Aflatoxin Literature: Protective Agents

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Ascorbic Acid

Móricz A. M., Ott P. G., Billes F., Otta K. H., Tyihák E.. The influence of L-ascorbic acid on the antibacterial-toxic activity of aflatoxins on adsorbent layer. Journal of applied microbiology.  2007;103:2525–2532.

Yousef M. I., Salem M. H., Kamel K. I., Hassan G. A., El-Nouty F. D.. Influence of ascorbic acid supplementation on the haematological and clinical biochemistry parameters of male rabbits exposed to aflatoxin B1.  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.  2003;38:193–209.

Verma R. J., Shukla R. S., Mehta D. N.. Interaction of aflatoxin with L-ascorbic acid: a kinetic and mechanistic approach. Natural toxins.  1999;7:25–29.

Netke S. P., Roomi M. W., Tsao C., Niedzwiecki A.. Ascorbic acid protects guinea pigs from acute aflatoxin toxicity. Toxicology and applied pharmacology.  1997;143:429–435.

Kanazawa Y., Kitada M., Mori T., et al. Ascorbic acid deficiency decreases specific forms of cytochrome P-450 in liver microsomes of guinea pigs.  Molecular pharmacology.  1991;39:456–460.

Yokota F., Igarashi Y., Suzue R.. Hyperlipidemia in guinea-pigs induced by ascorbic acid deficiency. The effects of cholesterol, DL-ethionine and aflatoxin. Atherosclerosis.  1981;38:249–254.

 

BHT

Guarisco John A., Hall Jeffery O., Coulombe Roger A.. Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis–inhibition of aflatoxin B1 metabolism. Toxicology and applied pharmacology. 2008;227:339–346.

Williams Gary M.. Butylated hydroxytoluene (BHT) at 1000 and 4000 ppm in the diet protected turkeys against aflatoxicosis. Toxicology and applied pharmacology. 2003;189.

Klein P. J., Van Vleet T. R., Hall J. O., Coulombe R. A.. Effects of dietary butylated hydroxytoluene on aflatoxin B1-relevant metabolic enzymes in turkeys. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2003;41:671–678.

Klein Patrick J., Van Vleet Terry R., Hall Jeffery O., Coulombe Roger A.. Dietary butylated hydroxytoluene protects against aflatoxicosis in Turkeys. Toxicology and applied pharmacology. 2002;182:11–19.

Williams G. M., Iatropoulos M. J.. Inhibition of the hepatocarcinogenicity of aflatoxin B1 in rats by low levels of the phenolic antioxidants butylated hydroxyanisole and butylated hydroxytoluene. Cancer letters. 1996;104:49–53.

Choi C. Y., Park S. H., Park E. H., Cha Y. N.. Alteration of aflatoxin B1 metabolic profiles and reduction of aflatoxin B1 mutagenicity by hepatic microsomes of rats fed butylated hydroxyanisole. The Journal of toxicological sciences. 1991;16 Suppl 1:119–132.

Jhee E. C., Ho L. L., Tsuji K., Gopalan P., Lotlikar P. D.. Effect of butylated hydroxyanisole pretreatment on aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation in isolated hepatocytes from rats. Cancer research. 1989;49:1357–1360.

Goeger D. E., Shelton D. W., Hendricks J. D., Pereira C., Bailey G. S.. Comparative effect of dietary butylated hydroxyanisole and beta-naphthoflavone on aflatoxin B1 metabolism, DNA adduct formation, and carcinogenesis in rainbow trout. Carcinogenesis. 1988;9:1793–1800.

Jhee E. C., Ho L. L., Lotlikar P. D.. Effect of butylated hydroxyanisole pretreatment on in vitro hepatic aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation in rats. Cancer research. 1988;48:2688–2692.

Ehrich M., Acha M., Larsen C.. Interactions of aflatoxin and the antioxidant butylated hydroxytoluene in two-week-old chicks. Veterinary research communications. 1988;12:329–333.

Monroe D. H., Eaton D. L.. Comparative effects of butylated hydroxyanisole on hepatic in vivo DNA binding and in vitro biotransformation of aflatoxin B1 in the rat and mouse. Toxicology and applied pharmacology. 1987;90:401–409.

Ehrich M., Driscoll C., Larsen C.. Ability of ethoxyquin and butylated hydroxytoluene to counteract deleterious effects of dietary aflatoxin in chicks. Avian diseases. 1986;30:802–807.

Williams G. M., Tanaka T., Maeura Y.. Dose-related inhibition of aflatoxin B1 induced hepatocarcinogenesis by the phenolic antioxidants, butylated hydroxyanisole and butylated hydroxytoluene. Carcinogenesis. 1986;7:1043–1050.

Fukayama M. Y., Hsieh D. P.. Effect of butylated hydroxytoluene pretreatment on the excretion, tissue distribution and DNA binding of [14C]aflatoxin B1 in the rat. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1985;23:567–573.

Salocks C. B., Hsieh D. P., Byard J. L.. Effects of butylated hydroxytoluene pretreatment on the metabolism and genotoxicity of aflatoxin B1 in primary cultures of adult rat hepatocytes: selective reduction of nucleic acid binding. Toxicology and applied pharmacology. 1984;76:498–509.

Fukayama M. Y., Helferich W. G., Hsieh D. P.. Effect of butylated hydroxytoluene on the disposition of [14C]aflatoxin B1 in the lactating rat. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1984;22:857–860.

Lotlikar P. D., Clearfield M. S., Jhee E. C.. Effect of butylated hydroxyanisole on in vivo and in vitro hepatic aflatoxin B1-DNA binding in rats. Cancer letters. 1984;24:241–250.

Fukayama M. Y., Hsieh D. P.. The effects of butylated hydroxytoluene on the in vitro metabolism, DNA-binding and mutagenicity of aflatoxin B1 in the rat. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1984;22:355–360.

Salocks C. B., Hsieh D. P., Byard J. L.. Butylated hydroxytoluene pretreatment protects against cytotoxicity and reduces covalent binding of aflatoxin B1 in primary hepatocyte cultures. Toxicology and applied pharmacology. 1981;59:331–345.

Guarisco J. A., Hall J. O., Coulombe R. A.. Butylated hydroxytoluene chemoprevention of aflatoxicosis – effects on aflatoxin B(1) bioavailability, hepatic DNA adduct formation, and biliary excretion. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008;46:3727–3731.

Allameh A., Saxena M., Raj H. G.. Lack of influence of butylated hydroxytoluene on modification of lung microsome mediated aflatoxin B1-DNA binding: role of pulmonary glutathione S-transferase. Cancer letters. 1988;43:125–131.

Allameh A., Saxena M., Raj H. G.. Differential effects of butylated hydroxyanisole on metabolism of aflatoxin B1 in vitro by liver and lung microsomes. Cancer letters. 1988;40:49–57.

 

Binders

Bhatti SA, Khan MZ, Saleemi MK, Saqib M, Khan A, Ul-Hassan Z. Protective role of bentonite against aflatoxin B1- and ochratoxin A-induced immunotoxicity in broilers. J Immunotoxicol. 2017 Dec;14(1):66-76. PMID: 28094577

Di Gregorio MC, Jager AV, Souto PCMC, Costa AA, Rottinghaus GE, Passarelli D, Budiño FEL, Corassin CH, Oliveira CAF. Determination of serum aflatoxin B1-lysine to evaluate the efficacy of an aflatoxin-adsorbing feed additive in pigs fed an aflatoxin B1-contaminated diet. Mycotoxin Res. 2017 May;33(2):93-102. PMID: 28035652

Shannon TA, Ledoux DR, Rottinghaus GE, Shaw DP, Dakovic A, Markovic M. The efficacy of raw and concentrated bentonite clay in reducing the toxic effects of aflatoxin in broiler chicks. Poult Sci. 2017 Jun 1;96(6):1651-1658. PMID: 27837119

Sulzberger SA, Melnichenko S, Cardoso FC. Effects of clay after an aflatoxin challenge on aflatoxin clearance, milk production, and metabolism of Holstein cows. J Dairy Sci. 2017 Mar;100(3):1856-1869. PMID: 28088422

Awuor AO, Yard E, Daniel JH, Martin C, Bii C, Romoser A, Oyugi E, Elmore S, Amwayi S, Vulule J, Zitomer NC, Rybak ME, Phillips TD, Montgomery JM, Lewis LS. Evaluation of the efficacy, acceptability and palatability of calcium montmorillonite clay used to reduce aflatoxin B1 dietary exposure in a crossover study in Kenya. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Jan;34(1):93-102. PMID: 27603954

Pollock BH, Elmore S, Romoser A, Tang L, Kang MS, Xue K, Rodriguez M, Dierschke NA, Hayes HG, Hansen HA, Guerra F, Wang JS, Phillips T. Intervention trial with calcium montmorillonite clay in a south Texas population exposed to aflatoxin. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Aug;33(8):1346-54. PMID: 27321368

Ben Salah-Abbès J, Jebali R, Sharafi H, Akbari Noghabi K, Oueslati R, Abbès S. Immuno-physiological alterations from AFB1 in rats counteracted by treatments with Lactobacillus paracasei BEJ01 and montmorillonite clay mixture. J Immunotoxicol. 2016 Sep;13(5):628-37. PMID: 27294391

Romero A, Ares I, Ramos E, Castellano V, Martínez M, Martínez-Larrañaga MR, Anadón A, Martínez MA. Mycotoxins modify the barrier function of Caco-2 cells through differential gene expression of specific claudin isoforms: Protective effect of illite mineral clay. Toxicology. 2016 Apr 15;353-354:21-33. PMID: 27153755

Lala AO, Ajayi OL, Oso AO, Ajao MO, Oni OO, Okwelum N, Idowu OM. Effect of dietary supplementation with clay-based binders on biochemical and histopathological changes in organs of turkey fed with aflatoxin-contaminated diets. J Anim Physiol Anim Nutr (Berl). 2016 Dec;100(6):1191-1202. PMID: 27870288

Nones J, Nones J, Poli A, Trentin AG, Riella HG, Kuhnen NC. Organophilic treatments of bentonite increase the adsorption of aflatoxin B1 and protect stem cells against cellular damage. Colloids Surf B Biointerfaces. 2016 Sep 1;145:555-61. PMID: 27281241

Pappas AC, Tsiplakou E, Tsitsigiannis DI, Georgiadou M, Iliadi MK, Sotirakoglou K, Zervas G. The role of bentonite binders in single or concomitant mycotoxin contamination of chicken diets. Br Poult Sci. 2016 Aug;57(4):551-8. PMID: 27172005

Monge Mdel P, Magnoli AP, Bergesio MV, Tancredi N, Magnoli CE, Chiacchiera SM. Activated carbons as potentially useful non-nutritive additives to prevent the effect of fumonisin B1 on sodium bentonite activity against chronic aflatoxicosis. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Jun;33(6):1043-52. PMID: 27159550

Magnoli AP, Copia P, Monge MP, Magnoli CE, Dalcero AM, Chiacchiera SM. Negligible effects of tryptophan on the aflatoxin adsorption of sodium bentonite. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(12):2063-70. PMID: 25363215

Chen X, Horn N, Applegate TJ. Efficiency of hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of graded levels of aflatoxin B1 in broiler chicks. Poult Sci. 2014 Aug;93(8):2037-47. PMID: 24894529

Elmore SE, Mitchell N, Mays T, Brown K, Marroquin-Cardona A, Romoser A, Phillips TD. Common African cooking processes do not affect the aflatoxin binding efficacy of refined calcium montmorillonite clay. Food Control. 2014 Mar;37. PMID: 24311894

Mitchell NJ, Xue KS, Lin S, Marroquin-Cardona A, Brown KA, Elmore SE, Tang L, Romoser A, Gelderblom WC, Wang JS, Phillips TD. Calcium montmorillonite clay reduces AFB1 and FB1 biomarkers in rats exposed to single and co-exposures of aflatoxin and fumonisin. J Appl Toxicol. 2014 Jul;34(7):795-804. PMID: 24193864

Eckhardt JC, Santurio JM, Zanette RA, Rosa AP, Scher A, Dal Pozzo M, Alves SH, Ferreiro L. Efficacy of a Brazilian calcium montmorillonite against toxic effects of dietary aflatoxins on broilers reared to market weight. Br Poult Sci. 2014;55(2):215-20. PMID: 24423730

Attia Y. A., Allakany H. F., Abd Al-Hamid A. E., Al-Saffar A. A., Hassan R. A., Mohamed N. A.. Capability of different non-nutritive feed additives on improving productive and physiological traits of broiler chicks fed diets with or without aflatoxin during the first 3 weeks of life. Journal of animal physiology and animal nutrition. 2013;97:754–772.

Neeff D. V., Ledoux D. R., Rottinghaus G. E., et al. In vitro and in vivo efficacy of a hydrated sodium calcium aluminosilicate to bind and reduce aflatoxin residues in tissues of broiler chicks fed aflatoxin B1. Poultry science. 2013;92:131–137.

Siloto EV, Oliveira EF, Sartori JR, Fascina VB, Martins BA, Ledoux DR, Rottinghaus GE, Sartori DR. Lipid metabolism of commercial layers fed diets containing aflatoxin, fumonisin, and a binder. Poult Sci. 2013 Aug;92(8):2077-83. PMID: 23873555

Siloto E. V., Oliveira E. F., Sartori J. R., et al. Lipid metabolism of commercial layers fed diets containing aflatoxin, fumonisin, and a binder. Poultry science. 2013;92:2077–2083.

Cao Jigang, Wang Wenjun. Effects of astaxanthin and esterified glucomannan on hematological and serum parameters, and liver pathological changes in broilers fed aflatoxin-B1-contaminated feed. Animal science journal = Nihon chikusan Gakkaiho. 2013.

Brown K. A., Mays T., Romoser A., et al. Modified hydra bioassay to evaluate the toxicity of multiple mycotoxins and predict the detoxification efficacy of a clay-based sorbent. Journal of applied toxicology : JAT. 2012.

Robinson A, Johnson NM, Strey A, Taylor JF, Marroquin-Cardona A, Mitchell NJ, Afriyie-Gyawu E, Ankrah NA, Williams JH, Wang JS, Jolly PE, Nachman RJ, Phillips TD. Calcium montmorillonite clay reduces urinary biomarkers of fumonisin B1 exposure in rats and humans. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012; 29(5): 809-18.

Sur Emrah, Dönmez Hasan Hüseyin H., Boydak Murat, Ataman Mehmet Bozkurt B.. Effects of glucomannan on the sacculus rotundus and peripheral blood lymphocytes in New Zealand rabbits during aflatoxicosis. TheScientificWorldJournal. 2012;2012.

Colakoglu Fatma, Donmez Hasan Hüseyin H.. Effects of aflatoxin on liver and protective effectiveness of esterified glucomannan in Merino rams. TheScientificWorldJournal. 2012;2012.

Dönmez Nurcan, Dönmez H. H., Keskin E., Kısadere İ.. Effects of aflatoxin on some haematological parameters and protective effectiveness of esterified glucomannan in Merino rams. TheScientificWorldJournal. 2012;2012.

Joannis-Cassan Claire, Tozlovanu Mariana, Hadjeba-Medjdoub Kheira, Ballet Nathalie, Pfohl-Leszkowicz Annie. Binding of zearalenone, aflatoxin B1, and ochratoxin A by yeast-based products: a method for quantification of adsorption performance. Journal of food protection. 2011;74:1175–1185.

Jaynes William F., Zartman Richard E.. Aflatoxin toxicity reduction in feed by enhanced binding to surface-modified clay additives. Toxins. 2011;3:551–565.

Magnoli A. P., Texeira M., Rosa C. A., et al. Sodium bentonite and monensin under chronic aflatoxicosis in broiler chickens. Poultry science. 2011;90:352–357.

Magnoli A. P., Monge M. P., Miazzo R. D., et al. Effect of low levels of aflatoxin B₁ on performance, biochemical parameters, and aflatoxin B₁ in broiler liver tissues in the presence of monensin and sodium bentonite. Poultry science. 2011;90:48–58.

Gallo A., Masoero F., Bertuzzi T., Piva G., Pietri A.. Effect of the inclusion of adsorbents on aflatoxin B1 quantification in animal feedstuffs. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2010;27:54–63.

Zhao J., Shirley R. B., Dibner J. D., et al. Comparison of hydrated sodium calcium aluminosilicate and yeast cell wall on counteracting aflatoxicosis in broiler chicks. Poultry science. 2010;89:2147–2156.

Marroquín-Cardona A., Deng Y., Taylor J. F., Hallmark C. T., Johnson N. M., Phillips T. D.. In vitro and in vivo characterization of mycotoxin-binding additives used for animal feeds in Mexico. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2009;26:733–743.

Afriyie-Gyawu E, Wang Z, Ankrah NA, Xu L, Johnson NM, Tang L, Guan H, Huebner HJ, Jolly PE, Ellis WO, Taylor R, Brattin B, Ofori-Adjei D, Williams JH, Wang JS, Phillips TD. NovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosis. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 July; 25(7): 872-84.

Afriyie-Gyawu E., Ankrah N-A A., Huebner H. J., et al. NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis. I. Study design and clinical outcomes. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2008;25:76–87.

Thieu N. Q., Pettersson H.. In vitro evaluation of the capacity of zeolite and bentonite to adsorb aflatoxin B1 in simulated gastrointestinal fluids. Mycotoxin research. 2008;24:124–129.

Phillips T. D., Afriyie-Gyawu E., Williams J., et al. Reducing human exposure to aflatoxin through the use of clay: a review. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2008;25:134–145.

Wang P., Afriyie-Gyawu E., Tang Y., et al. NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis: II. Reduction in biomarkers of aflatoxin exposure in blood and urine. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2008;25:622–634.

Thieu Nguyen Quang Q., Ogle Brian, Pettersson Hans. Efficacy of bentonite clay in ameliorating aflatoxicosis in piglets fed aflatoxin contaminated diets. Tropical animal health and production. 2008;40:649–656.

Türkez Hasan, Sişman Turgay. Anti-genotoxic effect of hydrated sodium calcium aluminosilicate on genotoxicity to human lymphocytes induced by aflatoxin B1. Toxicology and industrial health. 2007;23:83–89.

Sişman Turgay. The protective effect of hydrated sodium calcium aluminosilicate against the adverse effects of aflatoxin B1 on D. melanogaster. Toxicology and industrial health. 2006;22:173–179.

Afriyie-Gyawu Evans, Mackie John, Dash Bhagirathi, et al. Chronic toxicological evaluation of dietary NovaSil clay in Sprague-Dawley rats. Food additives and contaminants. 2005;22:259–269.

Wang J-S S., Luo H., Billam M., et al. Short-term safety evaluation of processed calcium montmorillonite clay (NovaSil) in humans. Food additives and contaminants. 2005;22:270–279.

Miazzo R., Peralta M. F., Magnoli C., et al. Efficacy of sodium bentonite as a detoxifier of broiler feed contaminated with aflatoxin and fumonisin. Poultry science. 2005;84:1–8.

Aravind K. L., Patil V. S., Devegowda G., Umakantha B., Ganpule S. P.. Efficacy of esterified glucomannan to counteract mycotoxicosis in naturally contaminated feed on performance and serum biochemical and hematological parameters in broilers. Poultry science. 2003;82:571–576.

Murthy T. N., Reddy B. N., Devegowda G.. Evaluation of glucomannan for its adsorbing ability of Aflatoxin B1 and T-2 Toxin in the Gastrointestinal Tract of Broiler Chickens. Mycotoxin research. 2002;18 Suppl 1:20–23.

Diaz Duarte E., Hagler Winston M., Hopkins Brinton A., Whitlow Lon W.. Aflatoxin binders I: in vitro binding assay for aflatoxin B1 by several potential sequestering agents. Mycopathologia. 2002;156:223–226.

Raju M. V., Devegowda G.. Influence of esterified-glucomannan on performance and organ morphology, serum biochemistry and haematology in broilers exposed to individual and combined mycotoxicosis (aflatoxin, ochratoxin and T-2 toxin). British poultry science. 2000;41:640–650.

Miazzo R., Rosa C. A., De Queiroz Carvalho E. C., et al. Efficacy of synthetic zeolite to reduce the toxicity of aflatoxin in broiler chicks. Poultry science. 2000;79:1–6.

Ibrahim I. K., Shareef A. M., Al-Joubory K. M.. Ameliorative effects of sodium bentonite on phagocytosis and Newcastle disease antibody formation in broiler chickens during aflatoxicosis. Research in veterinary science. 2000;69:119–122.

