Aflatoxin Literature: Genetic Effects

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Dai Y, Huang K, Zhang B, Zhu L, Xu W. Aflatoxin B1-induced epigenetic alterations: An overview. Food Chem Toxicol. 2017 Jun 20 PMID: 28645871

Iatropoulos MJ, Kobets T, Duan JD, Brunnemann KD, Vock E, Deschl U, Williams GM. Chicken egg fetal liver DNA and histopathologic effects of structurally diverse carcinogens and non-carcinogens. Exp Toxicol Pathol. 2017 May 11. PMID: 28502747

Feng WH, Xue KS, Tang L, Williams PL, Wang JS. Aflatoxin B₁-Induced Developmental and DNA Damage in Caenorhabditis elegans. Toxins (Basel). 2016 Dec 26;9(1). PMID: 28035971

Lin YC, Owen N, Minko IG, Lange SS, Li L, Stone MP, Wood RD, McCullough AK, Lloyd RS. DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13774-13779. PMID: 27849610

Bakheet SA, Alhuraishi AM, Al-Harbi NO, Al-Hosaini KA, Al-Sharary SD, Attia MM, Alhoshani AR, Al-Shabanah OA, Al-Harbi MM, Imam F, Ahmad SF, Attia SM. Alleviation of Aflatoxin B1-Induced Genomic Damage by Proanthocyanidins via Modulation of DNA Repair. J Biochem Mol Toxicol. 2016 Nov;30(11):559-566. PMID: 27301782

Zimmermann CE, Cruz IB, Cadoná FC, Machado AK, Assmann C, Schlemmer KB, Zanette RA, Leal DB, Santurio JM. Cytoprotective and genoprotective effects of β-glucans against aflatoxin B₁-induced DNA damage in broiler chicken lymphocytes. Toxicol In Vitro. 2015 Apr;29(3):538-43. PMID: 25615424

Jiang M, Fang J, Peng X, Cui H, Yu Z. Effect of aflatoxin B₁ on IgA⁺ cell number and immunoglobulin mRNA expression in the intestine of broilers. Immunopharmacol Immunotoxicol. 2015;37(5):450-7. PMID: 26357012

Mulder JE, Bondy GS, Mehta R, Massey TE. The impact of chronic Aflatoxin B1 exposure and p53 genotype on base excision repair in mouse lung and liver. Mutat Res. 2015 Mar;773:63-8. PMID: 25847422

Buick JK, Moffat I, Williams A, Swartz CD, Recio L, Hyduke DR, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL. Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells. Environ Mol Mutagen. 2015 Jul;56(6):520-34. PMID: 25733247

Fasullo M, Smith A, Egner P, Cera C. Activation of aflatoxin B1 by expression of human CYP1A2 polymorphisms in Saccharomyces cerevisiae. Mutat Res Genet Toxicol Environ Mutagen. 2014 Feb;761:18-26. PMID: 24472830

Kensler KH, Slocum SL, Chartoumpekis DV, Dolan PM, Johnson NM, Ilic Z, Crawford DR, Sell S, Groopman JD, Kensler TW, Egner PA. Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice. Toxicol Sci. 2014 Jun;139(2):293-300. PMID: 24675090

Valencia-Quintana R, Sánchez-Alarcón J, Tenorio-Arvide MG, Deng Y, Montiel-González JM, Gómez-Arroyo S, Villalobos-Pietrini R, Cortés-Eslava J, Flores-Márquez AR, Arenas-Huertero F. The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review. Front Microbiol. 2014 Mar 18;5:102. PMID: 24672518

Yang W, Lian J, Feng Y, Srinivas S, Guo Z, Zhong H, Zhuang Z, Wang S. Genome-wide miRNA-profiling of aflatoxin B1-induced hepatic injury using deep sequencing. Toxicol Lett. 2014 Apr 21;226(2):140-9. PMID: 24472605

Mulder JE, Bondy GS, Mehta R, Massey TE. Up-regulation of nucleotide excision repair in mouse lung and liver following chronic exposure to aflatoxin B₁ and its dependence on p53 genotype. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):96-103. PMID: 24380836

