Aflatoxin Literature: Synergies with Other Substances

 

 

Casein

Bell R. C., Golemboski K. A., Dietert R. R., Campbell T. C.. Long-term intake of a low-casein diet is associated with higher relative NK cell cytotoxic activity in F344 rats. Nutrition and cancer.  1994;22:151–162.

Blanck A., Lindhe B., Porsch Hällström I., Lindeskog P., Gustafsson J. A.. Influence of different levels of dietary casein on initiation of male rat liver carcinogenesis with a single dose of aflatoxin B1.  Carcinogenesis.  1992;13:171–176.

Brackett R. E., Marth E. H.. Association of aflatoxin M1 with casein.  Zeitschrift für Lebensmittel-Untersuchung und -Forschung.  1982;174:439–441.

 

Ethanol

Adedara I. A., Owumi S. E., Uwaifo A. O., Farombi E. O.. Aflatoxin B₁ and ethanol co-exposure induces hepatic oxidative damage in mice.  Toxicology and industrial health.  2010;26:717–724.

Tsutsumi N., Miyazaki K.. Enhancing effect of ethanol on aflatoxin b1-induced DNA-damage in glutathione-depleted rat hepatocytes. International journal of oncology.  1994;4:123–127.

Sahaphong S., Toskulkao C., Glinsukon T.. Enhanced hepatotoxicity of aflatoxin B1 in the rat by ethanol: ultrastructural changes. Toxicology letters.  1992;61:89–98.

Okoye Z. S., Neal G. E.. An examination of the effect of pretreatment of rats with Sacoglottis gabonensis bark extract, a Nigerian palmwine additive, and ethanol on macromolecular binding of aflatoxin B1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.  1991;29:21–24.

Toskulkao C., Glinsukon T.. Hepatic mitochondrial function and lysosomal enzyme activity in ethanol-potentiated aflatoxin B1 hepatotoxicity. Toxicology letters.  1990;52:179–190.

Wang C. J., Wang S. W., Shiah H. S., Lin J. K.. Effect of ethanol on hepatotoxicity and hepatic DNA-binding of aflatoxin B1 in rats.  Biochemical pharmacology.  1990;40:715–721.

Tanaka T., Nishikawa A., Iwata H., et al. Enhancing effect of ethanol on aflatoxin B1-induced hepatocarcinogenesis in male ACI/N rats.  Japanese journal of cancer research : Gann.  1989;80:526–530.

Okoye Z. S., Neal G. E.. Enhanced ethanol-induced changes in disposition and toxic response to dietary aflatoxin B1 due to Sacoglottis gabonensis bark extract, a Nigerian alcoholic beverage additive. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.  1988;26:679–689.

Toskulkao C., Glinsukon T.. Hepatic lipid peroxidation and intracellular calcium accumulation in ethanol potentiated aflatoxin B1 toxicity.  Journal of pharmacobio-dynamics.  1988;11:191–197.

Toskulkao C., Yoshida T., Glinsukon T., Kuroiwa Y.. Potentiation of aflatoxin B1 induced hepatotoxicity in male Wistar rats with ethanol pretreatment. The Journal of toxicological sciences.  1986;11:41–51.

Toskulkao C., Glinsukon T.. Effect of ethanol on the in vivo covalent binding and in vitro metabolism of aflatoxin B1 in rats. Toxicology letters.  1986;30:151–157.

Marinovich M., Lutz W. K.. Covalent binding of aflatoxin B1 to liver DNA in rats pretreated with ethanol. Experientia.  1985;41:1338–1340.

Toskulkao C., Taycharpipranai S., Glinsukon T.. Enhanced hepatotoxicity of aflatoxin B1 by pretreatment of rats with ethanol. Research communications in chemical pathology and pharmacology.  1982;36:477–491.

Obidoa O., Okolo T. C.. Effect of ethanol administration on the metabolism of aflatoxin B1. Biochemical medicine.  1979;22:145–148.

Korte A., Slacik-Erben R., Obe G.. The influence of ethanol treatment of cytogenetic effects in bone marrow cells of Chinese hamsters by cyclophosphamide, aflatoxin B1 and patulin. Toxicology.  1979;12:53–61.

Glinsukon T., Taycharpipranai S., Toskulkao C.. Aflatoxin B1 hepatotoxicity in rats pretreated with ethanol. Experientia.  1978;34:869–870.

 

Insecticide-Producing Bacteria

Boutibonnes P.. [Effect of aflatoxin B1 on the enzymatic activities of Bacillus thuringiensis (Berliner)]. Canadian journal of microbiology.  1977;23:931–932.