Nowar M., El-Gaafary M., Tawfeek M., Ibrahim Z.. Aflatoxicosis in rabbits: Effectiveness of Egyptian raw bentonite in prevention or diminution the detrimental effects of naturally aflatoxin contaminated diets. Mycotoxin research. 2000;16 Suppl 2:199–203.

Ledoux D. R., Rottinghaus G. E., Bermudez A. J., Alonso-Debolt M.. Efficacy of a hydrated sodium calcium aluminosilicate to ameliorate the toxic effects of aflatoxin in broiler chicks. Poultry science. 1999;78:204–210.

Santurio J. M., Mallmann C. A., Rosa A. P., et al. Effect of sodium bentonite on the performance and blood variables of broiler chickens intoxicated with aflatoxins. British poultry science. 1999;40:115–119.

Phillips T. D.. Dietary clay in the chemoprevention of aflatoxin-induced disease. Toxicological sciences : an official journal of the Society of Toxicology. 1999;52:118–126.

Abdel-Wahhab M. A., Nada S. A., Amra H. A.. Effect of aluminosilicates and bentonite on aflatoxin-induced developmental toxicity in rat. Journal of applied toxicology : JAT. 1999;19:199–204.

Grant P. G., Phillips T. D.. Isothermal Adsorption of Aflatoxin B(1) on HSCAS Clay. Journal of agricultural and food chemistry. 1998;46:599–605.

Abdel-Wahhab M. A., Nada S. A., Farag I. M., Abbas N. F., Amra H. A.. Potential protective effect of HSCAS and bentonite against dietary aflatoxicosis in rat: with special reference to chromosomal aberrations. Natural toxins. 1998;6:211–218.

Bailey R. H., Kubena L. F., Harvey R. B., Buckley S. A., Rottinghaus G. E.. Efficacy of various inorganic sorbents to reduce the toxicity of aflatoxin and T-2 toxin in broiler chickens. Poultry science. 1998;77:1623–1630.

Mayura K., Abdel-Wahhab M. A., McKenzie K. S., et al. Prevention of maternal and developmental toxicity in rats via dietary inclusion of common aflatoxin sorbents: potential for hidden risks. Toxicological sciences : an official journal of the Society of Toxicology. 1998;41:175–182.

Keçeci T., Oğuz H., Kurtoğlu V., Demet O.. Effects of polyvinylpolypyrrolidone, synthetic zeolite and bentonite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis. British poultry science. 1998;39:452–458.

Edrington T. S., Kubena L. F., Harvey R. B., Rottinghaus G. E.. Influence of a superactivated charcoal on the toxic effects of aflatoxin or T-2 toxin in growing broilers. Poultry science. 1997;76:1205–1211.

Abo-Norag M., Edrington T. S., Kubena L. F., Harvey R. B., Phillips T. D.. Influence of a hydrated sodium calcium aluminosilicate and virginiamycin on aflatoxicosis in broiler chicks. Poultry science. 1995;74:626–632.

Sarr A. B., Mayura K., Kubena L. F., Harvey R. B., Phillips T. D.. Effects of phyllosilicate clay on the metabolic profile of aflatoxin B1 in Fischer-344 rats. Toxicology letters. 1995;75:145–151.

Phillips T. D., Sarr A. B., Grant P. G.. Selective chemisorption and detoxification of aflatoxins by phyllosilicate clay. Natural toxins. 1995;3.

Márquez Márquez R. N., Hernandez I.. Aflatoxin adsorbent capacity of two Mexican aluminosilicates in experimentally contaminated chick diets. Food additives and contaminants. 1995;12:431–433.

Harvey R. B., Kubena L. F., Elissalde M. H., Corrier D. E., Phillips T. D.. Comparison of two hydrated sodium calcium aluminosilicate compounds to experimentally protect growing barrows from aflatoxicosis. Journal of veterinary diagnostic investigation. 1994;6:88–92.

Jindal N., Mahipal S. K., Mahajan N. K.. Toxicity of aflatoxin B1 in broiler chicks and its reduction by activated charcoal. Research in veterinary science. 1994;56:37–40.

Schell T. C., Lindemann M. D., Kornegay E. T., Blodgett D. J., Doerr J. A.. Effectiveness of different types of clay for reducing the detrimental effects of aflatoxin-contaminated diets on performance and serum profiles of weanling pigs. Journal of animal science. 1993;71:1226–1231.

Schell T. C., Lindemann M. D., Kornegay E. T., Blodgett D. J.. Effects of feeding aflatoxin-contaminated diets with and without clay to weanling and growing pigs on performance, liver function, and mineral metabolism. Journal of animal science. 1993;71:1209–1218.

Harvey R. B., Kubena L. F., Elissalde M. H., Phillips T. D.. Efficacy of zeolitic ore compounds on the toxicity of aflatoxin to growing broiler chickens. Avian diseases. 1993;37:67–73.

Kubena L. F., Harvey R. B., Huff W. E., et al. Efficacy of a hydrated sodium calcium aluminosilicate to reduce the toxicity of aflatoxin and diacetoxyscirpenol. Poultry science. 1993;72:51–59.

Scheideler S. E.. Effects of various types of aluminosilicates and aflatoxin B1 on aflatoxin toxicity, chick performance, and mineral status. Poultry science. 1993;72:282–288.

Madden U. A., Stahr H. M.. Effect of soil on aflatoxin tissue retention in chicks when added to aflatoxin-contaminated poultry rations. Veterinary and human toxicology. 1992;34:521–523.

Huff W. E., Kubena L. F., Harvey R. B., Phillips T. D.. Efficacy of hydrated sodium calcium aluminosilicate to reduce the individual and combined toxicity of aflatoxin and ochratoxin A. Poultry science. 1992;71:64–69.

Bonna R. J., Aulerich R. J., Bursian S. J., Poppenga R. H., Braselton W. E., Watson G. L.. Efficacy of hydrated sodium calcium aluminosilicate and activated charcoal in reducing the toxicity of dietary aflatoxin to mink. Archives of environmental contamination and toxicology. 1991;20:441–447.

Kubena L. F., Huff W. E., Harvey R. B., et al. Effects of a hydrated sodium calcium aluminosilicate on growing turkey poults during aflatoxicosis. Poultry science. 1991;70:1823–1830.

Harvey R. B., Kubena L. F., Phillips T. D., Corrier D. E., Elissalde M. H., Huff W. E.. Diminution of aflatoxin toxicity to growing lambs by dietary supplementation with hydrated sodium calcium aluminosilicate. American journal of veterinary research. 1991;52:152–156.

Phillips T. D., Clement B. A., Kubena L. F., Harvey R. B.. Detection and detoxification of aflatoxins: prevention of aflatoxicosis and aflatoxin residues with hydrated sodium calcium aluminosilicate. Veterinary and human toxicology. 1990;32 Suppl:15–19.

Kubena L. F., Harvey R. B., Huff W. E., Corrier D. E., Phillips T. D., Rottinghaus G. E.. Efficacy of a hydrated sodium calcium aluminosilicate to reduce the toxicity of aflatoxin and T-2 toxin. Poultry science. 1990;69:1078–1086.

Beaver R. W., Wilson D. M., James M. A., et al. Distribution of aflatoxins in tissues of growing pigs fed an aflatoxin-contaminated diet amended with a high affinity aluminosilicate sorbent. Veterinary and human toxicology. 1990;32:16–18.

Colvin B. M., Sangster L. T., Haydon K. D., Beaver R. W., Wilson D. M.. Effect of a high affinity aluminosilicate sorbent on prevention of aflatoxicosis in growing pigs. Veterinary and human toxicology. 1989;31:46–48.

Dalvi R. R., Ademoyero A. A.. Toxic effects of aflatoxin B1 in chickens given feed contaminated with Aspergillus flavus and reduction of the toxicity by activated charcoal and some chemical agents. Avian diseases. 1984;28:61–69.

Ademoyero A. A., Dalvi R. R.. Efficacy of activated charcoal and other agents in the reduction of hepatotoxic effects of a single dose of aflatoxin B1 in chickens. Toxicology letters. 1983;16:153–157.

Perry M. J., Adlard M. W., Holt G.. The effect of the synergy between sterigmatocystin and a fungal metabolite on Bacillus subtilis. The Journal of applied bacteriology. 1982;52:91–96.

Hatch R. C., Clark J. D., Jain A. V., Weiss R.. Induced acute aflatoxicosis in goats: treatment with activated charcoal or dual combinations of oxytetracycline, stanozolol, and activated charcoal. American journal of veterinary research. 1982;43:644–648.

Decker W. J., Corby D. G.. Activated charcoal adsorbs aflatoxin B1. Veterinary and human toxicology. 1980;22:388–389.

Masimango N., Remacle J., Ramaut J.. [Elimination of aflatoxin B1 by clays from contaminated substrates]. Annales de la nutrition et de l’alimentation. 1979;33:137–147.

Boutibonnes P.. [Determination of the antibacterial activity of various mycotoxins using Bacillus thuringiensis (Berliner)]. Mycopathologia. 1979;67:45–50.

Lemarinier S., Boutibonnes P., Jacquet J.. [Morphologic alterations induced by aflatoxin B1 in Bacillus thuringiensis (Berliner)]. Comptes rendus hebdomadaires des séances de l’Académie des sciences. Série D: Sciences naturelles. 1977;285:201–203.

 

Caloric Restriction

Chou M. W., Lu M. H., Pegram R. A., et al. Effect of caloric restriction on aflatoxin B1-induced DNA synthesis, AFB1-DNA binding and cell proliferation in Fischer 344 rats. Mechanisms of ageing and development. 1993;70:23–33.

Gao P., Chou M. W.. Effect of caloric restriction on hepatic nuclear DNA damage in male Fischer 344 rats treated with aflatoxin B1. Toxicology letters. 1992;61:233–242.

Hart R. W., Leakey J. E., Chou M., Duffy P. H., Allaben W. T., Feuers R. J.. Modulation of chemical toxicity by modification of caloric intake. Advances in experimental medicine and biology. 1992;322:73–81.

Pegram R. A., Allaben W. T., Chou M. W.. Effect of caloric restriction on aflatoxin B1-DNA adduct formation and associated factors in Fischer 344 rats: preliminary findings. Mechanisms of ageing and development. 1989;48:167–177.

Rizvi T. A., Mathur M., Nayak N. C.. Effect of protein calorie malnutrition and cell replication on aflatoxin B1-induced hepatocarcinogenesis in rats. Journal of the National Cancer Institute. 1987;79:817–830.

Alozie T. C., Arowosegbe B. A.. Short-term effects of the interaction of protein-calorie malnutrition and aflatoxin intake in the rat. Materia medica Polona. Polish journal of medicine and pharmacy. 1985;17:79–84.

Todd G. C., Shalkop W. T., Dooley K. L., Wiseman H. G.. Effects of ration modifications on aflatoxicosis in the rat. American journal of veterinary research. 1968;29:1855–1861.

 

Carnitine

Citil M., Gunes V., Atakisi O., Ozcan Ayla, Tuzcu M., Dogan A.. Protective effect of L-carnitine against oxidative damage caused by experimental chronic aflatoxicosis in quail (Coturnix coturnix). Acta veterinaria Hungarica. 2005;53:319–324.

Yatim A. M., Sachan D. S.. Carnitine alters binding of aflatoxin to DNA and proteins in rat hepatocytes and cell-free systems. The Journal of nutrition. 2001;131:1903–1908.

Sachan D. S., Yatim A. M.. Suppression of aflatoxin B1-induced lipid abnormalities and macromolecule-adduct formation by L-carnitine. Journal of environmental pathology, toxicology and oncology. 1992;11:205–210.

 

Chlorophyllin

Abdel-Latif MS, Elmeleigy KM, Aly TAA, Khattab MS, Mohamed SM. Pathological and biochemical evaluation of coumarin and chlorophyllin against aflatoxicosis in rat. Exp Toxicol Pathol. 2017 Jun 14;69(5):285-291. PMID: 28190563

Kumar M., Verma V., Nagpal R., et al. Anticarcinogenic effect of probiotic fermented milk and chlorophyllin on aflatoxin-B₁-induced liver carcinogenesis in rats. The British journal of nutrition. 2012;107:1006–1016.

Kumar Manoj, Verma Vinod, Nagpal Ravinder, et al. Effect of probiotic fermented milk and chlorophyllin on gene expressions and genotoxicity during AFB₁-induced hepatocellular carcinoma. Gene. 2011;490:54–59.

Jubert Carole, Mata John, Bench Graham, et al. Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers. Cancer prevention research (Philadelphia, Pa.). 2009;2:1015–1022.

Hsu Ching-Yun Y., Chen Yue-Hwa H., Chao Pi-Yu Y., Chen Chiao-Ming M., Hsieh Ling-Ling L., Hu Shene-Pin P.. Naturally occurring chlorophyll derivatives inhibit aflatoxin B1-DNA adduct formation in hepatoma cells. Mutation research. 2008;657:98–104.

Simonich Michael T., Egner Patricia A., Roebuck Bill D., et al. Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis. 2007;28:1294–1302.

Orner Gayle A., Roebuck Bill D., Dashwood Roderick H., Bailey George S.. Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats. Journal of carcinogenesis. 2006;5.

Mata John E., Yu Zhen, Gray John E., Williams David E., Rodriguez-Proteau Rosita. Effects of chlorophyllin on transport of dibenzo(a, l)pyrene, 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, and aflatoxin B(1) across Caco-2 cell monolayers. Toxicology. 2004;196:117–125.

Egner Patricia A., Muñoz Alvaro, Kensler Thomas W.. Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin. Mutation research. 2003;523-524:209–216.

Díaz G. Darío, Li Qingjie, Dashwood Roderick H.. Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer research. 2003;63:1254–1261.

Breinholt V., Arbogast D., Loveland P., et al. Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms. Toxicology and applied pharmacology. 1999;158:141–151.

Yun C. H., Jeong H. G., Jhoun J. W., Guengerich F. P.. Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes. Carcinogenesis. 1995;16:1437–1440.

Breinholt V., Schimerlik M., Dashwood R., Bailey G.. Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen. Chemical research in toxicology. 1995;8:506–514.

Breinholt V., Hendricks J., Pereira C., Arbogast D., Bailey G.. Dietary chlorophyllin is a potent inhibitor of aflatoxin B1 hepatocarcinogenesis in rainbow trout. Cancer research. 1995;55:57–62.

Dashwood R. H., Breinholt V., Bailey G. S.. Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay. Carcinogenesis. 1991;12:939–942.

Whong W. Z., Stewart J., Brockman H. E., Ong T. M.. Comparative antimutagenicity of chlorophyllin and five other agents against aflatoxin B1-induced reversion in Salmonella typhimurium strain TA98. Teratogenesis, carcinogenesis, and mutagenesis. 1988;8:215–224.

 

Coffee

Cavin C., Marin-Kuan M., Langouët S., et al. Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008;46:1239–1248.

Huber Wolfgang W., Parzefall Wolfram. Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk. Methods in enzymology. 2005;401:307–341.

Batista Luis Roberto R., Chalfoun Sára Maria M., Prado Guilherme, Schwan Rosane Freitas F., Wheals Alan E.. Toxigenic fungi associated with processed (green) coffee beans (Coffea arabica L.). International journal of food microbiology. 2003;85:293–300.

Soliman K. M.. Incidence, level, and behavior of aflatoxins during coffee bean roasting and decaffeination. Journal of agricultural and food chemistry. 2002;50:7477–7481.

Huber Wolfgang W., Scharf Gerlinde, Rossmanith Walter, et al. The coffee components kahweol and cafestol induce gamma-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat. Archives of toxicology. 2002;75:685–694.

Cavin C., Mace K., Offord E. A., Schilter B.. Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2001;39:549–556.

Cavin C., Holzhäuser D., Constable A., Huggett A. C., Schilter B.. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis. 1998;19:1369–1375.

Micco C., Miraglia M., Brera C., Desiderio C., Masci V.. The effect of roasting on the fate of aflatoxin B1 in artificially contaminated green coffee beans. Mycotoxin research. 1992;8:93–97.

Rauch P., Víden I., Davídek T., Velísek J., Fukal L.. Caffeine as main interfering compound in radioimmunoassay of aflatoxin B1 in coffee samples. Journal – Association of Official Analytical Chemists. 1989;72:1015–1017.

Buchanan R. L., Lewis D. F.. Caffeine inhibition of aflatoxin synthesis: probable site of action. Applied and environmental microbiology. 1984;47:1216–1220.

 

Curcumin

Hu Y, Zhang J, Kong W, Zhao G, Yang M. Mechanisms of antifungal and anti-aflatoxigenic properties of essential oil derived from turmeric (Curcuma longa L.) on Aspergillus flavus. Food Chem. 2017 Apr 1;220:1-8. PMID: 27855875

Zhang NY, Qi M, Zhao L, Zhu MK, Guo J, Liu J, Gu CQ, Rajput SA, Krumm CS, Qi DS, Sun LH. Curcumin Prevents Aflatoxin B₁ Hepatoxicity by Inhibition of Cytochrome P450 Isozymes in Chick Liver. Toxins (Basel). 2016 Nov 10;8(11). pii: E327. PMID: 27834912

Abdel-Wahhab MA, Salman AS, Ibrahim MI, El-Kady AA, Abdel-Aziem SH, Hassan NS, Waly AI. Curcumin nanoparticles loaded hydrogels protects against aflatoxin B1-induced genotoxicity in rat liver. Food Chem Toxicol. 2016 Aug;94:159-71. PMID: 27288928

El-Barbary MI. Detoxification and antioxidant effects of garlic and curcumin in Oreochromis niloticus injected with aflatoxin B₁ with reference to gene expression of glutathione peroxidase (GPx) by RT-PCR. Fish Physiol Biochem. 2016 Apr;42(2):617-29. PMID: 26590820

Gholami-Ahangaran M, Rangsaz N, Azizi S. Evaluation of turmeric (Curcuma longa) effect on biochemical and pathological parameters of liver and kidney in chicken aflatoxicosis. Pharm Biol. 2016;54(5):780-7. PMID: 26450181

Poapolathep S, Imsilp K, Machii K, Kumagai S, Poapolathep A. The Effects of Curcumin on Aflatoxin B1- Induced Toxicity in Rats. Biocontrol Sci. 2015;20(3):171-7. PMID: 26412696

El-Mahalaway AM. Protective effect of curcumin against experimentally induced aflatoxicosis on the renal cortex of adult male albino rats: a histological and immunohisochemical study. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6019-30. PMID: 26261479

El-Bahr SM. Effect of curcumin on hepatic antioxidant enzymes activities and gene expressions in rats intoxicated with aflatoxin B1. Phytother Res. 2015 Jan;29(1):134-40. PMID: 25639897

Alm-Eldeen AA, Mona MH, Shati AA, El-Mekkawy HI. Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1 in rats. Toxicol Ind Health. 2015 Dec;31(12):1269-80. PMID: 23796760

Dos Anjos FR, Ledoux DR, Rottinghaus GE, Chimonyo M. Efficacy of adsorbents (bentonite and diatomaceous earth) and turmeric (Curcuma longa) in alleviating the toxic effects of aflatoxin in chicks. Br Poult Sci. 2015;56(4):459-69. PMID: 25990012

Alm-Eldeen Abeer A., Mona Mohamed H., Shati Ali A., El-Mekkawy Haitham I.. Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1 in rats. Toxicology and industrial health. 2013.

Darvesh Altaf S., Aggarwal Bharat B., Bishayee Anupam. Curcumin and liver cancer: a review. Current pharmaceutical biotechnology. 2012;13:218–228.

Jahanshiri Z., Shams-Ghahfarokhi M., Allameh A., Razzaghi-Abyaneh M.. Effect of Curcumin on Aspergillus parasiticus Growth and Expression of Major Genes Involved in the Early and Late Stages of Aflatoxin Biosynthesis. Iranian journal of public health. 2012;41:72–79.

Rangsaz Nader, Ahangaran Majid Gholami G.. Evaluation of turmeric extract on performance indices impressed by induced aflatoxicosis in broiler chickens. Toxicology and industrial health. 2011;27:956–960.

Nayak Sujatha, Sashidhar R. B.. Metabolic intervention of aflatoxin B1 toxicity by curcumin. Journal of ethnopharmacology. 2010;127:641–644.

El-Agamy Dina S.. Comparative effects of curcumin and resveratrol on aflatoxin B(1)-induced liver injury in rats. Archives of toxicology. 2010;84:389–396.

Yarru L. P., Settivari R. S., Gowda N. K., Antoniou E., Ledoux D. R., Rottinghaus G. E.. Effects of turmeric (Curcuma longa) on the expression of hepatic genes associated with biotransformation, antioxidant, and immune systems in broiler chicks fed aflatoxin. Poultry science. 2009;88:2620–2627.