Forouharmehr A, Harkinezhad T, Qasemi-Panahi B. Evaluation of STAT5A Gene Expression in Aflatoxin B1 Treated Bovine Mammary Epithelial Cells. Adv Pharm Bull. 2013;3(2):461-4. PMID: 24312879

Yang L, Ji J, Chen Z, Wang H, Li J. Transcriptome profiling of malignant transformed rat hepatic stem-like cells by aflatoxin B1. Neoplasma. 2014;61(2):193-204. PMID: 2429931

Abu-Bakar A’edah, Hakkola Jukka, Juvonen Risto, Rahnasto-Rilla Minna, Raunio Hannu, Lang Matti A.. Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver. Current drug metabolism. 2013;14:137–150.

Wu Hui-Chen C., Wang Qiao, Yang Hwai-I I., Tsai Wei-Yann Y., Chen Chien-Jen J., Santella Regina M.. Global DNA methylation in a population with aflatoxin B 1 exposure. Epigenetics. 2013;8.

Souza Wagner R., Morais Enyara Rezende R., Krohn Nadia Graciele G., et al. Identification of Metabolic Pathways Influenced by the G-Protein Coupled Receptors GprB and GprD in Aspergillus nidulans. PloS one. 2013;8.

Poirier Miriam C.. Chemical-induced DNA damage and human cancer risk. Discovery medicine. 2012;14:283–288.

Hanioka Nobumitsu, Nonaka Yuko, Saito Keita, et al. Effect of aflatoxin B1 on UDP-glucuronosyltransferase mRNA expression in HepG2 cells. Chemosphere. 2012;89:526–529.

Ghaderi Masoumeh, Allameh Abdolamir, Soleimani Masoud, Rastegar Hossein, Ahmadi-Ashtiani Hamid Reza R.. A comparison of DNA damage induced by aflatoxin B1 in hepatocyte-like cells, their progenitor mesenchymal stem cells and CD34(+) cells isolated from umbilical cord blood. Mutation research. 2011;719:14–20.

Corcuera L. A., Arbillaga L., Vettorazzi A., Azqueta A., Cerain A.. Ochratoxin A reduces aflatoxin B1 induced DNA damage detected by the comet assay in Hep G2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011;49:2883–2889.

Lambert Marie-Pierre P., Paliwal Anupam, Vaissière Thomas, et al. Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. Journal of hepatology. 2011;54:705–715.

Paini Alicia, Scholz Gabriele, Marin-Kuan Maricel, et al. Quantitative comparison between in vivo DNA adduct formation from exposure to selected DNA-reactive carcinogens, natural background levels of DNA adduct formation and tumour incidence in rodent bioassays. Mutagenesis. 2011;26:605–618.

Fiala Jeannette L., Egner Patricia A., Wiriyachan Nirachara, et al. Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex. Toxicological sciences : an official journal of the Society of Toxicology. 2011;121:57–62.

Williams J. G., Deschl U., Williams G. M.. DNA damage in fetal liver cells of turkey and chicken eggs dosed with aflatoxin B1. Archives of toxicology. 2011;85:1167–1172.

Banitaba Mohammad Hossein H., Davarani Saied Saeed Hosseiny S., Mehdinia Ali. Study of interactions between DNA and aflatoxin B1 using electrochemical and fluorescence methods. Analytical biochemistry. 2011;411:218–222.

Ratajewski Marcin, Walczak-Drzewiecka Aurelia, SaŃkowska Anna, Dastych JarosŃaw. Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. Toxicology letters. 2011;205:146–153.

Chen Tao, Heflich Robert H., Moore Martha M., Mei Nan. Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice. Environmental and molecular mutagenesis. 2010;51:156–163.

Madrigal-Santillán Eduardo, Morales-González José A., Vargas-Mendoza Nancy, et al. Antigenotoxic studies of different substances to reduce the DNA damage induced by aflatoxin B(1) and ochratoxin A. Toxins. 2010;2:738–757.