Boutibonnes P., Auffray Y.. [Antibacterial properties of aflatoxin B1: cytotoxic effects on Bacilus thuringiensis (Berliner)]. Annales de la nutrition et de l’alimentation.  1977;31:831–840.

Boutibonnes P.. [Antibacterial effect of various mycotoxins and fungal metabolites against Bacillus thuringiensis (Berliner) strains sensitive or resistant to aflatoxin B1]. Canadian journal of microbiology.  1976;22:884–886.

Boutibonnes P.. [The mycotoxin sensitivity of several Bacillus thuringiensis (Berliner) strains sensitive and resistant to aflatoxin B1]. Comptes rendus hebdomadaires des séances de l’Académie des sciences. Série D: Sciences naturelles.  1975;280:1031–1034.

 

LPS

Barton C. C., Barton E. X., Ganey P. E., Kunkel S. L., Roth R. A.. Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor alpha. Hepatology (Baltimore, Md.).  2001;33:66–73.

 

Other Substances

Clarke R, Connolly L, Frizzell C, Elliott CT. Cytotoxic assessment of the regulated, co-existing mycotoxins aflatoxin B1, fumonisin B1 and ochratoxin, in single, binary and tertiary mixtures. Toxicon. 2014 Nov;90:70-81. PMID: 25110174

Klarić MS, Rašić D, Peraica M. Deleterious effects of mycotoxin combinations involving ochratoxin A. Toxins (Basel). 2013 Nov 1;5(11):1965-87. PMID: 24189375

Prabu P. C., Dwivedi P., Sharma A. K.. Toxicopathological studies on the effects of aflatoxin B(1), ochratoxin A and their interaction in New Zealand White rabbits. Experimental and toxicologic pathology. 2013;65:277–286.

Corcuera L. A., Vettorazzi A., Arbillaga L., González-Peñas E., Cerain A.. An approach to the toxicity and toxicokinetics of aflatoxin B1 and ochratoxin A after simultaneous oral administration to fasted F344 rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012;50:3440–3446.

Klarić Maja. Adverse effects of combined mycotoxins. Arhiv za higijenu rada i toksikologiju. 2012;63:519–530.

Bernabucci Umberto, Colavecchia Luciana, Danieli Pier Paolo P., et al. Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells. Toxicology in vitro : an international journal published in association with BIBRA. 2011;25:684–691.

Golli-Bennour Emna El E., Kouidhi Bochra, Bouslimi Amel, Abid-Essefi Salwa, Hassen Wafa, Bacha Hassen. Cytotoxicity and genotoxicity induced by aflatoxin B1, ochratoxin A, and their combination in cultured Vero cells. Journal of biochemical and molecular toxicology. 2010;24:42–50.

Orsi R. B., Oliveira C. A., Dilkin P., Xavier J. G., Direito G. M., Corrêa B.. Effects of oral administration of aflatoxin B1 and fumonisin B1 in rabbits (Oryctolagus cuniculus). Chemico-biological interactions. 2007;170:201–208.

Fraga M. E., Curvello F., Gatti M. J., Cavaglieri L. R., Dalcero A. M., Rocha Rosa C. A.. Potential aflatoxin and ochratoxin a production by Aspergillus species in poultry feed processing. Veterinary research communications. 2007;31:343–353.

McKean C., Tang L., Tang M., et al. Comparative acute and combinative toxicity of aflatoxin B1 and fumonisin B1 in animals and human cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2006;44:868–876.

McKean Christopher, Tang Lili, Billam Madhavi, et al. Comparative acute and combinative toxicity of aflatoxin B1 and T-2 toxin in animals and immortalized human cell lines. Journal of applied toxicology : JAT. 2006;26:139–147.

Sun Gui-ju J., Wang Shao-kang K., Wang Jia-sheng S.. [The combined toxity of two kinds of mycotoxin in Sprague-Dawley rats]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2006;40:319–323.

Tessari E. N., Oliveira C. A., Cardoso A. L., Ledoux D. R., Rottinghaus G. E.. Effects of aflatoxin B1 and fumonisin B1 on body weight, antibody titres and histology of broiler chicks. British poultry science. 2006;47:357–364.

Szkudelska K., DrzymaŃa H., Szkudelski T., Bukowska K., Nogowski L.. Lack of the effect of mycotoxins-aflatoxin B1 and ochratoxin A on some functions of rat adipocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2005;19:771–777.

Guerra M. C., Galvano F., Bonsi L., et al. Cyanidin-3-O-beta-glucopyranoside, a natural free-radical scavenger against aflatoxin B1- and ochratoxin A-induced cell damage in a human hepatoma cell line (Hep G2) and a human colonic adenocarcinoma cell line (CaCo-2). The British journal of nutrition. 2005;94:211–220.

