Aflatoxin Literature: Glutathione Effects

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Wang Y, Liu L, Huang J, Duan Y, Wang J, Fu M, Lin H. Response of a Mu-class glutathione S-transferase from black tiger shrimp Penaeus monodon to aflatoxin B1 exposure. Springerplus. 2016 Jun 22;5(1):825. PMID: 27386274

Paul S, Jakhar R, Bhardwaj M, Kang SC. Glutathione-S-transferase omega 1 (GSTO1-1) acts as mediator of signaling pathways involved in aflatoxin B1-induced apoptosis-autophagy crosstalk in macrophages. Free Radic Biol Med. 2015 Dec;89:1218-30. PMID: 26561775

Hernandez-Vargas H, Castelino J, Silver MJ, Dominguez-Salas P, Cros MP, Durand G, Le Calvez-Kelm F, Prentice AM, Wild CP, Moore SE, Hennig BJ, Herceg Z, Gong YY, Routledge MN. Exposure to aflatoxin B1 in utero is associated with DNA methylation in white blood cells of infants in The Gambia. Int J Epidemiol. 2015 Aug;44(4):1238-48. PMID: 25855716

Kim Ji Eun E., Bunderson Brett R., Croasdell Amanda, Reed Kent M., Coulombe Roger A.. Alpha-class glutathione S-transferases in wild turkeys (Meleagris gallopavo): characterization and role in resistance to the carcinogenic mycotoxin aflatoxin B1. PloS one. 2013;8.

Wu HC, Wang Q, Yang HI, Tsai WY, Chen CJ, Santella RM. Global DNA methylation in a population with aflatoxin B1 exposure. Epigenetics. 2013 Sep;8(9):962-9. PMID: 23867725

Ilic Zoran, Crawford Dana, Vakharia Dilip, Egner Patricia A., Sell Stewart. Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1. Toxicology and applied pharmacology. 2010;242:241–246.

Gao Shang Shang S., Chen Xiao Yan Y., Zhu Ri Zhe Z., Choi Byung-Min M., Kim Bok-Ryang R.. Sulforaphane induces glutathione S-transferase isozymes which detoxify aflatoxin B(1)-8,9-epoxide in AML 12 cells. BioFactors (Oxford, England). 2010;36:289–296.

Huang J-Q Q., Jiang H-F F., Zhou Y-Q Q., Lei Y., Wang S-Y Y., Liao B-S S.. Ethylene inhibited aflatoxin biosynthesis is due to oxidative stress alleviation and related to glutathione redox state changes in Aspergillus flavus. International journal of food microbiology. 2009;130:17–21.

Ziglari Tahereh, Allameh Abdolamir, Razzaghi-Abyaneh Mehdi, Khosravi Ali-Reza R., Yadegari Mohammad-Hossein H.. Comparison of glutathione S-transferase activity and concentration in aflatoxin-producing and their non-toxigenic counterpart isolates. Mycopathologia. 2008;166:219–226.

Tulayakul P., Sakuda S., Dong K. S., Kumagai S.. Comparative activities of glutathione-S-transferase and dialdehyde reductase toward aflatoxin B1 in livers of experimental and farm animals. Toxicon. 2005;46:204–209.

Strelić Natasa J., Saicić Zorica S., Magić Zvonko M., Spasić Mihajlo B., Trutić Natasa V., Krtolica Koviljka V.. Aflatoxin B1-induced changes of glutathione-S-transferase activity in the plasma and liver of the rat. Vojnosanitetski pregled. Military-medical and pharmaceutical review. 2003;60:415–420.

Jowsey Ian R., Jiang Qing, Itoh Ken, Yamamoto Masayuki, Hayes John D.. Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element. Molecular pharmacology. 2003;64:1018–1028.

Esaki H., Kumagai S.. Glutathione-S-transferase activity toward aflatoxin epoxide in livers of mastomys and other rodents. Toxicon. 2002;40:941–945.

Sahu S. C., Chou M. W., Sotomayor R. E., Hinton D. M., Barton C. N., O’Donnell M. W.. Effects of intermittent exposures of aflatoxin B(1) on hepatic and testicular glutathione S-transferase in rats. Journal of applied toxicology : JAT. 2000;20:215–219.

Allameh A., Farahani M., Zarghi A.. Kinetic studies of aflatoxin B1-glutathione conjugate formation in liver and kidneys of adult and weanling rats. Mechanisms of ageing and development. 2000;115:73–83.