Gross-Steinmeyer Kerstin, Stapleton Patricia L., Tracy Julia H., et al. Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols. Toxicological sciences : an official journal of the Society of Toxicology. 2009;112:303–310.

Gowda Nisarani K., Ledoux David R., Rottinghaus Goerge E., Bermudez Alex J., Chen Yin C.. Antioxidant efficacy of curcuminoids from turmeric ( Curcuma longa L.) powder in broiler chickens fed diets containing aflatoxin B1. The British journal of nutrition. 2009;102:1629–1634.

Verma Ramtej Jayram J., Mathuria Neeta. Effect of curcumin on aflatoxin-induced biochemical changes in testis of mice. Fertility and sterility. 2009;91:597–601.

Mathuria Neeta, Verma Ramtej Jayram J.. Curcumin ameliorates aflatoxin-induced toxicity in mice spermatozoa. Fertility and sterility. 2008;90:775–780.

Gowda N. K., Ledoux D. R., Rottinghaus G. E., Bermudez A. J., Chen Y. C.. Efficacy of turmeric (Curcuma longa), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks. Poultry science. 2008;87:1125–1130.

Mathuria Neeta, Verma Ramtej Jayram J.. Ameliorative effect of curcumin on aflatoxin-induced toxicity in serum of mice. Acta poloniae pharmaceutica. 2008;65:339–343.

Verma Ramtej J., Chakraborty Bhaswat S., Patel Chintan, Mathuria Neeta. Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice. Acta poloniae pharmaceutica. 2008;65:415–419.

Mathuria Neeta, Verma Ramtej Jayram J.. Aflatoxin induced hemolysis and its amelioration by turmeric extracts and curcumin in vitro. Acta poloniae pharmaceutica. 2007;64:165–168.

Mathuria Neeta, Verma Ramtej J.. Curcumin ameliorates aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice–an in vitro study. Acta poloniae pharmaceutica. 2007;64:413–416.

Mathuria Neeta, Verma Ramtej Jayram J.. Ameliorative effect of curcumin on aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice. Acta poloniae pharmaceutica. 2007;64:497–502.

Firozi P. F., Aboobaker V. S., Bhattacharya R. K.. Action of curcumin on the cytochrome P450-system catalyzing the activation of aflatoxin B1. Chemico-biological interactions. 1996;100:41–51.

Soni K. B., Rajan A., Kuttan R.. Reversal of aflatoxin induced liver damage by turmeric and curcumin. Cancer letters. 1992;66:115–121.

Verma Ramtej J., Mathuria Neeta. Curcumin ameliorates aflatoxin-induced lipid-peroxidation in liver and kidney of mice. Acta poloniae pharmaceutica. 2008;65:195–202.

 

DHEA

Orner G. A., Hendricks J. D., Arbogast D., Williams D. E.. Modulation of aflatoxin-B1 hepatocarcinogenesis in trout by dehydroepiandrosterone: initiation/post-initiation and latency effects. Carcinogenesis. 1998;19:161–167.

Prasanna H. R., Lu M. H., Beland F. A., Hart R. W.. Inhibition of aflatoxin B1 binding to hepatic DNA by dehydroepiandrosterone in vivo. Carcinogenesis. 1989;10:2197–2200.

Schwartz A. G., Perantoni A.. Protective effect of dehydroepiandrosterone against aflatoxin B1-and 7,12-dimethylbenz(a)anthracene-induced cytotoxicity and transformation in cultured cells. Cancer research. 1975;35:2482–2487.

 

Dietary Fats

Raju M. V., Rama Rao S. V., Radhika K., Panda A. K.. Effect of amount and source of supplemental dietary vegetable oil on broiler chickens exposed to aflatoxicosis. British poultry science. 2005;46:587–594.

Nyandieka H. S.. Effects of dietary fat and aflatoxin B1 on microsomal monooxygenase activity. Archives of toxicology. 1987;60:59–60.

Rogers A. E., Newberne P. M.. Aflatoxin B1 carcinogenesis in lipotrope-deficient rats. Cancer research. 1969;29:1965–1972.

 

Dietary Proteins/Amino Acids

Chen X, Zhang Q, Applegate TJ. Impact of dietary branched chain amino acids concentration on broiler chicks during aflatoxicosis. Poult Sci. 2016 Jun 1;95(6):1281-9. PMID: 26957625

Chen X, Naehrer K, Applegate TJ. Interactive effects of dietary protein concentration and aflatoxin B1 on performance, nutrient digestibility, and gut health in broiler chicks. Poult Sci. 2016 Jun 1;95(6):1312-25. PMID: 26944977

Fleming S. E., Youngman L. D., Ames B. N.. Intestinal cell proliferation is influenced by intakes of protein and energy, aflatoxin, and whole-body radiation. Nutrition and cancer. 1994;22:11–30.

Abdelhamid A. M., Dorra T. M., Mansy S. E., Sallam A. E.. Effect of raising dietary protein, amino acids and/or energy levels as an attempt to alleviate severity of the chronic aflatoxicosis by broiler chicks. 2. Biochemical characteristics. Archiv für Tierernährung. 1994;46:347–355.

Abdelhamid A. M., Dorra T. M., Mansy S. E., Sallam A. E.. Effect of raising dietary protein, amino acids and/or energy levels as an attempt to alleviate severity of the chronic aflatoxicosis by broiler chicks. 1. Performance and toxicity symptoms. Archiv für Tierernährung. 1994;46:339–345.

Mandel H. G., Judah D. J., Neal G. E.. Effect of dietary protein level on aflatoxin B1 actions in the liver of weanling rats. Carcinogenesis. 1992;13:1853–1857.

Horio F., Youngman L. D., Bell R. C., Campbell T. C.. Thermogenesis, low-protein diets, and decreased development of AFB1-induced preneoplastic foci in rat liver. Nutrition and cancer. 1991;16:31–41.

Mathur M., Rizvi T. A., Nayak N. C.. Effect of low protein diet on chronic aflatoxin B1-induced liver injury in rhesus monkeys. Mycopathologia. 1991;113:175–179.

Schulsinger D. A., Root M. M., Campbell T. C.. Effect of dietary protein quality on development of aflatoxin B1-induced hepatic preneoplastic lesions. Journal of the National Cancer Institute. 1989;81:1241–1245.

Coffey M. T., Hagler W. M., Cullen J. M.. Influence of dietary protein, fat or amino acids on the response of weanling swine to aflatoxin B1. Journal of animal science. 1989;67:465–472.

Dunaif G. E., Campbell T. C.. Dietary protein level and aflatoxin B1-induced preneoplastic hepatic lesions in the rat. The Journal of nutrition. 1987;117:1298–1302.

Richardson K. E., Nelson L. A., Hamilton P. B.. Interaction of dietary protein level on dose response relationships during aflatoxicosis in young chickens. Poultry science. 1987;66:969–976.

Dunaif G. E., Campbell T. C.. Relative contribution of dietary protein level and aflatoxin B1 dose in generation of presumptive preneoplastic foci in rat liver. Journal of the National Cancer Institute. 1987;78:365–369.

Ostrowski-Meissner H. T.. Effect of dietary aflatoxins on protein and energy utilization by two indonesian breeds of ducklings (Alabio and Tegal). Poultry science. 1983;62:599–607.

Appleton B. S., Campbell T. C.. Dietary protein intervention during the postdosing phase of aflatoxin B1-induced hepatic preneoplastic lesion development. Journal of the National Cancer Institute. 1983;70:547–549.

Prince L. O., Campbell T. C.. Effects of sex difference and dietary protein level on the binding of aflatoxin B1 to rat liver chromatin proteins in vivo. Cancer research. 1982;42:5053–5059.

Mainigi K. D.. Effects of low level of dietary protein and estrogen administration on the aflatoxin-protein complexes in rat liver cytosol. Toxicology letters. 1982;14:57–62.

Davis G. R.. Growth of larvae of Tenebrio molitor L. fed diets containing penicillic acid, aflatoxin B1, ochratoxin A, or rubratoxin B at three dietary protein levels (1). Archives internationales de physiologie et de biochimie. 1982;90:297–300.

Thabrew M. I., Obasi S. C., Emerole G. O.. Further studies on microsomal drug metabolizing enzyme activity and protein levels in animal models showing different susceptibilities to aflatoxicosis. Comparative biochemistry and physiology. C: Comparative pharmacology. 1982;73:289–292.

Appleton B. S., Campbell T. C.. Inhibition of aflatoxin-initiated preneoplastic liver lesions by low dietary protein. Nutrition and cancer. 1982;3:200–206.

Mainigi K. D., Campbell T. C.. Effects of low dietary protein and dietary aflatoxin on hepatic glutathione levels in F-344 rats. Toxicology and applied pharmacology. 1981;59:196–203.

Mirmomeni M. H., Suzangar M., Wise A., Messripour M., Emami H.. Biochemical studies during aflatoxin B1-induced liver damage in rats fed different levels of dietary protein. International journal of cancer. Journal international du cancer. 1979;24:471–476.

Stott W. T., Sinnhuber R. O.. Dietary protein levels and aflatoxin B metabolism in rainbow trout (Salmo gairdneri). Journal of environmental pathology and toxicology. 1978;2:379–388.

Lee D. J., Sinnhuber R. O., Wales J. H., Putnam G. B.. Effect of dietary protein on the response of rainbow trout (Salmo gairdneri) to aflatoxin B1. Journal of the National Cancer Institute. 1978;60:317–320.

Adekunle A. A., Hayes J. R., Campbell T. C.. Effect of protein deficiency on the hepatic microsomal mixed function oxidase. III-Influence on aflatoxin B1 metabolism and epoxide hydrase activity. Biochemistry and experimental biology. 1978;14:45–53.

Adekunle A. A., Hayes J. R., Campbell T. C.. Interrelationships of dietary protein level, aflatoxin B metabolism, and hepatic microsomal epoxide hydrase activity. Life sciences. 1977;21:1785–1792.

Preston R. S., Hayes J. R., Campbell T. C.. The effect of protein deficiency on the in vivo binding of aflatoxin B1 to rat liver macromolecules. Life sciences. 1976;19:1191–1197.

Wells P., Aftergood L., Alfin-Slater R. B.. Effect of varying levels of dietary protein on tumor development and lipid metabolism in rats exposed to aflatoxin. Journal of the American Oil Chemists’ Society. 1976;53:559–562.

Ashoor S. H., Chu F. S.. Interaction of aflatoxin B2a with amino acids and proteins. Biochemical pharmacology. 1975;24:1799–1805.

Sisk D. B., Carlton W. W.. Effect of dietary protein concentration on response of miniature swine to aflatoxins. American journal of veterinary research. 1972;33:107–114.

Pokrovskiĭ A. A., Valdes-Mendosa V., Staneva M. P., et al. [Aflatoxin effect on the liver with different protein allowances in the organism]. Voprosy pitaniia. 1969;28:3–8.

Hsu L. C., Tung T. C.. Effects of a low protein diet on aflatoxin toxicity in rats. Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association. 1969;68:468–477.

Madhavan T. V., Gopalan C.. The effect of dietary protein on carcinogenesis of aflatoxin. Archives of pathology. 1968;85:133–137.

Effect of dietary protein level on aflatoxin liver injury. Nutrition reviews. 1967;25:26–28.

Protein intake and aflatoxin injury in rats. Nutrition reviews. 1966;24:146–147.

Madhavan T. V., Rao K. S., Tulpule P. G.. Effect of dietary protein level on susceptibility of monkeys to aflatoxin liver injury. The Indian journal of medical research. 1965;53:984–989.

Madhavan T.V., Gopalan C., Effect of Dietary Protein on aflatoxin liver injury in weaning rats. Archives of pathology. 1965;80:123–126.

 

Garlic

Larypoor Mohaddeseh, Bayat Mansour, Zuhair Mohammad Hassan H., Akhavan Sepahy Abbas, Amanlou Masoud. Evaluation of The Number of CD4(+) CD25(+) FoxP3(+) Treg Cells in Normal Mice Exposed to AFB1 and Treated with Aged Garlic Extract. Cell journal. 2013;15:37–44.

Bergès Raymond, Siess Marie-Hélène H., Arnault Ingrid, et al. Comparison of the chemopreventive efficacies of garlic powders with different alliin contents against aflatoxin B1 carcinogenicity in rats. Carcinogenesis. 2004;25:1953–1959.

Guyonnet Denis, Belloir Christine, Suschetet Marc, Siess Marie-Hélène H., Le Bon Anne-Marie M.. Mechanisms of protection against aflatoxin B(1) genotoxicity in rats treated by organosulfur compounds from garlic. Carcinogenesis. 2002;23:1335–1341.

Sheen L. Y., Wu C. C., Lii C. K., Tsai S. J.. Effect of diallyl sulfide and diallyl disulfide, the active principles of garlic, on the aflatoxin B(1)-induced DNA damage in primary rat hepatocytes. Toxicology letters. 2001;122:45–52.

Mofty M. M., Sakr S. A., Essawy A., Abdel Gawad H. S.. Preventive action of garlic on aflatoxin B1-induced carcinogenesis in the toad Bufo regularis. Nutrition and cancer. 1994;21:95–100.

Yamasaki T., Teel R. W., Lau B. H.. Effect of allixin, a phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1. Cancer letters. 1991;59:89–94.

Tadi P. P., Teel R. W., Lau B. H.. Organosulfur compounds of garlic modulate mutagenesis, metabolism, and DNA binding of aflatoxin B1. Nutrition and cancer. 1991;15:87–95.

 

Ginseng

Hassan AM, Abdel-Aziem SH, El-Nekeety AA, Abdel-Wahhab MA. Panax ginseng extract modulates oxidative stress, DNA fragmentation and up-regulate gene expression in rats sub chronically treated with aflatoxin B1 and fumonisin B 1. Cytotechnology. 2015 Oct;67(5):861-71. PMID: 24748134

Kim Yong-Seong S., Kim Yong-Hoon H., Noh Jung-Ran R., Cho Eun-Sang S., Park Jong-Ho H., Son Hwa-Young Y.. Protective Effect of Korean Red Ginseng against Aflatoxin B1-Induced Hepatotoxicity in Rat. Journal of ginseng research. 2011;35:243–249.

Abdel-Wahhab Mosaad A., Hassan Nabila S., El-Kady Ahmed A., et al. Red ginseng extract protects against aflatoxin B1 and fumonisins-induced hepatic pre-cancerous lesions in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010;48:733–742.

 

Indole-3-Carbinol

Manson M. M., Hudson E. A., Ball H. W., et al. Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver–predicting the outcome using early biomarkers. Carcinogenesis. 1998;19:1829–1836.

Takahashi N., Stresser D. M., Williams D. E., Bailey G. S.. Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1 hepatocarcinogenesis in rainbow trout. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1995;33:841–850.

Stresser D. M., Bailey G. S., Williams D. E.. Indole-3-carbinol and beta-naphthoflavone induction of aflatoxin B1 metabolism and cytochromes P-450 associated with bioactivation and detoxication of aflatoxin B1 in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1994;22:383–391.

Dashwood R. H., Fong A. T., Williams D. E., Hendricks J. D., Bailey G. S.. Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency. Cancer research. 1991;51:2362–2365.

Bailey G. S., Dashwood R. H., Fong A. T., Williams D. E., Scanlan R. A., Hendricks J. D.. Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion. IARC scientific publications. 1991:275–280.

Fong A. T., Swanson H. I., Dashwood R. H., Williams D. E., Hendricks J. D., Bailey G. S.. Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation. Biochemical pharmacology. 1990;39:19–26.

Dashwood R. H., Fong A. T., Hendricks J. D., Bailey G. S.. Tumor dose-response studies with aflatoxin B1 and the ambivalent modulator indole-3-carbinol: inhibitory versus promotional potency. Basic life sciences. 1990;52:361–365.

Dashwood R. H., Arbogast D. N., Fong A. T., Hendricks J. D., Bailey G. S.. Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1. Carcinogenesis. 1988;9:427–432.

Goeger D. E., Shelton D. W., Hendricks J. D., Bailey G. S.. Mechanisms of anti-carcinogenesis by indole-3-carbinol: effect on the distribution and metabolism of aflatoxin B1 in rainbow trout. Carcinogenesis. 1986;7:2025–2031.

Nixon J. E., Hendricks J. D., Pawlowski N. E., Pereira C. B., Sinnhuber R. O., Bailey G. S.. Inhibition of aflatoxin B1 carcinogenesis in rainbow trout by flavone and indole compounds. Carcinogenesis. 1984;5:615–619.

Eisele T. A., Bailey G. S., Nixon J. E.. The effect of indole-3-carbinol, an aflatoxin B1 hepatocarcinoma inhibitor, and other indole analogs on the rainbow trout hepatic mixed function oxidase system. Toxicology letters. 1983;19:133–138.

Oganesian A., Hendricks J. D., Pereira C. B., Orner G. A., Bailey G. S., Williams D. E.. Potency of dietary indole-3-carbinol as a promoter of aflatoxin B1-initiated hepatocarcinogenesis: results from a 9000 animal tumor study. Carcinogenesis. 1999;20:453–458.

Stresser D. M., Williams D. E., McLellan L. I., Harris T. M., Bailey G. S.. Indole-3-carbinol induces a rat liver glutathione transferase subunit (Yc2) with high activity toward aflatoxin B1 exo-epoxide. Association with reduced levels of hepatic aflatoxin-DNA adducts in vivo. Drug metabolism and disposition: the biological fate of chemicals. 1994;22:392–399.

 

Lipoic Acid

Ma Q, Li Y, Fan Y, Zhao L, Wei H, Ji C, Zhang J. Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin B₁-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers. Toxins (Basel). 2015 Dec 14;7(12):5435-47. PMID: 26694462

Li Y, Ma QG, Zhao LH, Guo YQ, Duan GX, Zhang JY, Ji C. Protective Efficacy of Alpha-lipoic Acid against AflatoxinB1-induced Oxidative Damage in the Liver. Asian-Australas J Anim Sci. 2014 Jun;27(6):907-15. PMID: 25050030

Li Y, Ma QG, Zhao LH, Wei H, Duan GX, Zhang JY, Ji C. Effects of lipoic acid on immune function, the antioxidant defense system, and inflammation-related genes expression of broiler chickens fed aflatoxin contaminated diets. Int J Mol Sci. 2014 Apr 2;15(4):5649-62. PMID: 24699046

Karaman M., Ozen H., Tuzcu M., Ciğremiş Y., Onder F., Ozcan K.. Pathological, biochemical and haematological investigations on the protective effect of alpha-lipoic acid in experimental aflatoxin toxicosis in chicks. British poultry science. 2010;51:132–141.

 

Melatonin

Esteban-Zubero E, Alatorre-Jiménez MA, López-Pingarrón L, Reyes-Gonzales MC, Almeida-Souza P, Cantín-Golet A, Ruiz-Ruiz FJ, Tan DX, García JJ, Reiter RJ. Melatonin’s role in preventing toxin-related and sepsis-mediated hepatic damage: A review. Pharmacol Res. 2016 Mar;105:108-20. PMID: 26808084

Ozen Hasan, Karaman Musa, Ciğremiş Yilmaz, Tuzcu Mehmet, Ozcan Kadir, Erdağ Dinçer. Effectiveness of melatonin on aflatoxicosis in chicks. Research in veterinary science. 2009;86:485–489.

Gesing Adam, Karbownik-Lewinska Malgorzata. Protective effects of melatonin and N-acetylserotonin on aflatoxin B1-induced lipid peroxidation in rats. Cell biochemistry and function. 2008;26:314–319.

Meki Abdel-Raheim R., Esmail Emade El-Dein e. l. . D., Hussein Ahmed A., Hassanein Hamdy M.. Caspase-3 and heat shock protein-70 in rat liver treated with aflatoxin B1: effect of melatonin. Toxicon. 2004;43:93–100.

El-Gibaly I., Meki A. M., Abdel-Ghaffar S. K.. Novel B melatonin-loaded chitosan microcapsules: in vitro characterization and antiapoptosis efficacy for aflatoxin B1-induced apoptosis in rat liver. International journal of pharmaceutics. 2003;260:5–22.

Awney Hala A., Attih Ahmed M., Habib Sami L., Mostafa Mostafa H.. Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1). Toxicology. 2002;172:143–148.

Meki A. R., Abdel-Ghaffar S. K., El-Gibaly I.. Aflatoxin B1 induces apoptosis in rat liver: protective effect of melatonin. Neuro endocrinology letters. 2001;22:417–426.

 

Nutrients

Khan Wajid Arshad A., Khan Muhammad Zargham Z., Khan Ahrar, Ul Hassan Zahoor, Saleemi Muhammad Kashif K.. Potential for amelioration of aflatoxin B1-induced immunotoxic effects in progeny of white leghorn breeder hens co-exposed to vitamin E. Journal of immunotoxicology. 2013.

