Hungarica. 2007;55:21–27.

Zhou Bing-juan J., Li Yue-hong H., Zhang Xiang-hong H., et al. [Effects of vitamin C on apoptosis and proliferation inhibition of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2006;40:309–313.

Zhou Bing-juan J., Li Yue-hong H., Zhang Xiang-hong H., et al. [Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2006;40:314–318.

Vilà B., Jaradat Z. W., Marquardt R. R., Frohlich A. A.. Effect of T-2 toxin on in vivo lipid peroxidation and vitamin E status in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2002;40:479–486.

Hoehler D., Marquardt R. R.. Influence of vitamins E and C on the toxic effects of ochratoxin A and T-2 toxin in chicks. Poultry science. 1996;75:1508–1515.

Bilgrami K. S., Masood A., Rahman M. F.. Cumulative effect of T-2 toxin and vitamin C on chromosomal abnormalities in the bone marrow cells of mice (Mus musculus). Cytobios. 1995;81:171–174.

Sergeev I. N., Piliia N. M., Tutel’ian V. A., Spirichev V. B.. [Mechanism of impairment of calcium metabolism caused by toxin T-2; the role of the vitamin D-dependent endocrine system]. Voprosy medit͡sinskoĭ khimii. 1990;36:45–48.

Sergeev I. N., Kravchenko L. V., Piliia N. M., et al. [The effect of the trichothecene mycotoxin deoxynivalenol (vomitoxin) on calcium homeostasis, vitamin D metabolism and receptors in rats]. Voprosy medit͡sinskoĭ khimii. 1990;36:26–29.

Sergeev I. N., Arkhapchev Iu u. P., Kravchenko L. V., Kodentsova V. M., Piliia N. M.. [Effect of mycotoxins aflatoxin B1 and T-2 toxin on the vitamin D3 metabolism and binding of its hormonal form 1,25-dihydroxyvitamin D3 in rats]. Voprosy medit͡sinskoĭ khimii. 1988;34:51–57.

Yagen B., Halevy S.. Protective effect of vitamins against trichothecene toxicity towards Saccharomyces cerevisiae. Experientia. 1987;43:886–888.

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Frobose HL, Stephenson EW, Tokach MD, DeRouchey JM, Woodworth JC, Dritz SS, Goodband RD. Effects of potential detoxifying agents on growth performance and deoxynivalenol (DON) urinary balance characteristics of nursery pigs fed DON-contaminated wheat. J Anim Sci. 2017 Jan;95(1):327-337. PMID: 28177379

Wang L, Wang Y, Shao H, Luo X, Wang R, Li Y, Li Y, Luo Y, Zhang D, Chen Z. In vivo toxicity assessment of deoxynivalenol-contaminated wheat after ozone degradation. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Jan;34(1):103-112. PMID: 27796167

Saini A, Sharples AP, Al-Shanti N, Stewart CE. Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation. Biogerontology. 2017 Feb;18(1):109-129. PMID: 27864687

Park SH, Kim J, Kim D, Moon Y. Mycotoxin detoxifiers attenuate deoxynivalenol-induced pro-inflammatory barrier insult in porcine enterocytes as an in vitro evaluation model of feed mycotoxin reduction. Toxicol In Vitro. 2017 Feb;38:108-116. PMID: 27737795

Moosavi M, Rezaei M, Kalantari H, Behfar A, Varnaseri G. l-carnitine protects rat hepatocytes from oxidative stress induced by T-2 toxin. Drug Chem Toxicol. 2016 Oct;39(4):445-50. PMID: 26888052

Perczak A, Juś K, Marchwińska K, Gwiazdowska D, Waśkiewicz A, Goliński P. Degradation of Zearalenone by Essential Oils under In vitro Conditions. Front Microbiol. 2016 Aug 11;7:1224. PMID: 27563298

Van Le Thanh B, Lemay M, Bastien A, Lapointe J, Lessard M, Chorfi Y, Guay F. The potential effects of antioxidant feed additives in mitigating the adverse effects of corn naturally contaminated with Fusarium mycotoxins on antioxidant systems in the intestinal mucosa, plasma, and liver in weaned pigs. Mycotoxin Res. 2016 May;32(2):99-116. PMID: 27021614

Sang Y, Li W, Zhang G. The protective effect of resveratrol against cytotoxicity induced by mycotoxin, zearalenone. Food Funct. 2016 Sep 14;7(9):3703-15. PMID: 27489133

