Fusarium Literature – Immune System

 

 

Islam MR, Kim JW, Roh YS, Kim JH, Min HK, Kwon HJ, Lim CW, Kim B. Evaluation of immunomodulatory effects of zearalenone in mice. J Immunotoxicol. 2017 Dec;14(1):125-136. PMID: 28641471

Ren Z, Deng H, Deng Y, Liang Z, Deng J, Zuo Z, Hu Y, Shen L, Yu S, Cao S. Combined effects of deoxynivalenol and zearalenone on oxidative injury and apoptosis in porcine splenic lymphocytes in vitro. Exp Toxicol Pathol. 2017 Jun 3. pii: S0940-2993(17)30078-7. PMID: 28587827

Dąbrowski M, Jakimiuk E, Baranowski M, Gajęcka M, Zielonka Ł, Gajęcki MT. The Effect of Deoxynivalenol on Selected Populations of Immunocompetent Cells in Porcine Blood-A Preliminary Study. Molecules. 2017 Apr 26;22(5). PMID: 28445424

Li Y, Fan Y, Xia B, Xiao Q, Wang Q, Sun W, Zhang H, He C. The immunosuppressive characteristics of FB1 by inhibition of maturation and function of BMDCs. Int Immunopharmacol. 2017 Jun;47:206-211. PMID: 28432936

Aupanun S, Phuektes P, Poapolathep S, Sutjarit S, Giorgi M, Poapolathep A. Apoptosis and gene expression in Jurkat human T cells and lymphoid tissues of fusarenon-X-treated mice. Toxicon. 2016 Dec 1;123:15-24. PMID: 27773736

Ji J, Zhu P, Pi F, Sun C, Jiang H, Sun J, Wang X, Zhang Y, Sun X. GC-TOF/MS-based metabolomic strategy for combined toxicity effects of deoxynivalenol and zearalenone on murine macrophage ANA-1 cells. Toxicon. 2016 Sep 15;120:175-84. PMID: 27530666

Solhaug A, Karlsøen LM, Holme JA, Kristoffersen AB, Eriksen GS. Immunomodulatory effects of individual and combined mycotoxins in the THP-1 cell line. Toxicol In Vitro. 2016 Oct;36:120-132. PMID: 27453131

Ji J, Sun J, Pi F, Zhang S, Sun C, Wang X, Zhang Y, Sun X. GC-TOF/MS-based metabolomics approach to study the cellular immunotoxicity of deoxynivalenol on murine macrophage ANA-1 cells. Chem Biol Interact. 2016 Aug 25;256:94-101. PMID: 27350164

Kufuor-Mensah E, Reed WM, Sleight S, Pestka J, Fadly AM, Dunn JR. Effects of T-2 Toxin on Turkey Herpesvirus-Induced Vaccinal Immunity Against Marek’s Disease. Avian Dis. 2016 Mar;60(1):56-62. PMID: 26953944

Chen F, Lin P, Wang N, Yang D, Wen X, Zhou D, Wang A, Jin Y. Herp depletion inhibits zearalenone-induced cell death in RAW 264.7 macrophages. Toxicol In Vitro. 2016 Apr;32:115-22. PMID: 26723276

Ipcho S, Sundelin T, Erbs G, Kistler HC, Newman MA, Olsson S. Fungal Innate Immunity Induced by Bacterial Microbe-Associated Molecular Patterns (MAMPs). G3 (Bethesda). 2016 Jun 1;6(6):1585-95. PMID: 27172188

Ghareeb K, Awad WA, Zebeli Q, Böhm J. Deoxynivalenol in chicken feed alters the vaccinal immune response and clinical biochemical serum parameters but not the intestinal and carcass characteristics. J Anim Physiol Anim Nutr (Berl). 2016 Feb;100(1):53-60. PMID: 25900321

Obremski K, Wojtacha P, Podlasz P, Żmigrodzka M. The influence of experimental administration of low zearalenone doses on the expression of Th1 and Th2 cytokines and on selected subpopulations of lymphocytes in intestinal lymph nodes. Pol J Vet Sci. 2015;18(3):489-97. PMID: 26618580