Del Bianchi M., Oliveira C. A., Albuquerque R., Guerra J. L., Correa B.. Effects of prolonged oral administration of aflatoxin B1 and fumonisin B1 in broiler chickens. Poultry science. 2005;84:1835–1840.

Ogido R., Oliveira C. A., Ledoux D. R., et al. Effects of prolonged administration of aflatoxin B1 and fumonisin B1 in laying Japanese quail. Poultry science. 2004;83:1953–1958.

Dilkin P., Zorzete P., Mallmann C. A., et al. Toxicological effects of chronic low doses of aflatoxin B(1) and fumonisin B(1)-containing Fusarium moniliforme culture material in weaned piglets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2003;41:1345–1353.

Caldas Eloisa Dutra D., Silva Saulo Cardoso C., Oliveira João Nascimento N.. [Aflatoxins and ochratoxin A in food and risks to human health]. Revista de saúde pública. 2002;36:319–323.

Luyendyk James P., Shores Kate C., Ganey Patricia E., Roth Robert A.. Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury. Toxicological sciences : an official journal of the Society of Toxicology. 2002;68:220–225.

Pozzi C. R., Corrêa B., Xavier J. G., Direito G. M., Orsi R. B., Matarazzo S. V.. Effects of prolonged oral administration of fumonisin B1 and aflatoxin B1 in rats. Mycopathologia. 2001;151:21–27.

Casado J. M., Theumer M., Masih D. T., Chulze S., Rubinstein H. R.. Experimental subchronic mycotoxicoses in mice: individual and combined effects of dietary exposure to fumonisins and aflatoxin B1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2001;39:579–586.

Li B., Guo H.. [Study on the combined toxicity of aflatoxin B1 and deoxynivalenol]. Wei sheng yan jiu = Journal of hygiene research. 2000;29:393–395.

Barton C. C., Hill D. A., Yee S. B., Barton E. X., Ganey P. E., Roth R. A.. Bacterial lipopolysaccharide exposure augments aflatoxin B(1)-induced liver injury. Toxicological sciences : an official journal of the Society of Toxicology. 2000;55:444–452.

Schiller F., Lippold U., Heinze R., Hoffmann A., Seffner W.. Liver fibrosis in guinea pigs experimentally induced by combined copper and aflatoxin application. Experimental and toxicologic pathology. 1998;50:519–527.

Seffner W., Schiller F., Lippold U., Dieter H. H., Hoffmann A.. Experimental induction of liver fibrosis in young guinea pigs by combined application of copper sulphate and aflatoxin B1. Toxicology letters. 1997;92:161–172.

Oliver A. R., Silbart L. K., Keren D. F., Van Kruiningen H. J., Miller B. F., Rearick C.. Mucosal unresponsiveness to aflatoxin B1 is not broken by cholera toxin. Immunology and cell biology. 1997;75:47–53.

Kubena L. F., Edrington T. S., Kamps-Holtzapple C., Harvey R. B., Elissalde M. H., Rottinghaus G. E.. Effects of feeding fumonisin B1 present in Fusarium moniliforme culture material and aflatoxin singly and in combination to turkey poults. Poultry science. 1995;74:1295–1303.

Ueno Y., Umemori K., Niimi E., et al. Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells. Natural toxins.1995;3:129–137.

Weibking T. S., Ledoux D. R., Bermudez A. J., Rottinghaus G. E.. Individual and combined effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, and aflatoxin B1 in the young turkey poult. Poultry science. 1994;73:1517–1525.

Neiger R. D., Johnson T. J., Hurley D. J., Higgins K. F., Rottinghaus G. E., Stahr H.. The short-term effect of low concentrations of dietary aflatoxin and T-2 toxin on mallard ducklings. Avian diseases. 1994;38:738–743.

Abdelhamid A. M., Dorra T. M.. Effect of feed-borne pollution with some mycotoxin combinations on broiler chicks. Archiv für Tierernährung. 1993;44:29–40.

Blaude M. N., Goethals F. M., Ansay M. A., Roberfroid M. B.. Synergism between aflatoxin B1 and oxytetracycline on fatty acid esterification in isolated rat hepatocytes. Toxicology letters. 1992;61:159–166.

Smith E. E., Kubena L. F., Braithwaite C. E., Harvey R. B., Phillips T. D., Reine A. H.. Toxicological evaluation of aflatoxin and cyclopiazonic acid in broiler chickens. Poultry science. 1992;71:1136–1144.