Ranchal Isidora, González Raúl, Bello Rosario I., et al. The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity. International journal of cancer. Journal international du cancer. 2009;125:2270–2280.

Praml Christian, Schulz Wolfgang, Claas Andreas, et al. Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells. Cancer letters. 2008;272:160–166.

Miranda D. D., Arçari D. P., Ladeira M. S., et al. Analysis of DNA damage induced by aflatoxin B1 in Dunkin-Hartley guinea pigs. Mycopathologia. 2007;163:275–280.

Asare George A., Bronz Michelle, Naidoo Vivash, Kew Michael C.. Interactions between aflatoxin B1 and dietary iron overload in hepatic mutagenesis. Toxicology. 2007;234:157–166.

Bedard Leanne L., Massey Thomas E.. Aflatoxin B1-induced DNA damage and its repair. Cancer letters. 2006;241:174–183.

Madhusudhanan N., Kavithalakshmi S. N., Shanmugasundaram E. R., Shanmugasundaram K. R.. Aflatoxin B1-induced DNA damage in Labeo rohita: protective effect of an antioxidant supplement, Amrita Bindu. Basic & clinical pharmacology & toxicology. 2006;98:473–479.

Reddy Lalini, Odhav Bharti, Bhoola Kanti. Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage. Biological chemistry. 2006;387:87–93.

Guo Yingying, Breeden Linda L., Fan Wenhong, Zhao Lue Ping P., Eaton David L., Zarbl Helmut. Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarrays. Mutation research. 2006;593:121–142.

Guo Yingying, Breeden Linda L., Zarbl Helmut, Preston Bradley D., Eaton David L.. Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage. Molecular and cellular biology. 2005;25:5823–5833.

Turner Paul C., Sylla Abdoulaye, Kuang Shuang-Yuan Y., et al. Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposure. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2005;14:2053–2055.

Wojnowski Leszek, Turner Paul C., Pedersen Bonnie, et al. Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa. Pharmacogenetics. 2004;14:691–700.

Chan Kin-Tak T., Hsieh Dennis Paul Hsientang P., Lung Maria Li L.. In vitro aflatoxin B1-induced p53 mutations. Cancer letters. 2003;199:1–7.

Wild C. P., Yin F., Turner P. C., et al. Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia. International journal of cancer. Journal international du cancer. 2000;86:1–7.

Knight L. P., Primiano T., Groopman J. D., Kensler T. W., Sutter T. R.. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3. Carcinogenesis. 1999;20:1215–1223.

Wang S. S., O’Neill J. P., Qian G. S., et al. Elevated HPRT mutation frequencies in aflatoxin-exposed residents of daxin, Qidong county, People’s Republic of China. Carcinogenesis. 1999;20:2181–2184.

Stanley L. A., Mandel H. G., Riley J., et al. Mutations associated with in vivo aflatoxin B1-induced carcinogenesis need not be present in the in vitro transformations by this toxin. Cancer letters. 1999;137:173–181.

Han S. H., Jeon Y. J., Yea S. S., Yang K. H.. Suppression of the interleukin-2 gene expression by aflatoxin B1 is mediated through the down-regulation of the NF-AT and AP-1 transcription factors. Toxicology letters. 1999;108:1–10.

Lunn R. M., Langlois R. G., Hsieh L. L., Thompson C. L., Bell D. A.. XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer research. 1999;59:2557–2561.

Denissenko M. F., Cahill J., Koudriakova T. B., Gerber N., Pfeifer G. P.. Quantitation and mapping of aflatoxin B1-induced DNA damage in genomic DNA using aflatoxin B1-8,9-epoxide and microsomal activation systems. Mutation research. 1999;425:205–211.

Wang J. S., Groopman J. D.. DNA damage by mycotoxins. Mutation research. 1999;424:167–181.

Raj H. G., Parmar V. S., Jain S. C., et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B1-DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin. Bioorganic & medicinal chemistry. 1998;6:1895–1904.