Xue KS, Tang L, Cai Q, Shen Y, Su J, Wang JS. Mitigation of Fumonisin Biomarkers by Green Tea Polyphenols in a High-Risk Population of Hepatocellular Carcinoma. Sci Rep. 2015 Dec 2;5:17545. PMID: 26626148

Cano-Sancho G, González-Arias CA, Ramos AJ, Sanchis V, Fernández-Cruz ML. Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol. Toxicol In Vitro. 2015 Oct;29(7):1639-46. PMID: 26100224

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Zhang Y, Gao R, Liu M, Shi B, Shan A, Cheng B. Use of modified halloysite nanotubes in the feed reduces the toxic effects of zearalenone on sow reproduction and piglet development. Theriogenology. 2015 Mar 15;83(5):932-41. PMID: 25528463

Boeira SP, Funck VR, Borges Filho C, Del’Fabbro L, de Gomes MG, Donato F, Royes LF, Oliveira MS, Jesse CR, Furian AF. Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice. Chem Biol Interact. 2015 Mar 25;230:50-7. PMID: 25682699

Yin S, Meng Q, Zhang B, Shi B, Shan A, Li Z. Alleviation of zearalenone toxicity by modified halloysite nanotubes in the immune response of swine. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(1):87-99. PMID: 25486218

Li MM, Guan EQ, Bian K. Effect of ozone treatment on deoxynivalenol and quality evaluation of ozonised wheat. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(4):544-53. PMID: 25325346

Hassan AM, Abdel-Aziem SH, El-Nekeety AA, Abdel-Wahhab MA. Panax ginseng extract modulates oxidative stress, DNA fragmentation and up-regulate gene expression in rats sub chronically treated with aflatoxin B1 and fumonisin B 1. Cytotechnology. 2015 Oct;67(5):861-71. PMID: 24748134

Wu M, Xiao H, Ren W, Yin J, Hu J, Duan J, Liu G, Tan B, Xiong X, Oso AO, Adeola O, Yao K, Yin Y, Li T. An NMR-based metabolomic approach to investigate the effects of supplementation with glutamic acid in piglets challenged with deoxynivalenol. PLoS One. 2014 Dec 11;9(12):e113687. PMID: 25502722

El-Naggar MA, Thabit TM. Evaluation of β-D-glucan biopolymer as a novel mycotoxin binder for fumonisin and deoxynivalenol in soybean feed. Foodborne Pathog Dis. 2014 Jun;11(6):433-8. PMID: 24660841

Zhang Y, Gao R, Liu M, Yan C, Shan A. Adsorption of modified halloysite nanotubes in vitro and the protective effect in rats exposed to zearalenone. Arch Anim Nutr. 2014;68(4):320-35. PMID: 24979266

Wu M, Xiao H, Ren W, Yin J, Tan B, Liu G, Li L, Nyachoti CM, Xiong X, Wu G. Therapeutic effects of glutamic acid in piglets challenged with deoxynivalenol. PLoS One. 2014 Jul 1;9(7):e100591. PMID: 24984001

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Devreese Mathias, Pasmans Frank, De Backer Patrick, Croubels Siska. An in vitro model using the IPEC-J2 cell line for efficacy and drug interaction testing of mycotoxin detoxifying agents. Toxicology in vitro : an international journal published in association with BIBRA. 2013;27:157–163.

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Sugiyama Kei-Ichi, Kinoshita Mawo, Kamata Yoichi, Minai Yuji, Tani Fumito, Sugita-Konishi Yoshiko. Thioredoxin-1 contributes to protection against DON-induced oxidative damage in HepG2 cells. Mycotoxin research. 2012;28:163–168.

Sugiyama Kei-Ichi, Kinoshita Mawo, Kamata Yoichi, Minai Yuji, Tani Fumito, Sugita-Konishi Yoshiko. Thioredoxin-1 contributes to protection against DON-induced oxidative damage in HepG2 cells. Mycotoxin research. 2012;28:163–168.

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Krishnaswamy Rajashree, Devaraj S. Niranjali, Padma Vijaya V.. Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-kappaB nuclear localization and down regulation of NF-kappaB and Cyclo-Oxygenase-2 expression. Free radical biology & medicine. 2010;49:50–60.

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