Sotomayor R. E., Sahu S., Washington M., Hinton D. M., Chou M.. Temporal patterns of DNA adduct formation and glutathione S-transferase activity in the testes of rats fed aflatoxin B1: a comparison with patterns in the liver. Environmental and molecular mutagenesis. 1999;33:293–302.

Loe D. W., Stewart R. K., Massey T. E., Deeley R. G., Cole S. P.. ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene. Molecular pharmacology. 1997;51:1034–1041.

McHugh T. E., Atkins W. M., Racha J. K., Kunze K. L., Eaton D. L.. Binding of the aflatoxin-glutathione conjugate to mouse glutathione S-transferase A3-3 is saturated at only one ligand per dimer. The Journal of biological chemistry. 1996;271:27470–27474.

Stewart R. K., Serabjit-Singh C. J., Massey T. E.. Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B1 in rabbit lung and liver. Toxicology and applied pharmacology. 1996;140:499–507.

Griffiths S. A., Good V. M., Gordon L. A., et al. Characterization of a promoter for gamma-glutamyl transpeptidase activated in rat liver in response to aflatoxin B1 and ethoxyquin. Molecular carcinogenesis. 1995;14:251–262.

Kelley M. K., Bjeldanes L. F.. Modulation of glutathione S-transferase activity and isozyme pattern in liver and small intestine of rats fed goitrin- and T3-supplemented diets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1995;33:129–137.

Ankrah N. A., Sittie A., Addo P. G., Ekuban F. A.. Enhanced depletion of glutathione and increased liver oxidative damage in aflatoxin-fed mice infected with Plasmodium berghei. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1995;89:59–61.

Gopalan-Kriczky P., Jensen D. E., Lotlikar D.. Conjugation of microsome generated and synthetic aflatoxin B1-8,9 epoxide and styrene oxide to glutathione by purified glutathione S-transferases from hamster and mouse livers. Cancer letters. 1994;86:83–90.

McLellan L. I., Judah D. J., Neal G. E., Hayes J. D.. Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors. The Biochemical journal. 1994;300 ( Pt 1):117–124.

Gopalan-Kriczky P., Hiruma S., Lotlikar P. D.. Effect of glutathione levels on aflatoxin B1-DNA binding in livers and kidneys of male rats and hamsters pretreated with buthionine sulfoximine and dimethylmaleate. Cancer letters. 1994;76:25–30.

Buetler T. M., Slone D., Eaton D. L.. Comparison of the aflatoxin B1-8,9-epoxide conjugating activities of two bacterially expressed alpha class glutathione S-transferase isozymes from mouse and rat. Biochemical and biophysical research communications. 1992;188:597–603.

Behroozikha M., Saidee M., Allameh A.. Comparison of aflatoxin B1-DNA binding and glutathione conjugate formation by liver preparations from rats of different ages. Cancer letters. 1992;66:69–76.

Gopalan P., Jensen D. E., Lotlikar P. D.. Glutathione conjugation of microsome-mediated and synthetic aflatoxin B1-8,9-oxide by purified glutathione S-transferases from rats. Cancer letters. 1992;64:225–233.

Raney K. D., Meyer D. J., Ketterer B., Harris T. M., Guengerich F. P.. Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases. Chemical research in toxicology. 1992;5:470–478.

Hayes J. D., Judah D. J., McLellan L. I., Kerr L. A., Peacock S. D., Neal G. E.. Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide. The Biochemical journal. 1991;279 ( Pt 2):385–398.

Borroz K. I., Ramsdell H. S., Eaton D. L.. Mouse strain differences in glutathione S-transferase activity and aflatoxin B1 biotransformation. Toxicology letters. 1991;58:97–105.

Hayes J. D., Judah D. J., McLellan L. I., Neal G. E.. Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1. Pharmacology & therapeutics. 1991;50:443–472.

Hayes J. D., Kerr L. A., Harrison D. J., Cronshaw A. D., Ross A. G., Neal G. E.. Preferential over-expression of the class alpha rat Ya2 glutathione S-transferase subunit in livers bearing aflatoxin-induced pre-neoplastic nodules. Comparison of the primary structures of Ya1 and Ya2 with cloned class alpha glutathione S-transferase cDNA sequences. The Biochemical journal. 1990;268:295–302.