Giroir L. E., Huff W. E., Kubena L. F., et al. The individual and combined toxicity of kojic acid and aflatoxin in broiler chickens. Poultry science. 1991;70:1351–1356.

Ruff M. D., Huff W. E., Wilkins G. C.. Characterization of the toxicity of the mycotoxins aflatoxin, ochratoxin, and T-2 toxin in game birds. I. Chukar partridge. Avian diseases. 1990;34:717–720.

Harvey R. B., Kubena L. F., Corrier D. E., Huff W. E., Rottinghaus G. E.. Cutaneous ulceration and necrosis in pigs fed aflatoxin- and T-2 toxin-contaminated diets. Journal of veterinary diagnostic investigation. 1990;2:227–229.

Blaude M. N., Goethals F. M., Ansay M. A., Roberfroid M. B.. Interaction between aflatoxin B1 and oxytetracycline in isolated rat hepatocytes. Cell biology and toxicology. 1990;6:339–351.

Pearson S. A., Stanley V. G., Reine A. H., Huff W. E., Kubena L. F., Harvey R. B.. Single and combination effects of administering salinomycin and aflatoxin to broiler chicks. Poultry science. 1990;69:849–851.

Thurston J. R., Sacks J. M., Richard J. L., Peden W. M., Driftmier K.. Complement, bacteriostatic, and enzymatic activities in sera from guinea pigs given aflatoxin and/or rubratoxin. American journal of veterinary research. 1989;50:356–358.

Jaskiewicz K., Close P. M., Thiel P. G., Cole R. J.. Preliminary studies on toxic effects of cyclopiazonic acid alone and in combination with aflatoxin B1 in non-human primates. Toxicology. 1988;52:297–307.

Huff W. E., Harvey R. B., Kubena L. F., Rottinghaus G. E.. Toxic synergism between aflatoxin and T-2 toxin in broiler chickens. Poultry science. 1988;67:1418–1423.

Horikoshi N., Tashiro F., Tanaka N., Ueno Y.. Modulation of hormonal induction of tyrosine aminotransferase and glucocorticoid receptors by aflatoxin B1 and sterigmatocystin in Reuber hepatoma cells. Cancer research. 1988;48:5188–5192.

Huff W. E., Kubena L. F., Harvey R. B., Doerr J. A.. Mycotoxin interactions in poultry and swine. Journal of animal science. 1988;66:2351–2355.

Larsen C., Acha M., Ehrich M.. Chlortetracycline and aflatoxin interaction in two lines of chicks. Poultry science. 1988;67:1229–1232.

Morrissey R. E., Norred W. P., Hinton D. M., Cole R. J., Dorner J. W.. Combined effects of the mycotoxins aflatoxin B1 and cyclopiazonic acid on Sprague-Dawley rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1987;25:837–842.

Yates I. E., Cole R. J., Giles J. L., Dorner J. W.. Interaction of aflatoxin B1 and cyclopiazonic acid toxicities. Molecular toxicology. 1987;1:95–106.

Huff W. E., Kubena L. F., Harvey R. B., et al. Individual and combined effects of aflatoxin and deoxynivalenol (DON, vomitoxin) in broiler chickens. Poultry science. 1986;65:1291–1298.

Walters J. M., Combes R. D.. Activation of benzo[a]pyrene and aflatoxin B1 to mutagenic chemical species by microsomal preparations from rat liver and small intestine in relation to microsomal epoxide hydrolase. Mutagenesis. 1986;1:45–48.

Tapia M. O., Seawright A. A.. Experimental combined aflatoxin B1 and ochratoxin A intoxication in pigs. Australian veterinary journal. 1985;62:33–37.

Ehrich M., Driscoll C., Gross W. B.. Effect of dietary exposure to aflatoxin B1 on resistance of young chickens to organophosphate pesticide challenge. Avian diseases. 1985;29:715–720.

Galtier P., Larrieu G., Le Bars J.. Comparative incidence of oral ochratoxicosis and aflatoxicosis on the activity of drug-metabolizing enzymes in rat liver. Toxicology letters. 1984;23:341–347.

Huff W. E., Doerr J. A., Wabeck C. J., Chaloupka G. W., May J. D., Merkley J. W.. Individual and combined effects of aflatoxin and ochratoxin A on bruising in broiler chickens. Poultry science. 1983;62:1764–1771.

Chinnici J. P., Gunst K., Llewellyn G. C.. Effects of mycotoxin pretreatment on aflatoxin B1 post-treatment toxicity in Drosophila melanogaster (Diptera). Journal of invertebrate pathology. 1983;41:321–327.