Monaci L, Garbetta A, Angelis ED, Visconti A, Minervini F. Assessment of toxic potential of mycotoxin contaminated bread during in vitro human digestion on human B lymphoid cell line. Toxicol Lett. 2015 Jan 5;232(1):106-12. PMID: 25271005

Katika MR, Hendriksen PJ, van Loveren H, A C M Peijnenburg A. Characterization of the modes of action of deoxynivalenol (DON) in the human Jurkat T-cell line. J Immunotoxicol. 2015 Jul-Sep;12(3):206-16. PMID: 24988111

Pietsch C, Junge R, Burkhardt-Holm P. Immunomodulation by Zearalenone in Carp (Cyprinus carpio L.). Biomed Res Int. 2015;2015:420702. PMID: 26491670

Vacher G, Ciarlo E, Savova-Bianchi D, Le Roy D, Hantier G, Niculita-Hirzel H, Roger T. Innate Immune Sensing of Fusarium culmorum by Mouse Dendritic Cells. J Toxicol Environ Health A. 2015;78(13-14):871-85. PMID: 26167753

Chen F, Li Q, Zhang Z, Lin P, Lei L, Wang A, Jin Y. Endoplasmic Reticulum Stress Cooperates in Zearalenone-Induced Cell Death of RAW 264.7 Macrophages. Int J Mol Sci. 2015 Aug 20;16(8):19780-95. PMID: 26307968

Savard C, Gagnon CA, Chorfi Y. Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine. Vaccine. 2015 Jul 31;33(32):3881-6. PMID: 26117152

Pietsch C, Katzenback BA, Garcia-Garcia E, Schulz C, Belosevic M, Burkhardt-Holm P. Acute and subchronic effects on immune responses of carp (Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feed. Mycotoxin Res. 2015 Aug;31(3):151-64. PMID: 25989849

Obremski K, Poniatowska-Broniek G. Zearalenone induces apoptosis and inhibits proliferation in porcine ileal Peyer’s patch lymphocytes. Pol J Vet Sci. 2015;18(1):153-61. PMID: 25928923

Kankkunen Päivi, Välimäki Elina, Rintahaka Johanna, et al. Trichothecene mycotoxins activate NLRP3 inflammasome through a P2X7 receptor and Src tyrosine kinase dependent pathway. Human immunology. 2014;75:134–140.

Obremski K. Changes in Th1 and Th2 cytokine concentrations in ileal Peyer’s patches in gilts exposed to zearalenone. Pol J Vet Sci. 2014;17(1):53-9. PMID: 24724470

Pietsch C, Michel C, Kersten S, Valenta H, Dänicke S, Schulz C, Kloas W, Burkhardt-Holm P. In vivo effects of deoxynivalenol (DON) on innate immune responses of carp (Cyprinus carpio L.). Food Chem Toxicol. 2014 Jun;68:44-52. PMID: 24650758

Hueza IM, Raspantini PC, Raspantini LE, Latorre AO, Górniak SL. Zearalenone, an estrogenic mycotoxin, is an immunotoxic compound. Toxins (Basel). 2014 Mar 13;6(3):1080-95. PMID: 24632555

Li D, Ye Y, Lin S, Deng L, Fan X, Zhang Y, Deng X, Li Y, Yan H, Ma Y. Evaluation of deoxynivalenol-induced toxic effects on DF-1 cells in vitro: cell-cycle arrest, oxidative stress, and apoptosis. Environ Toxicol Pharmacol. 2014 Jan;37(1):141-9. PMID: 24322622

Abbès Samir, Ben Salah-Abbès Jalila, Sharafi Hakimeh, Oueslati Ridha, Noghabi Kambiz Akbari A.. Lactobacillus paracasei BEJ01 prevents immunotoxic effects during chronic zearalenone exposure in Balb/c mice. Immunopharmacology and immunotoxicology. 2013;35:341–348.

Awad Wageha, Ghareeb Khaled, Böhm Josef, Zentek Jürgen. The toxicological impacts of the Fusarium mycotoxin, deoxynivalenol, in poultry flocks with special reference to immunotoxicity. Toxins. 2013;5:912–925.