Alpsoy Lokman, Yalvac Mehmet Emir E.. Key roles of vitamins A, C, and E in aflatoxin B1-induced oxidative stress. Vitamins and hormones. 2011;86:287–305.

Tang L., Xu L., Afriyie-Gyawu E., et al. Aflatoxin-albumin adducts and correlation with decreased serum levels of vitamins A and E in an adult Ghanaian population. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2009;26:108–118.

Alpsoy L., Agar G., Ikbal M.. Protective role of vitamins A, C, and E against the genotoxic damage induced by aflatoxin B1 in cultured human lymphocytes. Toxicology and industrial health. 2009;25:183–188.

Alpsoy L., Yildirim A., Agar G.. The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes. Toxicology and industrial health. 2009;25:121–127.

Verma Ramtej J., Nair Anita, Mathuria Neeta. Vitamin E ameliorates aflatoxin-induced alterations in the epididymis of mice. Acta poloniae pharmaceutica. 2008;65:331–337.

Pimpukdee K., Kubena L. F., Bailey C. A., Huebner H. J., Afriyie-Gyawu E., Phillips T. D.. Aflatoxin-induced toxicity and depletion of hepatic vitamin A in young broiler chicks: protection of chicks in the presence of low levels of NovaSil PLUS in the diet. Poultry science. 2004;83:737–744.

Karakilcik Ali Ziya Z., Zerin Mustafa, Arslan Oktay, Nazligul Yasar, Vural Huseyin. Effects of vitamin C and E on liver enzymes and biochemical parameters of rabbits exposed to aflatoxin B1. Veterinary and human toxicology. 2004;46:190–192.

Cabassi E., Di Lecce R., De Angelis E., Fusari A., Perillo A., Borghetti P.. Aflatoxicosis and vitamins A and E supplementation in sows: immunological state of their piglets. Veterinary research communications. 2004;28 Suppl 1:275–277.

Sahoo P. K., Mukherjee S. C.. Immunomodulation by dietary vitamin C in healthy and aflatoxin B1-induced immunocompromised rohu (Labeo rohita). Comparative immunology, microbiology and infectious diseases. 2003;26:65–76.

Verma R. J., Nair A.. Effect of aflatoxins on testicular steroidogenesis and amelioration by vitamin E. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2002;40:669–672.

Verma R. J., Nair A.. Ameliorative effect of vitamin E on aflatoxin-induced lipid peroxidation in the testis of mice. Asian journal of andrology. 2001;3:217–221.

Salem M. H., Kamel K. I., Yousef M. I., Hassan G. A., EL-Nouty F. D.. Protective role of ascorbic acid to enhance semen quality of rabbits treated with sublethal doses of aflatoxin B(1). Toxicology. 2001;162:209–218.

Verma R. J., Shukla R. S., Mehta D. N.. Amelioration of cytotoxic effects of aflatoxin by vitamin A: an in vitro study on erythrocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2001;15:39–42.

Verma R. J., Nair A.. Vitamin E ameliorates aflatoxin-induced biochemical changes in the testis of mice. Asian journal of andrology. 2001;3:305–309.

Webster R. P., Gawde M. D., Bhattacharya R. K.. Effect of different vitamin A status on carcinogen-induced DNA damage and repair enzymes in rats. In vivo (Athens, Greece). 1996;10:113–118.

Harvey R. B., Kubena L. F., Elissalde M. H.. Influence of vitamin E on aflatoxicosis in growing swine. American journal of veterinary research. 1994;55:572–577.

Yu M. W., Zhang Y. J., Blaner W. S., Santella R. M.. Influence of vitamins A, C, and E and beta-carotene on aflatoxin B1 binding to DNA in woodchuck hepatocytes. Cancer. 1994;73:596–604.

Sinha S. P., Dharmshila K.. Vitamin A ameliorates the genotoxicity in mice of aflatoxin B1-containing Aspergillus flavus infested food. Cytobios. 1994;79:85–95.

Cassand P., Decoudu S., Lévêque F., Daubèze M., Narbonne J. F.. Effect of vitamin E dietary intake on in vitro activation of aflatoxin B1. Mutation research. 1993;319:309–316.

Decoudu S., Cassand P., Daubèze M., Frayssinet C., Narbonne J. F.. Effect of vitamin A dietary intake on in vitro and in vivo activation of aflatoxin B1. Mutation research. 1992;269:269–278.

Glahn R. P., Beers K. W., Bottje W. G., Wideman R. F., Huff W. E., Thomas W.. Aflatoxicosis alters avian renal function, calcium, and vitamin D metabolism. Journal of toxicology and environmental health. 1991;34:309–321.

Sergeev I. N., Piliia N. M., Kuz’mina E. E., et al. [Calcium and vitamin D metabolism and enzymes of xenobiotic metabolism during chronic action of mycotoxins]. Voprosy pitaniia. 1990:25–30.

Liu X. L., Zhou Y. Z.. [The effect of aflatoxin B1 on vitamin A status and on microsomal mixed function oxidase in male mouse]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 1989;23:218–221.

Bhattacharya R. K., Prabhu A. L., Aboobaker V. S.. In vivo effect of dietary factors on the molecular action of aflatoxin B1: role of vitamin A on the catalytic activity of liver fractions. Cancer letters. 1989;44:83–88.

Sergeev I. N., Arkhapchev Iu u. P., Kravchenko L. V., Kodentsova V. M., Piliia N. M.. [Effect of mycotoxins aflatoxin B1 and T-2 toxin on the vitamin D3 metabolism and binding of its hormonal form 1,25-dihydroxyvitamin D3 in rats]. Voprosy medit͡sinskoĭ khimii. 1988;34:51–57.

Asuzu I. U., Shetty S. N., Obidoa O.. The interaction of aflatoxin B1 with vitamin K, phenylbutazone, and sulfamethoxine in rats. Biochemical medicine and metabolic biology. 1988;39:158–167.

Bhattacharya R. K., Francis A. R., Shetty T. K.. Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of vitamins. Mutation research. 1987;188:121–128.

Firozi P. F., Aboobaker V. S., Bhattacharya R. K.. Action of vitamin A on DNA adduct formation by aflatoxin B1 in a microsome catalyzed reaction. Cancer letters. 1987;34:213–220.

Qin S., Huang C. C.. Influence of mouse liver stored vitamin A on the induction of mutations (Ames tests) and SCE of bone marrow cells by aflatoxin B1, benzo(a)pyrene, or cyclophosphamide. Environmental mutagenesis. 1986;8:839–847.

Vishwanath P., Basappa S. C., Murthy V. S.. Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium. Folia microbiologica. 1986;31:272–276.

Raina V., Gurtoo H. L.. Effects of vitamins A, C, and E on aflatoxin B1-induced mutagenesis in Salmonella typhimurium TA-98 and TA-100. Teratogenesis, carcinogenesis, and mutagenesis. 1985;5:29–40.

Nassar A. Y., Galal A. F., Mohamed M. A., Megalla S. E., Hafez A. H.. The effect of aflatoxin B1 on the utilization of serum calcium. Mycopathologia. 1985;91:127–131.

Emerole G. O., Thabrew M. I., Kwanashie H. O.. Effect of dietary vitamin E (alpha-tocopherol) on aflatoxin B metabolism. European journal of drug metabolism and pharmacokinetics. 1984;9:295–300.

Domngang F.. Hydroxylation activity of aflatoxin B1, and effect of vitamin C on rabbits. Biochemical pharmacology. 1983;32:2451–2453.

Israels L. G., Walls G. A., Ollmann D. J., Friesen E., Israels E. D.. Vitamin K as a regulator of benzo(a)pyrene metabolism, mutagenesis, and carcinogenesis. Studies with rat microsomes and tumorigenesis in mice. The Journal of clinical investigation. 1983;71:1130–1140.

Suphakarn V. S., Newberne P. M., Goldman M.. Vitamin A and aflatoxin: effect on liver and colon cancer. Nutrition and cancer. 1983;5:41–50.

Ahmed N., Jaiswal A. K., Vanamayya P. R.. Inhibition of ascorbate-induced and NADPH-dependent lipid peroxidation in hepatic nuclei by aflatoxin B1. Toxicon. 1983;21:562–566.

Uwaifo O. A.. Reversion by vitamin K of aflatoxin B1 (AFB)-induced inhibition of oxygen uptake in three AFB-susceptible bacteria. Toxicology letters. 1983;15:57–60.

Domngang F., Emerole G.. Metabolism of aflatoxin B1 (AFB1), aflatoxin G1 (AFG1) and vitamin C intake by guinea pig liver preparation in vitro. Biochemical pharmacology. 1982;31:2327–2330.

Nair C. R., Chauhan D. P., Gupta P. H., Mehta S. K.. Intestinal drug metabolizing systems (phase I and phase II) in rats fed vitamin A-deficient diet and aflatoxin B1. Digestion. 1982;24:190–194.

Huang C. C., Hsueh J. L., Chen H. H., Batt T. R.. Retinol (vitamin A) inhibits sister chromatid exchanges and cell cycle delay induced by cyclophosphamide and aflatoxin B1 in Chinese hamster V79 cells. Carcinogenesis. 1982;3:1–5.

Viogt M. N., Clarke J. D., Jain A. V., Ayres J. C., Koehler P. E., Hatch R. C.. Abnormal concentrations of B vitamins and amino acids in plasma and B vitamins in bile of rabbits with aflatoxicosis. Applied and environmental microbiology. 1981;41:919–923.

Domngang F., Bassir O.. Studies on the in vitro metabolism of aflatoxin B1 and G1 in the liver of rats fed at various levels of vitamin C. Biochemical pharmacology. 1981;30:3317–3322.

Bassir O., Adekunle A. A., Okoye Z. S.. Effect of vitamin A deficiency of anticoagulant action of aflatoxin B1. Toxicon. 1980;18:121–123.

Voigt M. N., Wyatt R. D., Ayres J. C., Koehler P. E.. Abnormal concentrations of B vitamins and amino acids in plasma, bile, and liver of chicks with aflatoxicosis. Applied and environmental microbiology. 1980;40:870–875.

Busk L., Ahlborg U. G.. Retinol (vitamin A) as an inhibitor of the mutagenicity of aflatoxin B. Toxicology letters. 1980;6:243–249.

Okoye Z. S., Adekunle A. A., Bassir O.. Aflatoxin B1 hydroxylation in vitamin A- and C-deficient guineapig liver. Indian journal of experimental biology. 1980;18:1024–1025.

Lanza G. M., Washburn K. W., Wyatt R. D., Edwards H. M.. Depressed 59 Fe absorption due to dietary aflatoxin. Poultry science. 1979;58:1439–1444.

Bryden W. L., Cumming R. B., Balnave D.. The influence of vitamin A status on the response of chickens to aflatoxin B1 and changes in liver lipid metabolism associated with aflatoxicosis. The British journal of nutrition. 1979;41:529–540.

Temcharoen P., Anukarahanonta T., Bhamarapravati N.. Influence of dietary protein and vitamin B12 on the toxicity and carcinogenicity of aflatoxins in rat liver. Cancer research. 1978;38:2185–2190.

Bassir O., Adekunle A. A., Okoye Z. S.. Effect of vitamin A deficiency and excess on aflatoxin metabolism in the rabbit. Biochemical pharmacology. 1978;27:833–838.

Adekunle A. A., Campbell T. C., Campbell S. C.. Aflatoxin metabolism and absence of cytochrome P-450 in rat colon tissue during vitamin A malnutrition. Experientia. 1978;34:230–232.

Adekunle A. A., Campbell S. W., Campbell T. C.. Effect of vitamin A deficiency on hepatic microsomal and colon mucosal mixed function oxidase. IV–Influence on aflatoxin B1 metabolism, ethylmorphine and epoxide hydrase activity. Biochemistry and experimental biology. 1978;14:55–64.

Britton W. M., Wyatt R. D.. Effect of dietary aflatoxin on vitamin D3 metabolism in chicks. Poultry science. 1978;57:163–165.

Hamilton P. B.. Interrelationships of mycotoxins with nutrition. Federation proceedings. 1977;36:1899–1902.

Bai N. J., Pai M. R., Venkitasubramanian T. A.. Carbohydrate metabolism in aflatoxin toxicity. Indian journal of biochemistry & biophysics. 1977;14:86–88.

Raj H. G., Venkitasubramanian T. A.. Carbohydrate metabolism in aflatoxin B-1 toxicity. Environmental physiology & biochemistry. 1974;4:181–187.

Hamilton P. B., Tung H. T., Wyatt R. D., Donaldson W. E.. Interaction of dietary aflatoxin with some vitamin deficiencies. Poultry science. 1974;53:871–877.

Reddy G. S., Tilak T. B., Krishnamurthi D.. Susceptibility of vitamin A-deficient rats to aflatoxin. Food and cosmetics toxicology. 1973;11:467–470.

Newberne P. M., Rogers A. E.. Rat colon carcinomas associated with aflatoxin and marginal vitamin A. Journal of the National Cancer Institute. 1973;50:439–448.

Hamilton P. B., Garlich J. D.. Failure of vitamin supplementation to alter the fatty liver syndrome caused by aflatoxin. Poultry science. 1972;51:688–692.

 

Oltipraz

Kuilman M. E., Maas R. F., Nijnanten F. M., Fink-Gremmels J.. Inhibition of aflatoxin M1 production by bovine hepatocytes after intervention with oltipraz. The Veterinary quarterly. 2000;22:30–35.

Bammler T. K., Slone D. H., Eaton D. L.. Effects of dietary oltipraz and ethoxyquin on aflatoxin B1 biotransformation in non-human primates. Toxicological sciences : an official journal of the Society of Toxicology. 2000;54:30–41.

Li Y., Su J., Qin L., et al. Reduction of aflatoxin B(1) adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis). Cancer letters. 2000;154:79–83.

Chi W. J., Doong S. L., Lin-Shiau S. Y., Boone C. W., Kelloff G. J., Lin J. K.. Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein. Carcinogenesis. 1998;19:2133–2138.

Langouët S., Mahéo K., Berthou F., et al. Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture. Carcinogenesis. 1997;18:1343–1349.

Scholl P., Musser S. M., Kensler T. W., Groopman J. D.. Inhibition of aflatoxin Ml excretion in rat urine during dietary intervention with oltipraz. Carcinogenesis. 1996;17:1385–1388.

Buetler T. M., Bammler T. K., Hayes J. D., Eaton D. L.. Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention. Cancer research. 1996;56:2306–2313.

Langouët S., Coles B., Morel F., et al. Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture. Cancer research. 1995;55:5574–5579.

Primiano T., Egner P. A., Sutter T. R., Kelloff G. J., Roebuck B. D., Kensler T. W.. Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases. Cancer research. 1995;55:4319–4324.

Egner P. A., Gange S. J., Dolan P. M., Groopman J. D., Muñoz A., Kensler T. W.. Levels of aflatoxin-albumin biomarkers in rat plasma are modulated by both long-term and transient interventions with oltipraz. Carcinogenesis. 1995;16:1769–1773.

Bolton M. G., Muñoz A., Jacobson L. P., et al. Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis. Cancer research. 1993;53:3499–3504.

Roebuck B. D., Liu Y. L., Rogers A. E., Groopman J. D., Kensler T. W.. Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry. Cancer research. 1991;51:5501–5506.

Liu Y. L., Roebuck B. D., Yager J. D., Groopman J. D., Kensler T. W.. Protection by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B1 in the rat. Toxicology and applied pharmacology. 1988;93:442–451.

Kensler T. W., Egner P. A., Dolan P. M., Groopman J. D., Roebuck B. D.. Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones. Cancer research. 1987;47:4271–4277.

 

Phenobarbitol

Govindwar S. P., Adav S. S.. Effects of aflatoxin B1 on the hepatic microsomal mixed function oxidase system during phenobarbital and benzo(a)pyrene treatment in chickens. Veterinary and human toxicology. 1999;41:210–212.

Gopalan P., Tsuji K., Lehmann K., et al. Modulation of aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci by pretreatment of rats with phenobarbital and buthionine sulfoximine. Carcinogenesis. 1993;14:1469–1470.

Lin D. X.. [Effects of harman and norharman on aflatoxin B1 and aminopyrine metabolism by phenobarbital and 3-methylcholanthrene-induced rat liver microsomes]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 1992;26:209–212.

Chen Z. Y., Eaton D. L.. Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats. Toxicology and applied pharmacology. 1991;111:132–144.

Manning R. O., Wyatt R. D., Marks H. L.. Effects of phenobarbital and beta-naphthoflavone on the in vivo toxicity and in vitro metabolism of aflatoxin in an aflatoxin-resistant and control line of chickens. Journal of toxicology and environmental health. 1990;31:291–311.

Lotlikar P. D., Raj H. G., Bohm L. S., et al. A mechanism of inhibition of aflatoxin B1-DNA binding in the liver by phenobarbital pretreatment of rats. Cancer research. 1989;49:951–957.

Holeski C. J., Eaton D. L., Monroe D. H., Bellamy G. M.. Effects of phenobarbital on the biliary excretion of aflatoxin P1-glucuronide and aflatoxin B1-S-glutathione in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1987;17:139–153.

Shirai T., Imaida K., Ohshima M., et al. Different responses to phenobarbital promotion in the development of gamma-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2-acetyl-aminofluorene and aflatoxin B1. Japanese journal of cancer research : Gann. 1985;76:16–19.

Loury D. J., Hsieh D. P., Byard J. L.. The effect of phenobarbital pretreatment on the metabolism, covalent binding, and cytotoxicity of aflatoxin B1 in primary cultures of rat hepatocytes. Journal of toxicology and environmental health. 1984;13:145–159.

Faris R. A., Campbell T. C.. Long-term effects of neonatal phenobarbital exposure on aflatoxin b1 disposition in adult rats. Cancer research. 1983;43:2576–2583.

McGrew P. B., Barnhart H. M., Mertens D. R., Wyatt R. D.. Some effects of phenobarbital dosing of dairy cattle on aflatoxin M1 and fat in milk. Journal of dairy science. 1982;65:1227–1233.

Wong Z. A., Wei C. I., Rice D. W., Hsieh D. P.. Effects of phenobarbital pretreatment on the metabolism and toxicokinetics of aflatoxin B1 in the rhesus monkey. Toxicology and applied pharmacology. 1981;60:387–397.

Metcalfe S. A., Colley P. J., Neal G. E.. A comparison of the effects of pretreatment with phenobarbitone and 3-methylcholanthrene on the metabolism of aflatoxin B1 by rat liver microsomes and isolated hepatocytes in vitro. Chemico-biological interactions. 1981;35:145–157.

Neal G. E., Godoy H. M.. The effect of pre-treatment with phenobarbitone on the activation of aflatoxin B1 by rat liver. Chemico-biological interactions. 1976;14:279–289.

Moulé Y., Lesage V., Darracq N., Rousseau N.. Opposite effects of phenobarbital pretreatment on aflatoxin B1-induced inhibition of transcription in rat and mouse liver. Biochemical pharmacology. 1975;24:1851–1854.

Mgbodile M. U., Holscher M., Neal R. A.. A possible protective role for reduced glutathione in aflatoxin B1 toxicity: effect of pretreatment of rats with phenobarbital and 3-methylcholanthrene on aflatoxin toxicity. Toxicology and applied pharmacology. 1975;34:128–142.

Garner R. C.. Reduction in binding of [14C] aflatoxin B1 to rat liver macromolecules by phenobarbitone pretreatment. Biochemical pharmacology. 1975;24:1553–1556.

Schabort J. C., Steyn M.. Aflatoxin B 1 and phenobarbital inducible aflatoxin- 2 -hydration by rat liver microsomes. Biochemical pharmacology. 1972;21:2931–2933.

McLean A. E., Marshall A.. Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone. British journal of experimental pathology. 1971;52:323–329.

Patterson D. S., Roberts B. A.. Differences in the effect of phenobarbital treatment on the in vitro metabolism of aflatoxin and aniline by duck and rat livers. Biochemical pharmacology. 1971;20:3377–3383.

Gumbmann M. R., Williams S. N.. Effect of phenobarbital pretreatment on the ability of aflatoxin B 1 to inhibit ribonucleic acid synthesis in rat liver. Biochemical pharmacology. 1970;19:2861–2866.

Schabort J. C., Steyn M.. Substrate and phenobarbital inducible aflatoxin-4-hydroxylation and aflatoxin metabolism by rat liver microsomes. Biochemical pharmacology. 1969;18:2241–2252.

Wilson R. G., Wortham J. S., Gelboin H. V.. The effect of methylcholanthrene, phenobarbital and aflatoxin on RNA polymerase of rat liver. Advances in enzyme regulation. 1967;5:385–395.

