Aflatoxin Literature: Liver Disease

 

 

Reye’s Syndrome

Burguera J. A.. Presence of aflatoxin B1 in human liver referred to as Reye’s syndrome in Venezuela. Acta científica venezolana. 1986;37:325–326.

Rogan W. J., Yang G. C., Kimbrough R. D.. Aflatoxin and Reye’s syndrome: a study of livers from deceased cases. Archives of environmental health. 1985;40:91–95.

Stora C., Dvorackova I., Ayraud N.. Aflatoxin and Reye’s syndrome. Journal of medicine. 1983;14:47–54.

Wray B.. Aflatoxin and Reye’s syndrome: a case control study. Pediatrics. 1981;68.

Nelson D. B., Kimbrough R., Landrigan P. S., Hayes A. W., Yang G. C., Benanides J.. Aflatoxin and Reye’s syndrome: a case control study. Pediatrics. 1980;66:865–869.

Ryan N. J., Hogan G. R., Hayes A. W., Unger P. D., Siraj M. Y.. Aflatoxin B1; its role in the etiology of Reye’s syndrome. Pediatrics. 1979;64:71–75.

Hogan G. R., Ryan N. J., Hayes A. W.. Aflatoxin B1 and Reye’s syndrome. Lancet. 1978;1.

Dvorácková I., Kusák V., Veselý D., Veselá J., Nesnídal P.. Aflatoxin and encephalopathy with fatty degeneration of viscera (Reye). Annales de la nutrition et de l’alimentation. 1977;31:977–989.

Chaves-Carballo E., Ellefson R. D., Gomez M. R.. An aflatoxin in the liver of a patient with Reye-Johnson syndrome. Mayo Clinic proceedings. 1976;51:48–50.

Harwig J., Przybylski W., Moodie C. A.. A link between Reye’s syndrome and aflatoxins? Canadian Medical Association journal. 1975;113.

Becroft D. M., Webster D. R.. Aflatoxins and Reye’s disease. British medical journal. 1972;4.

Bourgeois C. H., Shank R. C., Grossman R. A., Johnsen D. O., Wooding W. L., Chandavimol P.. Acute aflatoxin B1 toxicity in the macaque and its similarities to Reye’s syndrome. Laboratory investigation; a journal of technical methods and pathology. 1971;24:206–216.

 

Additional Articles

Liu W, Wang L, Yang X, Zeng H, Zhang R, Pu C, Zheng C, Tan Y, Luo Y, Feng X, Tian Y, Xiao G, Wang J, Huang Y, Luo J, Feng L, Wang F, Yuan C, Yao Y, Qiu Z, Chen JA, Wu L, Nong Q, Lin H, Shu W. Environmental Microcystin Exposure Increases Liver Injury Risk Induced by Hepatitis B Virus Combined with Aflatoxin: A Cross-Sectional Study in Southwest China. Environ Sci Technol. 2017 Jun 6;51(11):6367-6378. PMID: 28467052

Mary VS, Arias SL, Otaiza SN, Velez PA, Rubinstein HR, Theumer MG. The aflatoxin B1 -fumonisin B1 toxicity in BRL-3A hepatocytes is associated to induction of cytochrome P450 activity and arachidonic acid metabolism. Environ Toxicol. 2017 Jun;32(6):1711-1724. PMID: 28181396

Chang SY, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL. Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Toxicol In Vitro. 2017 Apr;40:170-183. PMID: 28089783

Mughal MJ, Xi P, Yi Z, Jing F. Aflatoxin B1 invokes apoptosis via death receptor pathway in hepatocytes. Oncotarget. 2017 Jan 31;8(5):8239-8249. PMID: 28030812

El-Nekeety AA, Salman AS, Hathout AS, Sabry BA, Abdel-Aziem SH, Hassan NS, Abdel-Wahhab MA. Evaluation of the bioactive extract of actinomyces isolated from the Egyptian environment against aflatoxin B1-induce cytotoxicity, genotoxicity and oxidative stress in the liver of rats. Food Chem Toxicol. 2017 Jul;105:241-255. PMID: 28442411

Chen B, Li D, Li M, Li S, Peng K, Shi X, Zhou L, Zhang P, Xu Z, Yin H, Wang Y, Zhao X, Zhu Q. Induction of mitochondria-mediated apoptosis and PI3K/Akt/ mTOR-mediated autophagy by aflatoxin B2 in hepatocytes of broilers. Oncotarget. 2016 Dec 20;7(51):84989-84998. PMID: 27863407

Qian G, Tang L, Lin S, Xue KS, Mitchell NJ, Su J, Gelderblom WC, Riley RT, Phillips TD, Wang JS. Sequential dietary exposure to aflatoxin B1 and fumonisin B1 in F344 rats increases liver preneoplastic changes indicative of a synergistic interaction. Food Chem Toxicol. 2016 Sep;95:188-95. PMID: 27430420

Afum C, Cudjoe L, Hills J, Hunt R, Padilla LA, Elmore S, Afriyie A, Opare-Sem O, Phillips T, Jolly PE. Association between Aflatoxin M₁ and Liver Disease in HBV/HCV Infected Persons in Ghana. Int J Environ Res Public Health. 2016 Mar 29;13(4):377. PMID: 27043586

Saad-Hussein A, Shahy EM, Shaheen W, Taha MM, Mahdy-Abdallah H, Ibrahim KS, Hafez SF, Fadl NN, El-Shamy KA. Comparative Hepatotoxicity of Aflatoxin B1 among Workers Exposed to Different Organic Dust with Emphasis on Polymorphism Role of Glutathione S-Transferase Gene. Open Access Maced J Med Sci. 2016 Jun 15;4(2):312-8. PMID: 27335608

Kang SJ, Lee HM, Park YI, Yi H, Lee H, So B, Song JY, Kang HG. Chemically induced hepatotoxicity in human stem cell-induced hepatocytes compared with primary hepatocytes and HepG2. Cell Biol Toxicol. 2016 Oct;32(5):403-17. PMID: 27287938

Rotimi OA, Rotimi SO, Oluwafemi F, Ademuyiwa O, Balogun EA. Coexistence of Aflatoxicosis with Protein Malnutrition Worsens Hepatic Oxidative Damage in Rats. J Biochem Mol Toxicol. 2016 Jun;30(6):269-76. PMID: 26804159

Liu Y, Wang W. Aflatoxin B1 impairs mitochondrial functions, activates ROS generation, induces apoptosis and involves Nrf2 signal pathway in primary broiler hepatocytes. Anim Sci J. 2016 Dec;87(12):1490-1500. PMID: 26997555