Islam Mohammad Rafiqul R., Roh Yoon Seok S., Kim Jinho, Lim Chae Woong W., Kim Bumseok. Differential immune modulation by deoxynivalenol (vomitoxin) in mice. Toxicology letters. 2013;221:152–163.

Jayasooriya Rajapaksha Gedara Prasad Tharanga G., Moon Dong-Oh O., Park Sang Rul R., et al. Combined treatment with verrucarin A and tumor necrosis factor-α sensitizes apoptosis by overexpression of nuclear factor-kappaB-mediated Fas. Environmental toxicology and pharmacology. 2013;36:303–310.

Pan Xiao, Whitten Douglas A., Wu Ming, Chan Christina, Wilkerson Curtis G., Pestka James J.. Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage. Toxicology and applied pharmacology. 2013;268:201–211.

Li Shao-Ji J., Pasmans Frank, Croubels Siska, et al. T-2 toxin impairs antifungal activities of chicken macrophages against Aspergillus fumigatus conidia but promotes the pro-inflammatory responses. Avian pathology : journal of the W.V.P.A. 2013;42:457–463.

Schmeits Peter C., Volger Oscar L., Zandvliet Ella T., Loveren Henk, Peijnenburg Ad A., Hendriksen Peter J.. Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics. Toxicology letters. 2013;217:1–13.

Choi Byung-Kook K., Jeong Sang-Hee H., Cho Joon-Hyung H., et al. Effects of oral deoxynivalenol exposure on immune-related parameters in lymphoid organs and serum of mice vaccinated with porcine parvovirus vaccine. Mycotoxin research. 2013;29:185–192.

Gauthier Thierry, Waché Yann, Laffitte Joëlle, et al. Deoxynivalenol impairs the immune functions of neutrophils. Molecular nutrition & food research. 2013;57:1026–1036.

Obremski K., Podlasz P., Zmigrodzka M., et al. The effect of T-2 toxin on percentages of CD4+, CD8+, CD4+ CD8+ and CD21+ lymphocytes, and mRNA expression levels of selected cytokines in porcine ileal Peyer’s patches. Polish journal of veterinary sciences. 2013;16:341–349.

Yunus A. W., Ghareeb K., Twaruzek M., Grajewski J., Böhm J.. Deoxynivalenol as a contaminant of broiler feed: effects on bird performance and response to common vaccines. Poultry science. 2012;91:844–851.

Bracarense Ana-Paula P., Lucioli Joelma, Grenier Bertrand, et al. Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets. The British journal of nutrition. 2012;107:1776–1786.

Khol-Parisini Annabella, Hellweg Petra, Razzazi-Fazeli Ebrahim, et al. Highly deoxynivalenol contaminated oats and immune function in horses. Archives of animal nutrition. 2012;66:149–161.

Choi BK, Cho JH, Jeong SH, Shin HS, Son SW, Yeo YK, Kang HG. Zearalenone affects immune-related parameters in lymphoid organs and serum of rats vaccinated with porcine parvovirus vaccine. Toxicol Res. 2012 Dec;28(4):279-88. PMID: 24278621

Yohannes T., Sharma A. K., Singh S. D., Goswami T. K.. Immunopathological effects of experimental T-2 mycotoxocosis in broiler chicken co-infected with infectious bronchitis virus (IBV). Veterinary immunology and immunopathology. 2012;146:245–253.

Nagashima Hitoshi, Nakagawa Hiroyuki, Kushiro Masayo. Opposite effects of two trichothecene mycotoxins, deoxynivalenol and nivalenol, on the levels of macrophage inflammatory protein (MIP)-1α and MIP-1β in HL60 cells. Environmental toxicology and pharmacology. 2012;34:1014–1017.

Seeboth Julie, Solinhac Romain, Oswald Isabelle P., Guzylack-Piriou Laurence. The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig. Veterinary research. 2012;43.

Chaytor A. C., See M. T., Hansen J. A., Souza A. L., Middleton T. F., Kim S. W.. Effects of chronic exposure of diets with reduced concentrations of aflatoxin and deoxynivalenol on growth and immune status of pigs. Journal of animal science. 2011;89:124–135.