 

Probiotics

Magnoli AP, Rodriguez MC, González Pereyra ML, Poloni VL, Peralta MF, Nilson AJ, Miazzo RD, Bagnis G, Chiacchiera SM, Cavaglieri LR. Use of yeast (Pichia kudriavzevii) as a novel feed additive to ameliorate the effects of aflatoxin B1 on broiler chicken performance. Mycotoxin Res. 2017 Jul 8. PMID: 28687999

Gonçalves BL, Gonçalves JL, Rosim RE, Cappato LP, Cruz AG, Oliveira CAF, Corassin CH. Effects of different sources of Saccharomyces cerevisiae biomass on milk production, composition, and aflatoxin M1 excretion in milk from dairy cows fed aflatoxin B1. J Dairy Sci. 2017 Jul;100(7):5701-5708. PMID: 28478008

Taheur FB, Fedhila K, Chaieb K, Kouidhi B, Bakhrouf A, Abrunhosa L. Adsorption of aflatoxin B1, zearalenone and ochratoxin A by microorganisms isolated from Kefir grains. Int J Food Microbiol. 2017 Jun 19;251:1-7. PMID: 28376398

Huang L, Duan C, Zhao Y, Gao L, Niu C, Xu J, Li S. Reduction of Aflatoxin B1 Toxicity by Lactobacillus plantarum C88: A Potential Probiotic Strain Isolated from Chinese Traditional Fermented Food “Tofu”. PLoS One. 2017 Jan 27;12(1):e0170109. PMID: 28129335

Xu L, Eisa Ahmed MF, Sangare L, Zhao Y, Selvaraj JN, Xing F, Wang Y, Yang H, Liu Y. Novel Aflatoxin-Degrading Enzyme from Bacillus shackletonii L7. Toxins (Basel). 2017 Jan 14;9(1). PMID: 28098812

Wang Y, Zhao C, Zhang D, Zhao M, Zheng D, Lyu Y, Cheng W, Guo P, Cui Z. Effective degradation of aflatoxin B1 using a novel thermophilic microbial consortium TADC7. Bioresour Technol. 2017 Jan;224:166-173. PMID: 27866802

Adebo OA, Njobeh PB, Gbashi S, Nwinyi OC, Mavumengwana V. Review on microbial degradation of aflatoxins. Crit Rev Food Sci Nutr. 2017 Oct 13;57(15):3208-3217. PMID: 26517507

Ghazvini RD, Kouhsari E, Zibafar E, Hashemi SJ, Amini A, Niknejad F. Antifungal Activity and Aflatoxin Degradation of Bifidobacterium Bifidum and Lactobacillus Fermentum Against Toxigenic Aspergillus Parasiticus. Open Microbiol J. 2016 Nov 30;10:197-201. PMID: 28077976

Zhang L, Ma Q, Ma S, Zhang J, Jia R, Ji C, Zhao L. Ameliorating Effects of Bacillus subtilis ANSB060 on Growth Performance, Antioxidant Functions, and Aflatoxin Residues in Ducks Fed Diets Contaminated with Aflatoxins. Toxins (Basel). 2016 Dec 22;9(1). PMID: 28025501

Lee KR, Yang SM, Cho SM, Kim M, Hong SY, Chung SH. Aflatoxin B1 Detoxification by Aspergillus oryzae from Meju, a Traditional Korean Fermented Soybean Starter. J Microbiol Biotechnol. 2016 Nov 4. PMID: 27817189

Verheecke C, Liboz T, Mathieu F. Microbial degradation of aflatoxin B1: Current status and future advances. Int J Food Microbiol. 2016 Nov 21;237:1-9. PMID: 27541976

Elsanhoty RM, Al-Turki IA, Ramadan MF. Application of lactic acid bacteria in removing heavy metals and aflatoxin B1 from contaminated water. Water Sci Technol. 2016;74(3):625-38. PMID: 27508367

Abbès S, Ben Salah-Abbès J, Jebali R, Younes RB, Oueslati R. Interaction of aflatoxin B1 and fumonisin B1 in mice causes immunotoxicity and oxidative stress: Possible protective role using lactic acid bacteria. J Immunotoxicol. 2016;13(1):46-54. PMID: 25585958

Ansari F, Khodaiyan F, Rezaei K, Rahmani A. Modelling of aflatoxin G1 reduction by kefir grain using response surface methodology. J Environ Health Sci Eng. 2015 May 2;13:40. PMID: 26019874.

Ahlberg SH, Joutsjoki V, Korhonen HJ. Potential of lactic acid bacteria in aflatoxin risk mitigation. Int J Food Microbiol. 2015 Aug 17;207:87-102. PMID: 26001523

Fernández Juri MG, Dalcero AM, Magnoli CE. In vitro aflatoxin B1 binding capacity by two Enterococcus faecium strains isolated from healthy dog faeces. J Appl Microbiol. 2015 Mar;118(3):574-82. PMID: 25495538

Jebali R, Abbès S, Salah-Abbès JB, Younes RB, Haous Z, Oueslati R. Ability of Lactobacillus plantarum MON03 to mitigate aflatoxins (B1 and M1) immunotoxicities in mice. J Immunotoxicol. 2015 Jul-Sep;12(3):290-9. PMID: 25441623

Ben Salah-Abbès J, Abbès S, Jebali R, Haous Z, Oueslati R. Potential preventive role of lactic acid bacteria against aflatoxin M₁ immunotoxicity and genotoxicity in mice. J Immunotoxicol. 2015 Apr-Jun;12(2):107-14. PMID: 24738739

Monson MS, Settlage RE, Mendoza KM, Rawal S, El-Nezami HS, Coulombe RA, Reed KM. Modulation of the spleen transcriptome in domestic turkey (Meleagris gallopavo) in response to aflatoxin B1 and probiotics. Immunogenetics. 2015 Mar;67(3):163-78. PMID: 25597949

Zoghi A, Khosravi-Darani K, Sohrabvandi S. Surface binding of toxins and heavy metals by probiotics. Mini Rev Med Chem. 2014 Jan;14(1):84-98. PMID: 24329992

Zuo RY, Chang J, Yin QQ, Wang P, Yang YR, Wang X, Wang GQ, Zheng QH. Effect of the combined probiotics with aflatoxin B₁-degrading enzyme on aflatoxin detoxification, broiler production performance and hepatic enzyme gene expression. Food Chem Toxicol. 2013 Sep;59:470-5. PMID: 23831311

McCormick SP. Microbial detoxification of mycotoxins. J Chem Ecol. 2013 Jul;39(7):907-18. PMID: 23846184

Pizzolitto R. P., Armando M. R., Salvano M. A., Dalcero A. M., Rosa C. A.. Evaluation of Saccharomyces cerevisiae as an antiaflatoxicogenic agent in broiler feedstuffs. Poultry science.  2013;92:1655–1663.

Zuo Rui-Yu Y., Chang Juan, Yin Qing-Qiang Q., et al. Effect of the combined probiotics with aflatoxin B1-degrading enzyme on aflatoxin detoxification, broiler production performance and hepatic enzyme gene expression. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.  2013.

Nikbakht Nasrabadi E., Jamaluddin R., Abdul Mutalib M. S., Khaza’ai H., Khalesi S., Mohd Redzwan S.. Reduction of aflatoxin level in aflatoxin-induced rats by the activity of probiotic Lactobacillus casei strain Shirota.  Journal of applied microbiology.  2013;114:1507–1515.

Ma Q. G., Gao X., Zhou T., et al. Protective effect of Bacillus subtilis ANSB060 on egg quality, biochemical and histopathological changes in layers exposed to aflatoxin B1. Poultry science.  2012;91:2852–2857.

Li Chaobo, Li Wenming, Yang Wenhua, Li Haixing, Liu Xiaohua, Cao Yusheng. [Isolation and characterisation of an aflatoxin B1-degrading bacterium]. Wei sheng wu xue bao = Acta microbiologica Sinica.  2012;52:1129–1136.

Gerbaldo Gisela A., Barberis Carla, Pascual Liliana, Dalcero Ana, Barberis Lucila. Antifungal activity of two Lactobacillus strains with potential probiotic properties. FEMS microbiology letters.  2012;332:27–33.

Armando M. R., Dogi C. A., Rosa C. A., Dalcero A. M., Cavaglieri L. R.. Saccharomyces cerevisiae strains and the reduction of Aspergillus parasiticus growth and aflatoxin B1 production at different interacting environmental conditions, in vitro. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.  2012;29:1443–1449.

Pizzolitto Romina P., Armando María R., Combina Mariana, Cavaglieri Lilia R., Dalcero Ana M., Salvano Mario A.. Evaluation of Saccharomyces cerevisiae strains as probiotic agent with aflatoxin B₁ adsorption ability for use in poultry feedstuffs. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.  2012;47:933–941.

Ismaiel Ahmed A., Ghaly Mohamed F., El-Naggar Ayman K.. Milk kefir: ultrastructure, antimicrobial activity and efficacy on aflatoxin B1 production by Aspergillus flavus. Current microbiology.  2011;62:1602–1609.

Fernández-Juri María Guillermina G., Muzzolón Julián A., Dalcero Ana María M., Magnoli Carina E.. Effect of acid lactic bacteria isolated from faeces of healthy dogs on growth parameters and aflatoxin B1 production by Aspergillus species in vitro. Mycotoxin research.  2011;27:273–280.

Hathout Amal S., Mohamed Sherif R., El-Nekeety Aziza A., Hassan Nabila S., Aly Soher E., Abdel-Wahhab Mosaad A.. Ability of Lactobacillus casei and Lactobacillus reuteri to protect against oxidative stress in rats fed aflatoxins-contaminated diet. Toxicon.  2011;58:179–186.

Matur E., Ergul E., Akyazi I., et al. Effects of Saccharomyces cerevisiae extract on haematological parameters, immune function and the antioxidant defence system in breeder hens fed aflatoxin contaminated diets.  British poultry science.  2011;52:541–550.

Krifaton Csilla, Kriszt Balázs, Szoboszlay Sándor, Cserháti Mátyás, Szucs Adám, Kukolya József. Analysis of aflatoxin-B1-degrading microbes by use of a combined toxicity-profiling method. Mutation research.  2011;726:1–7.

Dogi C. A., Armando R., Ludueña R., et al. Saccharomyces cerevisiae strains retain their viability and aflatoxin B1 binding ability under gastrointestinal conditions and improve ruminal fermentation. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.  2011;28:1705–1711.

Hernandez-Mendoza Adrián, González-Córdova Aarón Fernando F., Vallejo-Cordoba Belinda, Garcia Hugo Sergio S.. Effect of oral supplementation of Lactobacillus reuteri in reduction of intestinal absorption of aflatoxin B(1) in rats. Journal of basic microbiology.  2011;51:263–268.

Fox J. G., Feng Y., Theve E. J., et al. Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens.  Gut.  2010;59:88–97.

Topcu Ali, Bulat Tugba, Wishah Refaat, Boyaci Ismail H.. Detoxification of aflatoxin B1 and patulin by Enterococcus faecium strains. International journal of food microbiology.  2010;139:202–205.

Matur E., Ergul E., Akyazi I., Eraslan E., Cirakli Z. T.. The effects of Saccharomyces cerevisiae extract on the weight of some organs, liver, and pancreatic digestive enzyme activity in breeder hens fed diets contaminated with aflatoxins. Poultry science.  2010;89:2213–2220.

Slizewska Katarzyna, Nowak Adriana, Libudzisz Zdzislawa, Blasiak Janusz. Probiotic preparation reduces the faecal water genotoxicity in chickens fed with aflatoxin B1 contaminated fodder. Research in veterinary science.  2010;89:391–395.

Kabak Bulent, Brandon Esther F., Var Isil, Blokland Marco, Sips Adrienne J.. Effects of probiotic bacteria on the bioaccessibility of aflatoxin B(1) and ochratoxin A using an in vitro digestion model under fed conditions.  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.  2009;44:472–480.

Hernandez-Mendoza A., Garcia H. S., Steele J. L.. Screening of Lactobacillus casei strains for their ability to bind aflatoxin B1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.  2009;47:1064–1068.

Cenci G., Caldini G., Trotta F., Bosi P.. In vitro inhibitory activity of probiotic spore-forming bacilli against genotoxins. Letters in applied microbiology.  2008;46:331–337.

Halttunen T., Collado M. C., El-Nezami H., Meriluoto J., Salminen S.. Combining strains of lactic acid bacteria may reduce their toxin and heavy metal removal efficiency from aqueous solution. Letters in applied microbiology.  2008;46:160–165.

Gratz S., Wu Q. K., El-Nezami H., Juvonen R. O., Mykkänen H., Turner P. C.. Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity in Caco-2 Cells. Applied and environmental microbiology.  2007;73:3958–3964.

Bueno Dante J., Casale César H., Pizzolitto Romina P., Salvano Mario A., Oliver Guillermo. Physical adsorption of aflatoxin B1 by lactic acid bacteria and Saccharomyces cerevisiae: a theoretical model. Journal of food protection.  2007;70:2148–2154.

 Khanafari A., Soudi H., Miraboulfathi M., Osboo R. Karamei. An in vitro investigation of aflatoxin B1 biological control by Lactobacillus plantarum. Pakistan journal of biological sciences: PJBS.  2007;10:2553–2556.

Kusumaningtyas E., Widiastuti R., Maryam R.. Reduction of aflatoxin B1 in chicken feed by using Saccharomyces cerevisiae, Rhizopus oligosporus and their combination. Mycopathologia.  2006;162:307–311.

Mokoena M. P., Chelule P. K., Gqaleni N.. The toxicity and decreased concentration of aflatoxin B in natural lactic acid fermented maize meal. Journal of applied microbiology.  2006;100:773–777.

Gratz S., Täubel M., Juvonen R. O., et al. Lactobacillus rhamnosus strain GG modulates intestinal absorption, fecal excretion, and toxicity of aflatoxin B(1) in rats. Applied and environmental microbiology.  2006;72:7398–7400.

Madrigal-Santillán E., Madrigal-Bujaidar E., Márquez-Márquez R., Reyes A.. Antigenotoxic effect of Saccharomyces cerevisiae on the damage produced in mice fed with aflatoxin B(1) contaminated corn. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.  2006;44:2058–2063.

El-Nezami Hani S., Polychronaki Nektaria N., Ma Jing, et al. Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China. The American journal of clinical nutrition.  2006;83:1199–1203.

Gratz S., Mykkänen H., Ouwehand A. C., Juvonen R., Salminen S., El-Nezami H.. Intestinal mucus alters the ability of probiotic bacteria to bind aflatoxin B1 in vitro. Applied and environmental microbiology.  2004;70:6306–6308.

Turbic A., Ahokas J. T., Haskard C. A.. Selective in vitro binding of dietary mutagens, individually or in combination, by lactic acid bacteria. Food additives and contaminants.  2002;19:144–152.

Kelly Edward J., Erickson Kristin E., Sengstag Christian, Eaton David L.. Expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae reveals a functional role in aflatoxin B1 detoxification. Toxicological sciences : an official journal of the Society of Toxicology.  2002;65:35–42.

Parlat S. S., Ozcan M., Oguz H.. Biological suppression of aflatoxicosis in Japanese quail (Coturnix coturnix japonica) by dietary addition of yeast (Saccharomyces cerevisiae). Research in veterinary science.  2001;71:207–211.

Peltonen K., Nezami H., Haskard C., Ahokas J., Salminen S.. Aflatoxin B1 binding by dairy strains of lactic acid bacteria and bifidobacteria.  Journal of dairy science.  2001;84:2152–2156.

 Haskard C. A., El-Nezami H. S., Kankaanpää P. E., Salminen S., Ahokas J. T.. Surface binding of aflatoxin B(1) by lactic acid bacteria.  Applied and environmental microbiology.  2001;67:3086–3091.

Oatley J. T., Rarick M. D., Ji G. E., Linz J. E.. Binding of aflatoxin B1 to bifidobacteria in vitro. Journal of food protection.  2000;63:1133–1136.

Kankaanpää P., Tuomola E., El-Nezami H., Ahokas J., Salminen S. J.. Binding of aflatoxin B1 alters the adhesion properties of Lactobacillus rhamnosus strain GG in a Caco-2 model. Journal of food protection.  2000;63:412–414.

Haskard C., Binnion C., Ahokas J.. Factors affecting the sequestration of aflatoxin by Lactobacillus rhamnosus strain GG. Chemico-biological interactions.  2000;128:39–49.

El-Nezami H., Mykkänen H., Kankaanpää P., Salminen S., Ahokas J.. Ability of Lactobacillus and Propionibacterium strains to remove aflatoxin B, from the chicken duodenum. Journal of food protection.  2000;63:549–552.

Pierides M., El-Nezami H., Peltonen K., Salminen S., Ahokas J.. Ability of dairy strains of lactic acid bacteria to bind aflatoxin M1 in a food model. Journal of food protection.  2000;63:645–650.

El-Nezami H., Kankaanpaa P., Salminen S., Ahokas J.. Ability of dairy strains of lactic acid bacteria to bind a common food carcinogen, aflatoxin B1.  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.  1998;36:321–326.

Gourama H., Bullerman L. B.. Anti-aflatoxigenic activity of Lactobacillus casei pseudoplantarum. International journal of food microbiology.  1997;34:131–143.

Oleykowski C. A., Mayernik J. A., Lim S. E., et al. Repair of aflatoxin B1 DNA adducts by the UvrABC endonuclease of Escherichia coli. The Journal of biological chemistry.  1993;268:7990–8002.

Stanley V. G., Ojo R., Woldesenbet S., Hutchinson D. H., Kubena L. F.. The use of Saccharomyces cerevisiae to suppress the effects of aflatoxicosis in broiler chicks. Poultry science.  1993;72:1867–1872.

Rasić J. L., Skrinjar M., Markov S.. Decrease of aflatoxin B1 in yoghurt and acidified milks. Mycopathologia.  1991;113:117–119.

Kiessling K. H., Pettersson H., Sandholm K., Olsen M.. Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria. Applied and environmental microbiology.  1984;47:1070–1073.

Megalla S. E., Hafez A. H.. Detoxification of aflatoxin B1 by acidogenous yoghurt. Mycopathologia.  1982;77:89–91.

Jain N. K., Lahiri V. L., Bhatnagar V. K., Vadhera D. V.. Factors affecting toxicity of aflatoxin on procaryotic cells. Indian journal of experimental biology.  1980;18:661–663.

Mann R., Rehm H. J.. [Degradation of aflatoxin b1 by various microorganisms (author’s transl)]. Zeitschrift für Lebensmittel-Untersuchung und -Forschung.  1977;163:39–43.

Schoenhard G. L., Lee D. J., Howell S. E., Pawlowski N. E., Libbey L. M., Sinnhuber R. O.. Aflatoxin B1 metabolism to aflatoxicol and derivatives lethal to Bacillus subtilis GSY 1057 by rainbow trout (Salmo gairdneri) liver. Cancer research.  1976;36:2040–2045.

Schoenhard G. L., Bishop P. E., Lee D. J., Sinnhuber R. O.. Bacillus subtilis GSY 1057 assay for aflatoxin B activation by rainbow trout (Salmo gairdneri). Journal – Association of Official Analytical Chemists.  1975;58:1074–1076.

Hayes A. W., Melton R., Smith S. J.. Effect of aflatoxin B1, ochratoxin and rubratoxin B on a protozoan, Tetrahymena pyriformis HSM. Bulletin of environmental contamination and toxicology.  1974;11:321–325.

Mann R., Rehm H. J.. Degradation of aflatoxin B1 by microorganisms. Die Naturwissenschaften.  1975;62:537–538.

Lillehoj E. B., Ciegler A.. Aflatoxin B1 effect on enzyme biosynthesis in Bacillus cereus and Bacillus licheniformis. Canadian journal of microbiology.  1970;16:1059–1065.

Reiss J.. [The effect of aflatoxin B1 on the cytochemically detectable activity of various enzymes of Mucor hiemalis (Mucorales)]. Mycopathologia et mycologia applicata.  1970;42:225–231.

Lillehoj E. B., Ciegler A.. Aflatoxin B1 induction of lysogenic bacteria.  Applied microbiology.  1970;20:782–785.

Nezval J., Bösenberg H., Linzel U.. [Aflatoxin effect on bacteria].  Archiv für Hygiene und Bakteriologie.  1970;154:143–147.

Fehr P. M., Delage J.. [Effect of aflatoxin on rumen fermentations].  Comptes rendus hebdomadaires des séances de l’Académie des sciences. Série D: Sciences naturelles.  1970;270:550–553.