Akinrinmade FJ, Akinrinde AS, Amid A. Changes in serum cytokine levels, hepatic and intestinal morphology in aflatoxin B1-induced injury: modulatory roles of melatonin and flavonoid-rich fractions from Chromolena odorata. Mycotoxin Res. 2016 May;32(2):53-60. PMID: 26798045

Zhang NY, Qi M, Gao X, Zhao L, Liu J, Gu CQ, Song WJ, Krumm CS, Sun LH, Qi DS. Response of the hepatic transcriptome to aflatoxin B1 in ducklings. Toxicon. 2016 Mar 1;111:69-76. PMID: 26763128

Cox JA, Fellows MD, Hashizume T, White PA. The utility of metabolic activation mixtures containing human hepatic post-mitochondrial supernatant (S9) for in vitro genetic toxicity assessment. Mutagenesis. 2016 Mar;31(2):117-30. PMID: 26712374

Zhu L, Gao J, Huang K, Luo Y, Zhang B, Xu W. miR-34a screened by miRNA profiling negatively regulates Wnt/β-catenin signaling pathway in Aflatoxin B1 induced hepatotoxicity. Sci Rep. 2015 Nov 16;5:16732. PMID: 26567713

Liu C, Yu H, Zhang Y, Li D, Xing X, Chen L, Zeng X, Xu D, Fan Q, Xiao Y, Chen W, Wang Q. Upregulation of miR-34a-5p antagonizes AFB1-induced genotoxicity in F344 rat liver. Toxicon. 2015 Nov;106:46-56. PMID: 26385312

Rieswijk L, Brauers KJ, Coonen ML, van Breda SG, Jennen DG, Kleinjans JC. Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes. Mutagenesis. 2015 Nov;30(6):771-84. PMID: 25976910

Fowler J, Li W, Bailey C. Effects of a Calcium Bentonite Clay in Diets Containing Aflatoxin when Measuring Liver Residues of Aflatoxin B₁ in Starter Broiler Chicks. Toxins (Basel). 2015 Aug 26;7(9):3455-64. PMID: 26343723

Knipstein B, Huang J, Barr E, Sossenheimer P, Dietzen D, Egner PA, Groopman JD, Rudnick DA. Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance. Pediatr Res. 2015 Aug;78(2):120-7. PMID: 25938735

Sun LH, Lei MY, Zhang NY, Gao X, Li C, Krumm CS, Qi DS. Individual and combined cytotoxic effects of aflatoxin B1, zearalenone, deoxynivalenol and fumonisin B1 on BRL 3A rat liver cells. Toxicon. 2015 Mar;95:6-12. PMID: 25549941

Shi D, Liao S, Guo S, Li H, Yang M, Tang Z. Protective effects of selenium on aflatoxin B1-induced mitochondrial permeability transition, DNA damage, and histological alterations in duckling liver. Biol Trace Elem Res. 2015 Feb;163(1-2):162-8. PMID:m25431300

Gao W, Jiang L, Ge L, Chen M, Geng C, Yang G, Li Q, Ji F, Yan Q, Zou Y, Zhong L, Liu X. Sterigmatocystin-induced oxidative DNA damage in human liver-derived cell line through lysosomal damage. Toxicol In Vitro. 2015 Feb;29(1):1-7. PMID: 25176419

Sun LH, Lei MY, Zhang NY, Zhao L, Krumm CS, Qi DS. Hepatotoxic effects of mycotoxin combinations in mice. Food Chem Toxicol. 2014 Dec;74:289-93. PMID: 25445755

Chen X, Horn N, Cotter PF, Applegate TJ. Growth, serum biochemistry, complement activity, and liver gene expression responses of Pekin ducklings to graded levels of cultured aflatoxin B1. Poult Sci. 2014 Aug;93(8):2028-36. PMID: 24902705

Anitha S, Raghunadharao D, Waliyar F, Sudini H, Parveen M, Rao R, Kumar PL. The association between exposure to aflatoxin, mutation in TP53, infection with hepatitis B virus, and occurrence of liver disease in a selected population in Hyderabad, India.nMutat Res Genet Toxicol Environ Mutagen. 2014 May 15;766:23-8. PMID: 24657665

Cao J, Wang W. Effects of astaxanthin and esterified glucomannan on hematological and serum parameters, and liver pathological changes in broilers fed aflatoxin-B1-contaminated feed. Anim Sci J. 2014 Feb;85(2):150-7. PMID: 24033398

Merrick B. Alex, Phadke Dhiral P., Auerbach Scott S., et al. RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats. PloS one. 2013;8.

Arana S., Alves V. A., Sabino M., et al. Immunohistochemical Evidence for Myofibroblast-like Cells Associated with Liver Injury Induced by Aflatoxin B1 in Rainbow Trout (Oncorhynchus mykiss). Journal of comparative pathology. 2013.

Jetten MJ, Kleinjans JC, Claessen SM, Chesné C, van Delft JH. Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes. Toxicol In Vitro. 2013 Oct;27(7):2031-40. PMID: 23911569

Lu Xiaoyan, Hu Bin, Shao Li, et al. Integrated analysis of transcriptomics and metabonomics profiles in aflatoxin B1-induced hepatotoxicity in rat. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013;55:444–455.

Lu Jeng-Wei W., Yang Wan-Yu Y., Lin Yueh-Min M., Jin Shiow-Lian Catherine L., Yuh Chiou-Hwa H.. Hepatitis B virus X antigen and aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish. Acta histochemica. 2013.

Liu Ruijie, Jin Qingzhe, Huang Jianhua, et al. In vitro toxicity of aflatoxin B1 and its photodegradation products in HepG2 cells. Journal of applied toxicology : JAT. 2012;32:276–281.

Josse Rozenn, Dumont Julie, Fautrel Alain, Robin Marie-Anne A., Guillouzo André. Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicology and applied pharmacology. 2012;258:176–187.

Li Albert P., Uzgare Aarti, LaForge Yumiko S.. Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: results with model toxicants aflatoxin B1, cyclophosphamide and tamoxifen. Chemico-biological interactions. 2012;199:1–8.

Yang J., Bai F., Zhang K., et al. Effects of feeding corn naturally contaminated with aflatoxin B1 and B2 on hepatic functions of broilers. Poultry science. 2012;91:2792–2801.

Gong Yun Yun Y., Wilson Shona, Mwatha Joseph K., et al. Aflatoxin exposure may contribute to chronic hepatomegaly in Kenyan school children. Environmental health perspectives. 2012;120:893–896.

Ayed-Boussema Imen, Pascussi Jean-Marc M., Maurel Patrick, Bacha Hassen, Hassen Wafa. Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes. International journal of toxicology. 2012;31:86–93.