Troxel C. M., Buhler D. R., Hendricks J. D., Bailey G. S.. CYP1A induction by beta-naphthoflavone, Aroclor 1254, and 2,3,7,8-tetrachlorodibenzo-p-dioxin and its influence on aflatoxin B1 metabolism and DNA adduction in zebrafish. Toxicology and applied pharmacology. 1997;146:69–78.

Hong S. W., Park C.. The effect of aflatoxin B1 on the expression of early response genes and transforming growth factor-alpha in CCl4 induced rat liver injury. Yonsei medical journal. 1997;38:167–177.

Kobertz W. R., Wang D., Wogan G. N., Essigmann J. M.. An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot. Proceedings of the National Academy of Sciences of the United States of America. 1997;94:9579–9584.

Bailey E. A., Iyer R. S., Stone M. P., Harris T. M., Essigmann J. M.. Mutational properties of the primary aflatoxin B1-DNA adduct. Proceedings of the National Academy of Sciences of the United States of America. 1996;93:1535–1539.

Allan J. M., Routledge M. N., Garner R. C.. The Escherichia coli DNA repair protein UvrA can re-associate with the UvrB: aflatoxin B1-DNA complex in vitro. Mutation research. 1996;362:261–268.

Yu F. L., Cahill J. M., Lipinski L. J., Dipple A.. Effect of aflatoxin B1-8,9-epoxide-DNA adducts on transcription of a supF gene fragment. Cancer letters. 1996;109:77–83.

Liu Y. P., Lin Y., Ng M. L.. Immunochemical and genetic analysis of the p53 gene in liver preneoplastic nodules from aflatoxin-induced rats in one year. Annals of the Academy of Medicine, Singapore. 1996;25:31–36.

Takahashi N., Harttig U., Williams D. E., Bailey G. S.. The model Ah-receptor agonist beta-naphthoflavone inhibits aflatoxin B1-DNA binding in vivo in rainbow trout at dietary levels that do not induce CYP1A enzymes. Carcinogenesis. 1996;17:79–87.

Gallagher E. P., Kunze K. L., Stapleton P. L., Eaton D. L.. The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicology and applied pharmacology. 1996;141:595–606.

Raj H. G., Gupta S., Biswas G., et al. Chemoprevention of carcinogen-DNA binding: the relative role of different oxygenated substituents on 4-methylcoumarins in the inhibition of aflatoxin B1-DNA binding in vitro. Bioorganic & medicinal chemistry. 1996;4:2225–2228.

Webster R. P., Gawde M. D., Bhattacharya R. K.. Modulation by dietary copper of aflatoxin B1-induced activity of DNA repair enzymes poly (ADP-ribose) polymerase, DNA polymerase beta and DNA ligase. In vivo (Athens, Greece). 1996;10:533–536.

Hsieh D. P., Atkinson D. N.. Recent aflatoxin exposure and mutation at codon 249 of the human p53 gene: lack of association. Food additives and contaminants. 1995;12:421–424.

Kono M., Kumagai S.. In vitro microsome-mediated aflatoxin B1-DNA binding and its inhibition by cytosol of various organs of the hamster and quail. Mycopathologia. 1995;132:117–119.

Shibahara T., Ogawa H. I., Ryo H., Fujikawa K.. DNA-damaging potency and genotoxicity of aflatoxin M1 in somatic cells in vivo of Drosophila melanogaster. Mutagenesis. 1995;10:161–164.

Neal G. E.. Genetic implications in the metabolism and toxicity of mycotoxins. Toxicology letters. 1995;82-83:861–867.

Takahashi N., Miranda C. L., Henderson M. C., Buhler D. R., Williams D. E., Bailey G. S.. Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: alpha-naphthoflavone, beta-naphthoflavone and trout CYP1A1 peptide antibody. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. 1995;110:273–280.

Bailey G. S., Loveland P. M., Pereira C., Pierce D., Hendricks J. D., Groopman J. D.. Quantitative carcinogenesis and dosimetry in rainbow trout for aflatoxin B1 and aflatoxicol, two aflatoxins that form the same DNA adduct. Mutation research. 1994;313:25–38.