Costa André, Mijal Renée S., Keen Jeffrey N., Findlay John B., Wild Christopher P.. Proteomic analysis of the effects of the immunomodulatory mycotoxin deoxynivalenol. Proteomics. 2011;11:1903–1914.

Costa André, Keen Jeffrey N., Wild Christopher P., Findlay John B.. An analysis of the phosphoproteome of immune cell lines exposed to the immunomodulatory mycotoxin deoxynivalenol. Biochimica et biophysica acta. 2011;1814:850–857.

Sugiyama Kei-Ichi, Kawakami Hiroshi, Kamata Yoichi, Sugita-Konishi Yoshiko. Effect of a combination of deoxynivalenol and nivalenol on lipopolisaccharide-induced nitric oxide production by mouse macrophages. Mycotoxin research. 2011;27:57–62.

Becker Christiane, Reiter Martina, Pfaffl Michael W., Meyer Heinrich H., Bauer Johann, Meyer Karsten H.. Expression of immune relevant genes in pigs under the influence of low doses of deoxynivalenol (DON). Mycotoxin research. 2011;27:287–293.

Sugiyama Kei-ichi, Kinoshita Mawo, Kamata Yoichi, Minai Yuji, Sugita-Konishi Yoshiko. (-)-Epigallocatechin gallate suppresses the cytotoxicity induced by trichothecene mycotoxins in mouse cultural macrophages. Mycotoxin research. 2011;27:281–285.

Scholtz N. D., Halle I., Dänicke S., Hartmann G., Zur B., Sauerwein H.. Effects of an active immunization on the immune response of laying Japanese quail (Coturnix coturnix japonica) fed with or without genetically modified Bacillus thuringiensis-maize. Poultry science. 2010;89:1122–1128.

Xue C. Y., Wang G. H., Chen F., Zhang X. B., Bi Y. Z., Cao Y. C.. Immunopathological effects of ochratoxin A and T-2 toxin combination on broilers. Poultry science. 2010;89:1162–1166.

Malovrh T., Jakovac-Strajn B.. Feed contaminated with Fusarium toxins alter lymphocyte proliferation and apoptosis in primiparous sows during the perinatal period. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010;48:2907–2912.

Wada Kenji, Nabae Akiko, Higuchi Hidetoshi, Nagahata Hajime. Effects of mycotoxins on chemiluminescent response and cytokine mRNA expression of bovine neutrophils. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 2010;72:1507–1511.

Taranu Ionelia, Marina Daniela E., Burlacu Radu, Pinton Phillipe, Damian Virgil, Oswald Isabelle P.. Comparative aspects of in vitro proliferation of human and porcine lymphocytes exposed to mycotoxins. Archives of animal nutrition. 2010;64:383–393.

Luongo D., Severino L., Bergamo P., D’Arienzo R., Rossi M.. Trichothecenes NIV and DON modulate the maturation of murine dendritic cells. Toxicon. 2010;55:73–80.

Sugiyama Kei-ichi, Muroi Masashi, Tanamoto Ken-ichi, Nishijima Motohiro, Sugita-Konishi Yoshiko. Deoxynivalenol and nivalenol inhibit lipopolysaccharide-induced nitric oxide production by mouse macrophage cells. Toxicology letters. 2010;192:150–154.

Ramasamy T., Varshneya C., Katoch V. C.. Immunoprotective Effect of Seabuckthorn (Hippophae rhamnoides) and Glucomannan on T-2 Toxin-Induced Immunodepression in Poultry. Veterinary medicine international. 2010;2010.

Wang G. H., Xue C. Y., Chen F., et al. Effects of combinations of ochratoxin A and T-2 toxin on immune function of yellow-feathered broiler chickens. Poultry science. 2009;88:504–510.

Wu Xianai, Kohut Marian, Cunnick Joan, Bailey Ted, Hendrich Suzanne. Deoxynivalenol suppresses circulating and splenic leukocyte subpopulations in BALB/c mice: dose response, time course and sex differences. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2009;26:1070–1080.