Rustemeyer S. M., Lamberson W. R., Ledoux D. R., Wells K., Austin K. J., Cammack K. M.. Effects of dietary aflatoxin on the hepatic expression of apoptosis genes in growing barrows. Journal of animal science. 2011;89:916–925.

Kirby Gordon M., Nichols Kathleen D., Antenos Monica. CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis. Current drug metabolism. 2011;12:186–197.

Choi Ki-Choon C., Chung Wan-Tae T., Kwon Jung-Kee K., et al. Chemoprevention of a flavonoid fraction from Rhus verniciflua Stokes on aflatoxin B1-induced hepatic damage in mice. Journal of applied toxicology : JAT. 2011;31:150–156.

Hadley Tarah L., Grizzle Judith, Rotstein David S., et al. Determination of an oral aflatoxin dose that acutely impairs hepatic function in domestic pigeons (Columba livia). Journal of avian medicine and surgery. 2010;24:210–221.

Ribeiro Deise H., Ferreira Fabiane L., Silva Valéria N., Aquino Simone, Corrêa Benedito. Effects of aflatoxin b(1) and fumonisin b(1) on the viability and induction of apoptosis in rat primary hepatocytes. International journal of molecular sciences. 2010;11:1944–1955.

Gross-Steinmeyer Kerstin, Stapleton Patricia L., Tracy Julia H., Bammler Theo K., Strom Stephen C., Eaton David L.. Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicological sciences : an official journal of the Society of Toxicology. 2010;116:422–432.

He Cheng-Hua H., Fan Yan-Hong H., Wang Ying, Huang Chao-Ying Y., Wang Xi-Chun C., Zhang Hai-Bin B.. The individual and combined effects of deoxynivalenol and aflatoxin b(1) on primary hepatocytes of cyprinus carpio. International journal of molecular sciences. 2010;11:3760–3768.

Muriel Pablo. Role of free radicals in liver diseases. Hepatology international. 2009;3:526–536.

Vasatkova Anna, Krizova Sarka, Adam Vojtech, Zeman Ladislav, Kizek Rene. Changes in metallothionein level in rat hepatic tissue after administration of natural mouldy wheat. International journal of molecular sciences. 2009;10:1138–1160.

Yarru L. P., Settivari R. S., Antoniou E., Ledoux D. R., Rottinghaus G. E.. Toxicological and gene expression analysis of the impact of aflatoxin B1 on hepatic function of male broiler chicks. Poultry science. 2009;88:360–371.

Huţanaşu C., Sfarti C., Trifan Anca, Huţanaşu Mihaela, Stanciu C.. [Aflatoxin contamination of food: additional risk factor for chronic liver diseases]. Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 2009;113:1061–1065.

Liu Zhi-Ming M., Li Le-Qun Q., Peng Min-Hao H., et al. Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma. Cancer letters. 2008;263:212–222.

Yamazaki Yuko, Hashida Hiroko, Arita Anna, Hamaguchi Keiko, Shimura Fumio. High dose of commercial products of kava (Piper methysticum) markedly enhanced hepatic cytochrome P450 1A1 mRNA expression with liver enlargement in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008;46:3732–3738.

Grassi Tony Fernando F., Pires Paulo Wagner W., Barbisan Luis Fernando F., Pai-Silva Maeli Dal D., Said Roueda Abou A., Camargo João Lauro Viana L.. Liver lesions produced by aflatoxins in Rana catesbeiana (bullfrog). Ecotoxicology and environmental safety. 2007;68:71–78.

Chen Chien-Hung H., Wang Mei-Hui H., Wang Jing-Houng H., et al. Aflatoxin exposure and hepatitis C virus in advanced liver disease in a hepatitis C virus endemic area in Taiwan. The American journal of tropical medicine and hygiene. 2007;77:747–752.

Fatemi Faezeh, Allameh Abdolamir, Dadkhah Abolfazl, Forouzandeh Mehdi, Kazemnejad Somayeh, Sharifi Roya. Changes in hepatic cytosolic glutathione S-transferase activity and expression of its class-P during prenatal and postnatal period in rats treated with aflatoxin B1. Archives of toxicology. 2006;80:572–579.

Hassan Ahmed M., Sheashaa Hussein A., Abdel Fatah Mohamed F., Ibrahim Alla Z., Gaber Osama A.. Does aflatoxin as an environmental mycotoxin adversely affect the renal and hepatic functions of Egyptian lactating mothers and their infants? A preliminary report. International urology and nephrology. 2006;38:339–342.

Aninat Caroline, Piton Amélie, Glaise Denise, et al. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug metabolism and disposition: the biological fate of chemicals. 2006;34:75–83.

Farkas Dora, Tannenbaum Steven R.. Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2005;85:927–934.

Farkas Dora, Tannenbaum Steven R.. In vitro methods to study chemically-induced hepatotoxicity: a literature review. Current drug metabolism. 2005;6:111–125.

Kimura Masatomo, Lehmann Kiyoko, Gopalan-Kriczky Prathima, Lotlikar Prabhakar D.. Effect of diet on aflatoxin B1-DNA binding and aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci in the rat. Experimental & molecular medicine. 2004;36:351–357.

Doi Adriana M., Patterson Paula E., Gallagher Evan P.. Variability in aflatoxin B(1)-macromolecular binding and relationship to biotransformation enzyme expression in human prenatal and adult liver. Toxicology and applied pharmacology. 2002;181:48–59.

López Clara, Ramos Laura, Bulacio Lucía, Ramadán Silvana, Rodríguez Fernanda. Aflatoxin B1 content in patients with hepatic diseases. Medicina. 2002;62:313–316.

Adenuga G. A.. Consequence of aflatoxin B1 ingestion on the membrane-bound liver endoplasmic reticulum Ca2+-ATPase of protein-undernourished Fischer F344 rats. Bioscience reports. 2001;21:873–877.

Mistry K. J., Krishna M., Bhattacharya R. K.. Effect of aflatoxin B1 on phosphoinositide signal transduction pathway during regeneration of liver cells following partial hepatectomy. Indian journal of biochemistry & biophysics. 2001;38:270–273.

Guerre P., Pineau T., Costet P., Burgat V., Galtier P.. Effects of AFB1 on CYP 1A1, 1A2 and 3A6 mRNA, and P450 expression in primary culture of rabbit hepatocytes. Toxicology letters. 2000;111:243–251.

Wang C., Bammler T. K., Guo Y., Kelly E. J., Eaton D. L.. Mu-class GSTs are responsible for aflatoxin B(1)-8, 9-epoxide-conjugating activity in the nonhuman primate macaca fascicularis liver. Toxicological sciences : an official journal of the Society of Toxicology. 2000;56:26–36.