Sengstag C., Würgler F. E.. DNA recombination induced by aflatoxin B1 activated by cytochrome P450 1A enzymes. Molecular carcinogenesis. 1994;11:227–235.

Anwar W. A., Khalil M. M., Wild C. P.. Micronuclei, chromosomal aberrations and aflatoxin-albumin adducts in experimental animals after exposure to aflatoxin B1. Mutation research. 1994;322:61–67.

Cariello N. F., Cui L., Skopek T. R.. In vitro mutational spectrum of aflatoxin B1 in the human hypoxanthine guanine phosphoribosyltransferase gene. Cancer research. 1994;54:4436–4441.

Müller K., Kasper P., Müller L.. Lack of AFB(1)-induced mutagenicity in the in vitro hepatocyte micronucleus assay: Investigation of possible mechanisms. Toxicology in vitro : an international journal published in association with BIBRA. 1994;8:533–534.

Courtemanche C., Anderson A.. Shuttle-vector mutagenesis by aflatoxin B1 in human cells: effects of sequence context on the supF mutational spectrum. Mutation research. 1994;306:143–151.

Tseng T., Chu C., Wang C.. Comparison of geniposide and its acetylated derivative for the inhibition of aflatoxin b1-induced DNA-repair synthesis in rat primary hepatocyte. Oncology reports. 1994;1:165–168.

Gallagher E. P., Wienkers L. C., Stapleton P. L., Kunze K. L., Eaton D. L.. Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1. Cancer research. 1994;54:101–108.

Hamilton J. W., Louis C. A., Doherty K. A., Hunt S. R., Reed M. J., Treadwell M. D.. Preferential alteration of inducible gene expression in vivo by carcinogens that induce bulky DNA lesions. Molecular carcinogenesis. 1993;8:34–43.

Larson P. S., McMahon G., Wogan G. N.. Modulation of c-myc gene expression in rat livers by aflatoxin B1 exposure and age. Fundamental and applied toxicology. 1993;20:316–324.

Raney V. M., Harris T. M., Stone M. P.. DNA conformation mediates aflatoxin B1-DNA binding and the formation of guanine N7 adducts by aflatoxin B1 8,9-exo-epoxide. Chemical research in toxicology. 1993;6:64–68.

Taylor E. R.. Aflatoxin B1 and DNA adducts. Proposed model for surface noncovalent and covalent complexes with N(7) of guanine. II. Journal of biomolecular structure & dynamics. 1992;10:533–550.

Imaoka S., Ikemoto S., Shimada T., Funae Y.. Mutagenic activation of aflatoxin B1 by pulmonary, renal, and hepatic cytochrome P450s from rats. Mutation research. 1992;269:231–236.

Royal I., Gourdeau H., Blouin R., Marceau N.. Down-regulation of cytokeratin 14 mRNA in polyoma virus middle T-transformed rat liver epithelial cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1992;3:589–596.

Tjälve H., Larsson P., Andersson C., Busk L.. Bioactivation of aflatoxin B1 in the bovine olfactory mucosa: DNA binding, mutagenicity and induction of sister chromatid exchanges. Carcinogenesis. 1992;13:1345–1350.

Norred W. P., Plattner R. D., Vesonder R. F., Bacon C. W., Voss K. A.. Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1992;30:233–237.

Trottier Y., Waithe W. I., Anderson A.. Kinds of mutations induced by aflatoxin B1 in a shuttle vector replicating in human cells transiently expressing cytochrome P4501A2 cDNA. Molecular carcinogenesis. 1992;6:140–147.

Sawada M., Kitamura R., Kamataki T.. Stable expression of monkey cytochrome P-450IA1 cDNA in Chinese hamster CHL cells and its application for detection of mutagenicity of aflatoxin B1. Mutation research. 1992;265:23–29.

Groopman J. D., Roebuck B. D., Kensler T. W.. Molecular dosimetry of aflatoxin DNA adducts in humans and experimental rat models. Progress in clinical and biological research. 1992;374:139–155.