Ramsdell H. S., Eaton D. L.. Mouse liver glutathione S-transferase isoenzyme activity toward aflatoxin B1-8,9-epoxide and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide. Toxicology and applied pharmacology. 1990;105:216–225.

Harrison D. J., May L., Hayes J. D., Neal G. E.. Glutathione S-transferase localization in aflatoxin B1-treated rat livers. Carcinogenesis. 1990;11:927–931.

Carrillo M. C., Carnovale C. E., Monti J. A.. Effect of aflatoxin B1 treatment in vivo on the in vitro activity of hepatic and extrahepatic glutathione S-transferase. Toxicology letters. 1990;50:107–116.

Rajpurohit R., Krishnaswamy K.. Differences in response of glucuronide and glutathione conjugating enzymes to aflatoxin B1 and N-acetylaminofluorene in underfed rats. Journal of toxicology and environmental health. 1988;24:103–109.

Valsta L. M., Hendricks J. D., Bailey G. S.. The significance of glutathione conjugation for aflatoxin B1 metabolism in rainbow trout and coho salmon. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1988;26:129–135.

Neal G. E., Nielsch U., Judah D. J., Hulbert P. B.. Conjugation of model substrates or microsomally-activated aflatoxin B1 with reduced glutathione, catalysed by cytosolic glutathione-S-transferases in livers of rats, mice and guinea pigs. Biochemical pharmacology. 1987;36:4269–4276.

Power C., Sinha S., Webber C., Manson M. M., Neal G. E.. Transformation related expression of glutathione-S-transferase P in rat liver cells. Carcinogenesis. 1987;8:797–801.

Power C. A., Griffiths S. A., Simpson J. L., Laperche Y., Guellaen G., Manson M. M.. Induction of gamma-glutamyl transpeptidase mRNA by aflatoxin B1 and ethoxyquin in rat liver. Carcinogenesis. 1987;8:737–740.

Manson M. M., Neal G. E.. The effect of feeding aflatoxin-contaminated groundnut meal, with or without ammoniation, on the development of gamma-glutamyl transferase positive lesions in the livers of Fischer 344 rats. Food additives and contaminants. 1987;4:141–147.

Coles B., Meyer D. J., Ketterer B., Stanton C. A., Garner R. C.. Studies on the detoxication of microsomally-activated aflatoxin B1 by glutathione and glutathione transferases in vitro. Carcinogenesis. 1985;6:693–697.

Moss E. J., Neal G. E., Judah D. J.. The mercapturic acid pathway metabolites of a glutathione conjugate of aflatoxin B1. Chemico-biological interactions.1985;55:139–155.

Godlewski C. E., Boyd J. N., Sherman W. K., Anderson J. L., Stoewsand G. S.. Hepatic glutathione S-transferase activity and aflatoxin B1-induced enzyme altered foci in rats fed fractions of brussels sprouts. Cancer letters. 1985;28:151–157.

Lotlikar P. D., Jhee E. C., Insetta S. M., Clearfield M. S.. Modulation of microsome-mediated aflatoxin B1 binding to exogenous and endogenous DNA by cytosolic glutathione S-transferases in rat and hamster livers. Carcinogenesis. 1984;5:269–276.

Moss E. J., Judah D. J., Przybylski M., Neal G. E.. Some mass-spectral and n.m.r. analytical studies of a glutathione conjugate of aflatoxin B1. The Biochemical journal. 1983;210:227–233.

Clark J. D., Hatch R. C., Jain A. V., Weiss R.. Effect of enzyme inducers and inhibitors and glutathione precursor and depleter on induced acute aflatoxicosis in rabbits. American journal of veterinary research. 1982;43:1027–1033.

Emerole G. O.. Excretion of aflatoxin B1 as a glutathione conjugate. European journal of drug metabolism and pharmacokinetics. 1981;6:265–268.

Lotlikar P. D., Insetta S. M., Lyons P. R., Jhee E. C.. Inhibition of microsome-mediated binding of aflatoxin B1 to DNA by glutathione S-transferase. Cancer letters. 1980;9:143–149.

Degen G. H., Neumann H. G.. The major metabolite of aflatoxin B1 in the rat is a glutathione conjugate. Chemico-biological interactions. 1978;22:239–255.

Raj H. G., Santhanam K., Gupta R. P., Venkitasubramanian T. A.. Oxidative metabolism of aflatoxin B1: observations on the formation of epoxide-glutathione conjugate. Chemico-biological interactions. 1975;11:301–305.