O’Brien T., Babcock G., Cornelius J., et al. A comparison of apoptosis and necrosis induced by hepatotoxins in HepG2 cells. Toxicology and applied pharmacology. 2000;164:280–290.

Kuilman M. E., Maas R. F., Fink-Gremmels J.. Cytochrome P450-mediated metabolism and cytotoxicity of aflatoxin B(1) in bovine hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2000;14:321–327.

Amaya-Farfan J.. Aflatoxin B1-induced hepatic steatosis: role of carbonyl compounds and active diols on steatogenesis. Lancet. 1999;353:747–748.

Pasupathy K., Krishna M., Bhattacharya R. K.. Alterations of phosphatidylinositol signal transduction pathway in hepatic mitochondria following aflatoxin B1 administration. Indian journal of experimental biology. 1999;37:876–880.

Guerre P., Larrieu G., Burgat V., Galtier P.. Cytochrome P450 decreases are correlated to increased microsomal oxidative damage in rabbit liver and primary cultures of rabbit hepatocytes exposed to AFB1. Toxicology letters. 1999;104:117–125.

Harris A. J., Shaddock J. G., Manjanatha M. G., Lisenbey J. A., Casciano D. A.. Identification of differentially expressed genes in aflatoxin B1-treated cultured primary rat hepatocytes and Fischer 344 rats. Carcinogenesis. 1998;19:1451–1458.

Ha T. G., Kim N. D.. 2-(allylthio)pyrazine inhibition of aflatoxin B1-induced hepatotoxicity in rats: inhibition of cytochrome P450 2B- and 3A2-mediated bioactivation. Research communications in molecular pathology and pharmacology. 1998;102:69–78.

Obasi S. C., Obidoa O.. Comparative effects of scopoletin and aflatoxin B1 on bovine hepatic mitochondrial respiration in vitro. Zeitschrift für Naturforschung. C, Journal of biosciences. 1997;52:680–686.

Sajan M. P., Satav J. G., Bhattacharya R. K.. Effect of aflatoxin B in vitro on rat liver mitochondrial respiratory functions. Indian journal of experimental biology. 1997;35:1187–1190.

Guerre P., Burgat V., Galtier P.. Dose-related increase in liver heme catabolism during rabbit aflatoxicosis. Toxicology letters. 1997;92:101–108.

Adav S. S., Govindwar S. P.. Effects of aflatoxin B1 on liver microsomal enzymes in different strains of chickens. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. 1997;118:185–189.

Maxuitenko Y. Y., North W. G., Roebuck B. D.. Urinary taurine as a non-invasive marker of aflatoxin B1-induced hepatotoxicity: success and failure. Toxicology. 1997;118:159–169.

Kirby G. M., Batist G., Alpert L., Lamoureux E., Cameron R. G., Alaoui-Jamali M. A.. Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis. Toxicologic pathology. 1996;24:458–467.

Bhat R. V.. Aflatoxin and liver injury. Tropical gastroenterology. 1996;17:153–160.

Sajan M. P., Satav J. G., Bhattacharya R. K.. Alteration of energy-linked functions in rat hepatic mitochondria following aflatoxin B1 administration. Journal of biochemical toxicology. 1996;11:235–241.

Shen H. M., Shi C. Y., Shen Y., Ong C. N.. Detection of elevated reactive oxygen species level in cultured rat hepatocytes treated with aflatoxin B1. Free radical biology & medicine. 1996;21:139–146.

Langouet S., Coles B., Morel F., Maheo K., Ketterer B., Guillouzo A.. Metabolism of aflatoxin B1 by human hepatocytes in primary culture. Advances in experimental medicine and biology. 1996;387:439–442.

Yarborough A., Zhang Y. J., Hsu T. M., Santella R. M.. Immunoperoxidase detection of 8-hydroxydeoxyguanosine in aflatoxin B1-treated rat liver and human oral mucosal cells. Cancer research. 1996;56:683–688.

Heinonen J. T., Fisher R., Brendel K., Eaton D. L.. Determination of aflatoxin B1 biotransformation and binding to hepatic macromolecules in human precision liver slices. Toxicology and applied pharmacology. 1996;136:1–7.

Hiruma S., Qin G. Z., Gopalan-Kriczky P., Shinozuka H., Sato K., Lotlikar P. D.. Effect of cell proliferation on initiation of aflatoxin B1-induced enzyme altered hepatic foci in rats and hamsters. Carcinogenesis. 1996;17:2495–2499.

Gemechu-Hatewu M., Platt K. L., Oesch F., Steinberg P.. Distribution and induction of aflatoxin B1-9a-hydroxylase activity in rat liver parenchymal and non-parenchymal cells. Archives of toxicology. 1996;70:553–558.

Gallagher E. P., Eaton D. L.. In vitro biotransformation of aflatoxin B1 (AFB1) in channel catfish liver. Toxicology and applied pharmacology. 1995;132:82–90.

Sajan M. P., Satav J. G., Bhattacharya R. K.. Activity of some respiratory enzymes and cytochrome contents in rat hepatic mitochondria following aflatoxin B1 administration. Toxicology letters. 1995;80:55–60.

Slone D. H., Gallagher E. P., Ramsdell H. S., et al. Human variability in hepatic glutathione S-transferase-mediated conjugation of aflatoxin B1-epoxide and other substrates. Pharmacogenetics. 1995;5:224–233.

Lye M. S., Ghazali A. A., Mohan J., Alwin N., Nair R. C.. An outbreak of acute hepatic encephalopathy due to severe aflatoxicosis in Malaysia. The American journal of tropical medicine and hygiene. 1995;53:68–72.

Shen H. M., Ong C. N., Shi C. Y.. Involvement of reactive oxygen species in aflatoxin B1-induced cell injury in cultured rat hepatocytes. Toxicology. 1995;99:115–123.

Shen H. M., Ong C. N., Lee B. L., Shi C. Y.. Aflatoxin B1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA. Carcinogenesis. 1995;16:419–422.

Ozturk M.. p53 mutations in nonmalignant human liver: fingerprints of aflatoxins? Hepatology (Baltimore, Md.). 1995;21:600–601.

Ankrah N. A., Rikimaru T., Ekuban F. A.. Observations on aflatoxins and the liver status of Ghanaian subjects. East African medical journal. 1994;71:739–741.

Raza H., Montague W.. Metabolism of benzo(a)pyrene, dimethylbenzanthracene and aflatoxin B1 by camel liver microsomes. Comparative biochemistry and physiology. Pharmacology, toxicology and endocrinology. 1994;107:379–386.

Bechtel D. G., Lee L. E.. Effects of aflatoxin B(1) in a liver cell line from rainbow trout (Oncorhynchus mykiss). Toxicology in vitro : an international journal published in association with BIBRA. 1994;8:317–328.