Osuna O., Edds G. T., Simpson C. F.. Toxicology of aflatoxin B1, warfarin, and cadmium in young pigs: metal residues and pathology. American journal of veterinary research. 1982;43:1395–1400.

Reichmann K. G., Blaney B. J., Connor J. K., Runge B. M.. The significance of aflatoxin and ochratoxin in the diet of Australian chickens. Australian veterinary journal. 1982;58:211–212.

Gunst K., Chinnici J. P., Llewellyn G. C.. Effects of aflatoxin B, aflatoxin B, aflatoxin G and sterigmatocystin on viability, rates of development, and body length in two strains of Drosophila melanogaster (Diptera). Journal of invertebrate pathology. 1982;39:388–394.

Patterson D. S., Shreeve B. J., Roberts B. A., et al. Effect on calves of barley naturally contaminated with ochratoxin A and groundnut meal contaminated with low concentrations of aflatoxin B1. Research in veterinary science. 1981;31:213–218.

Arora R. G.. Enhanced susceptibility to aflatoxin B1 toxicity in weanling mice pretreated with carbon tetrachloride. Acta pathologica et microbiologica Scandinavica. Section A, Pathology. 1981;89:303–308.

Huff W. E., Doerr J. A.. Synergism between aflatoxin and ochratoxin A in broiler chickens. Poultry science. 1981;60:550–555.

Dale N. M., Wyatt R. D., Fuller H. L.. Additive toxicity of aflatoxin and dietary tannins in broiler chicks. Poultry science. 1980;59:2417–2420.

Decloitre F., Hamon G.. Species-dependent effects of dietary lindane and/or zineb on the activation of aflatoxin B1 into mutagenic derivatives. Mutation research. 1980;79:185–192.

Newberne P. M., Connor M.. Effects of sequential exposure to aflatoxin B1 and diethylnitrosamine on vascular and stomach tissue and additional target organs in rats. Cancer research. 1980;40:4037–4042.

Uwaifo A., Bassir O.. Interaction of the aflatoxins with classical antibiotics which inhibit Bacillus brevis (2611). African journal of medicine and medical sciences. 1979;8:35–39.

Llewellyn G. C.. Toxic responses in gerbils treated topically with aflatoxin B1 and dimethylformamide. Bulletin of environmental contamination and toxicology. 1978;19:747–754.

Cooper J. T., Goldstein S.. Toxicity testing in vitro. I. The effects of delta 9-tetrahydrocannabinol and aflatoxin B1 on the growth of cultured human fibroblasts. Canadian journal of physiology and pharmacology. 1976;54:541–545.

Hayes A. W.. Effect of aflatoxin B and rubratoxin B on bacteriophage and rabbit cornea cells. Bulletin of environmental contamination and toxicology. 1976;15:665–669.

Stich H. F., Laishes B. A.. The response of Xeroderma pigmentosum cells and controls to the activated mycotoxins, aflatoxins and sterigmatocystin. International journal of cancer. Journal international du cancer. 1975;16:266–274.

Smith J. A., Adekunle A. A., Bassir O.. Comparative histopathological effects of aflatoxin B1 and palmotoxins B0 and G0 on some organs of different strains of the newly hatched chick (Gallus domesticus). Toxicology. 1975;3:177–185.

Kunimoto T., Kurimoto Y., Aibara K., Miyaki K.. Inhibition of nucleoside transport by aflatoxins and sterigmatocystin. Cancer research. 1974;34:968–973.

Hayes A. W., Hannan C. J.. Effects of rubratoxin and aflatoxin on oxygen consumption of Krebs cycle intermediates. Toxicology and applied pharmacology. 1973;25:30–41.

Edwards G. S., Allfrey V. G.. Aflatoxin B1 and actinomycin D effects on histone: acetylation and deacetylation in the liver. Biochimica et biophysica acta. 1973;299:354–366.

Wyatt R. D., Tung H. T., Hamilton P. B.. Effect of simultaneous feeding of aflatoxin and rubratoxin to chickens. Poultry science. 1973;52:395–397.

Pokrovskiĭ A. A., Kravchenko L. V., Tutel’ian V. A.. [Effect of aflatoxin and mitomycin C on the activity of lysosomal enzymes]. Biokhimii͡a (Moscow, Russia). 1971;36:690–696.

Engelbrecht J. C., Purchase I. F.. Changes in morphology of cell cultures after treatment with aflatoxin and ochratoxin. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 1969;43:524–528.

Gurtoo H. L., Campbell T. C., Webb R. E., Plowman K. M.. Effect of aflatoxin and benzpyrene pretreatment upon the kinetics of benzpyrene hydroxylase. Biochemical and biophysical research communications. 1968;31:588–595.