Bose S., Sinha S. P.. Aflatoxin-induced structural chromosomal changes and mitotic disruption in mouse bone marrow. Mutation research. 1991;261:15–19.

Zeilmaker M. J., Teylingen C. M., Helten J. B., Mohn G. R.. The use of EDTA-permeabilized E. coli cells as indicators of aflatoxin B1-induced differential lethality in the DNA repair host-mediated assay. Mutation research. 1991;263:137–142.

Rubano D. C., Teel R. W., Strother A.. Effect of glucose administration on hamster liver S9-mediated mutagenesis, metabolism and DNA-binding of benzo[a]pyrene and aflatoxin B1. Cancer letters. 1990;52:123–131.

Zawahri M. M., Morad M. M., Khishin A. F.. Mutagenic effect of aflatoxin G1 in comparison with B1. Journal of environmental pathology, toxicology and oncology. 1990;10:45–51.

Yoshizawa H., Uchimaru R., Ito T., Tashiro F., Ueno Y.. Nuclear envelope-dependent binding of aflatoxin B1 to DNA. Journal of environmental pathology, toxicology and oncology. 1990;10:79–88.

Steinberg P., Schlemper B., Molitor E., Platt K. L., Seidel A., Oesch F.. Rat liver endothelial and Kupffer cell-mediated mutagenicity of polycyclic aromatic hydrocarbons and aflatoxin B1. Environmental health perspectives. 1990;88:71–76.

Mallett A. K., Bearne C. A., Lake B. G., Rowland I. R.. Modified mutagen activation in hepatic fractions from rats fed dietary rutin–interaction between gut flora and host metabolism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1989;27:607–611.

Delcuve G. P., Moyer R., Bailey G., Davie J. R.. Gene-specific differences in the aflatoxin B1 adduction of chicken erythrocyte chromatin. Cancer research. 1988;48:7146–7149.

Koser P. L., Faletto M. B., Maccubbin A. E., Gurtoo H. L.. The genetics of aflatoxin B1 metabolism. Association of the induction of aflatoxin B1-4-hydroxylase with the transcriptional activation of cytochrome P3-450 gene. The Journal of biological chemistry. 1988;263:12584–12595.

Stone M. P., Gopalakrishnan S., Harris T. M., Graves D. E.. Carcinogen-nucleic acid interactions: equilibrium binding studies of aflatoxins B1 and B2 with DNA and the oligodeoxynucleotide d(ATGCAT)2. Journal of biomolecular structure & dynamics. 1988;5:1025–1041.

Mashaly R. I., Habib S. L., Salem M. H., Deeb S. A., Safwat M. M., Sarhan F.. In vitro effect of aflatoxin B1 on the transcriptional activity of DNA template, chromatin and soluble DNA-dependent RNA polymerases in buffalo liver. Toxicology letters. 1988;41:69–75.

Yu F. L., Geronimo I. H., Bender W., Permthamsin J.. Correlation studies between the binding of aflatoxin B1 to chromatin components and the inhibition of RNA synthesis. Carcinogenesis. 1988;9:527–532.

Yu F. L., Bender W., Geronimo I. H.. The binding of aflatoxin B1 to rat liver nuclear proteins and its effect on DNA-dependent RNA synthesis. Carcinogenesis. 1988;9:533–540.

Shimada T., Nakamura S., Imaoka S., Funae Y.. Genotoxic and mutagenic activation of aflatoxin B1 by constitutive forms of cytochrome P-450 in rat liver microsomes. Toxicology and applied pharmacology. 1987;91:13–21.

Jacobsen J. S., Refolo L. M., Conley M. P., Sambamurti K., Humayun M. Z.. DNA replication-blocking properties of adducts formed by aflatoxin B1-2,3-dichloride and aflatoxin B1-2,3-oxide. Mutation research. 1987;179:89–101.

Groopman J. D., Kensler T. W.. The use of monoclonal antibody affinity columns for assessing DNA damage and repair following exposure to aflatoxin B1. Pharmacology & therapeutics. 1987;34:321–334.