Korosteleva S. N., Smith T. K., Boermans H. J.. Effects of feed naturally contaminated with Fusarium mycotoxins on metabolism and immunity of dairy cows. Journal of dairy science. 2009;92:1585–1593.

Edmondson David A., Barrios Christy S., Brasel Trevor L., Straus David C., Kurup Viswanath P., Fink Jordan N.. Immune response among patients exposed to molds. International journal of molecular sciences. 2009;10:5471–5484.

Ferrari L., Cantoni A. M., Borghetti P., De Angelis E., Corradi A.. Cellular immune response and immunotoxicity induced by DON (deoxynivalenol) in piglets. Veterinary research communications. 2009;33 Suppl 1:133–135.

Kankkunen Päivi, Rintahaka Johanna, Aalto Annika, et al. Trichothecene mycotoxins activate inflammatory response in human macrophages. Journal of immunology (Baltimore, Md. : 1950). 2009;182:6418–6425.

Shi Yuhui, Pestka James J.. Mechanisms for suppression of interleukin-6 expression in peritoneal macrophages from docosahexaenoic acid-fed mice. The Journal of nutritional biochemistry. 2009;20:358–368.

Shi Yuhui, Porter Katie, Parameswaran Narayanan, Bae Hee Kyong K., Pestka James J.. Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicological sciences : an official journal of the Society of Toxicology. 2009;109:247–255.

Waché Yann J., Hbabi-Haddioui Laila, Guzylack-Piriou Laurence, Belkhelfa Haouaria, Roques Christine, Oswald Isabelle P.. The mycotoxin deoxynivalenol inhibits the cell surface expression of activation markers in human macrophages. Toxicology. 2009;262:239–244.

Marzocco Stefania, Russo Rosario, Bianco Giuseppe, Autore Giuseppina, Severino Lorella. Pro-apoptotic effects of nivalenol and deoxynivalenol trichothecenes in J774A.1 murine macrophages. Toxicology letters. 2009;189:21–26.

Shi Yuhui, Porter Katie, Parameswaran Narayanan, Bae Hee Kyong K., Pestka James J.. Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicological sciences : an official journal of the Society of Toxicology. 2009;109:247–255.

Döll Susanne, Schrickx Jan A., Dänicke Sven, Fink-Gremmels Johanna. Deoxynivalenol-induced cytotoxicity, cytokines and related genes in unstimulated or lipopolysaccharide stimulated primary porcine macrophages. Toxicology letters. 2009;184:97–106.

Hymery N., Léon K., Carpentier F-G G., Jung J-L L., Parent-Massin D.. T-2 toxin inhibits the differentiation of human monocytes into dendritic cells and macrophages. Toxicology in vitro : an international journal published in association with BIBRA. 2009;23:509–519.

Hellgren Ulla-Maija M., Leino Marina, Aarnisalo Antti A., Mussalo-Rauhamaa Helena, Alenius Harri, Reijula Kari. Low tumor necrosis factor alpha levels and neutrophil counts in nasal lavage after mold exposure. Annals of allergy, asthma & immunology. 2009;102:210–215.

Ahmadi Kazem, Riazipour Majid. Effects of T-2 toxin on cytokine production by mice peritoneal macrophages and lymph node T-cells. Iranian journal of immunology : IJI. 2008;5:177–180.

Li Maoxiang, Pestka James J.. Comparative induction of 28S ribosomal RNA cleavage by ricin and the trichothecenes deoxynivalenol and T-2 toxin in the macrophage. Toxicological sciences : an official journal of the Society of Toxicology. 2008;105:67–78.

Severino L., Russo R., Luongo D., De Luna R., Ciarcia R., Rossi M.. Immune effects of four Fusarium-toxins (FB1, ZEA, NIV, DON) on the proliferation of Jurkat cells and porcine lymphocytes: in vitro study. Veterinary research communications. 2008;32 Suppl 1.

Bae Hee Kyong K., Pestka James J.. Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. Toxicological sciences : an official journal of the Society of Toxicology. 2008;105:59–66.

Pinton Philippe, Accensi Francesc, Beauchamp Erwan, et al. Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses. Toxicology letters. 2008;177:215–222.