Shen H. M., Shi C. Y., Lee H. P., Ong C. N.. Aflatoxin B1-induced lipid peroxidation in rat liver. Toxicology and applied pharmacology. 1994;127:145–150.

Judah D. J., Davies R., Hayes J. D., McLellan L. I., Neal G. E.. The primary and secondary metabolism of aflatoxin B1 by rat hepatocytes cultured on matrigel. Toxicology and applied pharmacology. 1994;125:27–33.

Biswas G., Raj H. G., Allameh A., Saxena M., Srivastava N., Mukerji K. G.. Comparative kinetic studies on aflatoxin B1 binding to pulmonary and hepatic DNA of rat and hamster receiving the carcinogen intratracheally. Teratogenesis, carcinogenesis, and mutagenesis. 1993;13:259–268.

Iwaki M., Kumagai S., Akamatsu Y., Kitagawa T.. Aflatoxin B1-binding proteins in primary cultured hepatocytes of chicken embryo: studies in vivo and in vitro. Biochimica et biophysica acta. 1993;1225:83–88.

Nyathi C. B., Dube N., Hasler J. A., Obwolo M. J., Fuhrmann H., Sallmann H. P.. The effect of diet on aflatoxin B1 binding to hepatic macromolecules in rats. Research communications in chemical pathology and pharmacology. 1993;82:199–207.

Seawright A. A., Snowden R. T., Olubuyide I. O., Riley J., Judah D. J., Neal G. E.. A comparison of the effects of aflatoxin B1 on the livers of rats and duck hepatitis B virus-infected and noninfected ducks. Hepatology (Baltimore, Md.). 1993;18:188–197.

Ueno Y., Yabe T., Hashimoto H., et al. Enhancement of GST-P-positive liver cell foci development by nivalenol, a trichothecene mycotoxin. Carcinogenesis. 1992;13:787–791.

Raney K. D., Shimada T., Kim D. H., Groopman J. D., Harris T. M., Guengerich F. P.. Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1. Chemical research in toxicology. 1992;5:202–210.

Tsuji K., Gopalan P., Lehmann K., et al. Species and sex differences of aflatoxin B1-induced glutathione S-transferase placental form in single hepatocytes. Cancer letters. 1992;66:249–254.

Beers K. W., Glahn R. P., Bottje W. G., Huff W. E.. Aflatoxin and glutathione in domestic fowl (Gallus domesticus)–II. Effects on hepatic blood flow. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 1992;101:463–467.

Gawai K. R., Vodela J. K., Dalvi P. S., Dalvi R. R.. Comparative assessment of the effect of aflatoxin B1 on hepatic dysfunction in some mammalian and avian species. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 1992;101:415–418.

Petr T., Bárta I., Adámková M., Hrabal P.. The effect of partial hepatectomy on the genotoxicity of aflatoxin B1. II. Neoplasma. 1992;39:241–244.

Alvarez M. T., Castañeda C., Escobar A., Fragoso T.. [Aflatoxin detection in urine in liver diseases in childhood]. G.E.N. 1991;45:205–209.

Rao M. S., Subbarao V., Sato K., Reddy J. K.. Alterations of pancreatic hepatocytes in rats exposed to carcinogens. The American journal of pathology. 1991;139:1111–1117.

Ch’ih J. J., Biedrzycka D. W., Devlin T. M.. Isolated hepatocytes are capable of excreting aflatoxin metabolites. Biochemical and biophysical research communications. 1991;178:1002–1007.

Ewaskiewicz J. I., Devlin T. M., Ch’ih J. J.. The in vivo disposition of aflatoxin B1 in rat liver. Biochemical and biophysical research communications. 1991;179:1095–1100.

Olubuyide I. O., Judah D. J., Riley J., Neal G. E.. The isolation and culture of DHBV-infected embryo and duckling hepatocytes and the effect of aflatoxin B1 or irradiation on these cells. British journal of cancer. 1991;63:378–385.

Ho L. L., Jhee E. C., Gopalan P., Tsuji K., Lotlikar P. D.. Aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation with isolated hepatocytes from rats and hamsters. IARC scientific publications. 1991:427–430.

Petr T., Bárta I., Adámková M., Hrabal P., Bártová J.. The effect of partial hepatectomy on the genotoxicity of aflatoxin B1. Neoplasma. 1991;38:77–83.

Aoyama T., Yamano S., Guzelian P. S., Gelboin H. V., Gonzalez F. J.. Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1. Proceedings of the National Academy of Sciences of the United States of America. 1990;87:4790–4793.

Lai T. S., Chiang J. Y.. Aflatoxin B1 metabolism by 3-methylcholanthrene-induced hamster hepatic cytochrome P-450s. Journal of biochemical toxicology. 1990;5:147–153.

Kirby G. M., Stalker M., Metcalfe C., Kocal T., Ferguson H., Hayes M. A.. Expression of immunoreactive glutathione S-transferases in hepatic neoplasms induced by aflatoxin B1 or 1,2-dimethylbenzanthracene in rainbow trout (Oncorhynchus mykiss). Carcinogenesis. 1990;11:2255–2257.

Shayiq R. M., Avadhani N. G.. Purification and characterization of a hepatic mitochondrial cytochrome P-450 active in aflatoxin B1 metabolism. Biochemistry. 1989;28:7546–7554.

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Agüero R. M., Guibert E. E.. Early influence of aflatoxin B1 on the functional state of isolated rat hepatocytes. Toxicology letters. 1989;45:133–140.

Gil R., Callaghan R., Boix J., Pellin A., Llombart-Bosch A.. Morphometric and cytophotometric nuclear analysis of altered hepatocyte foci induced by N-nitrosomorpholine (NNM) and aflatoxin B1 (AFB1) in liver of Wistar rats. Virchows Archiv. B, Cell pathology including molecular pathology. 1988;54:341–349.

Moore M. A., Nakagawa K., Ishikawa T.. Selection pressure and altered hepatocellular islands after a single injection of aflatoxin B1. Japanese journal of cancer research : Gann. 1988;79:187–194.

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Yourtee D. M., Bean T. A., Kirk-Yourtee C. L.. Human aflatoxin B1 metabolism: an investigation of the importance of aflatoxin Q1 as a metabolite of hepatic post-mitochondrial fraction. Toxicology letters. 1987;38:213–224.

Refolo L. M., Bennett C. B., Humayun M. Z.. Mechanisms of frameshift mutagenesis by aflatoxin B1-2,3-dichloride. Journal of molecular biology. 1987;193:609–636.

Merkley J. W., Maxwell R. J., Phillips J. G., Huff W. E.. Hepatic fatty acid profiles in aflatoxin-exposed broiler chickens. Poultry science. 1987;66:59–67.