Bauer L., Leistner L.. [The effect of aflatoxin B1 on amebas]. Archiv für Hygiene und Bakteriologie.  1969;153:397–402.

Lillehoj E. B., Ciegler A.. Inhibition of deoxyribonucleic acid synthesis in Flavobacterium aurantiacum by aflatoxin B1. Journal of bacteriology.  1967;94:787–788.

Wragg J. B., Ross V. C., Legator M. S.. Effect of aflatoxin B1 on the deoxyribonucleic acid polymerase of Escherichia coli. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).  1967;125:1052–1055.

Lillehoj E. B., Ciegler A., Hall H. H.. Aflatoxin B 1 uptake by Flavobacterium aurantiacum and resulting toxic effects. Journal of bacteriology.  1967;93:464–471.

Burmeister H. R., Hesseltine C. W.. Survey of the sensitivity of microorganisms to aflatoxin. Applied microbiology.  1966;14:403–404.

Ciegler A., Lillehoj E. B., Peterson R. E., Hall H. H.. Microbial detoxification of aflatoxin. Applied microbiology.  1966;14:934–939.

 

Resveratrol

Sridhar M, Suganthi RU, Thammiaha V. Effect of dietary resveratrol in ameliorating aflatoxin B1-induced changes in broiler birds. J Anim Physiol Anim Nutr (Berl). 2015 Dec;99(6):1094-104. PMID: 25319220

Türkez Hasan, Sisman Turgay. The genoprotective activity of resveratrol on aflatoxin B₁-induced DNA damage in human lymphocytes in vitro. Toxicology and industrial health. 2012;28:474–480.

Bishayee Anupam, Politis Themos, Darvesh Altaf S.. Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma. Cancer treatment reviews. 2010;36:43–53.

Billings P. C., Uwaifo A. O., Heidelberger C.. Influence of benzoflavone on aflatoxin B1-induced cytotoxicity, mutation, and transformation of C3H/10T1/2 cells. Cancer research. 1983;43:2659–2663.

 

Selenium & Zinc

Chen X, Che C, Korolchuk VI, Gan F, Pan C, Huang K. Selenomethionine Alleviates AFB1-Induced Damage in Primary Chicken Hepatocytes by Inhibiting CYP450 1A5 Expression via Upregulated SelW Expression. J Agric Food Chem. 2017 Mar 29;65(12):2495-2502. PMID: 28285519

Cao Z, Shao B, Xu F, Liu Y, Li Y, Zhu Y. Protective Effect of Selenium on Aflatoxin B1-Induced Testicular Toxicity in Mice. Biol Trace Elem Res. 2017 Mar 27. PMID: 28349382

Nones J, Solhaug A, Eriksen GS, Macuvele DLP, Poli A, Soares C, Trentin AG, Riella HG, Nones J. Bentonite modified with zinc enhances aflatoxin B1 adsorption and increase survival of fibroblasts (3T3) and epithelial colorectal adenocarcinoma cells (Caco-2). J Hazard Mater. 2017 Sep 5;337:80-89. PMID: 28511044

Mughal MJ, Peng X, Kamboh AA, Zhou Y, Fang J. Aflatoxin B1 Induced Systemic Toxicity in Poultry and Rescue Effects of Selenium and Zinc. Biol Trace Elem Res. 2017 Jan 7. PMID: 28064414

Sun LH, Zhang NY, Zhu MK, Zhao L, Zhou JC, Qi DS. Prevention of Aflatoxin B1 Hepatoxicity by Dietary Selenium Is Associated with Inhibition of Cytochrome P450 Isozymes and Up-Regulation of 6 Selenoprotein Genes in Chick Liver. J Nutr. 2016 Mar 9. PMID: 26962192

Yang X, Lv Y, Huang K, Luo Y, Xu W. Zinc inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in human hepatocytes (HepG2 cells). Food Chem Toxicol. 2016 Jun;92:17-25. PMID: 27017951

Hao S, Hu J, Song S, Huang D, Xu H, Qian G, Gan F, Huang K. Selenium Alleviates Aflatoxin B₁-Induced Immune Toxicity through Improving Glutathione Peroxidase 1 and Selenoprotein S Expression in Primary Porcine Splenocytes. J Agric Food Chem. 2016 Feb 17;64(6):1385-93. PMID: 26806088

Yu Z, Wang F, Liang N, Wang C, Peng X, Fang J, Cui H, Jameel Mughal M, Lai W. Effect of Selenium Supplementation on Apoptosis and Cell Cycle Blockage of Renal Cells in Broilers Fed a Diet Containing Aflatoxin B1. Biol Trace Elem Res. 2015 Nov;168(1):242-51. PMID: 25931191

Liang N, Wang F, Peng X, Fang J, Cui H, Chen Z, Lai W, Zhou Y, Geng Y. Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B₁. Int J Environ Res Public Health. 2015 Sep 9;12(9):11196-208. PMID: 26371027

Peng X, Zhang S, Fang J, Cui H, Zuo Z, Deng J. Protective roles of sodium selenite against aflatoxin B1-induced apoptosis of jejunum in broilers. Int J Environ Res Public Health. 2014 Dec 17;11(12):13130-43. PMID: 25526081

He Y, Fang J, Peng X, Cui H, Zuo Z, Deng J, Chen Z, Geng Y, Lai W, Shu G, Tang L. Effects of sodium selenite on aflatoxin B1-induced decrease of ileal IgA+ cell numbers and immunoglobulin contents in broilers. Biol Trace Elem Res. 2014 Jul;160(1):49-55. PMID: 24909240

Zhang S, Peng X, Fang J, Cui H, Zuo Z, Chen Z. Effects of aflatoxin B1 exposure and sodium selenite supplementation on the histology, cell proliferation, and cell cycle of jejunum in broilers. Biol Trace Elem Res. 2014 Jul;160(1):32-40. PMID: 24880257

He Y, Fang J, Peng X, Cui H, Zuo Z, Deng J, Chen Z, Lai W, Shu G, Tang L. Effects of sodium selenite on aflatoxin B1-induced decrease of ileac T cell and the mRNA contents of IL-2, IL-6, and TNF-α in broilers. Biol Trace Elem Res. 2014 Jun;159(1-3):167-73. PMID: 24807686

Parveen F, Nizamani ZA, Gan F, Chen X, Shi X, Kumbhar S, Zeb A, Huang K. Protective effect of selenomethionine on aflatoxin B1-induced oxidative stress in MDCK cells. Biol Trace Elem Res. 2014 Mar;157(3):266-74. PMID: 24425350

Liao S, Shi D, Clemons-Chevis CL, Guo S, Su R, Qiang P, Tang Z. Protective role of selenium on aflatoxin b1-induced hepatic dysfunction and apoptosis of liver in ducklings. Biol Trace Elem Res. 2014 Dec;162(1-3):296-301. PMID: 25274191

Chen K, Fang J, Peng X, Cui H, Chen J, Wang F, Chen Z, Zuo Z, Deng J, Lai W, Zhou Y. Effect of selenium supplementation on aflatoxin B₁-induced histopathological lesions and apoptosis in bursa of Fabricius in broilers. Food Chem Toxicol. 2014 Dec;74:91-7. PMID: 25261862

Chen K, Peng X, Fang J, Cui H, Zuo Z, Deng J, Chen Z, Geng Y, Lai W, Tang L, Yang Q. Effects of dietary selenium on histopathological changes and T cells of spleen in broilers exposed to aflatoxin B1. Int J Environ Res Public Health. 2014 Feb 10;11(2):1904-13. PMID: 24518648

Liu C, Zuo Z, Zhu P, Zheng Z, Peng X, Fang J, Cui H, Zhou Y, Ouyang P, Geng Y, Deng J, Sun Y. Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil. Oncotarget. 2017 Apr 13. PMID: 28467783

Wang Fengyuan, Shu Gang, Peng Xi, et al. Protective effects of sodium selenite against aflatoxin B1-induced oxidative stress and apoptosis in broiler spleen. International journal of environmental research and public health. 2013;10:2834–2844.

Chen K, Shu G, Peng X, Fang J, Cui H, Chen J, Wang F, Chen Z, Zuo Z, Deng J, Geng Y, Lai W. Protective role of sodium selenite on histopathological lesions, decreased T-cell subsets and increased apoptosis of thymus in broilers intoxicated with aflatoxin B₁. Food Chem Toxicol. 2013 Sep;59:446-54. PMID: 23810797

Wang F, Shu G, Peng X, Fang J, Chen K, Cui H, Chen Z, Zuo Z, Deng J, Geng Y, Lai W. Protective effects of sodium selenite against aflatoxin B1-induced oxidative stress and apoptosis in broiler spleen. Int J Environ Res Public Health. 2013 Jul 9;10(7):2834-44. PMID: 23839060

Agar Guleray, Alpsoy Lokman, Bozari Sedat, Erturk Filiz Aygun A., Yildirim Nalan. Determination of protective role of selenium against aflatoxin B1-induced DNA damage. Toxicology and industrial health. 2013;29:396–403.

Shi Dayou, Guo Shining, Liao Shenquan, et al. Protection of selenium on hepatic mitochondrial respiratory control ratio and respiratory chain complex activities in ducklings intoxicated with aflatoxin B₁. Biological trace element research. 2012;145:312–317.
Shi Dayou, Guo Shining, Liao Shenquan, et al. Influence of selenium on hepatic mitochondrial antioxidant capacity in ducklings intoxicated with aflatoxin B₁. Biological trace element research. 2012;145:325–329.

Guo Shining, Shi Dayou, Liao Shenquan, et al. Influence of selenium on body weights and immune organ indexes in ducklings intoxicated with aflatoxin B₁. Biological trace element research. 2012;146:167–170.

Alpsoy Lokman, Kotan Elif, Tatar Abdulgani, Agar Guleray. Protective effects of selenium against sister chromatid exchange induced by AFG 1 in human lymphocytes in vitro. Human & experimental toxicology. 2011;30:515–519.

Darvesh Altaf S., Bishayee Anupam. Selenium in the prevention and treatment of hepatocellular carcinoma. Anti-cancer agents in medicinal chemistry. 2010;10:338–345.

Jakhar K. K., Sadana J. R.. Sequential pathology of experimental aflatoxicosis in quail and the effect of selenium supplementation in modifying the disease process. Mycopathologia. 2004;157:99–109.

Irmak Meliha Burcu B., Ince Gulayse, Ozturk Mehmet, Cetin-Atalay Rengul. Acquired tolerance of hepatocellular carcinoma cells to selenium deficiency: a selective survival mechanism? Cancer research. 2003;63:6707–6715.

Methenitou G., Maravelias C., Athanaselis S., Dona A., Koutselinis A.. Immunomodulative effects of aflatoxins and selenium on human natural killer cells. Veterinary and human toxicology. 2001;43:232–234.

Hegazy S. M., Adachi Y.. Comparison of the effects of dietary selenium, zinc, and selenium and zinc supplementation on growth and immune response between chick groups that were inoculated with Salmonella and aflatoxin or Salmonella. Poultry science. 2000;79:331–335.

Chen S. Y., Chen C. J., Tsai W. Y., et al. Associations of plasma aflatoxin B1-albumin adduct level with plasma selenium level and genetic polymorphisms of glutathione S-transferase M1 and T1. Nutrition and cancer. 2000;38:179–185.

McLeod R., Ellis E. M., Arthur J. R., et al. Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin. Cancer research. 1997;57:4257–4266.

Methenitou G., Maravelias C., Koutsogeorgopoulou L., Athanaselis S., Koutselinis A.. Immunomodulative effects of aflatoxins and selenium on human peripheral blood lymphocytes. Veterinary and human toxicology. 1996;38:274–277.

Shi C. Y., Hew Y. C., Ong C. N.. Inhibition of aflatoxin B1-induced cell injury by selenium: an in vitro study. Human & experimental toxicology. 1995;14:55–60.

Shi C. Y., Chua S. C., Lee H. P., Ong C. N.. Inhibition of aflatoxin B1-DNA binding and adduct formation by selenium in rats. Cancer letters. 1994;82:203–208.

Knizhnikov V. A., Komleva V. A., Tutel’ian V. A., et al. [The effect of an increased dietary intake of organic selenium on the resistance of rats to ionizing radiation, aflatoxin B1 and infection]. Voprosy pitaniia. 1991:52–55.

Petr T., Bárta I., Turek B.. In vivo effect of selenium on the mutagenic activity of aflatoxin B1. Journal of hygiene, epidemiology, microbiology, and immunology. 1990;34:123–128.

Lei D. N., Wang L. Q., Ruebner B. H., et al. Effect of selenium on aflatoxin hepatocarcinogenesis in the rat. Biomedical and environmental sciences : BES. 1990;3:65–80.

Wang L. Q.. [The effect of selenium on hepatocarcinogenesis of rats induced by aflatoxin B1]. Zhonghua bing li xue za zhi Chinese journal of pathology. 1990;19:46–49.

Wang L. Q.. [The study of aflatoxin B1-induced hepatocarcinogenesis of rats and mechanism of selenium’s inhibitory effect on carcinogenesis]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 1989;23:289–292.

Baldwin S., Parker R. S.. Influence of dietary fat and selenium in initiation and promotion of aflatoxin B1-induced preneoplastic foci in rat liver. Carcinogenesis. 1987;8:101–107.

Brucato M., Sundlof S. F., Bell J. U., Edds G. T.. Aflatoxin B1 toxicosis in dairy calves pretreated with selenium-vitamin E. American journal of veterinary research. 1986;47:179–183.

Baldwin S., Parker R. S.. The effects of dietary fat and selenium on the development of preneoplastic lesions in rat liver. Nutrition and cancer. 1986;8:273–282.

Milks M. M., Wilt S. R., Ali I. I., Couri D.. The effects of selenium on the emergence of aflatoxin B1-induced enzyme-altered foci in rat liver. Fundamental and applied toxicology. 1985;5:320–326.

Gregory J. F., Edds G. T.. Effect of dietary selenium on the metabolism of aflatoxin B1 in turkeys. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1984;22:637–642.

Davila J. C., Edds G. T., Osuna O., Simpson C. F.. Modification of the effects of aflatoxin B1 and warfarin in young pigs given selenium. American journal of veterinary research. 1983;44:1877–1883.

Burguera J. A., Edds G. T., Osuna O.. Influence of selenium on aflatoxin B1 or crotalaria toxicity in turkey poults. American journal of veterinary research. 1983;44:1714–1717.

Chen J., Goetchius M. P., Campbell T. C., Combs G. F.. Effects of dietary selenium and vitamin E on hepatic mixed-function oxidase activities and in vivo covalent binding of aflatoxin B1 in rats. The Journal of nutrition. 1982;112:324–331.

Chen J., Goetchius M. P., Combs G. F., Campbell T. C.. Effects of dietary selenium and vitamin E on covalent binding of aflatoxin to chick liver cell macromolecules. The Journal of nutrition. 1982;112:350–355.

Aleksandrowicz J., Dobrowolski J., Lisiewicz J., Skotnicki A., Smyk B.. Selenium effect on the growth of carcinogenic fungi and cytotoxic action of aflatoxin B1 on lymphocyte culture and on embryonal development of Xenopus laevis. Polish medical sciences and history bulletin. 1975;15:453–459.

Aleksandrowicz J., Dobrowolski J., Lieiewicz J., Smyk B., Skotnicki A.. [Effect of selenium on the growth of carcinogenic fungi and the cytotoxic action of aflatoxin B-1 in cell of lymphocytes and on the embryonal development of Xenopus laevis]. Polskie Archiwum Medycyny Wewnętrznej. 1975;53:209–217.

Aleksandrowicz J., Lisiewicz J., Skotnicki A., Waszek Z.. Selenium, aflatoxins and lymphocyte reactivity (author’s transl). Folia clínica internacional. 1974;24:795–796.

 

Silymarin

Jahanian E, Mahdavi AH, Asgary S, Jahanian R. Effects of dietary inclusion of silymarin on performance, intestinal morphology and ileal bacterial count in aflatoxin-challenged broiler chicks. J Anim Physiol Anim Nutr (Berl). 2017 Jan 4. PMID: 28052409

Naseer O, Khan JA, Khan MS, Omer MO, Chishti GA, Sohail ML, Saleem MU. Comparative Efficacy of Silymarin and Choline Chloride (Liver Tonics) in Preventing the Effects of Aflatoxin B1 in Bovine Calves. Pol J Vet Sci. 2016 Sep 1;19(3):545-551. PMID: 27760040

Amiridumari H, Sarir H, Afzali N, Fanimakki O. Effects of milk thistle seed against aflatoxin B1 in broiler model. J Res Med Sci. 2013 Sep;18(9):786-90. PMID: 24381623

Angeli José Pedro Friedmann P., Barcelos Gustavo Rafael Mazzaron R., Serpeloni Juliana Mara M., Barbosa Fernando, Nersesyan Armen, Mantovani Mario Sergio S.. Evaluation of the genotoxic and anti-genotoxic activities of silybin in human hepatoma cells (HepG2). Mutagenesis.  2010;25:223–229.

Grizzle Judith, Hadley Tarah L., Rotstein David S., et al. Effects of dietary milk thistle on blood parameters, liver pathology, and hepatobiliary scintigraphy in white carneaux pigeons (Columba livia) challenged with B1 aflatoxin. Journal of avian medicine and surgery.  2009;23:114–124.

Tedesco D., Steidler S., Galletti S., Tameni M., Sonzogni O., Ravarotto L.. Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks. Poultry science.  2004;83:1839–1843.

Rastogi R., Srivastava A. K., Rastogi A. K.. Long term effect of aflatoxin B(1) on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin. Phytotherapy research : PTR.  2001;15:307–310.

Rastogi R., Srivastava A. K., Srivastava M., Rastogi A. K.. Hepatocurative effect of picroliv and silymarin against aflatoxin B1 induced hepatotoxicity in rats. Planta medica.  2000;66:709–713.

 

Tea

Linardaki ZI, Lamari FN, Margarity M. Saffron (Crocus sativus L.) Tea Intake Prevents Learning/Memory Defects and Neurobiochemical Alterations Induced by Aflatoxin B1 Exposure in Adult Mice. Neurochem Res. 2017 May 2. PMID: 28462452

Lu H, Liu F, Zhu Q, Zhang M, Li T, Chen J, Huang Y, Wang X, Sheng J. Aflatoxin B1 can be complexed with oxidised tea polyphenols and the absorption of the complexed aflatoxin B1 is inhibited in rats. J Sci Food Agric. 2017 Apr;97(6):1910-1915. PMID: 27539359

Mo Hai Zhen Z., Zhang Hao, Wu Qing Hua H., Hu Liang Bin B.. Inhibitory effects of tea extract on aflatoxin production by Aspergillus flavus. Letters in applied microbiology.  2013.

Mo H. Z., Zhang H., Wu Q. H., Hu L. B.. Inhibitory effects of tea extract on aflatoxin production by Aspergillus flavus. Letters in applied microbiology.  2013;56:462–466.

Jha Anamika, Shah Komal, Verma Ramtej J.. Aflatoxin-induced biochemical changes in liver of mice and its mitigation by black tea extract. Acta poloniae pharmaceutica.  2012;69:851–857.

Tang Lili, Tang Meng, Xu Li, et al. Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention. Carcinogenesis.  2008;29:411–417.

Tulayakul P., Dong K. S., Li J. Y., Manabe N., Kumagai S.. The effect of feeding piglets with the diet containing green tea extracts or coumarin on in vitro metabolism of aflatoxin B1 by their tissues. Toxicon.  2007;50:339–348.

Choudhary Anamika, Verma Ramtej Jayram J.. Black tea ameliorates aflatoxin-induced lipid peroxidation in the kidney of mice. Acta poloniae pharmaceutica.  2006;63:307–310.

Luo Haitao, Tang Lili, Tang Meng, et al. Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine.  Carcinogenesis.  2006;27:262–268.

Halder Babli, Pramanick Swapan, Mukhopadhyay Sibabrata, Giri Ashok Kumar K.. Anticlastogenic effects of black tea polyphenols theaflavins and thearubigins in human lymphocytes in vitro. Toxicology in vitro : an international journal published in association with BIBRA.  2006;20:608–613.

Choudhary Anamika, Verma R. J.. Ameliorative effects of black tea extract on aflatoxin-induced lipid peroxidation in the liver of mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.  2005;43:99–104.

Catterall Fenton, Copeland Emma, Clifford Michael N., Ioannides Costas. Effects of black tea theafulvins on aflatoxin B(1) mutagenesis in the Ames test. Mutagenesis.  2003;18:145–150.