Meissonnier G. M., Laffitte J., Raymond I., et al. Subclinical doses of T-2 toxin impair acquired immune response and liver cytochrome P450 in pigs. Toxicology. 2008;247:46–54.

Kubosaki Atsutaka, Aihara Maki, Park Bong Joo J., et al. Immunotoxicity of nivalenol after subchronic dietary exposure to rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008;46:253–258.

Pestka James J., Islam Zahidul, Amuzie Chidozie J.. Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse. Toxicology letters. 2008;178:83–87.

Gouze Marie-Estelle E., Laffitte Joëlle, Pinton Philippe, et al. Effect of subacute oral doses of nivalenol on immune and metabolic defence systems in mice. Veterinary research. 2007;38:635–646.

Bimczok Diane, Döll Susanne, Rau Henriette, et al. The Fusarium toxin deoxynivalenol disrupts phenotype and function of monocyte-derived dendritic cells in vivo and in vitro. Immunobiology. 2007;212:655–666.

Jun Do Youn Y., Kim Jun Seok S., Park Hae Sun S., Song Woo Sun S., Bae Young Seuk S., Kim Young Ho H.. Cytotoxicity of diacetoxyscirpenol is associated with apoptosis by activation of caspase-8 and interruption of cell cycle progression by down-regulation of cdk4 and cyclin B1 in human Jurkat T cells. Toxicology and applied pharmacology. 2007;222:190–201.

Wu Xianai, Murphy Patricia, Cunnick Joan, Hendrich Suzanne. Synthesis and characterization of deoxynivalenol glucuronide: its comparative immunotoxicity with deoxynivalenol. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007;45:1846–1855.

Nasri Thanakarn, Bosch Remko R., Voorde Sandra ten t., Fink-Gremmels Johanna. Differential induction of apoptosis by type A and B trichothecenes in Jurkat T-lymphocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2006;20:832–840.

Pestka James, Zhou Hui-Ren R.. Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants. Toxicological sciences : an official journal of the Society of Toxicology. 2006;92:445–455.

Islam Zahidul, Gray Jennifer S., Pestka James J.. p38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes. Toxicology and applied pharmacology. 2006;213:235–244.

Goyarts Tanja, Dänicke Sven, Tiemann Ute, Rothkötter Hermann-Josef J.. Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2006;20:858–867.

Hymery N., Sibiril Y., Parent-Massin D.. In vitro effects of trichothecenes on human dendritic cells. Toxicology in vitro : an international journal published in association with BIBRA. 2006;20:899–909.

Tiemann U., Brüssow K-P P., Jonas L., Pöhland R., Schneider F., Dänicke S.. Effects of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected immunological and histological measurements in the spleen of gilts. Journal of animal science. 2006;84:236–245.

Döll S., Goyarts T., Rothkötter H. J., Dänicke S.. Research note: Effects of deoxynivalenol on immunohistological parameters in pigs. Mycotoxin research. 2006;22:178–182.

Li Maoxiang, Harkema Jack R., Islam Zahidul, Cuff Chistopher F., Pestka James J.. T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis. Toxicology and applied pharmacology. 2006;217:76–85.

Jaradat Ziad W., Viià Borja, Marquardt Ronal R.. Adverse effects of T-2 toxin on chicken lymphocytes blastogenesis and its protection with Vitamin E. Toxicology. 2006;225:90–96.

Landgren C. A., Hendrich S., Kohut M. L.. Low-level dietary deoxynivalenol and acute exercise stress result in immunotoxicity in BALB/c mice. Journal of immunotoxicology. 2006;3:173–178.

Li Maoxiang, Cuff Christopher F., Pestka James J.. T-2 toxin impairment of enteric reovirus clearance in the mouse associated with suppressed immunoglobulin and IFN-gamma responses. Toxicology and applied pharmacology. 2006;214:318–325.

Pestka James J., Uzarski Rebecca L., Islam Zahidul. Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes. Toxicology. 2005;206:207–219.

Vlata Zaharenia, Porichis Filippos, Tzanakakis George, Tsatsakis Aristidis, Krambovitis Elias. In vitro cytopathic effects of mycotoxin T-2 on human peripheral blood T lymphocytes. Toxicology letters. 2005;160:60–68.