Raj H. G., Prasanna H. R., Magee P. N., Lotlikar P. D.. Effect of purified rat and hamster hepatic glutathione S-transferases on the microsome mediated binding of aflatoxin B1 to DNA. Cancer letters. 1986;33:1–9.

Chaturvedi A., Khanna Y. P., Taneja S. K., Venkitasubramanian T. A., Raj H. G.. Changes in liver polyamines due to aflatoxin B1. Toxicology letters. 1986;34:1–4.

Hayes M. A., Murray C. A., Rushmore T. H.. Influences of glutathione status on different cytocidal responses of monolayer rat hepatocytes exposed to aflatoxin B1 or acetaminophen. Toxicology and applied pharmacology. 1986;85:1–10.

Cole K. E., Hsu I. C., Trump B. F.. Comparative ultrastructural effects of aflatoxin B1 on mouse, rat, and human hepatocytes in primary culture. Cancer research. 1986;46:1290–1296.

Shanks E. T., Statkiewicz W. R., Llwelleyn G. C., Dashek W. V.. Tissue distribution and hepatic ultrastructural effects of aflatoxin B1 in Japanese quail. Polskie archiwum weterynaryjne. 1986;26:117–131.

Carrillo M. C., Rodriguez J. V., Monti J. A., Rodriguez Garay E. A.. Hepatic transport and biliary excretion of sulfobromophthalein in aflatoxin B1-treated rats. Toxicology and applied pharmacology. 1985;77:353–357.

Lyman B. A., Devlin T. M., Ch’ih J. J.. Effect of aflatoxin B1 on translation in isolated hepatocytes. Biochemical pharmacology. 1985;34:4184–4186.

Hayes M. A., Pickering D. B.. Comparative cytopathology of primary rat hepatocyte cultures exposed to aflatoxin B1, acetaminophen, and other hepatotoxins. Toxicology and applied pharmacology. 1985;80:345–356.

Mohapatra N. K., Roberts J. F.. In vitro effect of aflatoxin B1 on rat liver macrophages (Kuffer cells). Toxicology letters. 1985;29:177–181.

Wei C. I., Hsieh D. P.. Characterization of water-soluble glucuronide and sulphate conjugates of aflatoxin B1. 2. Studies in primary cultures of rat hepatocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1985;23:821–825.

Wilson T. M., Nelson P. E., Knepp C. R.. Hepatic neoplastic nodules, adenofibrosis, and cholangiocarcinomas in male Fisher 344 rats fed corn naturally contaminated with Fusarium moniliforme. Carcinogenesis. 1985;6:1155–1160.

Pugh G. W., Richard J. L., Kopecky K. E., McDonald T. J.. Effects of aflatoxin ingestion on the development of Moraxella bovis infectious bovine keratoconjunctivitis. The Cornell veterinarian. 1984;74:96–110.

Manson M. M., Neal G. E.. The influence of partial hepatectomy on the biphasic response of gamma glutamyl transpeptidase to aflatoxin B1. Cancer letters. 1984;25:81–87.

Niranjan B. G., Wilson N. M., Jefcoate C. R., Avadhani N. G.. Hepatic mitochondrial cytochrome P-450 system. Distinctive features of cytochrome P-450 involved in the activation of aflatoxin B1 and benzo(a)pyrene. The Journal of biological chemistry. 1984;259:12495–12501.

Ch’ih J. J., Devlin T. M.. The distribution and intracellular translocation of aflatoxin B1 in isolated hepatocytes. Biochemical and biophysical research communications. 1984;122:1–8.

Mori H., Kawai K., Ohbayashi F., et al. Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. Cancer research. 1984;44:2918–2923.

Santa Cruz G., Faa G., Mazzoleni A. P., Corongiu F. P.. [Hepatic lesions in rats with aflatoxin B1 poisoning]. Pathologica. 1984;76:465–474.

Raj H. G., Clearfield M. S., Lotlikar P. D.. Comparative kinetic studies on aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation with rat and hamster livers in vitro. Carcinogenesis. 1984;5:879–884.

Moss E. J., Manson M. M., Neal G. E.. Effect of manipulation of gamma-glutamyl transpeptidase levels on biliary excretion of aflatoxin B1 conjugates. Carcinogenesis. 1984;5:869–874.

Brookes C., Wright A., Evans P. J., Mayer R. J.. Aflatoxin B1: effect on the synthesis and degradation of mitochondrial proteins in hepatocyte monolayers. Carcinogenesis. 1984;5:759–765.

Uwaifo A. O.. Inhibition of oxygen uptake in liver slices of three mammalian species (rat, rabbit, guinea-pig) by aflatoxin B1 (AFB1). Toxicology. 1984;31:33–39.

Gill B. S., Roy K. S., Saigal R. P.. Histoenzymological study of the liver in induced chronic aflatoxicosis in the rabbit. Mykosen. 1984;27:259–264.

Hanigan H. M., Laishes B. A.. Toxicity of aflatoxin B1 in rat and mouse hepatocytes in vivo and in vitro. Toxicology. 1984;30:185–193.

Wang J. J., Liu J. C., Chang J. P.. Cytochemical and ultrastructural changes in aflatoxin-induced injury to rat liver cells. Proceedings of the National Science Council, Republic of China. Part B, Life sciences. 1984;8:135–142.

Irvin T. R., Wogan G. N.. Quantitation of aflatoxin B1 adduction within the ribosomal RNA gene sequences of rat liver DNA. Proceedings of the National Academy of Sciences of the United States of America. 1984;81:664–668.

Krystev L. P., Vasilev T., Borov B. I., Kamenova B. B.. [Morphologic and morphometric studies of the liver of the white rat during inadequate feeding and aflatoxin poisoning]. Voprosy pitaniia. 1984:57–60.

Coulombe R. A., Bailey G. S., Nixon J. E.. Comparative activation of aflatoxin B1 to mutagens by isolated hepatocytes from rainbow trout (Salmo gairdneri) and coho salmon (Oncorhynchus kisutch). Carcinogenesis. 1984;5:29–33.

Caviezel M., Aeschbach A. P., Lutz W. K., Schlatter C.. Reduction of covalent binding of aflatoxin B1 to rabbit liver DNA after immunization against this carcinogen. Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement. 1984;7:249–252.

Loury D. N., Hsieh D. P.. Effects of chronic exposure to aflatoxin B1 and aflatoxin M1 on the in vivo covalent binding of aflatoxin B1 to hepatic macromolecules. Journal of toxicology and environmental health. 1984;13:575–587.