Qin G., Ning Y., Lotlikar P. D.. Chemoprevention of aflatoxin B1-initiated and carbon tetrachloride-promoted hepatocarcinogenesis in the rat by green tea. Nutrition and cancer.  2000;38:215–222.

Catterall F., Copeland E., Clifford M. N., Ioannides C.. Contribution of theafulvins to the antimutagenicity of black tea: their mechanism of action. Mutagenesis.  1998;13:631–636.

Qin G., Gopalan-Kriczky P., Su J., Ning Y., Lotlikar P. D.. Inhibition of aflatoxin B1-induced initiation of hepatocarcinogenesis in the rat by green tea. Cancer letters.  1997;112:149–154.

Ito Y., Ohnishi S., Fujie K.. Chromosome aberrations induced by aflatoxin B1 in rat bone marrow cells in vivo and their suppression by green tea.  Mutation research.  1989;222:253–261.

 

Temperature

Zhang Q., Suorsa-Super K., Curtis L. R.. Temperature-modulated aflatoxin B1 hepatic disposition and formation and persistence of DNA adducts in rainbow trout. Toxicology and applied pharmacology. 1992;113:253–259.

Manning R. O., Wyatt R. D.. Effect of cold acclimation on the broiler chicks’ resistance to acute aflatoxicosis. Poultry science. 1990;69:388–396.

Manning R. O., Wyatt R. D., Fletcher O. J.. Effect of cold acclimation on the broiler chicks’ resistance to dietary aflatoxin. Poultry science. 1990;69:915–921.

Dafalla R., Hassan Y. M., Adam S. E.. Fatty and hemorrhagic liver and kidney syndrome in breeding hens caused by aflatoxin B1 and heat stress in the Sudan. Veterinary and human toxicology. 1987;29:252–254.

Wyatt R. D., Lockhart W. C., Huston T. M.. Increased resistance of chickens to acute aflatoxicosis by acclimation to low environmental temperatures. Poultry science. 1977;56:1648–1651.

Tilak T. B., Nagarajan V., Tulpule P. G.. Resistance of cold-exposed rats to aflatoxin. Experientia. 1976;32:1179–1180.

Wyatt R. D., Thaxton P., Hamilton P. B.. Interaction of aflatoxicosis with heat stress. Poultry science. 1975;54:1065–1070.

 

Vegetables

Odongo GA, Schlotz N, Herz C, Hanschen FS, Baldermann S, Neugart S, Trierweiler B, Frommherz L, Franz CM, Ngwene B, Luvonga AW, Schreiner M, Rohn S, Lamy E. The role of plant processing for the cancer preventive potential of Ethiopian kale (Brassica carinata). Food Nutr Res. 2017 Jan 31;61(1):1271527. PMID: 28326001

Kensler Thomas W., Chen Jian-Guo G., Egner Patricia A., et al. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People’s Republic of China. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2005;14:2605–2613.

Ramsdell H. S., Eaton D. L.. Modification of aflatoxin B1 biotransformation in vitro and DNA binding in vivo by dietary broccoli in rats. Journal of toxicology and environmental health. 1988;25:269–284.

Whitty J. P., Bjeldanes L. F.. The effects of dietary cabbage on xenobiotic-metabolizing enzymes and the binding of aflatoxin B1 to hepatic DNA in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1987;25:581–587.

Boyd J. N., Misslbeck N., Stoewsand G. S.. Changes in preneoplastic response to aflatoxin B1 in rats fed green beans, beets or squash. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1983;21:37–40.

Boyd J. N., Babish J. G., Stoewsand G. S.. Modification of beet and cabbage diets of aflatoxin B1-induced rat plasma alpha-foetoprotein elevation, hepatic tumorigenesis, and mutagenicity of urine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1982;20:47–52.

Boyd J. N., Sell S., Stoewsand G. S.. Inhibition of aflatoxin-induced serum alpha-fetoprotein in rats fed cauliflower. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1979;161:473–475.

Stoewsand G. S., Babish J. B., Wimberly H. C.. Inhibition of hepatic toxicities from polybrominated biphenyls and aflatoxin B in rats fed cauliflower. Journal of environmental pathology and toxicology. 1978;2:399–406.

 

Other

A V V, K RR, Kurrey NK, K A AA, G V. Protective effects of phenolics rich extract of ginger against Aflatoxin B1-induced oxidative stress and hepatotoxicity. Biomed Pharmacother. 2017 Jul;91:415-424. PMID: 28475920

Gómez-Espinosa D, Cervantes-Aguilar FJ, Del Río-García JC, Villarreal-Barajas T, Vázquez-Durán A, Méndez-Albores A. Ameliorative Effects of Neutral Electrolyzed Water on Growth Performance, Biochemical Constituents, and Histopathological Changes in Turkey Poults during Aflatoxicosis. Toxins (Basel). 2017 Mar 14;9(3). PMID: 28335412

Nurul Adilah Z, Mohd Redzwan S. Effect of dietary macronutrients on aflatoxicosis: a mini-review. J Sci Food Agric. 2017 Jun;97(8):2277-2281. PMID: 28111762

da Silva Cardoso V, Vermelho AB, Ribeiro de Lima CA, Mendes de Oliveira J, Freire de Lima ME, Pinto da Silva LH, Direito GM, Miranda Danelli MD. Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1. Toxins (Basel). 2016 Oct 31;8(11). PMID: 27809242

Liu T, Ma Q, Zhao L, Jia R, Zhang J, Ji C, Wang X. Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B₁. Toxins (Basel). 2016 Sep 24;8(10). PMID: 27669305

Gambacorta L, Pinton P, Avantaggiato G, Oswald IP, Solfrizzo M. Grape Pomace, an Agricultural Byproduct Reducing Mycotoxin Absorption: In Vivo Assessment in Pig Using Urinary Biomarkers. J Agric Food Chem. 2016 Sep 7;64(35):6762-71. PMID: 27509142

Iram W, Anjum T, Iqbal M, Ghaffar A, Abbas M, Khan AM. Structural Analysis and Biological Toxicity of Aflatoxins B1 and B2 Degradation Products Following Detoxification by Ocimum basilicum and Cassia fistula Aqueous Extracts. Front Microbiol. 2016 Jul 14;7:1105. PMID: 27471501

Yaman T, Yener Z, Celik I. Histopathological and biochemical investigations of protective role of honey in rats with experimental aflatoxicosis. BMC Complement Altern Med. 2016 Jul 21;16:232. PMID: 27440086

Rasouli-Hiq AA, Bagherzadeh-Kasmani F, Mehri M, Karimi-Torshizi MA. Nigella sativa (black cumin seed) as a biological detoxifier in diet contaminated with aflatoxin B1. J Anim Physiol Anim Nutr (Berl). 2016 Aug 24. PMID: 27553624

Rushing BR, Selim MI. Effect of dietary acids on the formation of aflatoxin B2a as a means to detoxify aflatoxin B1. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Sep;33(9):1456-67. PMID: 27467853

Escobedo-González R, Méndez-Albores A, Villarreal-Barajas T, Aceves-Hernández JM, Miranda-Ruvalcaba R, Nicolás-Vázquez I. A Theoretical Study of 8-Chloro-9-Hydroxy-Aflatoxin B₁, the Conversion Product of Aflatoxin B₁ by Neutral Electrolyzed Water. Toxins (Basel). 2016 Jul 21;8(7). PMID: 27455324

Chen KH, Gao T, Pan JF, Wei HM, Jia CH, Lan J, Chen ZX, Pan D, Bai XC. Docosahexaenoic acid inhibits aflatoxin B1-induced migration and invasion in hepatocellular carcinoma cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Jun 20;36(7):952-6. PMID: 27435775

Long M, Zhang Y, Li P, Yang SH, Zhang WK, Han JX, Wang Y, He JB. Intervention of Grape Seed Proanthocyanidin Extract on the Subchronic Immune Injury in Mice Induced by Aflatoxin B1. Int J Mol Sci. 2016 Apr 8;17(4):516. PMID: 27070584

Shar ZH, Fletcher MT, Sumbal GA, Sherazi ST, Giles C, Bhanger MI, Nizamani SM. Banana peel: an effective biosorbent for aflatoxins. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 May;33(5):849-60. PMID: 27052947

Bakheet SA, Attia SM, Alwetaid MY, Ansari MA, Zoheir KM, Nadeem A, Al-Shabanah OA, Al-Harbi MM, Ahmad SF. β-1,3-Glucan reverses aflatoxin B1-mediated suppression of immune responses in mice. Life Sci. 2016 May 1;152:1-13. PMID: 26997472

Uyar A, Yener Z, Dogan A. Protective effects of Urtica dioica seed extract in aflatoxicosis: histopathological and biochemical findings. Br Poult Sci. 2016 Apr;57(2):235-45. PMID: 26947348

Oskoueian E, Abdullah N, Zulkifli I, Ebrahimi M, Karimi E, Goh YM, Oskoueian A, Shakeri M. Cytoprotective effect of palm kernel cake phenolics against aflatoxin B1-induced cell damage and its underlying mechanism of action.,BMC Complement Altern Med. 2015 Oct 30;15:392. PMID: 26518905

Abdel-Hamid AA, Firgany Ael-D. Vitamin E supplementation ameliorates aflatoxin B1-induced nephrotoxicity in rats. Acta Histochem. 2015 Oct;117(8):767-79. PMID: 26315992

Shcherbakova L, Statsyuk N, Mikityuk O, Nazarova T, Dzhavakhiya V. Aflatoxin B1 Degradation by Metabolites of Phoma glomerata PG41 Isolated From Natural Substrate Colonized by Aflatoxigenic Aspergillus flavus. Jundishapur J Microbiol. 2015 Jan 23;8(1):e24324. PMID: 25789135

Wang T, Li C, Liu Y, Li T, Zhang J, Sun Y. Inhibition effects of Chinese cabbage powder on aflatoxin B1-induced liver cancer. Food Chem. 2015 Nov 1;186:13-9. PMID: 25976785

Khan WA, Khan MZ, Khan A, Hassan ZU, Rafique S, Saleemi MK, Ahad A. Dietary vitamin E in White Leghorn layer breeder hens: a strategy to combat aflatoxin B1-induced damage. Avian Pathol. 2014;43(5):389-95. PMID: 25011613

Yehia RS. Aflatoxin detoxification by manganese peroxidase purified from Pleurotus ostreatus. Braz J Microbiol. 2014 May 19;45(1):127-33. PMID: 24948923′

Khan WA, Khan MZ, Khan A, Ul Hassan Z, Saleemi MK. Potential for amelioration of aflatoxin B1-induced immunotoxic effects in progeny of White Leghorn breeder hens co-exposed to vitamin E. J Immunotoxicol. 2014 Apr-Jun;11(2):116-25. PMID: 23782308

Di Stefano V, Pitonzo R, Cicero N, D’Oca MC. Mycotoxin contamination of animal feeding stuff: detoxification by gamma-irradiation and reduction of aflatoxins and ochratoxin A concentrations. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(12):2034-9. PMID: 25255390

Chen R, Ma F, Li PW, Zhang W, Ding XX, Zhang Q, Li M, Wang YR, Xu BC. Effect of ozone on aflatoxins detoxification and nutritional quality of peanuts. Food Chem. 2014 Mar 1;146:284-8. PMID: 24176344

Weaver AC, See MT, Hansen JA, Kim YB, De Souza AL, Middleton TF, Kim SW. The use of feed additives to reduce the effects of aflatoxin and deoxynivalenol on pig growth, organ health and immune status during chronic exposure. Toxins (Basel). 2013 Jul 17;5(7):1261-81. PMID: 23867763

Lin HR, Wu CC, Wu YH, Hsu CW, Cheng ML, Chiu DT. Proteome-wide dysregulation by glucose-6-phosphate dehydrogenase (G6PD) reveals a novel protective role for G6PD in aflatoxin B₁-mediated cytotoxicity. J Proteome Res. 2013 Jul 5;12(7):3434-48. PMID: 23742107

Eraslan G, Kanbur M, Aslan Ö, Karabacak M. The antioxidant effects of pumpkin seed oil on subacute aflatoxin poisoning in mice. Environ Toxicol. 2013 Dec;28(12):681-8. PMID: 24591108

Abdel-Aziem SH, Hassan AM, El-Denshary ES, Hamzawy MA, Mannaa FA, Abdel-Wahhab MA. Ameliorative effects of thyme and calendula extracts alone or in combination against aflatoxins-induced oxidative stress and genotoxicity in rat liver. Cytotechnology. 2014 May;66(3):457-70. PMID: 24096837
Akçam Mustafa, Artan Reha, Yilmaz Aygen, Ozdem Sebahat, Gelen Tekinalp, Nazıroğlu Mustafa. Caffeic acid phenethyl ester modulates aflatoxin B1-induced hepatotoxicity in rats. Cell biochemistry and function. 2013.

Kumar D. Senthil, Rao Suguna, Satyanaryana Ml, Kumar Pg Pradeep P., Anitha N.. Amelioration of hepatotoxicity induced by aflatoxin using citrus fruit oil in broilers (Gallus domesticus). Toxicology and industrial health. 2013.

Mannaa Fathia A., Abdel-Wahhab Khaled G., Abdel-Wahhab Mosaad A.. Prevention of cardiotoxicity of aflatoxin B1 via dietary supplementation of papaya fruit extracts in rats. Cytotechnology. 2013.

Kumar Ajit, Ponnan Prija, Raj Hanumantharao G., Parmar Virinder S., Saso Luciano. Comparative specificities of Calreticulin Transacetylase to O-acetyl, N-acetyl and S-acetyl derivative of 4-methylcoumarins and their inhibitory effect on AFB1-induced genotoxicity in vitro and in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013;52:216–224.

Nones Jader, Nones Janaína, Trentin Andrea Gonçalves G.. Flavonoid hesperidin protects neural crest cells from death caused by aflatoxin B(1). Cell biology international. 2013;37:181–186.

Solcan Carmen, Gogu Mihaela, Floristean Viorel, Oprisan Bogdan, Solcan Gheorghe. The hepatoprotective effect of sea buckthorn (Hippophae rhamnoides) berries on induced aflatoxin B1 poisoning in chickens 1. Poultry science. 2013;92:966–974.

Gholami-Ahangaran Majid, Zia-Jahromi Noosha. Nanosilver effects on growth parameters in experimental aflatoxicosis in broiler chickens. Toxicology and industrial health. 2013;29:121–125.

Brinda Rajendran, Vijayanandraj Selvaraj, Uma Doraiswamy, Malathi Dorairaj, Paranidharan Vaikuntavasan, Velazhahan Rethinasamy. Role of Adhatoda vasica (L.) Nees leaf extract in the prevention of aflatoxin-induced toxicity in Wistar rats. Journal of the science of food and agriculture. 2013.

Aslan Ali, Agar Guleray, Alpsoy Lokman, Kotan Elif, Ceker Selcuk. Protective role of methanol extracts of two lichens on oxidative and genotoxic damage caused by AFB1 in human lymphocytes in vitro. Toxicology and industrial health. 2012;28:505–512.

Gholami-Ahangaran Majid, Zia-Jahromi Noosha. Effect of nanosilver on blood parameters in chickens having aflatoxicosis. Toxicology and industrial health. 2012.

Magnoli A. P., Monge M. P., Nazar F. N., et al. Combined effects of aflatoxin B1 and corticosterone treatment on selected performance indices and liver histopathology in Japanese quail. Poultry science. 2012;91:354–361.

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Hassan Aziza M., Abdel-Aziem Sekena H., Abdel-Wahhab Mosaad A.. Modulation of DNA damage and alteration of gene expression during aflatoxicosis via dietary supplementation of Spirulina (Arthrospira) and Whey protein concentrate. Ecotoxicology and environmental safety. 2012;79:294–300.

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Gross-Steinmeyer Kerstin, Eaton David L.. Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1). Toxicology. 2012;299:69–79.

Bhouri Wissem, Sghaier Mohamed Ben B., Kilani Soumaya, et al. Evaluation of antioxidant and antigenotoxic activity of two flavonoids from Rhamnus alaternus L. (Rhamnaceae): kaempferol 3-O-β-isorhamninoside and rhamnocitrin 3-O-β-isorhamninoside. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011;49:1167–1173.

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Wang Jianqiao, Ogata Makoto, Hirai Hirofumi, Kawagishi Hirokazu. Detoxification of aflatoxin B1 by manganese peroxidase from the white-rot fungus Phanerochaete sordida YK-624. FEMS microbiology letters. 2011;314:164–169.

Brahmi Dalel, Bouaziz Chayma, Ayed Yousra, Ben Mansour Hédi, Zourgui Lazhar, Bacha Hassen. Chemopreventive effect of cactus Opuntia ficus indica on oxidative stress and genotoxicity of aflatoxin B1. Nutrition & metabolism. 2011;8:73+.

Nili-Ahmadabadi A., Tavakoli F., Hasanzadeh Gr, Rahimi Hr, Sabzevari O.. Protective effect of pretreatment with thymoquinone against Aflatoxin B(1) induced liver toxicity in mice. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2011;19:282–287.

Kotan Elif, Alpsoy Lokman, Anar Mustafa, Aslan Ali, Agar Guleray. Protective role of methanol extract of Cetraria islandica (L.) against oxidative stress and genotoxic effects of AFB₁ in human lymphocytes in vitro. Toxicology and industrial health. 2011;27:599–605.

Kanbur Murat, Eraslan Gökhan, Sarıca Zeynep Soyer S., Aslan Oznur. The effects of evening primrose oil on lipid peroxidation induced by subacute aflatoxin exposure in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011;49:1960–1964.

El-Nekeety Aziza A., Mohamed Sherif R., Hathout Amal S., Hassan Nabila S., Aly Soher E., Abdel-Wahhab Mosaad A.. Antioxidant properties of Thymus vulgaris oil against aflatoxin-induce oxidative stress in male rats. Toxicon. 2011;57:984–991.

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Turkez Hasan, Geyikoglu Fatime. Boric acid: a potential chemoprotective agent against aflatoxin b(1) toxicity in human blood. Cytotechnology. 2010;62:157–165.

Bouhlel Ines, Limem Ilef, Skandrani Ines, et al. Assessment of isorhamnetin 3-O-neohesperidoside from Acacia salicina: protective effects toward oxidation damage and genotoxicity induced by aflatoxin B1 and nifuroxazide. Journal of applied toxicology : JAT. 2010;30:551–558.

Choi K-C C., Chung W-T T., Kwon J-K K., et al. Inhibitory effects of quercetin on aflatoxin B1-induced hepatic damage in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010;48:2747–2753.

Shyamal S., Latha P. G., Suja S. R., et al. Hepatoprotective effect of three herbal extracts on aflatoxin B1-intoxicated rat liver. Singapore medical journal. 2010;51:326–331.

Limem Ilef, Bouhlel Ines, Bouchemi Meriem, et al. Phlomis mauritanica extracts reduce the xanthine oxidase activity, scavenge the superoxide anions, and inhibit the aflatoxin B1-, sodium azide-, and 4-nitrophenyldiamine-induced mutagenicity in bacteria. Journal of medicinal food. 2010;13:717–724.

Alberts J. F., Gelderblom W. C., Botha A., Zyl W. H.. Degradation of aflatoxin B(1) by fungal laccase enzymes. International journal of food microbiology. 2009;135:47–52.

Sharmila Banu G., Kumar Ganeshan, Murugesan A. G.. Ethanolic leaves extract of Trianthema portulacastrum L. ameliorates aflatoxin B(1) induced hepatic damage in rats. Indian journal of clinical biochemistry : IJCB. 2009;24:250–256.

Costa Stefano, Schwaiger Stefan, Cervellati Rinaldo, Stuppner Hermann, Speroni Ester, Guerra Maria Clelia C.. In vitro evaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol-induced cell damage. Journal of applied toxicology : JAT. 2009;29:7–14.

Yen Chia-Hung H., Hung Jung-Hsien H., Ueng Yune-Fang F., et al. Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect. Toxicology and applied pharmacology. 2009;235:296–304.

Hao Yan-rong R., Yang Fang, Cao Ji, et al. [Ginkgo biloba extracts (EGb761) inhibits aflatoxin B1-induced hepatocarcinogenesis in Wistar rats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2009;32:92–96.

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Park S., Kim A. J., Lee M.. Synergic effects of alpha-tocopherol and beta-carotene on tert-butylhydroperoxide-induced HepG2 cell injury. Toxicology and industrial health. 2009;25:311–320.

Yener Zabit, Celik Ismail, Ilhan Fatma, Bal Ramazan. Effects of Urtica dioica L. seed on lipid peroxidation, antioxidants and liver pathology in aflatoxin-induced tissue injury in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009;47:418–424.