Li Maoxiang, Cuff Christopher F., Pestka James. Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol. Toxicological sciences : an official journal of the Society of Toxicology. 2005;87:134–145.

Takayama Hideko, Shimada Nobuaki, Mikami Osamu, Murata Hideo. Suppressive effect of deoxynivalenol, a Fusarium mycotoxin, on bovine and porcine neutrophil chemiluminescence: an in vitro study. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 2005;67:531–533.

Zhou Hui-Ren R., Jia Qunshan, Pestka James J.. Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck. Toxicological sciences : an official journal of the Society of Toxicology. 2005;85:916–926.

Li Yue-hong H., Zhang Xiang-hong H., Xing Ling-xiao X., Yan Xia, Wang Jun-ling L., Wang Feng-rong R.. [The inhibitory effect of deoxynivalenol on TAP-1 expression in human peripheral blood mononuclear cells in vitro]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2005;21:246–248.

Kamalavenkatesh P., Vairamuthu S., Balachandran C., Manohar B. Murali, raj G. Dhinakar. Immunopathological effect of the mycotoxins cyclopiazonic acid and T-2 toxin on broiler chicken. Mycopathologia. 2005;159:273–279.

Zhou Hui-Ren R., Islam Zahidul, Pestka James J.. Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol. Toxicological sciences : an official journal of the Society of Toxicology. 2005;87:113–122.

Minervini Fiorenza, Fornelli Francesca, Lucivero Giacomo, Romano Ciro, Visconti Angelo. T-2 toxin immunotoxicity on human B and T lymphoid cell lines. Toxicology. 2005;210:81–91.

Drochner Winfried, Schollenberger Margit, Piepho Hans-Peter P., et al. Serum IgA-promoting effects induced by feed loads containing isolated deoxynivalenol (DON) in growing piglets. Journal of toxicology and environmental health. Part A. 2004;67:1051–1067.

Pestka James J., Zhou Hui-Ren R., Moon Y., Chung Y. J.. Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox. Toxicology letters. 2004;153:61–73.

Swamy H. V., Smith T. K., Karrow N. A., Boermans H. J.. Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on growth and immunological parameters of broiler chickens. Poultry science. 2004;83:533–543.

Poapolathep Amnart, Nagata Takayuki, Suzuki Hodaka, Kumagai Susumu, Doi Kunio. Development of early apopotosis and changes in lymphocyte subsets in lymphoid organs of mice orally inoculated with nivalenol. Experimental and molecular pathology. 2003;75:74–79.

Uzarski Rebecca L., Pestka James J.. Comparative susceptibility of B cells with different lineages to cytotoxicity and apoptosis induction by translational inhibitors. Journal of toxicology and environmental health. Part A. 2003;66:2105–2118.

Moon Yuseok, Uzarski Rebecca, Pestka James J.. Relationship of trichothecene structure to COX-2 induction in the macrophage: selective action of type B (8-keto) trichothecenes. Journal of toxicology and environmental health. Part A. 2003;66:1967–1983.

Zielonka L., Gajecki M., Obremski K., Zwierzchowski W.. Influence of low doses of deoxynivalenol applied per os on chosen indexes of immune response in swine. Polish journal of veterinary sciences. 2003;6:74–77.

Pestka James J.. Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions. Toxicology letters. 2003;140-141:287–295.

Yang Gi Hyeok H., Pestka James J.. Vomitoxin (deoxynivalenol)-mediated inhibition of nuclear protein binding to NRE-A, an IL-2 promoter negative regulatory element, in EL-4 cells. Toxicology. 2002;172:169–179.

Sun Xu-Ming M., Zhang Xiang-Hong H., Wang Hui-Yan Y., et al. Effects of sterigmatocystin, deoxynivalenol and aflatoxin G1 on apoptosis of human peripheral blood lymphocytes in vitro. Biomedical and environmental sciences : BES. 2002;15:145–152.

Berek Lívia, Petri I. B., Mesterházy A., Téren J.. The immunosuppressive effect of Fusarium mycotoxin as a function of HLA antigens. Acta microbiologica et immunologica Hungarica. 2002;49:99–104.

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