Ishii K., Maeda K., Kamataki T., Kato R.. Mutagenic activation of aflatoxin B1 by several forms of purified cytochrome P-450. Mutation research. 1986;174:85–88.

Jacobsen J. S., Humayun M. Z.. Chloroperbenzoic acid induced DNA damage and peracid activation of alfatoxin B1. Carcinogenesis. 1986;7:491–493.

Yu F. L., Dowe R. J., Geronimo I. H., Bender W.. Evidence for an indirect mechanism of aflatoxin B1 inhibition of rat liver nuclear RNA polymerase II activity in vivo. Carcinogenesis. 1986;7:253–257.

Stĕtina R., Votava M.. Induction of DNA single-strand breaks and DNA synthesis inhibition by patulin, ochratoxin A, citrinin, and aflatoxin B1 in cell lines CHO and AWRF. Folia biologica. 1986;32:128–144.

Refolo L. M., Conley M. P., Sambamurti K., Jacobsen J. S., Humayun M. Z.. Sequence context effects in DNA replication blocks induced by aflatoxin B1. Proceedings of the National Academy of Sciences of the United States of America. 1985;82:3096–3100.

Pegram R. A., Wyatt R. D., Marks H. L.. Comparative responses of genetically resistant and nonselected Japanese quail to dietary aflatoxin. Poultry science. 1985;64:266–272.

Irvin T. R., Wogan G. N.. Quantitative and qualitative characterization of aflatoxin B1 adducts formed in vivo within the ribosomal RNA genes of rat liver DNA. Cancer research. 1985;45:3497–3502.

Mori H., Kitamura J., Sugie S., Kawai K., Hamasaki T.. Genotoxicity of fungal metabolites related to aflatoxin B1 biosynthesis. Mutation research. 1985;143:121–125.

Abdou R. F., Megalla S. E., Azab S. G.. Mutagenic effects of aflatoxin B-1 and G-1 on the Egyptian cotton leaf-worm, Spodoptera littoralis (Boisd.). Mycopathologia. 1984;88:23–26.

Amstad P., Levy A., Emerit I., Cerutti P.. Evidence for membrane-mediated chromosomal damage by aflatoxin B1 in human lymphocytes. Carcinogenesis. 1984;5:719–723.

Adzhigitov F. I., Kosichenko L. P., Popandopulo P. G., Gubeladze D. A., Dzhemilev Z. A.. [Incidence of chromosome aberrations in the bone marrow of monkeys and their progeny after exposure to aflatoxin B1]. T͡Sitologii͡a i genetika. 1984;18:173–176.

Walton D. G., Acton A. B., Stich H. F.. DNA repair synthesis following exposure to chemical mutagens in primary liver, stomach, and intestinal cells isolated from rainbow trout. Cancer research. 1984;44:1120–1121.

Rahimtula A. D., Martin M.. Dietary administration of 2(3)-t-butyl-4-hydroxyanisole elevates mouse liver microsome-mediated DNA binding and mutagenicity of aflatoxin B1. Chemico-biological interactions. 1984;48:207–220.

Adgigitov F. I., Kosichenko L. P., Popandopulo P. G., Gubeladze D. A., Djemilev Z. A.. Frequency of chromosome aberrations in bone marrow of monkeys and their F1 after aflatoxin B1 injection. Experimental pathology. 1984;26:163–169.

Bárta I., Adámková M., Markarjan D., Adzigitov F., Prokes K.. The mutagenic activity of aflatoxin B1 in the Cricetulus griseus hamster and Macaca mulatta monkey. Journal of hygiene, epidemiology, microbiology, and immunology. 1984;28:149–159.

Hamilton J. W., Bloom S. E.. Correlation between mixed-function oxidase enzyme induction and aflatoxin B1-induced unscheduled DNA synthesis in the chick embryo, in vivo. Environmental mutagenesis. 1984;6:41–48.

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Muench K. F., Misra R. P., Humayun M. Z.. Sequence specificity in aflatoxin B1–DNA interactions. Proceedings of the National Academy of Sciences of the United States of America. 1983;80:6–10.

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