Patel I. R., Rao K. K.. Prophage induction by liver microsomal metabolites of aflatoxin B1 in lysogenic Pseudomonas aeruginosa. Acta microbiologica Hungarica. 1984;31:359–364.

Manson M. M.. Biphasic early changes in rat liver gamma-glutamyl transpeptidase in response to aflatoxin B1. Carcinogenesis. 1983;4:467–472.

Kamdem L., Magdalou J., Siest G., Ban M., Zissu D.. Induced hepatotoxicity in female rats by aflatoxin B1 and ethynylestradiol interaction. Toxicology and applied pharmacology. 1983;67:26–40.

Robertson I. G., Zeiger E., Goldstein J. A.. Specificity of rat liver cytochrome P-450 isozymes in the mutagenic activation of benzo[a]pyrene, aromatic amines and aflatoxin B1. Carcinogenesis. 1983;4:93–96.

Dashek W. V., Barker S. M., Statkiewicz W. R., Shanks E. T., Llewellyn G. C.. Histochemical analysis of liver cells from short term, aflatoxin-dosed and nondosed Coturnix coturnix japonica. 1. Aflatoxin-sensitive quail. Poultry science. 1983;62:2347–2359.

Baetz A. L., McLoughlin M. E.. Serum concentration of bile acids in guinea pigs as an indicator of liver damage caused by aflatoxins. American journal of veterinary research. 1983;44:1971–1972.

Loveland P. M., Coulombe R. A., Libbey L. M., et al. Identification and mutagenicity of aflatoxicol-M1 produced by metabolism of aflatoxin B1 and aflatoxicol by liver fractions from rainbow trout (Salmo gairdneri) fed beta-naphthoflavone. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1983;21:557–562.

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Metcalfe S. A., Neal G. E.. Some studies on the relationship between the cytotoxicity of aflatoxin B1 to rat hepatocytes and metabolism of the toxin. Carcinogenesis. 1983;4:1013–1019.

Metcalfe S. A., Neal G. E.. The metabolism of aflatoxin B1 by hepatocytes isolated from rats following the in vivo administration of some xenobiotics. Carcinogenesis. 1983;4:1007–1012.

O’Brien K., Moss E., Judah D., Neal G.. Metabolic basis of the species difference to aflatoxin B1 induced hepatotoxicity. Biochemical and biophysical research communications. 1983;114:813–821.

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Rohrig T. P., Yourtee D. M.. In vitro metabolism of aflatoxin Q1 by rat liver post-mitochondrial homogenates. Research communications in chemical pathology and pharmacology. 1983;40:457–464.

Mathur M., Singhal V., Nayak N. C.. Variability in acute aflatoxin B1 induced liver injury. The Indian journal of medical research. 1983;77:668–678.

Lafarge-Frayssinet C., Morel-Chany E., Trincal G., Frayssinet C.. Promoting effect of biliverdin for liver cells initiated by aflatoxin B1. Cancer letters. 1983;18:277–282.

Pestka J. J., Beery J. T., Chu F. S.. Indirect immunoperoxidase localization of aflatoxin B1 in rat liver. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1983;21:41–48.

Ch’ih J. J., Lin T., Devlin T. M.. Activation and deactivation of aflatoxin B1 in isolated rat hepatocytes. Biochemical and biophysical research communications. 1983;110:668–674.

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Yu F. L.. Preferential binding of aflatoxin B1 to the transcriptionally active regions of rat liver nucleolar chromatin in vivo and in vitro. Carcinogenesis. 1983;4:889–893.

Carrillo M. C., Rodriguez J. V., Monti J. A., Pellegrino J. M., Rodriguez Garay E. A.. Impairment of bile secretion induced by aflatoxin B1 in the rat. Research communications in chemical pathology and pharmacology. 1982;38:521–524.

Boyd J. N., Misslbeck N., Stoewsand G. S.. alpha-Fetoprotein and gamma-glutamyl transpeptidase response in rats fed aflatoxin B1. Toxicology and applied pharmacology. 1982;66:118–123.

Wagner G., Unterreiner A. M.. Synthesis of transfer RNA in rat liver after acute and chronic aflatoxin B1 administration. Chemico-biological interactions. 1982;41:353–360.

Appleton B. S., Goetchius M. P., Campbell T. C.. Linear dose-response curve for the hepatic macromolecular binding of aflatoxin B1 in rats at very low exposures. Cancer research. 1982;42:3659–3662.

Eisele T. A., Loveland P. M., Kruk D. L., Meyers T. R., Sinnhuber R. O., Nixon J. E.. Effect of cyclopropenoid fatty acids on the hepatic microsomal mixed-function-oxidase system and aflatoxin metabolism in rabbits. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1982;20:407–412.

Manson M. M., Green J. A.. Effect of microsomally activated AFB1 on GGT activity in 3 rat liver cell lines. British journal of cancer. 1982;45:945–952.

Dhatt P. S., Parida N. K., Das Chaudhury P. K., Singh H.. Aflatoxins and Indian childhood cirrhosis. Indian pediatrics. 1982;19:407–408.

Yoshizawa H., Uchimaru R., Kamataki T., Kato R., Ueno Y.. Metabolism and activation of aflatoxin B1 by reconstituted cytochrome P-450 system of rat liver. Cancer research. 1982;42:1120–1124.

Green C. E., Rice D. W., Hsieh D. P., Byard J. L.. The comparative metabolism and toxic potency of aflatoxin B1 and aflatoxin M1 in primary cultures of adult-rat hepatocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1982;20:53–60.

Malkinson M., Shlosberg A., Egyed M. N., et al. Hepatic cirrhosis suggesting aflatoxicosis in a flock of geese. The Veterinary record. 1982;110:101–103.

Bermudez E., Mirsalis J. C., Eales H. C.. Detection of DNA damage in primary cultures of rat hepatocytes following in vivo and in vitro exposure to genotoxic agents. Environmental mutagenesis. 1982;4:667–679.

Krustev L. P., Dronzin R. T., Dontchev N. C., Borov B. I., Kamenova B. B., Beshevlieva M. S.. Ultrastructural changes in the liver of rats treated with aflatoxin B1 and undernutrition. Gegenbaurs morphologisches Jahrbuch. 1982;128:176–187.

Bailey G. S., Taylor M. J., Selivonchick D. P.. Aflatoxin B1 metabolism and DNA binding in isolated hepatocytes from rainbow trout (Salmo gairdneri). Carcinogenesis. 1982;3:511–518.

Wagner G., Unterreiner A. M.. Inhibition of rat liver aminoacyl-tRNA synthetases in vitro after acute and chronic aflatoxin B1 administration in vivo. Chemico-biological interactions. 1981;37:233–244.