Rasooli Iraj, Fakoor Mohammad Hadi H., Yadegarinia Davod, Gachkar Latif, Allameh Abdolamir, Rezaei Mohammad Bagher B.. Antimycotoxigenic characteristics of Rosmarinus officinalis and Trachyspermum copticum L. essential oils. International journal of food microbiology. 2008;122:135–139.

Zhou Qibing, Zhang Lin, Zuniga Miguel A., Tombes Robert M., Stewart Jennifer K.. Mixed inhibition of P450 3A4 as a chemoprotective mechanism against aflatoxin B1-induced cytotoxicity with cisterpenones. Chemical research in toxicology. 2008;21:732–738.

Razzaghi-Abyaneh Mehdi, Shams-Ghahfarokhi Masoomeh, Yoshinari Tomoya, et al. Inhibitory effects of Satureja hortensis L. essential oil on growth and aflatoxin production by Aspergillus parasiticus. International journal of food microbiology. 2008;123:228–233.

Yoshinari Tomoya, Yaguchi Atsushi, Takahashi-Ando Naoko, et al. Spiroethers of German chamomile inhibit production of aflatoxin G and trichothecene mycotoxin by inhibiting cytochrome P450 monooxygenases involved in their biosynthesis. FEMS microbiology letters. 2008;284:184–190.

Bodreddigari Sridevi, Jones Laundette Knight K., Egner Patricia A., et al. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. Chemical research in toxicology. 2008;21:1134–1142.

Umarani Mohanasundaram, Shanthi Palanivelu, Sachdanandam Panchanadham. Protective effect of Kalpaamruthaa in combating the oxidative stress posed by aflatoxin B1-induced hepatocellular carcinoma with special reference to flavonoid structure-activity relationship. Liver international. 2008;28:200–213.

Al-Ghasham Abdalla, Ata Hesham Saad S., El-Deep Said, Meki Abdel-Raheim R., Shehada Salah. Study of protective effect of date and nigella sativa on aflatoxin b(1) toxicity. International journal of health sciences. 2008;2:26–44.

Liby Karen, Yore Mark M., Roebuck Bill D., et al. A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin. Cancer research. 2008;68:6727–6733.

Kumar Rajesh, Mishra Ajay Kumar K., Dubey N. K., Tripathi Y. B.. Evaluation of Chenopodium ambrosioides oil as a potential source of antifungal, antiaflatoxigenic and antioxidant activity. International journal of food microbiology. 2007;115:159–164.

Sivanesan D., Begum V. Hazeena. Modulatory effect of Gynandropsis gynandra L. on glucose metabolizing enzymes in aflatoxin B1-induced hepatocellular carcinoma in rats. Indian journal of biochemistry & biophysics. 2007;44:477–480.

Donma Metin M., Donma Orkide. Hair zinc, aflatoxin and malnutrition. Medical hypotheses. 2007;68:461–462.

Naaz Farah, Javed Saleem, Abdin M. Z.. Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice. Journal of ethnopharmacology. 2007;113:503–509.

Kumar Ajit, Tyagi Yogesh K., Seema , et al. Ellagic acid peracetate is superior to ellagic acid in the prevention of genotoxicity due to aflatoxin B1 in bone marrow and lung cells. The Journal of pharmacy and pharmacology. 2007;59:81–86.

Kan Kees. Effect of dietary calcium propionate on performance, enzyme activities and aflatoxin residues in broilers fed a diet containing low levels of aflatoxin B1. Toxicon. 2007;49:1070–1071.

Sivanesan D., Begum V. Hazeena. Preventive role of Gynandropsis gynandra L., against aflatoxin B1 induced lipid peroxidation and antioxidant defense mechanism in rat. Indian journal of experimental biology. 2007;45:299–303.

Tang Lili, Guan Hongxia, Ding Xiaolin, Wang Jia-Sheng S.. Modulation of aflatoxin toxicity and biomarkers by lycopene in F344 rats. Toxicology and applied pharmacology. 2007;219:10–17.

Wilkinson J. R., Yu J., Bland J. M., Nierman W. C., Bhatnagar D., Cleveland T. E.. Amino acid supplementation reveals differential regulation of aflatoxin biosynthesis in Aspergillus flavus NRRL 3357 and Aspergillus parasiticus SRRC 143. Applied microbiology and biotechnology. 2007;74:1308–1319.

Abdel-Wahhab Mosaad A., Omara Enayat A., Abdel-Galil Mona M., et al. Zizyphus spina-christi extract protects against aflatoxin B1-initiated hepatic carcinogenicity. African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines. 2007;4:248–256.

Rastogi Shipra, Shukla Yogeshwer, Paul Bhola N., Chowdhuri D. Kar, Khanna Subhash K., Das Mukul. Protective effect of Ocimum sanctum on 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and aflatoxin B1 induced skin tumorigenesis in mice. Toxicology and applied pharmacology. 2007;224:228–240.

Costa Stefano, Utan Anelì, Speroni Ester, et al. Carnosic acid from rosemary extracts: a potential chemoprotective agent against aflatoxin B1. An in vitro study. Journal of applied toxicology : JAT. 2007;27:152–159.

Lin W. C., Liao Y. C., Liau M. C., Lii C. K., Sheen L. Y.. Inhibitory effect of CDA-II, a urinary preparation, on aflatoxin B(1)-induced oxidative stress and DNA damage in primary cultured rat hepatocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2006;44:546–551.

Pokharel Yuba Raj R., Han Eun Hee H., Kim Ji Young Y., et al. Potent protective effect of isoimperatorin against aflatoxin B1-inducible cytotoxicity in H4IIE cells: bifunctional effects on glutathione S-transferase and CYP1A. Carcinogenesis. 2006;27:2483–2490.

Zhou Qibing, Xie Hang, Zhang Lin, Stewart Jennifer K., Gu Xing-Xing X., Ryan John J.. cis-Terpenones as an effective chemopreventive agent against aflatoxin B1-induced cytotoxicity and TCDD-induced P450 1A/B activity in HepG2 cells. Chemical research in toxicology. 2006;19:1415–1419.

Rensburg C., Van Rensburg C. E., Van Ryssen J. B., Casey N. H., Rottinghaus G. E.. In vitro and in vivo assessment of humic acid as an aflatoxin binder in broiler chickens. Poultry science. 2006;85:1576–1583.

Jodynis-Liebert Jadwiga, MatŃawska Irena, Bylka WiesŃawa, Murias Marek. Protective effect of Aquilegia vulgaris L. on aflatoxin B(1)-induced hepatic damage in rats. Environmental toxicology and pharmacology. 2006;22:58–63.

Preetha S. P., Kanniappan M., Selvakumar E., Nagaraj M., Varalakshmi P.. Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2006;143:333–339.

Yates Melinda S., Kwak Mi-Kyoung K., Egner Patricia A., et al. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer research. 2006;66:2488–2494.

Abdel-Wahhab Mosaad A., Ahmed Hanaa H., Hagazi Mohamad M.. Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts. Journal of applied toxicology : JAT. 2006;26:229–238.

Bintvihok Anong, Kositcharoenkul Suparat. Effect of dietary calcium propionate on performance, hepatic enzyme activities and aflatoxin residues in broilers fed a diet containing low levels of aflatoxin B1. Toxicon. 2006;47:41–46.

Ezz El-Arab Aly M., Girgis Shenouda M., Hegazy Eman M., Abd El-Khalek Azzat B.. Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice. BMC complementary and alternative medicine. 2006;6.

Aziz Talaat Abdel A., Aziz Mohammed Abdel A., Fouad Hanan Hassan H., et al. Interferon-alpha gene therapy prevents aflatoxin and carbon tetrachloride promoted hepatic carcinogenesis in rats. International journal of molecular medicine. 2005;15:21–26.

Abdel-Wahhab M. A., Aly S. E.. Antioxidant property of Nigella sativa (black cumin) and Syzygium aromaticum (clove) in rats during aflatoxicosis. Journal of applied toxicology : JAT. 2005;25:218–223.

Joseph G. S., Jayaprakasha G. K., Selvi A. T., Jena B. S., Sakariah K. K.. Antiaflatoxigenic and antioxidant activities of Garcinia extracts. International journal of food microbiology. 2005;101:153–160.

Farombi E. O., Adepoju B. F., Ola-Davies O. E., Emerole G. O.. Chemoprevention of aflatoxin B1-induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural bioflavonoid of Garcinia kola seeds. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2005;14:207–214.

Lee Joon-Kyoung K., Choi Eun Hye H., Lee Kwang-Geun G., Chun Hyang Sook S.. Alleviation of aflatoxin B1-induced oxidative stress in HepG2 cells by volatile extract from Allii Fistulosi Bulbus. Life sciences. 2005;77:2896–2910.

Cuero R., Ouellet T.. Metal ions modulate gene expression and accumulation of the mycotoxins aflatoxin and zearalenone. Journal of applied microbiology. 2005;98:598–605.

Farombi E. O., Nwankwo J. O., Emerole G. O.. The effect of modulation of glutathione levels on markers for aflatoxin B1-induced cell damage. African journal of medicine and medical sciences. 2005;34:37–43.

Marnewick J. L., Batenburg W., Swart P., Joubert E., Swanevelder S., Gelderblom W. C.. Ex vivo modulation of chemical-induced mutagenesis by subcellular liver fractions of rats treated with rooibos (Aspalathus linearis) tea, honeybush (Cyclopia intermedia) tea, as well as green and black (Camellia sinensis) teas. Mutation research. 2004;558:145–154.

Thornton A. S., Oda Y., Stuart G. R., Holcroft J., Boer J. G.. The dioxin TCDD protects against aflatoxin-induced mutation in female rats, but not in male rats. Mutation research. 2004;561:147–152.

Renzulli C., Galvano F., Pierdomenico L., Speroni E., Guerra M. C.. Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2). Journal of applied toxicology : JAT. 2004;24:289–296.

Miyata Masaaki, Takano Hiroki, Guo Lian Q., Nagata Kiyoshi, Yamazoe Yasushi. Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity. Carcinogenesis. 2004;25:203–209.

Lee Y. K., El-Nezami H., Haskard C. A., et al. Kinetics of adsorption and desorption of aflatoxin B1 by viable and nonviable bacteria. Journal of food protection. 2003;66:426–430.

Abdel-Wahhab Mosaad A., Aly Soher E.. Antioxidants and radical scavenging properties of vegetable extracts in rats fed aflatoxin-contaminated diet. Journal of agricultural and food chemistry. 2003;51:2409–2414.

Chan Hoi-tak T., Chan Carrie, Ho John W.. Inhibition of glycyrrhizic acid on aflatoxin B1-induced cytotoxicity in hepatoma cells. Toxicology. 2003;188:211–217.

Shin Hea-Soon S., Kwon Soon-Kyoung K.. Synthesis of allylthiopyridazine derivatives and inhibition of aflatoxin B1-induced hepatotoxicity in rats. Archives of pharmacal research. 2003;26:351–357.

Bingham Allen K., Phillips Timothy D., Bauer John E.. Potential for dietary protection against the effects of aflatoxins in animals. Journal of the American Veterinary Medical Association. 2003;222:591–596.

Sabater Vilar Monica, Kuilman-Wahls Mariella E., Fink-Gremmels Johanna. Inhibition of aflatoxin B1 mutagenicity by cyclopiazonic acid in the presence of human liver preparations. Toxicology letters. 2003;143:291–299.

Tepsuwan Anong, Kupradinun Piengchai, Kusamran Wannee R.. Chemopreventive Potential of Neem Flowers on Carcinogen-Induced Rat Mammary and Liver Carcinogenesis. Asian Pacific journal of cancer prevention : APJCP. 2002;3:231–238.

Jun Hye-Seung S., Kim Sung-Eun E., Sung Mi-Kyung K.. Protective effect of soybean saponins and major antioxidants against aflatoxin B1-induced mutagenicity and DNA-adduct formation. Journal of medicinal food. 2002;5:235–240.

Lu Hong, Li Yan. Effects of dimethyl diphenyl bicarboxylate on the metabolism and hepatotoxicity of aflatoxin B1 in rats. Yao xue xue bao = Acta pharmaceutica Sinica. 2002;37:753–757.

Lu Hong, Li Yan. Effects of bicyclol on aflatoxin B1 metabolism and hepatotoxicity in rats. Acta pharmacologica Sinica. 2002;23:942–945.

Kohli Ekta, Raj Hanumantharao G., Kumari Ranju, et al. Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. Bioorganic & medicinal chemistry letters. 2002;12:2579–2582.

Kuilman-Wahls Mariëlla E., Vilar Mònica Sabater S., Nijs-Tjon Lilian, Maas Roel F., Fink-Gremmels Johanna. Cyclopiazonic acid inhibits mutagenic action of aflatoxin B(1). Environmental toxicology and pharmacology. 2002;11:207–212.

Raj H. G., Kohli E., Rohil V., et al. Acetoxy-4-methylcoumarins confer differential protection from aflatoxin B(1)-induced micronuclei and apoptosis in lung and bone marrow cells. Mutation research. 2001;494:31–40.

Ortatatli M., Oğuz H.. Ameliorative effects of dietary clinoptilolite on pathological changes in broiler chickens during aflatoxicosis. Research in veterinary science. 2001;71:59–66.

Liu J., Yang C. F., Wasser S., Shen H. M., Tan C. E., Ong C. N.. Protection of salvia miltiorrhiza against aflatoxin-B1-induced hepatocarcinogenesis in Fischer 344 rats dual mechanisms involved. Life sciences. 2001;69:309–326.

Valdivia A. G., Martínez A., Damián F. J., et al. Efficacy of N-acetylcysteine to reduce the effects of aflatoxin B1 intoxication in broiler chickens. Poultry science. 2001;80:727–734.

Rastogi R., Srivastava A. K., Rastogi A. K.. Biochemical changes induced in liver and serum of aflatoxin B1-treated male wistar rats: preventive effect of picroliv. Pharmacology & toxicology. 2001;88:53–58.

Ueng Y. F., Shyu C. C., Liu T. Y., et al. Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities. Biochemical pharmacology. 2001;62:1653–1660.

Yang C. F., Liu J., Wasser S., Shen H. M., Tan C. E., Ong C. N.. Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis. 2000;21:2237–2243.

Nwankwo J. O., Tahnteng J. G., Emerole G. O.. Inhibition of aflatoxin B1 genotoxicity in human liver-derived HepG2 cells by kolaviron biflavonoids and molecular mechanisms of action. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2000;9:351–361.

Shepherd A. G., Manson M. M., Ball H. W., McLellan L. I.. Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia. Carcinogenesis. 2000;21:1827–1834.

Lin Y. L., Hsu J. D., Chou F. P., Lee M. J., Shiow S. J., Wang C. J.. Suppressive effect of penta-acetyl geniposide on the development of gamma-glutamyl transpeptidase foci-induced by aflatoxin B(1) in rats. Chemico-biological interactions. 2000;128:115–126.

Kelly V. P., Ellis E. M., Manson M. M., et al. Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. Cancer research. 2000;60:957–969.

Yang C. F., Liu J., Shen H. M., Ong C. N.. Protective effect of ebselen on aflatoxin B1-induced cytotoxicity in primary rat hepatocytes. Pharmacology & toxicology. 2000;86:156–161.

Oğuz H., Kurtoğlu V.. Effect of clinoptilolite on performance of broiler chickens during experimental aflatoxicosis. British poultry science. 2000;41:512–517.

Liu J., Yang C. F., Lee B. L., Shen H. M., Ang S. G., Ong C. N.. Effect of Salvia miltiorrhiza on aflatoxin B1-induced oxidative stress in cultured rat hepatocytes. Free radical research. 1999;31:559–568.

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Goeger D. E., Hsie A. W., Anderson K. E.. Co-mutagenicity of coumarin (1,2-benzopyrone) with aflatoxin B1 and human liver S9 in mammalian cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1999;37:581–589.

Premalatha B., Sachdanandam P.. Semecarpus anacardium L. nut extract administration induces the in vivo antioxidant defence system in aflatoxin B1 mediated hepatocellular carcinoma. Journal of ethnopharmacology. 1999;66:131–139.

Ha T. G., Jang J. J., Kim S. G., Kim N. D.. 2-(Allylthio)pyrazine inhibition of aflatoxin B1-induced hepatocarcinogenesis in rats. Chemico-biological interactions. 1999;121:209–222.

Fields W. R., Morrow C. S., Doehmer J., Townsend A. J.. Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin B1 in hamster V79 cells expressing rat cytochrome P450-2B1. Carcinogenesis. 1999;20:1121–1125.

Premalatha B., Muthulakshmi V., Sachdanandam P.. Anticancer potency of the milk extract of Semecarpus anacardium Linn. nuts against aflatoxin B1 mediated hepatocellular carcinoma bearing Wistar rats with reference to tumour marker enzymes. Phytotherapy research : PTR. 1999;13:183–187.

Souza M. F., Tomé A. R., Rao V. S.. Inhibition by the bioflavonoid ternatin of aflatoxin B1-induced lipid peroxidation in rat liver. The Journal of pharmacy and pharmacology. 1999;51:125–129.

Sekijima M., Tsutsumi T., Yoshida T., et al. Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats. Carcinogenesis. 1999;20:161–165.

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Gyamfi M. A., Aniya Y.. Medicinal herb, Thonningia sanguinea protects against aflatoxin B1 acute hepatotoxicity in Fischer 344 rats. Human & experimental toxicology. 1998;17:418–423.

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Atroshi F., Rizzo A., Westermarck T., Ali-vehmas T.. Effects of tamoxifen, melatonin, coenzyme Q10, and L-carnitine supplementation on bacterial growth in the presence of mycotoxins. Pharmacological research : the official journal of the Italian Pharmacological Society. 1998;38:289–295.

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Prabhu A. L., Aboobaker V. S., Bhattacharya R. K.. In vivo effect of dietary factors on the molecular action of aflatoxin B1: role of copper on the catalytic activity of liver microsome. In vivo (Athens, Greece). 1989;3:389–392.

Prabhu A. L., Aboobaker V. S., Bhattacharya R. K.. In vivo effect of dietary factors on the molecular action of aflatoxin B1: role of riboflavin on the catalytic activity of liver fractions. Cancer letters. 1989;48:89–94.

Ch’ih J. J., Biedrzycka D. W., Lin T., Khoo M. O., Devlin T. M.. 2(3)-tert-butyl-4-hydroxyanisole inhibits oxidative metabolism of aflatoxin B1 in isolated rat hepatocytes. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1989;192:35–42.

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Zhu C. R., Du M. J., Lei D. N., Wan L. Q.. A study on the inhibition of aflatoxin B1 induced hepatocarcinogenesis by the Rhizopus delemar. Materia medica Polona. Polish journal of medicine and pharmacy. 1989;21:87–91.

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Chentanez T., Patradilok P., Glinsukon T., Piyachaturawat P.. Effects of cortisol pretreatment on the acute hepatotoxicity of aflatoxin B1. Toxicology letters. 1988;42:237–248.

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Kuroda K., Akao M., Terao K.. Fumaric acid enhances DNA synthesis of rat hepatocytes by counteracting the toxicities of mitomycin C and aflatoxin B1. Japanese journal of cancer research : Gann. 1986;77:750–758.

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Lin J. K., Wang C. J.. Protection of crocin dyes on the acute hepatic damage induced by aflatoxin B1 and dimethylnitrosamine in rats. Carcinogenesis. 1986;7:595–599.

Guobaitis R. J., Ellingham T. J., Maddock M. B.. The effects of pretreatment with cytochrome P-450 inducers and preincubation with a cytochrome P-450 effector on the mutagenicity of genotoxic carcinogens mediated by hepatic and renal S9 from two species of marine fish. Mutation research. 1986;164:59–70.

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Chinnici J. P., Bettinger D. A.. Effects of aflatoxin B1 and caffeine on viability in natural strains of Drosophila melanogaster. Journal of invertebrate pathology. 1984;44:263–266.

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Appleton B. S., Campbell T. C.. Effect of high and low dietary protein on the dosing and postdosing periods of aflatoxin B1-induced hepatic preneoplastic lesion development in the rat. Cancer research. 1983;43:2150–2154.

Uwaifo A. O., Billings P. C., Heidelberger C.. Mutation of Chinese Hamster V79 cells and transformation and mutation of mouse fibroblast C3H/10T1/2 clone 8 cells by aflatoxin B1 and four other furocoumarins isolated from two Nigerian medicinal plants. Cancer research. 1983;43:1054–1058.

Essigmann J. M., Green C. L., Croy R. G., Fowler K. W., Büchi G. H., Wogan G. N.. Interactions of aflatoxin B1 and alkylating agents with DNA: structural and functional studies. Cold Spring Harbor symposia on quantitative biology. 1983;47 Pt 1:327–337.

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