Jayaraj A., Richardson A.. Metabolic activation of aflatoxin B1 by liver tissue from male fischer F344 rats of various ages. Mechanisms of ageing and development. 1981;17:163–171.

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Obidoa O., Obonna E. E.. Aflatoxin inhibition of reversed electron transfer in rat liver mitochondria in vitro. Biochemical medicine. 1981;26:1–7.

Chu Y. H., Craig A. W., O’Connor P. J.. Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1. British journal of cancer. 1981;43:850–855.

Gayda D. P., Pariza M. W.. Activation of aflatoxin B1 by primary cultures of adult rat hepatocytes: effects of hepatocyte density. Chemico-biological interactions. 1981;35:255–265.

Neal G. E., Judah D. J., Stirpe F., Patterson D. S.. The formation of 2,3-dihydroxy-2,3-dihydro-aflatoxin B1 by the metabolism of aflatoxin B1 by liver microsomes isolated from certain avian and mammalian species and the possible role of this metabolite in the acute toxicity of aflatoxin B1. Toxicology and applied pharmacology. 1981;58:431–437.

Yu F. L.. Studies on the mechanism of aflatoxin B1 inhibition of rat liver nucleolar RNA synthesis. The Journal of biological chemistry. 1981;256:3292–3297.

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Kamdem L., Magdalou J., Siest G.. Effect of aflatoxin B1 on hepatic drug-metabolizing enzymes in female rats. Interaction with a contraceptive agent. Xenobiotica; the fate of foreign compounds in biological systems. 1981;11:275–279.

Yoshizawa H., Uchimaru R., Ueno Y.. Metabolism of aflatoxin B1 in the isolated nuclei of rat liver. Journal of biochemistry. 1981;89:443–452.

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Booth S. C., Bösenberg H., Garner R. C., Hertzog P. J., Norpoth K.. The activation of aflatoxin B1 in liver slices and in bacterial mutagenicity assays using livers from different species including man. Carcinogenesis. 1981;2:1063–1068.

Mathew T., Karunanithy R., Yee M. H., Natarajan P. N.. Hepatotoxicity of dimethylformamide and dimethylsulfoxide at and above the levels used in some aflatoxin studies. Laboratory investigation; a journal of technical methods and pathology. 1980;42:257–262.

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Obidoa O., Bababunmi E. A., Bassir O.. Aflatoxin interactions with rat hepatic mitochondrial dehydrogenases. Biochemical medicine. 1980;23:127–132.

Thurlow P. M., Desai R. K., Newberne P. M., Brown H.. Aflatoxin B1 acute effects on three hepatic urea cycle enzymes using semiautomated methods: a model for Reye’s syndrome. Toxicology and applied pharmacology. 1980;53:293–298.

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Adekunle A. A.. A comparative study on the biliary excretion of aflatoxin B1 in the albino rat (Rattus norvegicus) and the African giant rat (Cricetomys gambianus, Waterhouse). Comparative biochemistry and physiology. C: Comparative pharmacology. 1980;66C:105–109.

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Groopman J. D., Busby W. F., Wogan G. N.. Nuclear distribution of aflatoxin B1 and its interaction with histones in rat liver in vivo. Cancer research. 1980;40:4343–4351.

Lutz W. K., Jaggi W., Lüthy J., Sagelsdorff P., Schlatter C.. In vivo covalent binding of aflatoxin B1 and aflatoxin M1 to liver DNA of rat, mouse and pig. Chemico-biological interactions. 1980;32:249–256.

Bryden W. L., Cumming R. B.. Observations on the liver of the chicken following aflatoxin B1 ingestion. Avian pathology : journal of the W.V.P.A. 1980;9:551–556.

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Thabrew M. I., Bababunmi E. A.. Levels of microsomal drug-metabolizing enzymes in animals which are highly susceptible to aflatoxin carcinogenicity: the case of the duck. Cancer letters. 1980;9:333–338.

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Decad G. M., Dougherty K. K., Hsieh D. P., Byard J. L.. Metabolism of aflatoxin B1 in cultured mouse hepatocytes: comparison with rat and effects of cyclohexene oxide and diethyl maleate. Toxicology and applied pharmacology. 1979;50:429–436.

Cooper P.. Aflatoxins and the liver. Food and cosmetics toxicology. 1979;17:408–409.

Schaeffer W. I., Chuang A. H., Heintz N., Bresnick E.. Sensitivity of cultured rat hepatocytes to aflatoxin B1 and benzo(a)pyrene. In vitro. 1979;15:437–440.

Neal G. E., Colley P. J.. The formation of 2,3-dihydro-2,3-dihydroxy aflatoxin B1 by the metabolism of aflatoxin B1 in vitro by rat liver microsomes. FEBS letters. 1979;101:382–386.

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Nishiyama S., Kurebe M.. Effect of aflatoxin B1 on the ultrastructural and biochemical development of chick embryo liver during organ culture. The Journal of toxicological sciences. 1979;4:19–29.

Norpoth K., Grossmeier R., Bösenberg H., Themann H., Fleischer M.. Mutagenicity of aflatoxin B1, activated by S-9 fractions of human, rat, mouse, rabbit, and monkey liver, towards S. typhimurium TA 98. International archives of occupational and environmental health. 1979;42:333–339.

Desaiah D., Phillips T. D., Hayes A. W., Ho I. K.. Effects of the aflatoxins on ATPase activities in mouse and rat liver. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1979;14:265–278.

Campbell T. C., Hayes J. R., Newberne P. M.. Dietary lipotropes, hepatic microsomal mixed-function oxidase activities, and in vivo covalent binding of aflatoxin B1 in rats. Cancer research. 1978;38:4569–4573.

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Arora H. L., Butler W. H.. Histopathology, autoradiography and microphotometry of the rat liver after feeding with aflatoxin B1. Indian journal of cancer. 1978;15:8–13.

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Gurtoo H. L., Dahms R. P., Kanter P., Vaught J. B.. Association and dissociation of the Ah locus with the metabolism of aflatoxin B1 by mouse liver. Co-segregation of aflatoxin B1 hydroxylase induction with aryl hydrocarbon (benzo(a)pyrene) hydroxylase induction. The Journal of biological chemistry. 1978;253:3952–3961.

Buening M. K., Fortner J. G., Kappas A., Corney A. H.. 7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver. Biochemical and biophysical research communications. 1978;82:348–355.

Roebuck B. D., Siegel W. G., Wogan G. N.. In vitro metabolism of aflatoxin B2 by animal and human liver. Cancer research. 1978;38:999–1002.

Obidoa O., Siddiqui H. T.. Aflatoxin inhibition of avian hepatic mitochondria. Biochemical pharmacology. 1978;27:547–550.

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